|
dbAQP-SNP_ID |
Protein |
rsID |
Positioning of the amino acid |
Occurrence in the TM helical hundle |
Variation in the amino acid |
Implicated disease |
|---|
| 1 |
|
AQP0 |
rs1447833651 |
NP_036196.1 - 3 (TM1) |
Exposed to cytoplasm |
Glu (Charged) -> Lys (Charged) |
- |
| 2 |
|
AQP0 |
rs775392254 |
NP_036196.1 - 5 (TM1) |
Exposed to cytoplasm |
Arg (Charged) -> Gly (Small and Weakly Polar) |
- |
| 3 |
|
AQP0 |
rs1001940981 |
NP_036196.1 - 5 (TM1) |
Exposed to cytoplasm |
Arg (Charged) -> Pro (Proline) |
- |
| 4 |
|
AQP0 |
rs1001940981 |
NP_036196.1 - 5 (TM1) |
Exposed to cytoplasm |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 5 |
|
AQP0 |
rs201697509 |
NP_036196.1 - 7 (TM1) |
Exposed to cytoplasm |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 6 |
|
AQP0 |
rs745867500 |
NP_036196.1 - 7 (TM1) |
Exposed to cytoplasm |
Ala (Small and Weakly Polar) -> Pro (Proline) |
- |
| 7 |
|
AQP0 |
rs745867500 |
NP_036196.1 - 7 (TM1) |
Exposed to cytoplasm |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 8 |
|
AQP0 |
rs757336397 |
NP_036196.1 - 12 (TM1) |
Helix - helix interface (TM1 - TM2, TM1 - TM3) |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 9 |
|
AQP0 |
rs1267157493 |
NP_036196.1 - 13 (TM1) |
Helix - helix interface (TM1 - TM3) |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 10 |
|
AQP0 |
rs150017493 |
NP_036196.1 - 14 (TM1) |
Monomer - monomer interface |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 11 |
|
AQP0 |
rs758696671 |
NP_036196.1 - 15 (TM1) |
Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 12 |
|
AQP0 |
rs752998566 |
NP_036196.1 - 17 (TM1) |
Helix - helix interface (TM1 - TM3); Lipid facing |
Phe (Aromatic) -> Ile (Aliphatic hydrophobic) |
- |
| 13 |
|
AQP0 |
rs1161278653 |
NP_036196.1 - 21 (TM1) |
Helix - helix interface (TM1 - TM3) |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 14 |
|
AQP0 |
rs1421310753 |
NP_036196.1 - 22 (TM1) |
Monomer - monomer interface |
Phe (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 15 |
|
AQP0 |
rs1047944340 |
NP_036196.1 - 30 (TM1) |
Helix - helix interface (TM1 - TM2) |
Ser (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 16 |
|
AQP0 |
rs1475976365 |
NP_036196.1 - 30 (TM1) |
Helix - helix interface (TM1 - TM2) |
Ser (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 17 |
|
AQP0 |
rs139963297 |
NP_036196.1 - 33 (TM1) |
Monomer - monomer interface |
Arg (Charged) -> Pro (Proline) |
- |
| 18 |
|
AQP0 |
rs139963297 |
NP_036196.1 - 33 (TM1) |
Monomer - monomer interface |
Arg (Charged) -> His (Charged) |
- |
| 19 |
|
AQP0 |
rs864309693 |
NP_036196.1 - 33 (TM1) |
Monomer - monomer interface |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 20 |
|
AQP0 |
rs761428273 |
NP_036196.1 - 35 (Loop region after TM1) |
Loop A |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 21 |
|
AQP0 |
rs1337433964 |
NP_036196.1 - 36 (Loop region after TM1) |
Loop A |
Pro (Proline) -> Ala (Small and Weakly Polar) |
- |
| 22 |
|
AQP0 |
rs199567871 |
NP_036196.1 - 37 (Loop region after TM1) |
Loop A |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 23 |
|
AQP0 |
rs1203856217 |
NP_036196.1 - 38 (Loop region after TM1) |
Loop A |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 24 |
|
AQP0 |
rs1436119727 |
NP_036196.1 - 40 (Loop region after TM1) |
Loop A |
His (Charged) -> Arg (Charged) |
- |
| 25 |
|
AQP0 |
rs1436119727 |
NP_036196.1 - 40 (Loop region after TM1) |
Loop A |
His (Charged) -> Pro (Proline) |
- |
| 26 |
|
AQP0 |
rs188749994 |
NP_036196.1 - 45 (TM2) |
Helix - helix interface (TM2 - TM5) |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 27 |
|
AQP0 |
rs1216240733 |
NP_036196.1 - 45 (TM2) |
Helix - helix interface (TM2 - TM5) |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 28 |
|
AQP0 |
rs374156212 |
NP_036196.1 - 48 (TM2 - Ar/R Selectivity filter) |
Channel facing |
Phe (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 29 |
|
AQP0 |
rs923527666 |
NP_036196.1 - 51 (TM2) |
Monomer - monomer interface;Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 30 |
|
AQP0 |
rs923527666 |
NP_036196.1 - 51 (TM2) |
Monomer - monomer interface;Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 31 |
|
AQP0 |
rs762736739 |
NP_036196.1 - 52 (TM2) |
Channel facing |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 32 |
|
AQP0 |
rs769646517 |
NP_036196.1 - 56 (TM2) |
Channel facing;Helix - helix interface (TM2 - TM5) |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 33 |
|
AQP0 |
rs769646517 |
NP_036196.1 - 56 (TM2) |
Channel facing;Helix - helix interface (TM2 - TM5) |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 34 |
|
AQP0 |
rs1302955432 |
NP_036196.1 - 58 (TM2) |
Monomer - monomer interface |
Ser (Small and Weakly Polar) -> Tyr (Aromatic) |
- |
| 35 |
|
AQP0 |
rs745742587 |
NP_036196.1 - 59 (TM2) |
Helix - helix interface (TM1 - TM2);Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 36 |
|
AQP0 |
rs745742587 |
NP_036196.1 - 59 (TM2) |
Helix - helix interface (TM1 - TM2);Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 37 |
|
AQP0 |
rs1205062502 |
NP_036196.1 - 61 (TM2) |
Exposed to cytoplasm |
His (Charged) -> Arg (Charged) |
- |
| 38 |
|
AQP0 |
rs1410951587 |
NP_036196.1 - 65 (Loop region after TM2) |
Loop B |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 39 |
|
AQP0 |
rs77163805 |
NP_036196.1 - 67 (Loop region after TM2) |
Loop B |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 40 |
|
AQP0 |
rs1418898827 |
NP_036196.1 - 69 (LB - NPA1) |
Helix - helix interface (LE - LB, LB - TM3) |
Pro (Proline) -> Thr (Small and Weakly Polar) |
- |
| 41 |
|
AQP0 |
rs1299755067 |
NP_036196.1 - 71 (LB) |
Channel facing |
Val (Aliphatic hydrophobic) -> Asp (Charged) |
- |
| 42 |
|
AQP0 |
rs370988995 |
NP_036196.1 - 73 (LB) |
Lipid facing |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 43 |
|
AQP0 |
rs777950301 |
NP_036196.1 - 74 (LB) |
Helix - helix interface (LB - TM4, LB - TM6) |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 44 |
|
AQP0 |
rs925000932 |
NP_036196.1 - 75 (LB) |
Channel facing |
Phe (Aromatic) -> Ile (Aliphatic hydrophobic) |
- |
| 45 |
|
AQP0 |
rs1243767618 |
NP_036196.1 - 78 (LB) |
Helix - helix interface (LB - TM6) |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 46 |
|
AQP0 |
rs1458115258 |
NP_036196.1 - 78 (LB) |
Helix - helix interface (LB - TM6) |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 47 |
|
AQP0 |
rs541621233 |
NP_036196.1 - 81 (Loop region after LB) |
Loop B |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 48 |
|
AQP0 |
rs1475649789 |
NP_036196.1 - 84 (TM3) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 49 |
|
AQP0 |
rs142998145 |
NP_036196.1 - 85 (TM3) |
Channel facing |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 50 |
|
AQP0 |
rs142998145 |
NP_036196.1 - 85 (TM3) |
Channel facing |
Arg (Charged) -> Gly (Small and Weakly Polar) |
- |
| 51 |
|
AQP0 |
rs774106797 |
NP_036196.1 - 85 (TM3) |
Channel facing |
Arg (Charged) -> His (Charged) |
- |
| 52 |
|
AQP0 |
rs200727496 |
NP_036196.1 - 86 (TM3) |
Helix - helix interface (LB - TM3) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 53 |
|
AQP0 |
rs756723731 |
NP_036196.1 - 89 (TM3) |
Helix - helix interface (TM1 - TM3, LB - TM3) |
Tyr (Aromatic) -> Asn (Neutral polar) |
- |
| 54 |
|
AQP0 |
rs559008561 |
NP_036196.1 - 90 (TM3) |
Lipid facing |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 55 |
|
AQP0 |
rs763721329 |
NP_036196.1 - 92 (TM3) |
Helix - helix interface (TM1 - TM3) |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 56 |
|
AQP0 |
rs979131519 |
NP_036196.1 - 92 (TM3) |
Helix - helix interface (TM1 - TM3) |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 57 |
|
AQP0 |
rs1324431494 |
NP_036196.1 - 93 (TM3) |
Helix - helix interface (TM3 - TM1, TM3 - LB, TM3 - LE) |
Gln (Neutral polar) -> Pro (Proline) |
- |
| 58 |
|
AQP0 |
rs1463388264 |
NP_036196.1 - 94 (TM3) |
Lipid facing;Helix - helix interface (TM3 - LE) |
Leu (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 59 |
|
AQP0 |
rs1350818525 |
NP_036196.1 - 97 (TM3) |
Helix - helix interface (TM1 - TM3, TM3 - LE) |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 60 |
|
AQP0 |
rs140664808 |
NP_036196.1 - 101 (TM3) |
Helix - helix interface (TM1 - TM3, TM3 - LE) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 61 |
|
AQP0 |
rs140664808 |
NP_036196.1 - 101 (TM3) |
Helix - helix interface (TM1 - TM3, TM3 - LE) |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 62 |
|
AQP0 |
rs776459088 |
NP_036196.1 - 102 (TM3) |
Lipid facing |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 63 |
|
AQP0 |
rs1247030999 |
NP_036196.1 - 106 (TM3) |
Lipid facing |
Ser (Small and Weakly Polar) -> Arg (Charged) |
- |
| 64 |
|
AQP0 |
rs74641138 |
NP_036196.1 - 107 (TM3) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 65 |
|
AQP0 |
rs760722691 |
NP_036196.1 - 108 (TM3) |
Exposed to the extracellular environment |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 66 |
|
AQP0 |
rs367909155 |
NP_036196.1 - 112 (Loop region after TM3) |
Loop C |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 67 |
|
AQP0 |
rs774928445 |
NP_036196.1 - 113 (Loop region after TM3) |
Loop C |
Arg (Charged) -> Leu (Aliphatic hydrophobic) |
- |
| 68 |
|
AQP0 |
rs774928445 |
NP_036196.1 - 113 (Loop region after TM3) |
Loop C |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 69 |
|
AQP0 |
rs1314710813 |
NP_036196.1 - 113 (Loop region after TM3) |
Loop C |
Arg (Charged) -> Gly (Small and Weakly Polar) |
- |
| 70 |
|
AQP0 |
rs1240287821 |
NP_036196.1 - 117 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 71 |
|
AQP0 |
rs1369582895 |
NP_036196.1 - 119 (Loop region after TM3) |
Loop C |
Asn (Neutral polar) -> His (Charged) |
- |
| 72 |
|
AQP0 |
rs375320892 |
NP_036196.1 - 120 (Loop region after TM3) |
Loop C |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 73 |
|
AQP0 |
rs576079765 |
NP_036196.1 - 122 (Loop region after TM3) |
Loop C |
His (Charged) -> Tyr (Aromatic) |
- |
| 74 |
|
AQP0 |
rs1212357659 |
NP_036196.1 - 123 (Loop region after TM3) |
Loop C |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 75 |
|
AQP0 |
rs753492682 |
NP_036196.1 - 124 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 76 |
|
AQP0 |
rs753492682 |
NP_036196.1 - 124 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Glu (Charged) |
- |
| 77 |
|
AQP0 |
rs141238366 |
NP_036196.1 - 125 (Loop region after TM3) |
Loop C |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 78 |
|
AQP0 |
rs755958105 |
NP_036196.1 - 126 (Loop region after TM3) |
Loop C |
Ser (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 79 |
|
AQP0 |
rs909803550 |
NP_036196.1 - 126 (Loop region after TM3) |
Loop C |
Ser (Small and Weakly Polar) -> Asn (Neutral polar) |
- |
| 80 |
|
AQP0 |
rs767456401 |
NP_036196.1 - 127 (Loop region after TM3) |
Loop C |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 81 |
|
AQP0 |
rs1299235302 |
NP_036196.1 - 128 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 82 |
|
AQP0 |
rs1353749513 |
NP_036196.1 - 128 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 83 |
|
AQP0 |
rs1295314096 |
NP_036196.1 - 129 (TM4) |
Lipid facing |
Gln (Neutral polar) -> Leu (Aliphatic hydrophobic) |
- |
| 84 |
|
AQP0 |
rs761719502 |
NP_036196.1 - 130 (TM4) |
Helix - helix interface (TM4 - TM5) |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 85 |
|
AQP0 |
rs761719502 |
NP_036196.1 - 130 (TM4) |
Helix - helix interface (TM4 - TM5) |
Ala (Small and Weakly Polar) -> Glu (Charged) |
- |
| 86 |
|
AQP0 |
rs148039582 |
NP_036196.1 - 131 (TM4) |
Lipid facing;Helix - helix interface (TM4 - TM6) |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 87 |
|
AQP0 |
rs1297604925 |
NP_036196.1 - 132 (TM4) |
Lipid facing |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 88 |
|
AQP0 |
rs121917869 |
NP_036196.1 - 134 (TM4) |
Helix - helix interface (TM4 - TM5, TM4 - TM6) |
Glu (Charged) -> Gly (Small and Weakly Polar) |
Cataract |
| 89 |
|
AQP0 |
rs121917869 |
NP_036196.1 - 134 (TM4) |
Helix - helix interface (TM4 - TM5, TM4 - TM6) |
Glu (Charged) -> Ala (Small and Weakly Polar) |
- |
| 90 |
|
AQP0 |
rs879214385 |
NP_036196.1 - 136 (TM4) |
Monomer - monomer interface |
Phe (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 91 |
|
AQP0 |
rs121917867 |
NP_036196.1 - 138 (TM4) |
Helix - helix interface (LB - TM4, TM4 - TM6) |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 92 |
|
AQP0 |
rs121917867 |
NP_036196.1 - 138 (TM4) |
Helix - helix interface (LB - TM4, TM4 - TM6) |
Thr (Small and Weakly Polar) -> Arg (Charged) |
Cataract |
| 93 |
|
AQP0 |
rs748257915 |
NP_036196.1 - 138 (TM4) |
Helix - helix interface (LB - TM4, TM4 - TM6) |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 94 |
|
AQP0 |
rs1189165940 |
NP_036196.1 - 139 (TM4) |
Helix - helix interface (TM4 - TM6);Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 95 |
|
AQP0 |
rs1189165940 |
NP_036196.1 - 139 (TM4) |
Helix - helix interface (TM4 - TM6);Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 96 |
|
AQP0 |
rs1555179889 |
NP_036196.1 - 140 (TM4) |
Monomer - monomer interface |
Gln (Neutral polar) -> Lys (Charged) |
- |
| 97 |
|
AQP0 |
rs966166555 |
NP_036196.1 - 142 (TM4) |
Helix - helix interface (TM4 - TM6) |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 98 |
|
AQP0 |
rs966166555 |
NP_036196.1 - 142 (TM4) |
Helix - helix interface (TM4 - TM6) |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 99 |
|
AQP0 |
rs1259141595 |
NP_036196.1 - 144 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Cys (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 100 |
|
AQP0 |
rs1213498903 |
NP_036196.1 - 147 (TM4) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 101 |
|
AQP0 |
rs778327521 |
NP_036196.1 - 150 (TM4) |
Channel facing |
Asp (Charged) -> His (Charged) |
- |
| 102 |
|
AQP0 |
rs778327521 |
NP_036196.1 - 150 (TM4) |
Channel facing |
Asp (Charged) -> Asn (Neutral polar) |
- |
| 103 |
|
AQP0 |
rs754514029 |
NP_036196.1 - 151 (Loop region after TM4) |
Loop D |
Glu (Charged) -> Gly (Small and Weakly Polar) |
- |
| 104 |
|
AQP0 |
rs754514029 |
NP_036196.1 - 151 (Loop region after TM4) |
Loop D |
Glu (Charged) -> Ala (Small and Weakly Polar) |
- |
| 105 |
|
AQP0 |
rs1007727858 |
NP_036196.1 - 151 (Loop region after TM4) |
Loop D |
Glu (Charged) -> Lys (Charged) |
- |
| 106 |
|
AQP0 |
rs1389628769 |
NP_036196.1 - 152 (Loop region after TM4) |
Loop D |
Arg (Charged) -> Lys (Charged) |
- |
| 107 |
|
AQP0 |
rs143538578 |
NP_036196.1 - 153 (Loop region after TM4) |
Loop D |
Arg (Charged) -> Trp (Aromatic) |
- |
| 108 |
|
AQP0 |
rs779658566 |
NP_036196.1 - 153 (Loop region after TM4) |
Loop D |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 109 |
|
AQP0 |
rs750224118 |
NP_036196.1 - 156 (Loop region after TM4) |
Loop D |
Gln (Neutral polar) -> His (Charged) |
- |
| 110 |
|
AQP0 |
rs532144818 |
NP_036196.1 - 157 (Loop region after TM4) |
Loop D |
Leu (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 111 |
|
AQP0 |
rs1291876973 |
NP_036196.1 - 159 (TM5) |
Monomer - monomer interface |
Ser (Small and Weakly Polar) -> Pro (Proline) |
- |
| 112 |
|
AQP0 |
rs1362727575 |
NP_036196.1 - 159 (TM5) |
Monomer - monomer interface |
Ser (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 113 |
|
AQP0 |
rs1181032881 |
NP_036196.1 - 160 (TM5) |
Helix - helix interface (TM4 - TM5) |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 114 |
|
AQP0 |
rs751550655 |
NP_036196.1 - 161 (TM5) |
Helix - helix interface (TM2 - TM5) |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 115 |
|
AQP0 |
rs149279854 |
NP_036196.1 - 164 (TM5) |
Channel facing;Helix - helix interface (TM4 - TM5) |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 116 |
|
AQP0 |
rs886049692 |
NP_036196.1 - 165 (TM5) |
Helix - helix interface (TM2 - TM5) |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 117 |
|
AQP0 |
rs757035904 |
NP_036196.1 - 176 (TM5) |
Channel facing |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 118 |
|
AQP0 |
rs751497665 |
NP_036196.1 - 177 (TM5) |
Exposed to the extracellular environment |
Tyr (Aromatic) -> His (Charged) |
- |
| 119 |
|
AQP0 |
rs1324302266 |
NP_036196.1 - 178 (TM5) |
Exposed to the extracellular environment |
Tyr (Aromatic) -> His (Charged) |
- |
| 120 |
|
AQP0 |
rs1315794899 |
NP_036196.1 - 180 (Loop region after TM5) |
Loop E |
Gly (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 121 |
|
AQP0 |
rs777835431 |
NP_036196.1 - 181 (Loop region after TM5 - Ar/R Selectivity filter) |
Loop E |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 122 |
|
AQP0 |
rs758451632 |
NP_036196.1 - 183 (Loop region after TM5) |
Loop E |
Met (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 123 |
|
AQP0 |
rs1438043707 |
NP_036196.1 - 184 (LE - NPA2) |
Channel facing;Helix - helix interface (TM1 - LE, LB - LE) |
Asn (Neutral polar) -> Thr (Small and Weakly Polar) |
- |
| 124 |
|
AQP0 |
rs752820201 |
NP_036196.1 - 185 (LE - NPA2) |
Helix - helix interface (LE - LB, LE - TM6) |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 125 |
|
AQP0 |
rs759746926 |
NP_036196.1 - 187 (LE - Ar/R Selectivity filter) |
Channel facing |
Arg (Charged) -> Leu (Aliphatic hydrophobic) |
- |
| 126 |
|
AQP0 |
rs759746926 |
NP_036196.1 - 187 (LE - Ar/R Selectivity filter) |
Channel facing |
Arg (Charged) -> His (Charged) |
- |
| 127 |
|
AQP0 |
rs267603585 |
NP_036196.1 - 187 (LE - Ar/R Selectivity filter) |
Channel facing |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 128 |
|
AQP0 |
rs1475298701 |
NP_036196.1 - 190 (LE) |
Helix - helix interface (TM3 - LE) |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 129 |
|
AQP0 |
rs1371630020 |
NP_036196.1 - 192 (LE) |
Exposed to the extracellular environment |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 130 |
|
AQP0 |
rs766714787 |
NP_036196.1 - 195 (LE) |
Exposed to the extracellular environment |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 131 |
|
AQP0 |
rs1478261570 |
NP_036196.1 - 195 (LE) |
Exposed to the extracellular environment |
Thr (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 132 |
|
AQP0 |
rs1478261570 |
NP_036196.1 - 195 (LE) |
Exposed to the extracellular environment |
Thr (Small and Weakly Polar) -> Pro (Proline) |
- |
| 133 |
|
AQP0 |
rs773605949 |
NP_036196.1 - 197 (Loop region after LE) |
Loop E |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 134 |
|
AQP0 |
rs377515337 |
NP_036196.1 - 198 (Loop region after LE) |
Loop E |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 135 |
|
AQP0 |
rs772559899 |
NP_036196.1 - 198 (Loop region after LE) |
Loop E |
Phe (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 136 |
|
AQP0 |
rs1338583821 |
NP_036196.1 - 199 (Loop region after LE) |
Loop E |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 137 |
|
AQP0 |
rs373043054 |
NP_036196.1 - 201 (TM6) |
Lipid facing |
His (Charged) -> Gln (Neutral polar) |
- |
| 138 |
|
AQP0 |
rs1215596312 |
NP_036196.1 - 201 (TM6) |
Lipid facing |
His (Charged) -> Asn (Neutral polar) |
- |
| 139 |
|
AQP0 |
rs1296308908 |
NP_036196.1 - 203 (TM6) |
Helix - helix interface (TM4 - TM6) |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 140 |
|
AQP0 |
rs760950240 |
NP_036196.1 - 206 (TM6) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 141 |
|
AQP0 |
rs767879244 |
NP_036196.1 - 209 (TM6) |
Helix - helix interface (LB - TM6); Lipid facing |
Ile (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 142 |
|
AQP0 |
rs767879244 |
NP_036196.1 - 209 (TM6) |
Helix - helix interface (LB - TM6); Lipid facing |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 143 |
|
AQP0 |
rs1375283315 |
NP_036196.1 - 210 (TM6) |
Lipid facing |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 144 |
|
AQP0 |
rs762238203 |
NP_036196.1 - 211 (TM6) |
Helix - helix interface (TM4 - TM6) |
Gly (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 145 |
|
AQP0 |
rs1349100721 |
NP_036196.1 - 213 (TM6) |
Helix - helix interface (LB - TM6); Lipid facing |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 146 |
|
AQP0 |
rs1279190739 |
NP_036196.1 - 220 (TM6) |
Channel facing |
Asp (Charged) -> Glu (Charged) |
- |
| 147 |
|
AQP0 |
rs1394124537 |
NP_036196.1 - 220 (TM6) |
Channel facing |
Asp (Charged) -> Asn (Neutral polar) |
- |
| 148 |
|
AQP0 |
rs867478085 |
NP_036196.1 - 223 (TM6) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 149 |
|
AQP0 |
rs1484462074 |
NP_036196.1 - 223 (TM6) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 150 |
|
AQP0 |
rs769300904 |
NP_036196.1 - 224 (C terminus) |
C terminal domain |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 151 |
|
AQP0 |
rs1000243332 |
NP_036196.1 - 224 (C terminus) |
C terminal domain |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 152 |
|
AQP0 |
rs770704370 |
NP_036196.1 - 226 (C terminus) |
C terminal domain |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 153 |
|
AQP0 |
rs776248839 |
NP_036196.1 - 226 (C terminus) |
C terminal domain |
Arg (Charged) -> Trp (Aromatic) |
- |
| 154 |
|
AQP0 |
rs746716383 |
NP_036196.1 - 228 (C terminus) |
C terminal domain |
Lys (Charged) -> Arg (Charged) |
- |
| 155 |
|
AQP0 |
rs1180368759 |
NP_036196.1 - 229 (C terminus) |
C terminal domain |
Ser (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 156 |
|
AQP0 |
rs148370247 |
NP_036196.1 - 231 (C terminus) |
C terminal domain |
Ser (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 157 |
|
AQP0 |
rs773085032 |
NP_036196.1 - 232 (C terminus) |
C terminal domain |
Glu (Charged) -> Gln (Neutral polar) |
- |
| 158 |
|
AQP0 |
rs1555179699 |
NP_036196.1 - 233 (C terminus) |
C terminal domain |
Arg (Charged) -> Lys (Charged) |
- |
| 159 |
|
AQP0 |
rs368530037 |
NP_036196.1 - 237 (C terminus) |
C terminal domain |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 160 |
|
AQP0 |
rs755752015 |
NP_036196.1 - 238 (C terminus) |
C terminal domain |
Lys (Charged) -> Thr (Small and Weakly Polar) |
- |
| 161 |
|
AQP0 |
rs754983919 |
NP_036196.1 - 240 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 162 |
|
AQP0 |
rs200279042 |
NP_036196.1 - 243 (C terminus) |
Absent in the structure |
Asp (Charged) -> Asn (Neutral polar) |
- |
| 163 |
|
AQP0 |
rs756268051 |
NP_036196.1 - 245 (C terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Tyr (Aromatic) |
- |
| 164 |
|
AQP0 |
rs200894275 |
NP_036196.1 - 246 (C terminus) |
Absent in the structure |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 165 |
|
AQP0 |
rs750645433 |
NP_036196.1 - 250 (C terminus) |
Absent in the structure |
Glu (Charged) -> Asp (Charged) |
- |
| 166 |
|
AQP0 |
rs1292127398 |
NP_036196.1 - 250 (C terminus) |
Absent in the structure |
Glu (Charged) -> Lys (Charged) |
- |
| 167 |
|
AQP0 |
rs1350717352 |
NP_036196.1 - 251 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 168 |
|
AQP0 |
rs1301617256 |
NP_036196.1 - 253 (C terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 169 |
|
AQP0 |
rs1345311549 |
NP_036196.1 - 254 (C terminus) |
Absent in the structure |
Glu (Charged) -> Gln (Neutral polar) |
- |
| 170 |
|
AQP0 |
rs376788799 |
NP_036196.1 - 255 (C terminus) |
Absent in the structure |
Pro (Proline) -> Ala (Small and Weakly Polar) |
- |
| 171 |
|
AQP0 |
rs572877253 |
NP_036196.1 - 262 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 172 |
|
AQP0 |
rs1382176904 |
NP_036196.1 - 262 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Pro (Proline) |
- |
| 173 |
|
AQP0 |
rs1260940146 |
NP_036196.1 - 263 (C terminus) |
Absent in the structure |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 174 |
|
AQP1 |
rs144950903 |
NP_932766.1 - 2 (N terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 175 |
|
AQP1 |
rs574768358 |
NP_932766.1 - 3 (N terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Arg (Charged) |
- |
| 176 |
|
AQP1 |
rs574768358 |
NP_932766.1 - 3 (N terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Arg (Charged) |
- |
| 177 |
|
AQP1 |
rs1401166675 |
NP_932766.1 - 4 (N terminus) |
Absent in the structure |
Glu (Charged) -> Lys (Charged) |
- |
| 178 |
|
AQP1 |
rs1401166675 |
NP_932766.1 - 4 (N terminus) |
Absent in the structure |
Glu (Charged) -> Gln (Neutral polar) |
- |
| 179 |
|
AQP1 |
rs756931426 |
NP_932766.1 - 5 (N terminus) |
Absent in the structure |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 180 |
|
AQP1 |
rs767122207 |
NP_932766.1 - 5 (N terminus) |
Absent in the structure |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 181 |
|
AQP1 |
rs754247100 |
NP_932766.1 - 6 (N terminus) |
Absent in the structure |
Lys (Charged) -> Arg (Charged) |
- |
| 182 |
|
AQP1 |
rs755354795 |
NP_932766.1 - 7 (N terminus) |
Absent in the structure |
Lys (Charged) -> Arg (Charged) |
- |
| 183 |
|
AQP1 |
rs1269219164 |
NP_932766.1 - 8 (TM1) |
Exposed to cytoplasm |
Lys (Charged) -> Glu (Charged) |
- |
| 184 |
|
AQP1 |
rs1016862979 |
NP_932766.1 - 12 (TM1) |
Monomer - monomer interface |
Arg (Charged) -> Lys (Charged) |
- |
| 185 |
|
AQP1 |
rs1219898649 |
NP_932766.1 - 12 (TM1) |
Monomer - monomer interface |
Arg (Charged) -> Ser (Small and Weakly Polar) |
- |
| 186 |
|
AQP1 |
rs777773161 |
NP_932766.1 - 15 (TM1) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 187 |
|
AQP1 |
rs1291941073 |
NP_932766.1 - 16 (TM1) |
Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 188 |
|
AQP1 |
rs771328144 |
NP_932766.1 - 17 (TM1) |
Helix - helix interface (TM1 - TM2, TM1 - TM3) |
Glu (Charged) -> Lys (Charged) |
- |
| 189 |
|
AQP1 |
rs1476942158 |
NP_932766.1 - 19 (TM1) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 190 |
|
AQP1 |
rs1424356551 |
NP_932766.1 - 20 (TM1) |
Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 191 |
|
AQP1 |
rs746048942 |
NP_932766.1 - 21 (TM1) |
Helix - helix interface (TM1 - TM3) |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 192 |
|
AQP1 |
rs1393593188 |
NP_932766.1 - 22 (TM1) |
Helix - helix interface (TM1 - TM3) |
Thr (Small and Weakly Polar) -> Asn (Neutral polar) |
- |
| 193 |
|
AQP1 |
rs1280879987 |
NP_932766.1 - 23 (TM1) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 194 |
|
AQP1 |
rs775370815 |
NP_932766.1 - 26 (TM1) |
Helix - helix interface (TM1 - TM3);Monomer - monomer interface |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 195 |
|
AQP1 |
rs762860185 |
NP_932766.1 - 28 (TM1) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Ser (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 196 |
|
AQP1 |
rs1278450967 |
NP_932766.1 - 29 (TM1) |
Helix - helix interface (TM1 - TM2, TM1 - LE) |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 197 |
|
AQP1 |
rs147526690 |
NP_932766.1 - 30 (TM1) |
Helix - helix interface (TM1 - TM3);Monomer - monomer interface |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 198 |
|
AQP1 |
rs766962806 |
NP_932766.1 - 31 (TM1) |
Helix - helix interface (TM1 - TM2) |
Ser (Small and Weakly Polar) -> Tyr (Aromatic) |
- |
| 199 |
|
AQP1 |
rs750104687 |
NP_932766.1 - 32 (TM1) |
Channel facing |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 200 |
|
AQP1 |
rs1193745061 |
NP_932766.1 - 32 (TM1) |
Channel facing |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 201 |
|
AQP1 |
rs760251239 |
NP_932766.1 - 33 (TM1) |
Exposed to the extracellular environment |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 202 |
|
AQP1 |
rs1283558986 |
NP_932766.1 - 34 (TM1) |
Exposed to the extracellular environment |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 203 |
|
AQP1 |
rs1408614489 |
NP_932766.1 - 35 (TM1) |
Exposed to the extracellular environment |
Phe (Aromatic) -> Tyr (Aromatic) |
- |
| 204 |
|
AQP1 |
rs1485138944 |
NP_932766.1 - 36 (TM1) |
Channel facing |
Lys (Charged) -> Glu (Charged) |
- |
| 205 |
|
AQP1 |
rs145372510 |
NP_932766.1 - 37 (TM1) |
Exposed to the extracellular environment |
Tyr (Aromatic) -> His (Charged) |
- |
| 206 |
|
AQP1 |
rs1218986771 |
NP_932766.1 - 37 (TM1) |
Exposed to the extracellular environment |
Tyr (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 207 |
|
AQP1 |
rs104894004 |
NP_932766.1 - 38 (Loop region after TM1) |
Loop A |
Pro (Proline) -> Gln (Neutral polar) |
- |
| 208 |
|
AQP1 |
rs104894004 |
NP_932766.1 - 38 (Loop region after TM1) |
Loop A |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
Autosomal recessive Nephrogenic Diabetes Insipidus |
| 209 |
|
AQP1 |
rs1433395263 |
NP_932766.1 - 39 (Loop region after TM1) |
Loop A |
Val (Aliphatic hydrophobic) -> Gly (Small and Weakly Polar) |
- |
| 210 |
|
AQP1 |
rs1370673845 |
NP_932766.1 - 40 (Loop region after TM1) |
Loop A |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 211 |
|
AQP1 |
rs1402168267 |
NP_932766.1 - 40 (Loop region after TM1) |
Loop A |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 212 |
|
AQP1 |
rs1473387576 |
NP_932766.1 - 41 (Loop region after TM1) |
Loop A |
Asn (Neutral polar) -> Lys (Charged) |
- |
| 213 |
|
AQP1 |
rs1158595259 |
NP_932766.1 - 42 (Loop region after TM1) |
Loop A |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 214 |
|
AQP1 |
rs756198958 |
NP_932766.1 - 44 (Loop region after TM1) |
Loop A |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 215 |
|
AQP1 |
rs28362692 |
NP_932766.1 - 45 (Loop region after TM1) |
Loop A |
Ala (Small and Weakly Polar) -> Glu (Charged) |
- |
| 216 |
|
AQP1 |
rs28362692 |
NP_932766.1 - 45 (Loop region after TM1) |
Loop A |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 217 |
|
AQP1 |
rs17852043 |
NP_932766.1 - 45 (Loop region after TM1) |
Loop A |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 218 |
|
AQP1 |
rs377506522 |
NP_932766.1 - 47 (Loop region after TM1) |
Loop A |
Gln (Neutral polar) -> Arg (Charged) |
- |
| 219 |
|
AQP1 |
rs1314294921 |
NP_932766.1 - 48 (TM2) |
Exposed to the extracellular environment |
Asp (Charged) -> Gly (Small and Weakly Polar) |
- |
| 220 |
|
AQP1 |
rs1340576534 |
NP_932766.1 - 48 (TM2) |
Exposed to the extracellular environment |
Asp (Charged) -> Glu (Charged) |
- |
| 221 |
|
AQP1 |
rs770124156 |
NP_932766.1 - 49 (TM2) |
Helix - helix interface (TM2 - TM5) |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 222 |
|
AQP1 |
rs200496523 |
NP_932766.1 - 50 (TM2) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 223 |
|
AQP1 |
rs35115273 |
NP_932766.1 - 52 (TM2) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 224 |
|
AQP1 |
rs35115273 |
NP_932766.1 - 52 (TM2) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 225 |
|
AQP1 |
rs761702121 |
NP_932766.1 - 53 (TM2) |
Helix - helix interface (TM2 - TM5) |
Ser (Small and Weakly Polar) -> Trp (Aromatic) |
- |
| 226 |
|
AQP1 |
rs761702121 |
NP_932766.1 - 53 (TM2) |
Helix - helix interface (TM2 - TM5) |
Ser (Small and Weakly Polar) -> Leu (Aliphatic hydrophobic) |
- |
| 227 |
|
AQP1 |
rs1227385048 |
NP_932766.1 - 54 (TM2) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 228 |
|
AQP1 |
rs550724674 |
NP_932766.1 - 56 (TM2 - Ar/R Selectivity filter) |
Channel facing |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 229 |
|
AQP1 |
rs1412440334 |
NP_932766.1 - 57 (TM2) |
Helix - helix interface (TM2 - TM5) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 230 |
|
AQP1 |
rs1340343648 |
NP_932766.1 - 60 (TM2) |
Channel facing |
Ile (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 231 |
|
AQP1 |
rs1443085404 |
NP_932766.1 - 60 (TM2) |
Channel facing |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 232 |
|
AQP1 |
rs753051699 |
NP_932766.1 - 61 (TM2) |
Helix - helix interface (TM2 - TM5) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 233 |
|
AQP1 |
rs199545971 |
NP_932766.1 - 62 (TM2) |
Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 234 |
|
AQP1 |
rs898407370 |
NP_932766.1 - 64 (TM2) |
Channel facing;Helix - helix interface (TM2 - TM5) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 235 |
|
AQP1 |
rs558089401 |
NP_932766.1 - 65 (TM2) |
Monomer - monomer interface |
Gln (Neutral polar) -> Arg (Charged) |
- |
| 236 |
|
AQP1 |
rs968619407 |
NP_932766.1 - 68 (Loop region after TM2) |
Loop B |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 237 |
|
AQP1 |
rs757778816 |
NP_932766.1 - 69 (Loop region after TM2) |
Loop B |
His (Charged) -> Leu (Aliphatic hydrophobic) |
- |
| 238 |
|
AQP1 |
rs1236758861 |
NP_932766.1 - 70 (Loop region after TM2) |
Loop B |
Ile (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 239 |
|
AQP1 |
rs548913885 |
NP_932766.1 - 72 (Loop region after TM2) |
Loop B |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 240 |
|
AQP1 |
rs140979736 |
NP_932766.1 - 73 (Loop region after TM2) |
Loop B |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 241 |
|
AQP1 |
rs140979736 |
NP_932766.1 - 73 (Loop region after TM2) |
Loop B |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 242 |
|
AQP1 |
rs1274688559 |
NP_932766.1 - 74 (Loop region after TM2) |
Loop B |
His (Charged) -> Tyr (Aromatic) |
- |
| 243 |
|
AQP1 |
rs971080900 |
NP_932766.1 - 75 (Loop region after TM2) |
Loop B |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 244 |
|
AQP1 |
rs768530306 |
NP_932766.1 - 77 (LB - NPA1) |
Helix - helix interface (LB - LE, LB - TM3) |
Pro (Proline) -> Gln (Neutral polar) |
- |
| 245 |
|
AQP1 |
rs768530306 |
NP_932766.1 - 77 (LB - NPA1) |
Helix - helix interface (LB - LE, LB - TM3) |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 246 |
|
AQP1 |
rs1310237961 |
NP_932766.1 - 77 (LB - NPA1) |
Helix - helix interface (LB - LE, LB - TM3) |
Pro (Proline) -> Ala (Small and Weakly Polar) |
- |
| 247 |
|
AQP1 |
rs1310237961 |
NP_932766.1 - 77 (LB - NPA1) |
Helix - helix interface (LB - LE, LB - TM3) |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 248 |
|
AQP1 |
rs748092933 |
NP_932766.1 - 79 (LB) |
Channel facing |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 249 |
|
AQP1 |
rs1325277474 |
NP_932766.1 - 81 (LB) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 250 |
|
AQP1 |
rs1198153592 |
NP_932766.1 - 83 (LB) |
Channel facing |
Leu (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 251 |
|
AQP1 |
rs1459509459 |
NP_932766.1 - 86 (Loop region after LB) |
Loop B |
Ser (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 252 |
|
AQP1 |
rs1459509459 |
NP_932766.1 - 86 (Loop region after LB) |
Loop B |
Ser (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 253 |
|
AQP1 |
rs771986400 |
NP_932766.1 - 89 (Loop region after LB) |
Loop B |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 254 |
|
AQP1 |
rs957051800 |
NP_932766.1 - 90 (Loop region after LB) |
Loop B |
Ser (Small and Weakly Polar) -> Arg (Charged) |
- |
| 255 |
|
AQP1 |
rs957051800 |
NP_932766.1 - 90 (Loop region after LB) |
Loop B |
Ser (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 256 |
|
AQP1 |
rs772776753 |
NP_932766.1 - 91 (Loop region after LB) |
Loop B |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 257 |
|
AQP1 |
rs183830991 |
NP_932766.1 - 93 (Loop region after LB) |
Loop B |
Arg (Charged) -> His (Charged) |
- |
| 258 |
|
AQP1 |
rs760146829 |
NP_932766.1 - 93 (Loop region after LB) |
Loop B |
Arg (Charged) -> Gly (Small and Weakly Polar) |
- |
| 259 |
|
AQP1 |
rs760146829 |
NP_932766.1 - 93 (Loop region after LB) |
Loop B |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 260 |
|
AQP1 |
rs372063183 |
NP_932766.1 - 95 (TM3) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 261 |
|
AQP1 |
rs759042117 |
NP_932766.1 - 96 (TM3) |
Lipid facing |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 262 |
|
AQP1 |
rs1447366445 |
NP_932766.1 - 99 (TM3) |
Lipid facing |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 263 |
|
AQP1 |
rs1187645104 |
NP_932766.1 - 102 (TM3) |
Lipid facing;Helix - helix interface (TM3 - LE) |
Cys (Small and Weakly Polar) -> Tyr (Aromatic) |
- |
| 264 |
|
AQP1 |
rs762474222 |
NP_932766.1 - 103 (TM3) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 265 |
|
AQP1 |
rs762474222 |
NP_932766.1 - 103 (TM3) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 266 |
|
AQP1 |
rs762474222 |
NP_932766.1 - 103 (TM3) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 267 |
|
AQP1 |
rs1303659562 |
NP_932766.1 - 103 (TM3) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Gly (Small and Weakly Polar) |
- |
| 268 |
|
AQP1 |
rs1331949290 |
NP_932766.1 - 104 (TM3) |
Helix - helix interface (TM1 - TM3) |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 269 |
|
AQP1 |
rs1218057167 |
NP_932766.1 - 105 (TM3) |
Helix - helix interface (TM1 - TM3, TM3 - LE) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 270 |
|
AQP1 |
rs918080655 |
NP_932766.1 - 106 (TM3) |
Lipid facing;Helix - helix interface (TM3 - LE) |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 271 |
|
AQP1 |
rs35804488 |
NP_932766.1 - 107 (TM3) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 272 |
|
AQP1 |
rs147400857 |
NP_932766.1 - 107 (TM3) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Gly (Small and Weakly Polar) |
- |
| 273 |
|
AQP1 |
rs940136659 |
NP_932766.1 - 108 (TM3) |
Helix - helix interface (TM1 - TM3) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 274 |
|
AQP1 |
rs778827593 |
NP_932766.1 - 110 (TM3) |
Lipid facing |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 275 |
|
AQP1 |
rs778827593 |
NP_932766.1 - 110 (TM3) |
Lipid facing |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 276 |
|
AQP1 |
rs1436021836 |
NP_932766.1 - 110 (TM3) |
Lipid facing |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 277 |
|
AQP1 |
rs758373056 |
NP_932766.1 - 111 (TM3) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 278 |
|
AQP1 |
rs777709519 |
NP_932766.1 - 111 (TM3) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 279 |
|
AQP1 |
rs770477413 |
NP_932766.1 - 114 (TM3) |
Lipid facing |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 280 |
|
AQP1 |
rs1348109912 |
NP_932766.1 - 114 (TM3) |
Lipid facing |
Gly (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 281 |
|
AQP1 |
rs143467679 |
NP_932766.1 - 115 (TM3) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 282 |
|
AQP1 |
rs745590240 |
NP_932766.1 - 116 (TM3) |
Exposed to the extracellular environment |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 283 |
|
AQP1 |
rs1342448784 |
NP_932766.1 - 117 (Loop region after TM3) |
Loop C |
Ser (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 284 |
|
AQP1 |
rs1320488081 |
NP_932766.1 - 121 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 285 |
|
AQP1 |
rs762241529 |
NP_932766.1 - 122 (Loop region after TM3) |
Loop C |
Asn (Neutral polar) -> Lys (Charged) |
- |
| 286 |
|
AQP1 |
rs774892365 |
NP_932766.1 - 122 (Loop region after TM3) |
Loop C |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 287 |
|
AQP1 |
rs767949083 |
NP_932766.1 - 123 (Loop region after TM3) |
Loop C |
Ser (Small and Weakly Polar) -> Leu (Aliphatic hydrophobic) |
- |
| 288 |
|
AQP1 |
rs556371635 |
NP_932766.1 - 126 (Loop region after TM3) |
Loop C |
Arg (Charged) -> His (Charged) |
- |
| 289 |
|
AQP1 |
rs766496113 |
NP_932766.1 - 127 (Loop region after TM3) |
Loop C |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 290 |
|
AQP1 |
rs954478803 |
NP_932766.1 - 127 (Loop region after TM3) |
Loop C |
Asn (Neutral polar) -> Asp (Charged) |
- |
| 291 |
|
AQP1 |
rs747787357 |
NP_932766.1 - 131 (Loop region after TM3) |
Loop C |
Asp (Charged) -> Asn (Neutral polar) |
- |
| 292 |
|
AQP1 |
rs998224586 |
NP_932766.1 - 132 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 293 |
|
AQP1 |
rs1464085937 |
NP_932766.1 - 132 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 294 |
|
AQP1 |
rs11537655 |
NP_932766.1 - 133 (Loop region after TM3) |
Loop C |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 295 |
|
AQP1 |
rs781561245 |
NP_932766.1 - 135 (Loop region after TM3) |
Loop C |
Ser (Small and Weakly Polar) -> Leu (Aliphatic hydrophobic) |
- |
| 296 |
|
AQP1 |
rs267601481 |
NP_932766.1 - 136 (TM4) |
Lipid facing |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 297 |
|
AQP1 |
rs1329237099 |
NP_932766.1 - 136 (TM4) |
Lipid facing |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 298 |
|
AQP1 |
rs1281058035 |
NP_932766.1 - 138 (TM4) |
Helix - helix interface (TM4 - TM5) |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 299 |
|
AQP1 |
rs768670563 |
NP_932766.1 - 142 (TM4) |
Helix - helix interface (TM4 - TM5, TM4 - TM6) |
Glu (Charged) -> Lys (Charged) |
- |
| 300 |
|
AQP1 |
rs774464227 |
NP_932766.1 - 143 (TM4) |
Helix - helix interface (TM4 - TM6) |
Ile (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 301 |
|
AQP1 |
rs372033462 |
NP_932766.1 - 144 (TM4) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 302 |
|
AQP1 |
rs762031996 |
NP_932766.1 - 144 (TM4) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 303 |
|
AQP1 |
rs773049028 |
NP_932766.1 - 145 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 304 |
|
AQP1 |
rs1267145084 |
NP_932766.1 - 145 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Gly (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 305 |
|
AQP1 |
rs1431046001 |
NP_932766.1 - 146 (TM4) |
Helix - helix interface (LB - TM4, TM4 - TM6) |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 306 |
|
AQP1 |
rs200906195 |
NP_932766.1 - 153 (TM4) |
Channel facing |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 307 |
|
AQP1 |
rs764764878 |
NP_932766.1 - 158 (Loop region after TM4) |
Loop D |
Asp (Charged) -> Asn (Neutral polar) |
- |
| 308 |
|
AQP1 |
rs764764878 |
NP_932766.1 - 158 (Loop region after TM4) |
Loop D |
Asp (Charged) -> Tyr (Aromatic) |
- |
| 309 |
|
AQP1 |
rs567793834 |
NP_932766.1 - 159 (Loop region after TM4) |
Loop D |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 310 |
|
AQP1 |
rs752305447 |
NP_932766.1 - 159 (Loop region after TM4) |
Loop D |
Arg (Charged) -> Trp (Aromatic) |
- |
| 311 |
|
AQP1 |
rs201686828 |
NP_932766.1 - 161 (Loop region after TM4) |
Loop D |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 312 |
|
AQP1 |
rs746198215 |
NP_932766.1 - 161 (Loop region after TM4) |
Loop D |
Arg (Charged) -> His (Charged) |
- |
| 313 |
|
AQP1 |
rs746198215 |
NP_932766.1 - 161 (Loop region after TM4) |
Loop D |
Arg (Charged) -> Leu (Aliphatic hydrophobic) |
- |
| 314 |
|
AQP1 |
rs546847577 |
NP_932766.1 - 162 (Loop region after TM4) |
Loop D |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 315 |
|
AQP1 |
rs886892554 |
NP_932766.1 - 162 (Loop region after TM4) |
Loop D |
Arg (Charged) -> His (Charged) |
- |
| 316 |
|
AQP1 |
rs780558636 |
NP_932766.1 - 164 (Loop region after TM4) |
Loop D |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 317 |
|
AQP1 |
rs28362731 |
NP_932766.1 - 165 (Loop region after TM4) |
Loop D |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 318 |
|
AQP1 |
rs930047601 |
NP_932766.1 - 166 (TM5) |
Monomer - monomer interface |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 319 |
|
AQP1 |
rs1221622592 |
NP_932766.1 - 167 (TM5) |
Monomer - monomer interface |
Ser (Small and Weakly Polar) -> Leu (Aliphatic hydrophobic) |
- |
| 320 |
|
AQP1 |
rs1308474881 |
NP_932766.1 - 167 (TM5) |
Monomer - monomer interface |
Ser (Small and Weakly Polar) -> Pro (Proline) |
- |
| 321 |
|
AQP1 |
rs200005344 |
NP_932766.1 - 168 (TM5) |
Channel facing;Helix - helix interface (TM4 - TM5) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 322 |
|
AQP1 |
rs1421057826 |
NP_932766.1 - 170 (TM5) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 323 |
|
AQP1 |
rs941486831 |
NP_932766.1 - 171 (TM5) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 324 |
|
AQP1 |
rs192670428 |
NP_932766.1 - 172 (TM5) |
Channel facing |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 325 |
|
AQP1 |
rs1366429112 |
NP_932766.1 - 172 (TM5) |
Channel facing |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 326 |
|
AQP1 |
rs766229713 |
NP_932766.1 - 173 (TM5) |
Helix - helix interface (TM5 - TM2) |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 327 |
|
AQP1 |
rs766229713 |
NP_932766.1 - 173 (TM5) |
Helix - helix interface (TM5 - TM2) |
Gly (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 328 |
|
AQP1 |
rs1039881123 |
NP_932766.1 - 174 (TM5) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 329 |
|
AQP1 |
rs368024773 |
NP_932766.1 - 175 (TM5) |
Helix - helix interface (TM4 - TM5) |
Ser (Small and Weakly Polar) -> Pro (Proline) |
- |
| 330 |
|
AQP1 |
rs759480898 |
NP_932766.1 - 178 (TM5) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 331 |
|
AQP1 |
rs1215603718 |
NP_932766.1 - 179 (TM5) |
Helix - helix interface (TM4 - TM5) |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 332 |
|
AQP1 |
rs1248693752 |
NP_932766.1 - 183 (TM5) |
Channel facing |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 333 |
|
AQP1 |
rs377619784 |
NP_932766.1 - 184 (TM5) |
Channel facing |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 334 |
|
AQP1 |
rs1438385009 |
NP_932766.1 - 185 (Loop region after TM5) |
Loop E |
Asp (Charged) -> Glu (Charged) |
- |
| 335 |
|
AQP1 |
rs908216133 |
NP_932766.1 - 186 (Loop region after TM5) |
Loop E |
Tyr (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 336 |
|
AQP1 |
rs939743369 |
NP_932766.1 - 188 (Loop region after TM5) |
Loop E |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 337 |
|
AQP1 |
rs202089489 |
NP_932766.1 - 189 (Loop region after TM5) |
Loop E |
Cys (Small and Weakly Polar) -> Trp (Aromatic) |
- |
| 338 |
|
AQP1 |
rs751213937 |
NP_932766.1 - 189 (Loop region after TM5 - Ar/R Selectivity filter) |
Loop E |
Cys (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 339 |
|
AQP1 |
rs754202148 |
NP_932766.1 - 191 (Loop region after TM5) |
Loop E |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 340 |
|
AQP1 |
rs755480059 |
NP_932766.1 - 192 (LE - NPA2) |
Channel facing;Helix - helix interface (TM1 - LE, LB - LE) |
Asn (Neutral polar) -> Lys (Charged) |
- |
| 341 |
|
AQP1 |
rs753098391 |
NP_932766.1 - 195 (LE - Ar/R Selectivity filter) |
Channel facing |
Arg (Charged) -> Gly (Small and Weakly Polar) |
- |
| 342 |
|
AQP1 |
rs753098391 |
NP_932766.1 - 195 (LE - Ar/R Selectivity filter) |
Channel facing |
Arg (Charged) -> Trp (Aromatic) |
- |
| 343 |
|
AQP1 |
rs758538727 |
NP_932766.1 - 195 (LE - Ar/R Selectivity filter) |
Channel facing |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 344 |
|
AQP1 |
rs1204215950 |
NP_932766.1 - 196 (LE) |
Helix - helix interface (LE - TM6) |
Ser (Small and Weakly Polar) -> Tyr (Aromatic) |
- |
| 345 |
|
AQP1 |
rs777933728 |
NP_932766.1 - 198 (LE) |
Helix - helix interface (TM3 - LE) |
Gly (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 346 |
|
AQP1 |
rs546809019 |
NP_932766.1 - 200 (LE) |
Exposed to the extracellular environment |
Ala (Small and Weakly Polar) -> Glu (Charged) |
- |
| 347 |
|
AQP1 |
rs546809019 |
NP_932766.1 - 200 (LE) |
Exposed to the extracellular environment |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 348 |
|
AQP1 |
rs747249467 |
NP_932766.1 - 200 (LE) |
Exposed to the extracellular environment |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 349 |
|
AQP1 |
rs371391537 |
NP_932766.1 - 201 (LE) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 350 |
|
AQP1 |
rs745651824 |
NP_932766.1 - 201 (LE) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 351 |
|
AQP1 |
rs1427213285 |
NP_932766.1 - 205 (Loop region after LE) |
Loop E |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 352 |
|
AQP1 |
rs1481500259 |
NP_932766.1 - 205 (Loop region after LE) |
Loop E |
Asn (Neutral polar) -> Lys (Charged) |
- |
| 353 |
|
AQP1 |
rs1400278167 |
NP_932766.1 - 207 (TM6) |
Lipid facing |
Ser (Small and Weakly Polar) -> Arg (Charged) |
- |
| 354 |
|
AQP1 |
rs1408543232 |
NP_932766.1 - 208 (TM6) |
Helix - helix interface (TM4 - TM6) |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 355 |
|
AQP1 |
rs1331247328 |
NP_932766.1 - 209 (TM6) |
Helix - helix interface (LE - TM6) |
His (Charged) -> Asp (Charged) |
- |
| 356 |
|
AQP1 |
rs1445418068 |
NP_932766.1 - 212 (TM6) |
Helix - helix interface (TM4 - LE) |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 357 |
|
AQP1 |
rs983133460 |
NP_932766.1 - 213 (TM6) |
Lipid facing |
Trp (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 358 |
|
AQP1 |
rs765650073 |
NP_932766.1 - 215 (TM6) |
Helix - helix interface (TM4 - TM6) |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 359 |
|
AQP1 |
rs1162011127 |
NP_932766.1 - 216 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6, LE - TM6) |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 360 |
|
AQP1 |
rs375975852 |
NP_932766.1 - 218 (TM6) |
Lipid facing |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 361 |
|
AQP1 |
rs752063738 |
NP_932766.1 - 219 (TM6) |
Helix - helix interface (TM4 - TM6) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 362 |
|
AQP1 |
rs752063738 |
NP_932766.1 - 219 (TM6) |
Helix - helix interface (TM4 - TM6) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 363 |
|
AQP1 |
rs1198281617 |
NP_932766.1 - 220 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6) |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 364 |
|
AQP1 |
rs767634051 |
NP_932766.1 - 221 (TM6) |
Helix - helix interface (LB - TM6); Lipid facing |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 365 |
|
AQP1 |
rs750670054 |
NP_932766.1 - 222 (TM6) |
Helix - helix interface (TM4 - TM6); Lipid facing |
Leu (Aliphatic hydrophobic) -> Gln (Neutral polar) |
- |
| 366 |
|
AQP1 |
rs914070676 |
NP_932766.1 - 224 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6) |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 367 |
|
AQP1 |
rs1450399914 |
NP_932766.1 - 228 (TM6) |
Channel facing |
Asp (Charged) -> Asn (Neutral polar) |
- |
| 368 |
|
AQP1 |
rs375226621 |
NP_932766.1 - 234 (C terminus) |
Absent in the structure |
Arg (Charged) -> His (Charged) |
- |
| 369 |
|
AQP1 |
rs749008815 |
NP_932766.1 - 234 (C terminus) |
Absent in the structure |
Arg (Charged) -> Ser (Small and Weakly Polar) |
- |
| 370 |
|
AQP1 |
rs749008815 |
NP_932766.1 - 234 (C terminus) |
Absent in the structure |
Arg (Charged) -> Gly (Small and Weakly Polar) |
- |
| 371 |
|
AQP1 |
rs749008815 |
NP_932766.1 - 234 (C terminus) |
Absent in the structure |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 372 |
|
AQP1 |
rs1391711860 |
NP_932766.1 - 235 (C terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 373 |
|
AQP1 |
rs932635477 |
NP_932766.1 - 239 (C terminus) |
Absent in the structure |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 374 |
|
AQP1 |
rs748039521 |
NP_932766.1 - 241 (C terminus) |
Absent in the structure |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 375 |
|
AQP1 |
rs771575765 |
NP_932766.1 - 242 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 376 |
|
AQP1 |
rs771575765 |
NP_932766.1 - 242 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 377 |
|
AQP1 |
rs1182298604 |
NP_932766.1 - 244 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 378 |
|
AQP1 |
rs746735108 |
NP_932766.1 - 245 (C terminus) |
Absent in the structure |
Trp (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 379 |
|
AQP1 |
rs149637560 |
NP_932766.1 - 248 (C terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 380 |
|
AQP1 |
rs201414781 |
NP_932766.1 - 249 (C terminus) |
Absent in the structure |
Gln (Neutral polar) -> His (Charged) |
- |
| 381 |
|
AQP1 |
rs1406441754 |
NP_932766.1 - 249 (C terminus) |
Absent in the structure |
Gln (Neutral polar) -> Arg (Charged) |
- |
| 382 |
|
AQP1 |
rs1337448707 |
NP_932766.1 - 250 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 383 |
|
AQP1 |
rs1173818533 |
NP_932766.1 - 251 (C terminus) |
Absent in the structure |
Glu (Charged) -> Lys (Charged) |
- |
| 384 |
|
AQP1 |
rs144238098 |
NP_932766.1 - 253 (C terminus) |
Absent in the structure |
Tyr (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 385 |
|
AQP1 |
rs1445654696 |
NP_932766.1 - 254 (C terminus) |
Absent in the structure |
Asp (Charged) -> Glu (Charged) |
- |
| 386 |
|
AQP1 |
rs1445654696 |
NP_932766.1 - 254 (C terminus) |
Absent in the structure |
Asp (Charged) -> Glu (Charged) |
- |
| 387 |
|
AQP1 |
rs762347784 |
NP_932766.1 - 255 (C terminus) |
Absent in the structure |
Leu (Aliphatic hydrophobic) -> Gln (Neutral polar) |
- |
| 388 |
|
AQP1 |
rs575472927 |
NP_932766.1 - 256 (C terminus) |
Absent in the structure |
Asp (Charged) -> Glu (Charged) |
- |
| 389 |
|
AQP1 |
rs1406524465 |
NP_932766.1 - 257 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 390 |
|
AQP1 |
rs760999882 |
NP_932766.1 - 258 (C terminus) |
Absent in the structure |
Asp (Charged) -> Asn (Neutral polar) |
- |
| 391 |
|
AQP1 |
rs761409742 |
NP_932766.1 - 259 (C terminus) |
Absent in the structure |
Asp (Charged) -> Asn (Neutral polar) |
- |
| 392 |
|
AQP1 |
rs754801843 |
NP_932766.1 - 260 (C terminus) |
Absent in the structure |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 393 |
|
AQP1 |
rs1001031938 |
NP_932766.1 - 260 (C terminus) |
Absent in the structure |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 394 |
|
AQP1 |
rs1001031938 |
NP_932766.1 - 260 (C terminus) |
Absent in the structure |
Ile (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 395 |
|
AQP1 |
rs1202321358 |
NP_932766.1 - 263 (C terminus) |
Absent in the structure |
Arg (Charged) -> Lys (Charged) |
- |
| 396 |
|
AQP1 |
rs1462031633 |
NP_932766.1 - 265 (C terminus) |
Absent in the structure |
Glu (Charged) -> Gln (Neutral polar) |
- |
| 397 |
|
AQP1 |
rs778613724 |
NP_932766.1 - 267 (C terminus) |
Absent in the structure |
Lys (Charged) -> Asn (Neutral polar) |
- |
| 398 |
|
AQP2 |
rs1288385043 |
NP_000477.1 - 1 (N terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 399 |
|
AQP2 |
rs1288385043 |
NP_000477.1 - 1 (N terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 400 |
|
AQP2 |
rs1382799709 |
NP_000477.1 - 2 (N terminus) |
Mutated to Ser in PDB Structure - N terminal domain |
Trp (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 401 |
|
AQP2 |
rs779279677 |
NP_000477.1 - 3 (N terminus) |
N terminal domain |
Glu (Charged) -> Lys (Charged) |
- |
| 402 |
|
AQP2 |
rs372883230 |
NP_000477.1 - 4 (N terminus) |
N terminal domain |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 403 |
|
AQP2 |
rs1365398150 |
NP_000477.1 - 4 (N terminus) |
N terminal domain |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 404 |
|
AQP2 |
rs148006652 |
NP_000477.1 - 5 (N terminus) |
N terminal domain |
Arg (Charged) -> His (Charged) |
- |
| 405 |
|
AQP2 |
rs772585705 |
NP_000477.1 - 5 (N terminus) |
N terminal domain |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 406 |
|
AQP2 |
rs1278004193 |
NP_000477.1 - 7 (TM1) |
Exposed to cytoplasm |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 407 |
|
AQP2 |
rs1237811033 |
NP_000477.1 - 8 (TM1) |
Exposed to cytoplasm |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 408 |
|
AQP2 |
rs1354001307 |
NP_000477.1 - 8 (TM1) |
Exposed to cytoplasm |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 409 |
|
AQP2 |
rs1224587357 |
NP_000477.1 - 9 (TM1) |
Helix - helix interface (TM1 - TM3) |
Phe (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 410 |
|
AQP2 |
rs148085137 |
NP_000477.1 - 11 (TM1) |
Monomer - monomer interface |
Arg (Charged) -> Lys (Charged) |
- |
| 411 |
|
AQP2 |
rs775148085 |
NP_000477.1 - 14 (TM1) |
Monomer - monomer interface |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 412 |
|
AQP2 |
rs762574510 |
NP_000477.1 - 15 (TM1) |
Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 413 |
|
AQP2 |
rs763919973 |
NP_000477.1 - 17 (TM1) |
Helix - helix interface (TM1 - TM3); Lipid facing |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 414 |
|
AQP2 |
rs751311089 |
NP_000477.1 - 19 (TM1) |
Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 415 |
|
AQP2 |
rs1349575785 |
NP_000477.1 - 19 (TM1) |
Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 416 |
|
AQP2 |
rs1323425355 |
NP_000477.1 - 20 (TM1) |
Helix - helix interface (TM1 - TM3) |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 417 |
|
AQP2 |
rs757280714 |
NP_000477.1 - 21 (TM1) |
Helix - helix interface (TM1 - TM3) |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 418 |
|
AQP2 |
rs757280714 |
NP_000477.1 - 21 (TM1) |
Helix - helix interface (TM1 - TM3) |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 419 |
|
AQP2 |
rs1393300849 |
NP_000477.1 - 21 (TM1) |
Helix - helix interface (TM1 - TM3) |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 420 |
|
AQP2 |
rs104894336 |
NP_000477.1 - 22 (TM1) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
Autosomal recessive Nephrogenic Diabetes Insipidus |
| 421 |
|
AQP2 |
rs200706192 |
NP_000477.1 - 24 (TM1) |
Helix - helix interface (TM1 - TM3) |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 422 |
|
AQP2 |
rs778267384 |
NP_000477.1 - 27 (TM1) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 423 |
|
AQP2 |
rs1333138865 |
NP_000477.1 - 28 (TM1) |
Helix - helix interface (TM1 - TM3, TM1 - LE) |
Leu (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 424 |
|
AQP2 |
rs1333138865 |
NP_000477.1 - 28 (TM1) |
Helix - helix interface (TM1 - TM3, TM1 - LE) |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 425 |
|
AQP2 |
rs964170650 |
NP_000477.1 - 29 (TM1) |
Helix - helix interface (TM1 - TM3);Monomer - monomer interface |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 426 |
|
AQP2 |
rs1304396038 |
NP_000477.1 - 31 (TM1) |
Channel facing |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 427 |
|
AQP2 |
rs746338782 |
NP_000477.1 - 35 (Loop region after TM1) |
Loop A |
Pro (Proline) -> Thr (Small and Weakly Polar) |
- |
| 428 |
|
AQP2 |
rs746338782 |
NP_000477.1 - 35 (Loop region after TM1) |
Loop A |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 429 |
|
AQP2 |
rs762664471 |
NP_000477.1 - 42 (TM2) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 430 |
|
AQP2 |
rs763727714 |
NP_000477.1 - 43 (TM2) |
Monomer - monomer interface |
Gln (Neutral polar) -> Pro (Proline) |
- |
| 431 |
|
AQP2 |
rs763727714 |
NP_000477.1 - 43 (TM2) |
Monomer - monomer interface |
Gln (Neutral polar) -> Arg (Charged) |
- |
| 432 |
|
AQP2 |
rs1248655050 |
NP_000477.1 - 44 (TM2) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 433 |
|
AQP2 |
rs1284823222 |
NP_000477.1 - 45 (TM2) |
Helix - helix interface (TM2 - TM5) |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 434 |
|
AQP2 |
rs761515066 |
NP_000477.1 - 46 (TM2) |
Monomer - monomer interface |
Met (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 435 |
|
AQP2 |
rs767301067 |
NP_000477.1 - 46 (TM2) |
Monomer - monomer interface |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 436 |
|
AQP2 |
rs995684800 |
NP_000477.1 - 47 (TM2) |
Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Glu (Charged) |
- |
| 437 |
|
AQP2 |
rs995684800 |
NP_000477.1 - 47 (TM2) |
Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 438 |
|
AQP2 |
rs1172724582 |
NP_000477.1 - 48 (TM2 - Ar/R Selectivity filter) |
Channel facing |
Phe (Aromatic) -> Ile (Aliphatic hydrophobic) |
- |
| 439 |
|
AQP2 |
rs1466275664 |
NP_000477.1 - 54 (TM2) |
Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Asn (Neutral polar) |
- |
| 440 |
|
AQP2 |
rs1466275664 |
NP_000477.1 - 54 (TM2) |
Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 441 |
|
AQP2 |
rs1396199369 |
NP_000477.1 - 56 (TM2) |
Channel facing;Helix - helix interface (TM2 - TM5) |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 442 |
|
AQP2 |
rs28931580 |
NP_000477.1 - 57 (TM2) |
Monomer - monomer interface |
Gln (Neutral polar) -> Pro (Proline) |
Autosomal recessive Nephrogenic Diabetes Insipidus |
| 443 |
|
AQP2 |
rs145685755 |
NP_000477.1 - 58 (TM2) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 444 |
|
AQP2 |
rs575346865 |
NP_000477.1 - 58 (TM2) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 445 |
|
AQP2 |
rs1014984131 |
NP_000477.1 - 60 (TM2) |
Channel facing |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 446 |
|
AQP2 |
rs781600142 |
NP_000477.1 - 62 (TM2) |
Monomer - monomer interface;Helix - helix interface (TM1 - TM2) |
Ile (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 447 |
|
AQP2 |
rs1308492971 |
NP_000477.1 - 62 (TM2) |
Monomer - monomer interface;Helix - helix interface (TM1 - TM2) |
Ile (Aliphatic hydrophobic) -> Lys (Charged) |
- |
| 448 |
|
AQP2 |
rs1308492971 |
NP_000477.1 - 62 (TM2) |
Monomer - monomer interface;Helix - helix interface (TM1 - TM2) |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 449 |
|
AQP2 |
rs200279968 |
NP_000477.1 - 63 (TM2) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Ser (Small and Weakly Polar) -> Arg (Charged) |
- |
| 450 |
|
AQP2 |
rs746416707 |
NP_000477.1 - 63 (TM2) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Ser (Small and Weakly Polar) -> Asn (Neutral polar) |
- |
| 451 |
|
AQP2 |
rs104894326 |
NP_000477.1 - 64 (TM2) |
Channel facing |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 452 |
|
AQP2 |
rs147174725 |
NP_000477.1 - 65 (Loop region after TM2) |
Loop B |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 453 |
|
AQP2 |
rs544999593 |
NP_000477.1 - 65 (Loop region after TM2) |
Loop B |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 454 |
|
AQP2 |
rs544999593 |
NP_000477.1 - 65 (Loop region after TM2) |
Loop B |
Ala (Small and Weakly Polar) -> Pro (Proline) |
- |
| 455 |
|
AQP2 |
rs1256982565 |
NP_000477.1 - 66 (Loop region after TM2) |
Loop B |
His (Charged) -> Tyr (Aromatic) |
- |
| 456 |
|
AQP2 |
rs773903320 |
NP_000477.1 - 67 (Loop region after TM2) |
Loop B |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 457 |
|
AQP2 |
rs104894331 |
NP_000477.1 - 68 (LB - NPA1) |
Channel facing;Helix - helix interface (LB - LE, LB - TM3) |
Asn (Neutral polar) -> Thr (Small and Weakly Polar) |
- |
| 458 |
|
AQP2 |
rs104894331 |
NP_000477.1 - 68 (LB - NPA1) |
Channel facing;Helix - helix interface (LB - LE, LB - TM3) |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
Autosomal recessive Nephrogenic Diabetes Insipidus |
| 459 |
|
AQP2 |
rs149659001 |
NP_000477.1 - 71 (LB) |
Channel facing |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 460 |
|
AQP2 |
rs149659001 |
NP_000477.1 - 71 (LB) |
Channel facing |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 461 |
|
AQP2 |
rs193922494 |
NP_000477.1 - 75 (LB) |
Channel facing |
Cys (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 462 |
|
AQP2 |
rs144443773 |
NP_000477.1 - 75 (LB) |
Channel facing |
Cys (Small and Weakly Polar) -> Tyr (Aromatic) |
- |
| 463 |
|
AQP2 |
rs144443773 |
NP_000477.1 - 75 (LB) |
Channel facing |
Cys (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 464 |
|
AQP2 |
rs149823093 |
NP_000477.1 - 78 (LB) |
Helix - helix interface (LB - TM6) |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 465 |
|
AQP2 |
rs763156762 |
NP_000477.1 - 81 (Loop region after LB) |
Loop B |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 466 |
|
AQP2 |
rs945334171 |
NP_000477.1 - 81 (Loop region after LB) |
Loop B |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 467 |
|
AQP2 |
rs267603499 |
NP_000477.1 - 82 (TM3) |
Exposed to cytoplasm |
Ser (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 468 |
|
AQP2 |
rs751779733 |
NP_000477.1 - 83 (TM3) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 469 |
|
AQP2 |
rs543420016 |
NP_000477.1 - 84 (TM3) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 470 |
|
AQP2 |
rs1229039151 |
NP_000477.1 - 85 (TM3) |
Channel facing |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 471 |
|
AQP2 |
rs756417343 |
NP_000477.1 - 86 (TM3) |
Helix - helix interface (LB - TM3) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 472 |
|
AQP2 |
rs1279852191 |
NP_000477.1 - 86 (TM3) |
Helix - helix interface (LB - TM3) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 473 |
|
AQP2 |
rs749751111 |
NP_000477.1 - 87 (TM3) |
Lipid facing |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 474 |
|
AQP2 |
rs768070682 |
NP_000477.1 - 88 (TM3) |
Helix - helix interface (LB - TM3); Lipid facing |
Phe (Aromatic) -> Val (Aliphatic hydrophobic) |
- |
| 475 |
|
AQP2 |
rs891097409 |
NP_000477.1 - 89 (TM3) |
Helix - helix interface (TM1 - TM3, LB - TM3) |
Tyr (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 476 |
|
AQP2 |
rs1433972639 |
NP_000477.1 - 89 (TM3) |
Helix - helix interface (TM1 - TM3, LB - TM3) |
Tyr (Aromatic) -> Asn (Neutral polar) |
- |
| 477 |
|
AQP2 |
rs747794240 |
NP_000477.1 - 90 (TM3) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 478 |
|
AQP2 |
rs771750531 |
NP_000477.1 - 90 (TM3) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 479 |
|
AQP2 |
rs1172670485 |
NP_000477.1 - 92 (TM3) |
Helix - helix interface (TM1 - TM3) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 480 |
|
AQP2 |
rs1318426281 |
NP_000477.1 - 94 (TM3) |
Lipid facing;Helix - helix interface (TM3 - LE) |
Leu (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 481 |
|
AQP2 |
rs1162183069 |
NP_000477.1 - 96 (TM3) |
Helix - helix interface (TM1 - TM3) |
Gly (Small and Weakly Polar) -> Trp (Aromatic) |
- |
| 482 |
|
AQP2 |
rs759525877 |
NP_000477.1 - 98 (TM3) |
Lipid facing;Helix - helix interface (TM3 - LE) |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 483 |
|
AQP2 |
rs759525877 |
NP_000477.1 - 98 (TM3) |
Lipid facing;Helix - helix interface (TM3 - LE) |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 484 |
|
AQP2 |
rs1039778194 |
NP_000477.1 - 99 (TM3) |
Lipid facing |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 485 |
|
AQP2 |
rs104894338 |
NP_000477.1 - 100 (TM3) |
Helix - helix interface (TM1 - TM3) |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
Autosomal recessive Nephrogenic Diabetes Insipidus |
| 486 |
|
AQP2 |
rs1303076207 |
NP_000477.1 - 100 (TM3) |
Helix - helix interface (TM1 - TM3) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 487 |
|
AQP2 |
rs201047682 |
NP_000477.1 - 102 (TM3) |
Lipid facing |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 488 |
|
AQP2 |
rs201047682 |
NP_000477.1 - 102 (TM3) |
Lipid facing |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 489 |
|
AQP2 |
rs529388515 |
NP_000477.1 - 107 (TM3) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 490 |
|
AQP2 |
rs1248356231 |
NP_000477.1 - 107 (TM3) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 491 |
|
AQP2 |
rs1468828294 |
NP_000477.1 - 108 (TM3) |
Exposed to the extracellular environment |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 492 |
|
AQP2 |
rs1392977986 |
NP_000477.1 - 109 (Loop region after TM3) |
Loop C |
Pro (Proline) -> Thr (Small and Weakly Polar) |
- |
| 493 |
|
AQP2 |
rs866163323 |
NP_000477.1 - 111 (Loop region after TM3) |
Loop C |
Asp (Charged) -> Asn (Neutral polar) |
- |
| 494 |
|
AQP2 |
rs754388502 |
NP_000477.1 - 112 (Loop region after TM3) |
Loop C |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 495 |
|
AQP2 |
rs549442099 |
NP_000477.1 - 113 (Loop region after TM3) |
Loop C |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 496 |
|
AQP2 |
rs778352561 |
NP_000477.1 - 113 (Loop region after TM3) |
Loop C |
Arg (Charged) -> His (Charged) |
- |
| 497 |
|
AQP2 |
rs370232864 |
NP_000477.1 - 114 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 498 |
|
AQP2 |
rs777600378 |
NP_000477.1 - 114 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 499 |
|
AQP2 |
rs1280344383 |
NP_000477.1 - 117 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 500 |
|
AQP2 |
rs1444717994 |
NP_000477.1 - 117 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 501 |
|
AQP2 |
rs1222171942 |
NP_000477.1 - 118 (Loop region after TM3) |
Loop C |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 502 |
|
AQP2 |
rs11169226 |
NP_000477.1 - 121 (Loop region after TM3) |
Loop C |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 503 |
|
AQP2 |
rs749134912 |
NP_000477.1 - 122 (Loop region after TM3) |
Loop C |
Ser (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 504 |
|
AQP2 |
rs1430988017 |
NP_000477.1 - 123 (Loop region after TM3) |
Loop C |
Asn (Neutral polar) -> Asp (Charged) |
- |
| 505 |
|
AQP2 |
rs104894333 |
NP_000477.1 - 125 (Loop region after TM3) |
Loop C |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
Autosomal recessive Nephrogenic Diabetes Insipidus |
| 506 |
|
AQP2 |
rs1280566801 |
NP_000477.1 - 125 (Loop region after TM3) |
Loop C |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 507 |
|
AQP2 |
rs104894330 |
NP_000477.1 - 126 (TM4) |
Exposed to the extracellular environment |
Thr (Small and Weakly Polar) -> Lys (Charged) |
- |
| 508 |
|
AQP2 |
rs104894330 |
NP_000477.1 - 126 (TM4) |
Exposed to the extracellular environment |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
Autosomal recessive Nephrogenic Diabetes Insipidus |
| 509 |
|
AQP2 |
rs776661183 |
NP_000477.1 - 130 (TM4) |
Helix - helix interface (TM4 - TM5) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 510 |
|
AQP2 |
rs753295442 |
NP_000477.1 - 131 (TM4) |
Lipid facing;Helix - helix interface (TM4 - TM6) |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 511 |
|
AQP2 |
rs1395951397 |
NP_000477.1 - 133 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 512 |
|
AQP2 |
rs751098988 |
NP_000477.1 - 141 (TM4) |
Channel facing;Helix - helix interface (LB - TM4, TM4 - TM5) |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 513 |
|
AQP2 |
rs780992666 |
NP_000477.1 - 143 (TM4) |
Helix - helix interface (TM4 - TM6);Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 514 |
|
AQP2 |
rs1324514758 |
NP_000477.1 - 144 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Cys (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 515 |
|
AQP2 |
rs373700329 |
NP_000477.1 - 145 (TM4) |
Channel facing |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 516 |
|
AQP2 |
rs143886391 |
NP_000477.1 - 146 (TM4) |
Helix - helix interface (LB - TM4, TM4 - TM6) |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 517 |
|
AQP2 |
rs755964170 |
NP_000477.1 - 146 (TM4) |
Helix - helix interface (LB - TM4, TM4 - TM6) |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 518 |
|
AQP2 |
rs104894334 |
NP_000477.1 - 147 (TM4) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
Autosomal recessive Nephrogenic Diabetes Insipidus |
| 519 |
|
AQP2 |
rs146384248 |
NP_000477.1 - 149 (TM4) |
Channel facing |
Thr (Small and Weakly Polar) -> Asn (Neutral polar) |
- |
| 520 |
|
AQP2 |
rs146384248 |
NP_000477.1 - 149 (TM4) |
Channel facing |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 521 |
|
AQP2 |
rs770932012 |
NP_000477.1 - 150 (Loop region after TM4) |
Loop D |
Asp (Charged) -> Glu (Charged) |
- |
| 522 |
|
AQP2 |
rs770932012 |
NP_000477.1 - 150 (Loop region after TM4) |
Loop D |
Asp (Charged) -> Glu (Charged) |
- |
| 523 |
|
AQP2 |
rs1206293615 |
NP_000477.1 - 150 (Loop region after TM4) |
Loop D |
Asp (Charged) -> Asn (Neutral polar) |
- |
| 524 |
|
AQP2 |
rs150344189 |
NP_000477.1 - 152 (Loop region after TM4) |
Loop D |
Arg (Charged) -> His (Charged) |
- |
| 525 |
|
AQP2 |
rs150344189 |
NP_000477.1 - 152 (Loop region after TM4) |
Loop D |
Arg (Charged) -> Leu (Aliphatic hydrophobic) |
- |
| 526 |
|
AQP2 |
rs1463900828 |
NP_000477.1 - 152 (Loop region after TM4) |
Loop D |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 527 |
|
AQP2 |
rs139771821 |
NP_000477.1 - 153 (Loop region after TM4) |
Loop D |
Arg (Charged) -> His (Charged) |
- |
| 528 |
|
AQP2 |
rs1253955671 |
NP_000477.1 - 153 (Loop region after TM4) |
Loop D |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 529 |
|
AQP2 |
rs369214822 |
NP_000477.1 - 154 (Loop region after TM4) |
Loop D |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 530 |
|
AQP2 |
rs1258678763 |
NP_000477.1 - 156 (Loop region after TM4) |
Loop D |
Asn (Neutral polar) -> Lys (Charged) |
- |
| 531 |
|
AQP2 |
rs763610050 |
NP_000477.1 - 157 (Loop region after TM4) |
Loop D |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 532 |
|
AQP2 |
rs1382728989 |
NP_000477.1 - 158 (Loop region after TM4) |
Loop D |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 533 |
|
AQP2 |
rs1442941552 |
NP_000477.1 - 160 (TM5) |
Helix - helix interface (TM4 - TM5) |
Pro (Proline) -> His (Charged) |
- |
| 534 |
|
AQP2 |
rs1442941552 |
NP_000477.1 - 160 (TM5) |
Helix - helix interface (TM4 - TM5) |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 535 |
|
AQP2 |
rs1483226930 |
NP_000477.1 - 161 (TM5) |
Helix - helix interface (TM2 - TM5) |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 536 |
|
AQP2 |
rs752043181 |
NP_000477.1 - 164 (TM5) |
Channel facing;Helix - helix interface (TM4 - TM5) |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 537 |
|
AQP2 |
rs1218059646 |
NP_000477.1 - 164 (TM5) |
Channel facing;Helix - helix interface (TM4 - TM5) |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 538 |
|
AQP2 |
rs761436417 |
NP_000477.1 - 165 (TM5) |
Helix - helix interface (TM2 - TM5) |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 539 |
|
AQP2 |
rs1226419141 |
NP_000477.1 - 165 (TM5) |
Helix - helix interface (TM2 - TM5) |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 540 |
|
AQP2 |
rs766884762 |
NP_000477.1 - 167 (TM5) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Ser (Small and Weakly Polar) -> Pro (Proline) |
- |
| 541 |
|
AQP2 |
rs755694590 |
NP_000477.1 - 168 (TM5) |
Channel facing |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 542 |
|
AQP2 |
rs755694590 |
NP_000477.1 - 168 (TM5) |
Channel facing |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 543 |
|
AQP2 |
rs779968640 |
NP_000477.1 - 169 (TM5) |
Helix - helix interface (TM2 - TM5) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 544 |
|
AQP2 |
rs1274267263 |
NP_000477.1 - 171 (TM5) |
Helix - helix interface (TM4 - TM5) |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 545 |
|
AQP2 |
rs1189745136 |
NP_000477.1 - 172 (TM5 - Ar/R Selectivity filter) |
Channel facing;Helix - helix interface (TM2 - TM5) |
His (Charged) -> Gln (Neutral polar) |
- |
| 546 |
|
AQP2 |
rs104894335 |
NP_000477.1 - 175 (TM5) |
Helix - helix interface (TM4 - TM5) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
Autosomal recessive Nephrogenic Diabetes Insipidus |
| 547 |
|
AQP2 |
rs1177781346 |
NP_000477.1 - 176 (TM5) |
Channel facing |
Ile (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 548 |
|
AQP2 |
rs1214386015 |
NP_000477.1 - 177 (TM5) |
Monomer - monomer interface |
His (Charged) -> Tyr (Aromatic) |
- |
| 549 |
|
AQP2 |
rs147039983 |
NP_000477.1 - 180 (TM5) |
Channel facing |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 550 |
|
AQP2 |
rs147039983 |
NP_000477.1 - 180 (TM5) |
Channel facing |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 551 |
|
AQP2 |
rs104894337 |
NP_000477.1 - 181 (Loop region after TM5 - Ar/R Selectivity filter) |
Loop E |
Cys (Small and Weakly Polar) -> Trp (Aromatic) |
- |
| 552 |
|
AQP2 |
rs1235208924 |
NP_000477.1 - 181 (Loop region after TM5 - Ar/R Selectivity filter) |
Loop E |
Cys (Small and Weakly Polar) -> Tyr (Aromatic) |
- |
| 553 |
|
AQP2 |
rs1240185815 |
NP_000477.1 - 184 (LE - NPA2) |
Channel facing;Helix - helix interface (TM1 - LE, LB - LE) |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 554 |
|
AQP2 |
rs761713751 |
NP_000477.1 - 185 (LE - NPA2) |
Helix - helix interface (LB - LE, LE - TM6) |
Pro (Proline) -> Ala (Small and Weakly Polar) |
- |
| 555 |
|
AQP2 |
rs104894328 |
NP_000477.1 - 187 (LE - Ar/R Selectivity filter) |
Channel facing |
Arg (Charged) -> Cys (Small and Weakly Polar) |
Autosomal recessive Nephrogenic Diabetes Insipidus |
| 556 |
|
AQP2 |
rs193922495 |
NP_000477.1 - 187 (LE - Ar/R Selectivity filter) |
Channel facing |
Arg (Charged) -> His (Charged) |
- |
| 557 |
|
AQP2 |
rs1131690792 |
NP_000477.1 - 188 (LE) |
Helix - helix interface (LE - TM6) |
Ser (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 558 |
|
AQP2 |
rs104894341 |
NP_000477.1 - 190 (LE) |
Helix - helix interface (TM3 - LE) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
Autosomal recessive Nephrogenic Diabetes Insipidus |
| 559 |
|
AQP2 |
rs760109597 |
NP_000477.1 - 192 (LE) |
Exposed to the extracellular environment |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 560 |
|
AQP2 |
rs772051028 |
NP_000477.1 - 194 (LE) |
Helix - helix interface (LE - TM3) |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 561 |
|
AQP2 |
rs1401908251 |
NP_000477.1 - 195 (LE) |
Exposed to the extracellular environment |
Thr (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 562 |
|
AQP2 |
rs1377196697 |
NP_000477.1 - 198 (Loop region after LE) |
Loop E |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 563 |
|
AQP2 |
rs752474179 |
NP_000477.1 - 200 (Loop region after LE) |
Loop E |
Asp (Charged) -> Asn (Neutral polar) |
- |
| 564 |
|
AQP2 |
rs1003892725 |
NP_000477.1 - 201 (Loop region after LE) |
Loop E |
His (Charged) -> Leu (Aliphatic hydrophobic) |
- |
| 565 |
|
AQP2 |
rs779285601 |
NP_000477.1 - 203 (TM6) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 566 |
|
AQP2 |
rs1420691120 |
NP_000477.1 - 205 (TM6) |
Helix - helix interface(TM6 - LE, TM6 - TM3); Lipid facing |
Trp (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 567 |
|
AQP2 |
rs1163056099 |
NP_000477.1 - 208 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6, LE - TM6) |
Pro (Proline) -> Thr (Small and Weakly Polar) |
- |
| 568 |
|
AQP2 |
rs889586478 |
NP_000477.1 - 209 (TM6) |
Helix - helix interface (LB - TM6); Lipid facing |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 569 |
|
AQP2 |
rs1555165381 |
NP_000477.1 - 209 (TM6) |
Helix - helix interface (LB - TM6); Lipid facing |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 570 |
|
AQP2 |
rs752925390 |
NP_000477.1 - 210 (TM6) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 571 |
|
AQP2 |
rs142323499 |
NP_000477.1 - 212 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 572 |
|
AQP2 |
rs940378041 |
NP_000477.1 - 212 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6) |
Ala (Small and Weakly Polar) -> Pro (Proline) |
- |
| 573 |
|
AQP2 |
rs940378041 |
NP_000477.1 - 212 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6) |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 574 |
|
AQP2 |
rs778177446 |
NP_000477.1 - 214 (TM6) |
Helix - helix interface (TM4 - TM6); Lipid facing |
Leu (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 575 |
|
AQP2 |
rs104894329 |
NP_000477.1 - 216 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6) |
Ser (Small and Weakly Polar) -> Pro (Proline) |
Autosomal recessive Nephrogenic Diabetes Insipidus |
| 576 |
|
AQP2 |
rs199422215 |
NP_000477.1 - 216 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6) |
Ser (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 577 |
|
AQP2 |
rs1006730946 |
NP_000477.1 - 219 (TM6) |
Helix - helix interface (TM4 - TM6) |
Tyr (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 578 |
|
AQP2 |
rs1193417520 |
NP_000477.1 - 219 (TM6) |
Helix - helix interface (TM4 - TM6) |
Tyr (Aromatic) -> His (Charged) |
- |
| 579 |
|
AQP2 |
rs771414160 |
NP_000477.1 - 220 (TM6) |
Channel facing |
Asn (Neutral polar) -> Thr (Small and Weakly Polar) |
- |
| 580 |
|
AQP2 |
rs1341191085 |
NP_000477.1 - 221 (TM6) |
Lipid facing |
Tyr (Aromatic) -> His (Charged) |
- |
| 581 |
|
AQP2 |
rs781620316 |
NP_000477.1 - 222 (TM6) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 582 |
|
AQP2 |
rs781620316 |
NP_000477.1 - 222 (TM6) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 583 |
|
AQP2 |
rs1481844552 |
NP_000477.1 - 223 (C terminus) |
C terminal domain |
Leu (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 584 |
|
AQP2 |
rs775144060 |
NP_000477.1 - 224 (C terminus) |
C terminal domain |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 585 |
|
AQP2 |
rs1486287656 |
NP_000477.1 - 225 (C terminus) |
C terminal domain |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 586 |
|
AQP2 |
rs1367139465 |
NP_000477.1 - 229 (C terminus) |
C terminal domain |
Ser (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 587 |
|
AQP2 |
rs748006253 |
NP_000477.1 - 231 (C terminus) |
C terminal domain |
Ser (Small and Weakly Polar) -> Leu (Aliphatic hydrophobic) |
- |
| 588 |
|
AQP2 |
rs767578769 |
NP_000477.1 - 232 (C terminus) |
C terminal domain |
Glu (Charged) -> Asp (Charged) |
- |
| 589 |
|
AQP2 |
rs750321982 |
NP_000477.1 - 233 (C terminus) |
C terminal domain |
Arg (Charged) -> Gly (Small and Weakly Polar) |
- |
| 590 |
|
AQP2 |
rs750321982 |
NP_000477.1 - 233 (C terminus) |
C terminal domain |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 591 |
|
AQP2 |
rs1328020134 |
NP_000477.1 - 237 (C terminus) |
C terminal domain |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 592 |
|
AQP2 |
rs758616792 |
NP_000477.1 - 241 (C terminus) |
Absent in the structure |
Glu (Charged) -> Asp (Charged) |
- |
| 593 |
|
AQP2 |
rs1475186890 |
NP_000477.1 - 241 (C terminus) |
Absent in the structure |
Glu (Charged) -> Gly (Small and Weakly Polar) |
- |
| 594 |
|
AQP2 |
rs778056386 |
NP_000477.1 - 242 (C terminus) |
Absent in the structure |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 595 |
|
AQP2 |
rs781686280 |
NP_000477.1 - 243 (C terminus) |
Absent in the structure |
Asp (Charged) -> Gly (Small and Weakly Polar) |
- |
| 596 |
|
AQP2 |
rs769339416 |
NP_000477.1 - 244 (C terminus) |
Absent in the structure |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 597 |
|
AQP2 |
rs1254726402 |
NP_000477.1 - 245 (C terminus) |
Absent in the structure |
Asp (Charged) -> Val (Aliphatic hydrophobic) |
- |
| 598 |
|
AQP2 |
rs1363342807 |
NP_000477.1 - 245 (C terminus) |
Absent in the structure |
Asp (Charged) -> Asn (Neutral polar) |
- |
| 599 |
|
AQP2 |
rs1189628239 |
NP_000477.1 - 247 (C terminus) |
Absent in the structure |
Glu (Charged) -> Gly (Small and Weakly Polar) |
- |
| 600 |
|
AQP2 |
rs768344428 |
NP_000477.1 - 248 (C terminus) |
Absent in the structure |
Glu (Charged) -> Gln (Neutral polar) |
- |
| 601 |
|
AQP2 |
rs1175748856 |
NP_000477.1 - 249 (C terminus) |
Absent in the structure |
Arg (Charged) -> His (Charged) |
- |
| 602 |
|
AQP2 |
rs1267024673 |
NP_000477.1 - 250 (C terminus) |
Absent in the structure |
Glu (Charged) -> Lys (Charged) |
- |
| 603 |
|
AQP2 |
rs150666967 |
NP_000477.1 - 251 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 604 |
|
AQP2 |
rs139913957 |
NP_000477.1 - 253 (C terminus) |
Absent in the structure |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 605 |
|
AQP2 |
rs1387073795 |
NP_000477.1 - 254 (C terminus) |
Absent in the structure |
Arg (Charged) -> Trp (Aromatic) |
- |
| 606 |
|
AQP2 |
rs1362761842 |
NP_000477.1 - 257 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 607 |
|
AQP2 |
rs104894332 |
NP_000477.1 - 258 (C terminus) |
Absent in the structure |
Glu (Charged) -> Lys (Charged) |
Autosomal dominant Nephrogenic Diabetes Insipidus |
| 608 |
|
AQP2 |
rs376000406 |
NP_000477.1 - 261 (C terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Leu (Aliphatic hydrophobic) |
- |
| 609 |
|
AQP2 |
rs104894339 |
NP_000477.1 - 262 (C terminus) |
Absent in the structure |
Pro (Proline) -> Arg (Charged) |
- |
| 610 |
|
AQP2 |
rs104894339 |
NP_000477.1 - 262 (C terminus) |
Absent in the structure |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
Autosomal recessive Nephrogenic Diabetes Insipidus |
| 611 |
|
AQP2 |
rs527818482 |
NP_000477.1 - 265 (C terminus) |
Absent in the structure |
Leu (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 612 |
|
AQP2 |
rs1261913733 |
NP_000477.1 - 269 (C terminus) |
Absent in the structure |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 613 |
|
AQP2 |
rs1353477636 |
NP_000477.1 - 269 (C terminus) |
Absent in the structure |
Thr (Small and Weakly Polar) -> Asn (Neutral polar) |
- |
| 614 |
|
AQP2 |
rs1267962708 |
NP_000477.1 - 270 (C terminus) |
Absent in the structure |
Lys (Charged) -> Arg (Charged) |
- |
| 615 |
|
AQP2 |
rs1195772340 |
NP_000477.1 - 271 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 616 |
|
AQP2 |
rs1463809647 |
NP_000477.1 - 271 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Pro (Proline) |
- |
| 617 |
|
AQP3 |
rs1424334828 |
NP_004916.1 - 2 (N terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 618 |
|
AQP3 |
rs752949682 |
NP_004916.1 - 3 (N terminus) |
Absent in the structure |
Arg (Charged) -> Leu (Aliphatic hydrophobic) |
- |
| 619 |
|
AQP3 |
rs1481293569 |
NP_004916.1 - 4 (N terminus) |
Absent in the structure |
Gln (Neutral polar) -> Leu (Aliphatic hydrophobic) |
- |
| 620 |
|
AQP3 |
rs1481293569 |
NP_004916.1 - 4 (N terminus) |
Absent in the structure |
Gln (Neutral polar) -> Pro (Proline) |
- |
| 621 |
|
AQP3 |
rs765311734 |
NP_004916.1 - 5 (N terminus) |
Absent in the structure |
Lys (Charged) -> Arg (Charged) |
- |
| 622 |
|
AQP3 |
rs1180932340 |
NP_004916.1 - 7 (N terminus) |
Absent in the structure |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 623 |
|
AQP3 |
rs759820093 |
NP_004916.1 - 8 (N terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 624 |
|
AQP3 |
rs754206115 |
NP_004916.1 - 9 (N terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 625 |
|
AQP3 |
rs754206115 |
NP_004916.1 - 9 (N terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 626 |
|
AQP3 |
rs766881900 |
NP_004916.1 - 10 (N terminus) |
Absent in the structure |
Arg (Charged) -> Ser (Small and Weakly Polar) |
- |
| 627 |
|
AQP3 |
rs773909054 |
NP_004916.1 - 12 (N terminus) |
N terminal domain |
Gly (Small and Weakly Polar) -> Trp (Aromatic) |
- |
| 628 |
|
AQP3 |
rs773909054 |
NP_004916.1 - 12 (N terminus) |
N terminal domain |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 629 |
|
AQP3 |
rs773909054 |
NP_004916.1 - 12 (N terminus) |
N terminal domain |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 630 |
|
AQP3 |
rs1326007663 |
NP_004916.1 - 12 (N terminus) |
N terminal domain |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 631 |
|
AQP3 |
rs1326007663 |
NP_004916.1 - 12 (N terminus) |
N terminal domain |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 632 |
|
AQP3 |
rs368353913 |
NP_004916.1 - 13 (N terminus) |
N terminal domain |
Glu (Charged) -> Asp (Charged) |
- |
| 633 |
|
AQP3 |
rs900221905 |
NP_004916.1 - 14 (N terminus) |
N terminal domain |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 634 |
|
AQP3 |
rs1409387650 |
NP_004916.1 - 14 (N terminus) |
N terminal domain |
Met (Aliphatic hydrophobic) -> Lys (Charged) |
- |
| 635 |
|
AQP3 |
rs376385241 |
NP_004916.1 - 15 (N terminus) |
N terminal domain |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 636 |
|
AQP3 |
rs1348741263 |
NP_004916.1 - 16 (N terminus) |
N terminal domain |
His (Charged) -> Arg (Charged) |
- |
| 637 |
|
AQP3 |
rs1300008376 |
NP_004916.1 - 19 (TM1) |
Exposed to cytoplasm |
Tyr (Aromatic) -> His (Charged) |
- |
| 638 |
|
AQP3 |
rs1358573565 |
NP_004916.1 - 20 (TM1) |
Exposed to cytoplasm |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 639 |
|
AQP3 |
rs1332036044 |
NP_004916.1 - 21 (TM1) |
Helix - helix interface (TM1 - TM3) |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 640 |
|
AQP3 |
rs768201326 |
NP_004916.1 - 22 (TM1) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 641 |
|
AQP3 |
rs768201326 |
NP_004916.1 - 22 (TM1) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 642 |
|
AQP3 |
rs762440965 |
NP_004916.1 - 23 (TM1) |
Monomer - monomer interface |
Arg (Charged) -> Gly (Small and Weakly Polar) |
- |
| 643 |
|
AQP3 |
rs1158008302 |
NP_004916.1 - 23 (TM1) |
Monomer - monomer interface |
Arg (Charged) -> Leu (Aliphatic hydrophobic) |
- |
| 644 |
|
AQP3 |
rs775067063 |
NP_004916.1 - 25 (TM1) |
Helix - helix interface (TM1 - TM3) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 645 |
|
AQP3 |
rs1482639297 |
NP_004916.1 - 29 (TM1) |
Helix - helix interface (TM1 - TM3); Lipid facing |
Cys (Small and Weakly Polar) -> Arg (Charged) |
- |
| 646 |
|
AQP3 |
rs1201009715 |
NP_004916.1 - 31 (TM1) |
Helix - helix interface (TM1 - TM2) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 647 |
|
AQP3 |
rs867437626 |
NP_004916.1 - 32 (TM1) |
Helix - helix interface (TM1 - TM3) |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 648 |
|
AQP3 |
rs1237412703 |
NP_004916.1 - 33 (TM1) |
Helix - helix interface (TM1 - TM3) |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 649 |
|
AQP3 |
rs780924525 |
NP_004916.1 - 34 (TM1) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 650 |
|
AQP3 |
rs758362320 |
NP_004916.1 - 36 (TM1) |
Helix - helix interface (TM1 - TM3) |
Val (Aliphatic hydrophobic) -> Glu (Charged) |
- |
| 651 |
|
AQP3 |
rs1315402999 |
NP_004916.1 - 36 (TM1) |
Helix - helix interface (TM1 - TM3) |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 652 |
|
AQP3 |
rs1432636423 |
NP_004916.1 - 37 (TM1) |
Helix - helix interface (TM1 - TM3);Monomer - monomer interface |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 653 |
|
AQP3 |
rs34942735 |
NP_004916.1 - 43 (TM1) |
Channel facing |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 654 |
|
AQP3 |
rs59981139 |
NP_004916.1 - 45 (TM1) |
Monomer - monomer interface |
Gln (Neutral polar) -> His (Charged) |
- |
| 655 |
|
AQP3 |
rs1347722135 |
NP_004916.1 - 45 (TM1) |
Monomer - monomer interface |
Gln (Neutral polar) -> Pro (Proline) |
- |
| 656 |
|
AQP3 |
rs748149295 |
NP_004916.1 - 46 (TM1) |
Exposed to the extracellular environment |
Val (Aliphatic hydrophobic) -> Gly (Small and Weakly Polar) |
- |
| 657 |
|
AQP3 |
rs748149295 |
NP_004916.1 - 46 (TM1) |
Exposed to the extracellular environment |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 658 |
|
AQP3 |
rs778828841 |
NP_004916.1 - 47 (TM1) |
Exposed to the extracellular environment |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 659 |
|
AQP3 |
rs749513194 |
NP_004916.1 - 50 (Loop region after TM1) |
Loop A |
Arg (Charged) -> Trp (Aromatic) |
- |
| 660 |
|
AQP3 |
rs780493653 |
NP_004916.1 - 50 (Loop region after TM1) |
Loop A |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 661 |
|
AQP3 |
rs940868590 |
NP_004916.1 - 51 (Loop region after TM1) |
Loop A |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 662 |
|
AQP3 |
rs750756921 |
NP_004916.1 - 55 (Loop region after TM1) |
Loop A |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 663 |
|
AQP3 |
rs374961919 |
NP_004916.1 - 56 (TM2) |
Helix - helix interface (TM2 - TM5) |
Phe (Aromatic) -> Tyr (Aromatic) |
- |
| 664 |
|
AQP3 |
rs752146716 |
NP_004916.1 - 67 (TM2) |
Channel facing |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 665 |
|
AQP3 |
rs1360176337 |
NP_004916.1 - 67 (TM2) |
Channel facing |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 666 |
|
AQP3 |
rs1225083688 |
NP_004916.1 - 70 (TM2) |
Helix - helix interface (TM1 - TM2) |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 667 |
|
AQP3 |
rs1385987539 |
NP_004916.1 - 74 (TM2) |
Helix - helix interface (TM1 - TM2);Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 668 |
|
AQP3 |
rs1385987539 |
NP_004916.1 - 74 (TM2) |
Helix - helix interface (TM1 - TM2);Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 669 |
|
AQP3 |
rs765960239 |
NP_004916.1 - 75 (TM2) |
Channel facing |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 670 |
|
AQP3 |
rs1354430795 |
NP_004916.1 - 77 (TM2) |
Lipid facing;Helix - helix interface (TM1 - TM2) |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 671 |
|
AQP3 |
rs1009080611 |
NP_004916.1 - 79 (Loop region after TM2) |
Loop B |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 672 |
|
AQP3 |
rs778212126 |
NP_004916.1 - 80 (Loop region after TM2) |
Loop B |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 673 |
|
AQP3 |
rs781532774 |
NP_004916.1 - 80 (Loop region after TM2) |
Loop B |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 674 |
|
AQP3 |
rs1184048384 |
NP_004916.1 - 84 (LB - NPA1) |
Helix - helix interface (LB - LE, LB - TM3) |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 675 |
|
AQP3 |
rs1464221016 |
NP_004916.1 - 85 (LB - NPA1) |
Helix - helix interface (LB - TM4, LB - LE, LB - TM6) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 676 |
|
AQP3 |
rs758863165 |
NP_004916.1 - 86 (LB) |
Channel facing |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 677 |
|
AQP3 |
rs778133652 |
NP_004916.1 - 86 (LB) |
Channel facing |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 678 |
|
AQP3 |
rs1264388787 |
NP_004916.1 - 87 (LB) |
Helix - helix interface (LB - TM3) |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 679 |
|
AQP3 |
rs867265809 |
NP_004916.1 - 90 (LB) |
Channel facing |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 680 |
|
AQP3 |
rs867265809 |
NP_004916.1 - 90 (LB) |
Channel facing |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 681 |
|
AQP3 |
rs1401676584 |
NP_004916.1 - 94 (Loop region after LB) |
Loop B |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 682 |
|
AQP3 |
rs201240634 |
NP_004916.1 - 95 (Loop region after LB) |
Loop B |
Arg (Charged) -> His (Charged) |
- |
| 683 |
|
AQP3 |
rs779519202 |
NP_004916.1 - 96 (Loop region after LB) |
Loop B |
Glu (Charged) -> Lys (Charged) |
- |
| 684 |
|
AQP3 |
rs1316539605 |
NP_004916.1 - 96 (Loop region after LB) |
Loop B |
Glu (Charged) -> Asp (Charged) |
- |
| 685 |
|
AQP3 |
rs1316539605 |
NP_004916.1 - 96 (Loop region after LB) |
Loop B |
Glu (Charged) -> Asp (Charged) |
- |
| 686 |
|
AQP3 |
rs1385919354 |
NP_004916.1 - 98 (TM3) |
Lipid facing |
Trp (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 687 |
|
AQP3 |
rs1163076998 |
NP_004916.1 - 99 (TM3) |
Lipid facing |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 688 |
|
AQP3 |
rs1422821270 |
NP_004916.1 - 100 (TM3) |
Channel facing |
Lys (Charged) -> Asn (Neutral polar) |
- |
| 689 |
|
AQP3 |
rs1387022873 |
NP_004916.1 - 103 (TM3) |
Helix - helix interface (LB - TM3); Lipid facing |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 690 |
|
AQP3 |
rs1387022873 |
NP_004916.1 - 103 (TM3) |
Helix - helix interface (LB - TM3); Lipid facing |
Ile (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 691 |
|
AQP3 |
rs750041458 |
NP_004916.1 - 104 (TM3) |
Helix - helix interface (TM1 - TM3, LB - TM3) |
Tyr (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 692 |
|
AQP3 |
rs1240098654 |
NP_004916.1 - 105 (TM3) |
Lipid facing |
Thr (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 693 |
|
AQP3 |
rs767135708 |
NP_004916.1 - 106 (TM3) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 694 |
|
AQP3 |
rs1447267220 |
NP_004916.1 - 106 (TM3) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 695 |
|
AQP3 |
rs1266211169 |
NP_004916.1 - 107 (TM3) |
Helix - helix interface (TM1 - TM3) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 696 |
|
AQP3 |
rs761390305 |
NP_004916.1 - 109 (TM3) |
Helix - helix interface (TM1 - TM3, LB - TM3, TM3 - LE) |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 697 |
|
AQP3 |
rs1294602134 |
NP_004916.1 - 111 (TM3) |
Helix - helix interface (TM1 - TM3) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 698 |
|
AQP3 |
rs1247288996 |
NP_004916.1 - 112 (TM3) |
Helix - helix interface (TM1 - TM3, TM3 - LE) |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 699 |
|
AQP3 |
rs1339268891 |
NP_004916.1 - 112 (TM3) |
Helix - helix interface (TM1 - TM3, TM3 - LE) |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 700 |
|
AQP3 |
rs764008707 |
NP_004916.1 - 114 (TM3) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 701 |
|
AQP3 |
rs1258943974 |
NP_004916.1 - 119 (TM3) |
Helix - helix interface (TM1 - TM3) |
Val (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 702 |
|
AQP3 |
rs925234297 |
NP_004916.1 - 120 (TM3) |
Helix - helix interface (TM3 - LE) |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 703 |
|
AQP3 |
rs1327317379 |
NP_004916.1 - 122 (TM3) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 704 |
|
AQP3 |
rs1262959318 |
NP_004916.1 - 126 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 705 |
|
AQP3 |
rs768715017 |
NP_004916.1 - 129 (Loop region after TM3) |
Loop C |
His (Charged) -> Tyr (Aromatic) |
- |
| 706 |
|
AQP3 |
rs768715017 |
NP_004916.1 - 129 (Loop region after TM3) |
Loop C |
His (Charged) -> Asp (Charged) |
- |
| 707 |
|
AQP3 |
rs770956892 |
NP_004916.1 - 131 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 708 |
|
AQP3 |
rs774972543 |
NP_004916.1 - 131 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 709 |
|
AQP3 |
rs2231233 |
NP_004916.1 - 132 (Loop region after TM3) |
Loop C |
Asp (Charged) -> Tyr (Aromatic) |
- |
| 710 |
|
AQP3 |
rs2231233 |
NP_004916.1 - 132 (Loop region after TM3) |
Loop C |
Asp (Charged) -> Asn (Neutral polar) |
- |
| 711 |
|
AQP3 |
rs372392094 |
NP_004916.1 - 133 (Loop region after TM3) |
Loop C |
Asn (Neutral polar) -> Lys (Charged) |
- |
| 712 |
|
AQP3 |
rs748446670 |
NP_004916.1 - 133 (Loop region after TM3) |
Loop C |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 713 |
|
AQP3 |
rs769161680 |
NP_004916.1 - 135 (Loop region after TM3) |
Loop C |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 714 |
|
AQP3 |
rs769161680 |
NP_004916.1 - 135 (Loop region after TM3) |
Loop C |
Leu (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 715 |
|
AQP3 |
rs749786864 |
NP_004916.1 - 138 (Loop region after TM3) |
Loop C |
Ser (Small and Weakly Polar) -> Leu (Aliphatic hydrophobic) |
- |
| 716 |
|
AQP3 |
rs1470831829 |
NP_004916.1 - 140 (Loop region after TM3) |
Loop C |
Pro (Proline) -> Ala (Small and Weakly Polar) |
- |
| 717 |
|
AQP3 |
rs780717697 |
NP_004916.1 - 141 (Loop region after TM3) |
Loop C |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 718 |
|
AQP3 |
rs1157846018 |
NP_004916.1 - 142 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 719 |
|
AQP3 |
rs756763951 |
NP_004916.1 - 143 (Loop region after TM3) |
Loop C |
Thr (Small and Weakly Polar) -> Arg (Charged) |
- |
| 720 |
|
AQP3 |
rs777633399 |
NP_004916.1 - 145 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 721 |
|
AQP3 |
rs777633399 |
NP_004916.1 - 145 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 722 |
|
AQP3 |
rs758126339 |
NP_004916.1 - 146 (Loop region after TM3) |
Loop C |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 723 |
|
AQP3 |
rs1486781669 |
NP_004916.1 - 153 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 724 |
|
AQP3 |
rs1243052751 |
NP_004916.1 - 154 (Loop region after TM3) |
Loop C |
His (Charged) -> Asn (Neutral polar) |
- |
| 725 |
|
AQP3 |
rs753768669 |
NP_004916.1 - 157 (TM4) |
Exposed to the extracellular environment |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 726 |
|
AQP3 |
rs951030345 |
NP_004916.1 - 158 (TM4) |
Lipid facing |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 727 |
|
AQP3 |
rs766470887 |
NP_004916.1 - 161 (TM4) |
Lipid facing;Helix - helix interface (TM4 - TM6) |
Phe (Aromatic) -> Ile (Aliphatic hydrophobic) |
- |
| 728 |
|
AQP3 |
rs760813059 |
NP_004916.1 - 162 (TM4) |
Monomer - monomer interface |
Phe (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 729 |
|
AQP3 |
rs1315231562 |
NP_004916.1 - 164 (TM4) |
Helix - helix interface (TM4 - TM5, TM4 - TM6) |
Gln (Neutral polar) -> His (Charged) |
- |
| 730 |
|
AQP3 |
rs761988397 |
NP_004916.1 - 166 (TM4) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 731 |
|
AQP3 |
rs1369530776 |
NP_004916.1 - 167 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 732 |
|
AQP3 |
rs1263292742 |
NP_004916.1 - 168 (TM4) |
Helix - helix interface (LB - TM4, TM4 - TM6) |
Thr (Small and Weakly Polar) -> Pro (Proline) |
- |
| 733 |
|
AQP3 |
rs764503960 |
NP_004916.1 - 172 (TM4) |
Helix - helix interface (TM4 - TM6) |
Ile (Aliphatic hydrophobic) -> Asn (Neutral polar) |
- |
| 734 |
|
AQP3 |
rs371978889 |
NP_004916.1 - 173 (TM4) |
Helix - helix interface (TM4 - TM6);Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 735 |
|
AQP3 |
rs371978889 |
NP_004916.1 - 173 (TM4) |
Helix - helix interface (TM4 - TM6);Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 736 |
|
AQP3 |
rs1266911225 |
NP_004916.1 - 175 (TM4) |
Channel facing |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 737 |
|
AQP3 |
rs1488797059 |
NP_004916.1 - 176 (TM4) |
Helix - helix interface (LB - TM4, TM4 - TM6) |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 738 |
|
AQP3 |
rs763291383 |
NP_004916.1 - 178 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 739 |
|
AQP3 |
rs201119765 |
NP_004916.1 - 179 (TM4) |
Channel facing |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 740 |
|
AQP3 |
rs941195057 |
NP_004916.1 - 179 (TM4) |
Channel facing |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 741 |
|
AQP3 |
rs1222481278 |
NP_004916.1 - 180 (Loop region after TM4) |
Loop D |
Asp (Charged) -> Asn (Neutral polar) |
- |
| 742 |
|
AQP3 |
rs1343220667 |
NP_004916.1 - 181 (Loop region after TM4) |
Loop D |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 743 |
|
AQP3 |
rs1386832191 |
NP_004916.1 - 183 (Loop region after TM4) |
Loop D |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 744 |
|
AQP3 |
rs1392088327 |
NP_004916.1 - 183 (Loop region after TM4) |
Loop D |
Asn (Neutral polar) -> Lys (Charged) |
- |
| 745 |
|
AQP3 |
rs760141667 |
NP_004916.1 - 186 (Loop region after TM4) |
Loop D |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 746 |
|
AQP3 |
rs774162852 |
NP_004916.1 - 188 (Loop region after TM4) |
Loop D |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 747 |
|
AQP3 |
rs756008789 |
NP_004916.1 - 195 (TM5) |
Channel facing;Helix - helix interface (TM4 - TM5) |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 748 |
|
AQP3 |
rs1435385596 |
NP_004916.1 - 195 (TM5) |
Channel facing;Helix - helix interface (TM4 - TM5) |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 749 |
|
AQP3 |
rs139059204 |
NP_004916.1 - 201 (TM5) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 750 |
|
AQP3 |
rs763248020 |
NP_004916.1 - 202 (TM5) |
Helix - helix interface (TM4 - TM5) |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 751 |
|
AQP3 |
rs764153051 |
NP_004916.1 - 202 (TM5) |
Helix - helix interface (TM4 - TM5) |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 752 |
|
AQP3 |
rs752953538 |
NP_004916.1 - 204 (TM5) |
Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Asn (Neutral polar) |
- |
| 753 |
|
AQP3 |
rs1390206714 |
NP_004916.1 - 206 (TM5) |
Helix - helix interface (TM4 - TM5) |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 754 |
|
AQP3 |
rs1385647315 |
NP_004916.1 - 207 (TM5) |
Channel facing |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 755 |
|
AQP3 |
rs777336721 |
NP_004916.1 - 211 (Loop region after TM5) |
Loop E |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 756 |
|
AQP3 |
rs771706066 |
NP_004916.1 - 212 (Loop region after TM5 - Ar/R Selectivity filter) |
Loop E |
Tyr (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 757 |
|
AQP3 |
rs1174482062 |
NP_004916.1 - 213 (Loop region after TM5) |
Loop E |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 758 |
|
AQP3 |
rs1007352635 |
NP_004916.1 - 214 (Loop region after TM5) |
Loop E |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 759 |
|
AQP3 |
rs376189651 |
NP_004916.1 - 218 (LE - Ar/R Selectivity filter) |
Channel facing |
Arg (Charged) -> Trp (Aromatic) |
- |
| 760 |
|
AQP3 |
rs539666664 |
NP_004916.1 - 218 (LE - Ar/R Selectivity filter) |
Channel facing |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 761 |
|
AQP3 |
rs1214546935 |
NP_004916.1 - 220 (LE) |
Helix - helix interface (LE - TM6, TM3 - LE); Lipid facing |
Phe (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 762 |
|
AQP3 |
rs1459767839 |
NP_004916.1 - 221 (LE) |
Helix - helix interface (TM3 - LE) |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 763 |
|
AQP3 |
rs745787916 |
NP_004916.1 - 222 (LE) |
Helix - helix interface (TM3 - LE) |
Pro (Proline) -> Arg (Charged) |
- |
| 764 |
|
AQP3 |
rs374165388 |
NP_004916.1 - 223 (LE) |
Exposed to the extracellular environment |
Arg (Charged) -> His (Charged) |
- |
| 765 |
|
AQP3 |
rs781170322 |
NP_004916.1 - 223 (LE) |
Exposed to the extracellular environment |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 766 |
|
AQP3 |
rs781170322 |
NP_004916.1 - 223 (LE) |
Exposed to the extracellular environment |
Arg (Charged) -> Gly (Small and Weakly Polar) |
- |
| 767 |
|
AQP3 |
rs781170322 |
NP_004916.1 - 223 (LE) |
Exposed to the extracellular environment |
Arg (Charged) -> Ser (Small and Weakly Polar) |
- |
| 768 |
|
AQP3 |
rs751533899 |
NP_004916.1 - 224 (LE) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 769 |
|
AQP3 |
rs1356545174 |
NP_004916.1 - 227 (LE) |
Exposed to the extracellular environment |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 770 |
|
AQP3 |
rs534635127 |
NP_004916.1 - 228 (LE) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 771 |
|
AQP3 |
rs758509314 |
NP_004916.1 - 229 (Loop region after LE) |
Loop E |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 772 |
|
AQP3 |
rs758509314 |
NP_004916.1 - 229 (Loop region after LE) |
Loop E |
Ala (Small and Weakly Polar) -> Glu (Charged) |
- |
| 773 |
|
AQP3 |
rs1336439105 |
NP_004916.1 - 232 (Loop region after LE) |
Loop E |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 774 |
|
AQP3 |
rs1396871163 |
NP_004916.1 - 232 (Loop region after LE) |
Loop E |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 775 |
|
AQP3 |
rs1384500434 |
NP_004916.1 - 234 (Loop region after LE) |
Loop E |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 776 |
|
AQP3 |
rs1160084548 |
NP_004916.1 - 235 (Loop region after LE) |
Loop E |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 777 |
|
AQP3 |
rs1421587540 |
NP_004916.1 - 236 (Loop region after LE) |
Loop E |
Phe (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 778 |
|
AQP3 |
rs754260945 |
NP_004916.1 - 237 (Loop region after LE) |
Loop E |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 779 |
|
AQP3 |
rs1162797219 |
NP_004916.1 - 237 (Loop region after LE) |
Loop E |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 780 |
|
AQP3 |
rs867084194 |
NP_004916.1 - 239 (Loop region after LE) |
Loop E |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 781 |
|
AQP3 |
rs1021095972 |
NP_004916.1 - 239 (Loop region after LE) |
Loop E |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 782 |
|
AQP3 |
rs1282788039 |
NP_004916.1 - 243 (TM6) |
Lipid facing |
Trp (Aromatic) -> Gly (Small and Weakly Polar) |
- |
| 783 |
|
AQP3 |
rs1403174817 |
NP_004916.1 - 245 (TM6) |
Helix - helix interface (TM4 - TM6) |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 784 |
|
AQP3 |
rs1010085722 |
NP_004916.1 - 248 (TM6) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 785 |
|
AQP3 |
rs750992616 |
NP_004916.1 - 249 (TM6) |
Helix - helix interface (TM4 - TM6) |
Ser (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 786 |
|
AQP3 |
rs1262988887 |
NP_004916.1 - 254 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6) |
Ser (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 787 |
|
AQP3 |
rs190275678 |
NP_004916.1 - 255 (TM6) |
Helix - helix interface (LB - TM6); Lipid facing |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 788 |
|
AQP3 |
rs190275678 |
NP_004916.1 - 255 (TM6) |
Helix - helix interface (LB - TM6); Lipid facing |
Ile (Aliphatic hydrophobic) -> Asn (Neutral polar) |
- |
| 789 |
|
AQP3 |
rs762587298 |
NP_004916.1 - 256 (TM6) |
Helix - helix interface (TM4 - TM6); Lipid facing |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 790 |
|
AQP3 |
rs567712244 |
NP_004916.1 - 259 (TM6) |
Lipid facing |
Phe (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 791 |
|
AQP3 |
rs759206638 |
NP_004916.1 - 260 (TM6) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Gly (Small and Weakly Polar) |
- |
| 792 |
|
AQP3 |
rs996796069 |
NP_004916.1 - 260 (TM6) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 793 |
|
AQP3 |
rs776368604 |
NP_004916.1 - 261 (TM6) |
Helix - helix interface (TM4 - TM6) |
Tyr (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 794 |
|
AQP3 |
rs770798272 |
NP_004916.1 - 263 (TM6) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 795 |
|
AQP3 |
rs746897748 |
NP_004916.1 - 264 (TM6) |
Lipid facing |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 796 |
|
AQP3 |
rs773268552 |
NP_004916.1 - 265 (C terminus) |
C terminal domain |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 797 |
|
AQP3 |
rs748183538 |
NP_004916.1 - 266 (C terminus) |
C terminal domain |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 798 |
|
AQP3 |
rs779158909 |
NP_004916.1 - 267 (C terminus) |
C terminal domain |
Cys (Small and Weakly Polar) -> Trp (Aromatic) |
- |
| 799 |
|
AQP3 |
rs1296906912 |
NP_004916.1 - 267 (C terminus) |
C terminal domain |
Cys (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 800 |
|
AQP3 |
rs749564614 |
NP_004916.1 - 272 (C terminus) |
C terminal domain |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 801 |
|
AQP3 |
rs1369762847 |
NP_004916.1 - 273 (C terminus) |
C terminal domain |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 802 |
|
AQP3 |
rs756563695 |
NP_004916.1 - 274 (C terminus) |
C terminal domain |
Pro (Proline) -> Arg (Charged) |
- |
| 803 |
|
AQP3 |
rs756563695 |
NP_004916.1 - 274 (C terminus) |
C terminal domain |
Pro (Proline) -> His (Charged) |
- |
| 804 |
|
AQP3 |
rs143366138 |
NP_004916.1 - 277 (C terminus) |
Absent in the structure |
Glu (Charged) -> Lys (Charged) |
- |
| 805 |
|
AQP3 |
rs1465944747 |
NP_004916.1 - 279 (C terminus) |
Absent in the structure |
Glu (Charged) -> Asp (Charged) |
- |
| 806 |
|
AQP3 |
rs781673441 |
NP_004916.1 - 281 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 807 |
|
AQP3 |
rs1290543883 |
NP_004916.1 - 283 (C terminus) |
Absent in the structure |
Leu (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 808 |
|
AQP3 |
rs1307038150 |
NP_004916.1 - 284 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 809 |
|
AQP3 |
rs550836704 |
NP_004916.1 - 285 (C terminus) |
Absent in the structure |
His (Charged) -> Asp (Charged) |
- |
| 810 |
|
AQP3 |
rs753537520 |
NP_004916.1 - 289 (C terminus) |
Absent in the structure |
Lys (Charged) -> Arg (Charged) |
- |
| 811 |
|
AQP3 |
rs760451989 |
NP_004916.1 - 291 (C terminus) |
Absent in the structure |
Gln (Neutral polar) -> Lys (Charged) |
- |
| 812 |
|
AQP3 |
rs139300345 |
NP_004916.1 - 292 (C terminus) |
Absent in the structure |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 813 |
|
AQP3 |
rs1242784049 |
NP_004916.1 - 292 (C terminus) |
Absent in the structure |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 814 |
|
AQP3 |
rs1242784049 |
NP_004916.1 - 292 (C terminus) |
Absent in the structure |
Ile (Aliphatic hydrophobic) -> Asn (Neutral polar) |
- |
| 815 |
|
AQP4 |
rs1169754594 |
NP_001641.1 - 1 (N terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 816 |
|
AQP4 |
rs375551135 |
NP_001641.1 - 2 (N terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Asn (Neutral polar) |
- |
| 817 |
|
AQP4 |
rs780943816 |
NP_001641.1 - 3 (N terminus) |
Absent in the structure |
Asp (Charged) -> Glu (Charged) |
- |
| 818 |
|
AQP4 |
rs1420421864 |
NP_001641.1 - 3 (N terminus) |
Absent in the structure |
Asp (Charged) -> Gly (Small and Weakly Polar) |
- |
| 819 |
|
AQP4 |
rs1474508608 |
NP_001641.1 - 5 (N terminus) |
Absent in the structure |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 820 |
|
AQP4 |
rs1456380723 |
NP_001641.1 - 7 (N terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 821 |
|
AQP4 |
rs772226682 |
NP_001641.1 - 9 (N terminus) |
Absent in the structure |
Arg (Charged) -> Trp (Aromatic) |
- |
| 822 |
|
AQP4 |
rs779120344 |
NP_001641.1 - 9 (N terminus) |
Absent in the structure |
Arg (Charged) -> Pro (Proline) |
- |
| 823 |
|
AQP4 |
rs779120344 |
NP_001641.1 - 9 (N terminus) |
Absent in the structure |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 824 |
|
AQP4 |
rs774486714 |
NP_001641.1 - 10 (N terminus) |
Absent in the structure |
Trp (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 825 |
|
AQP4 |
rs774486714 |
NP_001641.1 - 10 (N terminus) |
Absent in the structure |
Trp (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 826 |
|
AQP4 |
rs1206989233 |
NP_001641.1 - 10 (N terminus) |
Absent in the structure |
Trp (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 827 |
|
AQP4 |
rs1261662938 |
NP_001641.1 - 10 (N terminus) |
Absent in the structure |
Trp (Aromatic) -> Gly (Small and Weakly Polar) |
- |
| 828 |
|
AQP4 |
rs1261662938 |
NP_001641.1 - 10 (N terminus) |
Absent in the structure |
Trp (Aromatic) -> Arg (Charged) |
- |
| 829 |
|
AQP4 |
rs756380305 |
NP_001641.1 - 11 (N terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 830 |
|
AQP4 |
rs749543943 |
NP_001641.1 - 13 (N terminus) |
Absent in the structure |
Cys (Small and Weakly Polar) -> Arg (Charged) |
- |
| 831 |
|
AQP4 |
rs199674181 |
NP_001641.1 - 15 (N terminus) |
Absent in the structure |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 832 |
|
AQP4 |
rs199674181 |
NP_001641.1 - 15 (N terminus) |
Absent in the structure |
Pro (Proline) -> Thr (Small and Weakly Polar) |
- |
| 833 |
|
AQP4 |
rs544987084 |
NP_001641.1 - 15 (N terminus) |
Absent in the structure |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 834 |
|
AQP4 |
rs1361101798 |
NP_001641.1 - 16 (N terminus) |
Absent in the structure |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 835 |
|
AQP4 |
rs1291878555 |
NP_001641.1 - 17 (N terminus) |
Absent in the structure |
Cys (Small and Weakly Polar) -> Tyr (Aromatic) |
- |
| 836 |
|
AQP4 |
rs150587304 |
NP_001641.1 - 19 (N terminus) |
Absent in the structure |
Arg (Charged) -> Ile (Aliphatic hydrophobic) |
- |
| 837 |
|
AQP4 |
rs150587304 |
NP_001641.1 - 19 (N terminus) |
Absent in the structure |
Arg (Charged) -> Thr (Small and Weakly Polar) |
- |
| 838 |
|
AQP4 |
rs371918868 |
NP_001641.1 - 19 (N terminus) |
Absent in the structure |
Arg (Charged) -> Gly (Small and Weakly Polar) |
- |
| 839 |
|
AQP4 |
rs747267333 |
NP_001641.1 - 20 (N terminus) |
Absent in the structure |
Glu (Charged) -> Asp (Charged) |
- |
| 840 |
|
AQP4 |
rs781604412 |
NP_001641.1 - 20 (N terminus) |
Absent in the structure |
Glu (Charged) -> Gln (Neutral polar) |
- |
| 841 |
|
AQP4 |
rs1391868783 |
NP_001641.1 - 20 (N terminus) |
Absent in the structure |
Glu (Charged) -> Gly (Small and Weakly Polar) |
- |
| 842 |
|
AQP4 |
rs1009044175 |
NP_001641.1 - 21 (N terminus) |
Absent in the structure |
Asn (Neutral polar) -> Lys (Charged) |
- |
| 843 |
|
AQP4 |
rs1014713773 |
NP_001641.1 - 21 (N terminus) |
Absent in the structure |
Asn (Neutral polar) -> Asp (Charged) |
- |
| 844 |
|
AQP4 |
rs757831249 |
NP_001641.1 - 22 (N terminus) |
Absent in the structure |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 845 |
|
AQP4 |
rs1440335187 |
NP_001641.1 - 22 (N terminus) |
Absent in the structure |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 846 |
|
AQP4 |
rs1476758680 |
NP_001641.1 - 23 (N terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 847 |
|
AQP4 |
rs141793428 |
NP_001641.1 - 27 (N terminus) |
Absent in the structure |
Lys (Charged) -> Arg (Charged) |
- |
| 848 |
|
AQP4 |
rs141793428 |
NP_001641.1 - 27 (N terminus) |
Absent in the structure |
Lys (Charged) -> Thr (Small and Weakly Polar) |
- |
| 849 |
|
AQP4 |
rs1411558805 |
NP_001641.1 - 28 (N terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 850 |
|
AQP4 |
rs369686896 |
NP_001641.1 - 29 (N terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 851 |
|
AQP4 |
rs764731008 |
NP_001641.1 - 30 (N terminus) |
Absent in the structure |
Trp (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 852 |
|
AQP4 |
rs759391350 |
NP_001641.1 - 31 (N terminus) |
Absent in the structure |
Thr (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 853 |
|
AQP4 |
rs776354988 |
NP_001641.1 - 31 (N terminus) |
Absent in the structure |
Thr (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 854 |
|
AQP4 |
rs201354429 |
NP_001641.1 - 34 (TM1) |
Helix - helix interface (TM1 - TM3) |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 855 |
|
AQP4 |
rs1269230456 |
NP_001641.1 - 35 (TM1) |
Lipid facing |
Trp (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 856 |
|
AQP4 |
rs371760940 |
NP_001641.1 - 36 (TM1) |
Monomer - monomer interface |
Lys (Charged) -> Asn (Neutral polar) |
- |
| 857 |
|
AQP4 |
rs778208236 |
NP_001641.1 - 38 (TM1) |
Helix - helix interface (TM1 - TM3) |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 858 |
|
AQP4 |
rs778208236 |
NP_001641.1 - 38 (TM1) |
Helix - helix interface (TM1 - TM3) |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 859 |
|
AQP4 |
rs1001463702 |
NP_001641.1 - 39 (TM1) |
Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 860 |
|
AQP4 |
rs200221507 |
NP_001641.1 - 40 (TM1) |
Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 861 |
|
AQP4 |
rs200221507 |
NP_001641.1 - 40 (TM1) |
Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 862 |
|
AQP4 |
rs200221507 |
NP_001641.1 - 40 (TM1) |
Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Glu (Charged) |
- |
| 863 |
|
AQP4 |
rs978351847 |
NP_001641.1 - 40 (TM1) |
Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 864 |
|
AQP4 |
rs1316232427 |
NP_001641.1 - 43 (TM1) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 865 |
|
AQP4 |
rs1225175406 |
NP_001641.1 - 45 (TM1) |
Helix - helix interface (TM1 - TM3) |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 866 |
|
AQP4 |
rs1304612448 |
NP_001641.1 - 45 (TM1) |
Helix - helix interface (TM1 - TM3) |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 867 |
|
AQP4 |
rs768884671 |
NP_001641.1 - 46 (TM1) |
Helix - helix interface (TM1 - TM3) |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 868 |
|
AQP4 |
rs201582782 |
NP_001641.1 - 47 (TM1) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 869 |
|
AQP4 |
rs775791118 |
NP_001641.1 - 47 (TM1) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 870 |
|
AQP4 |
rs769965179 |
NP_001641.1 - 48 (TM1) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 871 |
|
AQP4 |
rs55839024 |
NP_001641.1 - 53 (TM1) |
Helix - helix interface (TM1 - TM3, TM1 - LE) |
Leu (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 872 |
|
AQP4 |
rs55946817 |
NP_001641.1 - 53 (TM1) |
Helix - helix interface (TM1 - TM3, TM1 - LE) |
Leu (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 873 |
|
AQP4 |
rs747540951 |
NP_001641.1 - 55 (TM1) |
Helix - helix interface (TM1 - TM2) |
Ser (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 874 |
|
AQP4 |
rs757911333 |
NP_001641.1 - 59 (Loop region after TM1) |
Loop A |
Trp (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 875 |
|
AQP4 |
rs778217275 |
NP_001641.1 - 59 (Loop region after TM1) |
Loop A |
Trp (Aromatic) -> Arg (Charged) |
- |
| 876 |
|
AQP4 |
rs200232760 |
NP_001641.1 - 60 (Loop region after TM1) |
Loop A |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 877 |
|
AQP4 |
rs764792847 |
NP_001641.1 - 61 (Loop region after TM1) |
Loop A |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 878 |
|
AQP4 |
rs754624399 |
NP_001641.1 - 62 (Loop region after TM1) |
Loop A |
Thr (Small and Weakly Polar) -> Arg (Charged) |
- |
| 879 |
|
AQP4 |
rs367543329 |
NP_001641.1 - 64 (Loop region after TM1) |
Loop A |
Lys (Charged) -> Glu (Charged) |
- |
| 880 |
|
AQP4 |
rs367543329 |
NP_001641.1 - 64 (Loop region after TM1) |
Loop A |
Lys (Charged) -> Gln (Neutral polar) |
- |
| 881 |
|
AQP4 |
rs373708376 |
NP_001641.1 - 65 (Loop region after TM1) |
Loop A |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 882 |
|
AQP4 |
rs773287416 |
NP_001641.1 - 65 (Loop region after TM1) |
Loop A |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 883 |
|
AQP4 |
rs1360695259 |
NP_001641.1 - 66 (Loop region after TM1) |
Loop A |
Leu (Aliphatic hydrophobic) -> Ser (Small and Weakly Polar) |
- |
| 884 |
|
AQP4 |
rs767503231 |
NP_001641.1 - 67 (Loop region after TM1) |
Loop A |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 885 |
|
AQP4 |
rs1423385040 |
NP_001641.1 - 68 (Loop region after TM1) |
Loop A |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 886 |
|
AQP4 |
rs746127378 |
NP_001641.1 - 69 (TM2) |
Monomer - monomer interface |
Asp (Charged) -> Gly (Small and Weakly Polar) |
- |
| 887 |
|
AQP4 |
rs771316211 |
NP_001641.1 - 70 (TM2) |
Helix - helix interface (TM2 - TM5);Monomer - monomer interface |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 888 |
|
AQP4 |
rs776865043 |
NP_001641.1 - 70 (TM2) |
Helix - helix interface (TM2 - TM5);Monomer - monomer interface |
Met (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 889 |
|
AQP4 |
rs778270166 |
NP_001641.1 - 76 (TM2) |
Helix - helix interface (TM1 - TM2);Monomer - monomer interface |
Cys (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 890 |
|
AQP4 |
rs1407332952 |
NP_001641.1 - 76 (TM2) |
Helix - helix interface (TM1 - TM2);Monomer - monomer interface |
Cys (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 891 |
|
AQP4 |
rs754458451 |
NP_001641.1 - 81 (TM2) |
Channel facing |
Ile (Aliphatic hydrophobic) -> Ser (Small and Weakly Polar) |
- |
| 892 |
|
AQP4 |
rs754458451 |
NP_001641.1 - 81 (TM2) |
Channel facing |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 893 |
|
AQP4 |
rs778332411 |
NP_001641.1 - 81 (TM2) |
Channel facing |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 894 |
|
AQP4 |
rs779786050 |
NP_001641.1 - 84 (TM2) |
Helix - helix interface (TM1 - TM2) |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 895 |
|
AQP4 |
rs1461680936 |
NP_001641.1 - 86 (TM2) |
Monomer - monomer interface |
Gln (Neutral polar) -> Pro (Proline) |
- |
| 896 |
|
AQP4 |
rs755985700 |
NP_001641.1 - 89 (TM2) |
Channel facing |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 897 |
|
AQP4 |
rs750299550 |
NP_001641.1 - 90 (TM2) |
Monomer - monomer interface |
His (Charged) -> Arg (Charged) |
- |
| 898 |
|
AQP4 |
rs767415035 |
NP_001641.1 - 91 (TM2) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 899 |
|
AQP4 |
rs1253372069 |
NP_001641.1 - 92 (TM2) |
Helix - helix interface (TM1 - TM2) |
Ser (Small and Weakly Polar) -> Arg (Charged) |
- |
| 900 |
|
AQP4 |
rs1228387793 |
NP_001641.1 - 93 (TM2) |
Channel facing |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 901 |
|
AQP4 |
rs761699060 |
NP_001641.1 - 95 (Loop region after TM2) |
Loop B |
His (Charged) -> Tyr (Aromatic) |
- |
| 902 |
|
AQP4 |
rs1384097895 |
NP_001641.1 - 96 (Loop region after TM2) |
Loop B |
Ile (Aliphatic hydrophobic) -> Asn (Neutral polar) |
- |
| 903 |
|
AQP4 |
rs949486328 |
NP_001641.1 - 99 (LB) |
Helix - helix interface (LB - TM6) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 904 |
|
AQP4 |
rs1004067780 |
NP_001641.1 - 100 (LB) |
Channel facing |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 905 |
|
AQP4 |
rs1413183985 |
NP_001641.1 - 101 (LB) |
Helix - helix interface (LB - TM3) |
Thr (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 906 |
|
AQP4 |
rs759620679 |
NP_001641.1 - 103 (LB) |
Helix - helix interface (LB - TM4, LB - TM6) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 907 |
|
AQP4 |
rs776847346 |
NP_001641.1 - 105 (LB) |
Helix - helix interface (LB - TM3) |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 908 |
|
AQP4 |
rs1370874543 |
NP_001641.1 - 107 (LB) |
Helix - helix interface (LB - TM4, LB - TM6) |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 909 |
|
AQP4 |
rs1184830434 |
NP_001641.1 - 108 (Loop region after LB) |
Loop B |
Arg (Charged) -> Ser (Small and Weakly Polar) |
- |
| 910 |
|
AQP4 |
rs866688547 |
NP_001641.1 - 109 (Loop region after LB) |
Loop B |
Lys (Charged) -> Arg (Charged) |
- |
| 911 |
|
AQP4 |
rs1445177741 |
NP_001641.1 - 110 (Loop region after LB) |
Loop B |
Ile (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 912 |
|
AQP4 |
rs1555661648 |
NP_001641.1 - 111 (TM3) |
Exposed to cytoplasm |
Ser (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 913 |
|
AQP4 |
rs771087375 |
NP_001641.1 - 112 (TM3) |
Lipid facing |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 914 |
|
AQP4 |
rs1055721158 |
NP_001641.1 - 112 (TM3) |
Lipid facing |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 915 |
|
AQP4 |
rs760876531 |
NP_001641.1 - 113 (TM3) |
Lipid facing |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 916 |
|
AQP4 |
rs773634880 |
NP_001641.1 - 114 (TM3) |
Channel facing |
Lys (Charged) -> Asn (Neutral polar) |
- |
| 917 |
|
AQP4 |
rs772401034 |
NP_001641.1 - 115 (TM3) |
Helix - helix interface (LB - TM3) |
Ser (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 918 |
|
AQP4 |
rs1250945568 |
NP_001641.1 - 115 (TM3) |
Helix - helix interface (LB - TM3) |
Ser (Small and Weakly Polar) -> Pro (Proline) |
- |
| 919 |
|
AQP4 |
rs1250945568 |
NP_001641.1 - 115 (TM3) |
Helix - helix interface (LB - TM3) |
Ser (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 920 |
|
AQP4 |
rs779432395 |
NP_001641.1 - 117 (TM3) |
Lipid facing |
Phe (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 921 |
|
AQP4 |
rs768052232 |
NP_001641.1 - 118 (TM3) |
Helix - helix interface (TM3 - TM1, TM3 - LB, TM3 - TM2) |
Tyr (Aromatic) -> His (Charged) |
- |
| 922 |
|
AQP4 |
rs140271115 |
NP_001641.1 - 120 (TM3) |
Lipid facing |
Ala (Small and Weakly Polar) -> Pro (Proline) |
- |
| 923 |
|
AQP4 |
rs140271115 |
NP_001641.1 - 120 (TM3) |
Lipid facing |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 924 |
|
AQP4 |
rs907517980 |
NP_001641.1 - 121 (TM3) |
Helix - helix interface (TM3 - TM1) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 925 |
|
AQP4 |
rs954633303 |
NP_001641.1 - 125 (TM3) |
Helix - helix interface (TM3 - TM1) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 926 |
|
AQP4 |
rs954633303 |
NP_001641.1 - 125 (TM3) |
Helix - helix interface (TM3 - TM1) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 927 |
|
AQP4 |
rs1329916459 |
NP_001641.1 - 125 (TM3) |
Helix - helix interface (TM3 - TM1) |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 928 |
|
AQP4 |
rs1309676611 |
NP_001641.1 - 126 (TM3) |
Helix - helix interface (TM3 - TM1, TM3 - LE) |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 929 |
|
AQP4 |
rs61731042 |
NP_001641.1 - 128 (TM3) |
Lipid facing |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 930 |
|
AQP4 |
rs753980839 |
NP_001641.1 - 130 (TM3) |
Helix - helix interface (TM3 - TM1, TM3 - LE) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 931 |
|
AQP4 |
rs1384043903 |
NP_001641.1 - 130 (TM3) |
Helix - helix interface (TM3 - TM1, TM3 - LE) |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 932 |
|
AQP4 |
rs766445261 |
NP_001641.1 - 131 (TM3) |
Lipid facing |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 933 |
|
AQP4 |
rs1233277666 |
NP_001641.1 - 132 (TM3) |
Lipid facing |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 934 |
|
AQP4 |
rs928081822 |
NP_001641.1 - 134 (TM3) |
Exposed to the extracellular environment |
Tyr (Aromatic) -> His (Charged) |
- |
| 935 |
|
AQP4 |
rs1279838602 |
NP_001641.1 - 135 (TM3) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 936 |
|
AQP4 |
rs200102632 |
NP_001641.1 - 136 (TM3) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 937 |
|
AQP4 |
rs200102632 |
NP_001641.1 - 136 (TM3) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 938 |
|
AQP4 |
rs1224964281 |
NP_001641.1 - 137 (TM3) |
Exposed to the extracellular environment |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 939 |
|
AQP4 |
rs957857361 |
NP_001641.1 - 138 (Loop region after TM3) |
Loop C |
Pro (Proline) -> His (Charged) |
- |
| 940 |
|
AQP4 |
rs1277616436 |
NP_001641.1 - 138 (Loop region after TM3) |
Loop C |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 941 |
|
AQP4 |
rs1490547064 |
NP_001641.1 - 139 (Loop region after TM3) |
Loop C |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 942 |
|
AQP4 |
rs1353386405 |
NP_001641.1 - 142 (Loop region after TM3) |
Loop C |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 943 |
|
AQP4 |
rs1238857287 |
NP_001641.1 - 146 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 944 |
|
AQP4 |
rs1205421946 |
NP_001641.1 - 147 (Loop region after TM3) |
Loop C |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 945 |
|
AQP4 |
rs1349012154 |
NP_001641.1 - 147 (Loop region after TM3) |
Loop C |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 946 |
|
AQP4 |
rs202114851 |
NP_001641.1 - 149 (Loop region after TM3) |
Loop C |
Met (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 947 |
|
AQP4 |
rs202114851 |
NP_001641.1 - 149 (Loop region after TM3) |
Loop C |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 948 |
|
AQP4 |
rs749806789 |
NP_001641.1 - 149 (Loop region after TM3) |
Loop C |
Met (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 949 |
|
AQP4 |
rs763601797 |
NP_001641.1 - 150 (Loop region after TM3) |
Loop C |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 950 |
|
AQP4 |
rs1432358024 |
NP_001641.1 - 150 (Loop region after TM3) |
Loop C |
Val (Aliphatic hydrophobic) -> Gly (Small and Weakly Polar) |
- |
| 951 |
|
AQP4 |
rs745315140 |
NP_001641.1 - 156 (TM4) |
Lipid facing |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 952 |
|
AQP4 |
rs769461423 |
NP_001641.1 - 156 (TM4) |
Lipid facing |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 953 |
|
AQP4 |
rs1176801311 |
NP_001641.1 - 157 (TM4) |
Lipid facing |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 954 |
|
AQP4 |
rs1189691152 |
NP_001641.1 - 158 (TM4) |
Monomer - monomer interface |
His (Charged) -> Arg (Charged) |
- |
| 955 |
|
AQP4 |
rs1424794479 |
NP_001641.1 - 158 (TM4) |
Monomer - monomer interface |
His (Charged) -> Asn (Neutral polar) |
- |
| 956 |
|
AQP4 |
rs372503562 |
NP_001641.1 - 160 (TM4) |
Helix - helix interface (TM4 - TM6); Lipid facing |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 957 |
|
AQP4 |
rs770679453 |
NP_001641.1 - 160 (TM4) |
Helix - helix interface (TM4 - TM6); Lipid facing |
Leu (Aliphatic hydrophobic) -> His (Charged) |
- |
| 958 |
|
AQP4 |
rs748111407 |
NP_001641.1 - 174 (TM4) |
Channel facing |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 959 |
|
AQP4 |
rs1265392557 |
NP_001641.1 - 174 (TM4) |
Channel facing |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 960 |
|
AQP4 |
rs925043159 |
NP_001641.1 - 176 (TM4) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Pro (Proline) |
- |
| 961 |
|
AQP4 |
rs925043159 |
NP_001641.1 - 176 (TM4) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 962 |
|
AQP4 |
rs151292719 |
NP_001641.1 - 182 (Loop region after TM4) |
Loop D |
Arg (Charged) -> Trp (Aromatic) |
- |
| 963 |
|
AQP4 |
rs187543361 |
NP_001641.1 - 182 (Loop region after TM4) |
Loop D |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 964 |
|
AQP4 |
rs767489782 |
NP_001641.1 - 183 (Loop region after TM4) |
Loop D |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 965 |
|
AQP4 |
rs61731038 |
NP_001641.1 - 184 (Loop region after TM4) |
Loop D |
Asp (Charged) -> Glu (Charged) |
- |
| 966 |
|
AQP4 |
rs61731038 |
NP_001641.1 - 184 (Loop region after TM4) |
Loop D |
Asp (Charged) -> Glu (Charged) |
- |
| 967 |
|
AQP4 |
rs764543071 |
NP_001641.1 - 185 (Loop region after TM4) |
Loop D |
Val (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 968 |
|
AQP4 |
rs763370831 |
NP_001641.1 - 186 (Loop region after TM4) |
Loop D |
Thr (Small and Weakly Polar) -> Pro (Proline) |
- |
| 969 |
|
AQP4 |
rs776145722 |
NP_001641.1 - 186 (Loop region after TM4) |
Loop D |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 970 |
|
AQP4 |
rs1381314537 |
NP_001641.1 - 188 (TM5) |
Monomer - monomer interface |
Ser (Small and Weakly Polar) -> Leu (Aliphatic hydrophobic) |
- |
| 971 |
|
AQP4 |
rs140954190 |
NP_001641.1 - 189 (TM5) |
Channel facing |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 972 |
|
AQP4 |
rs140954190 |
NP_001641.1 - 189 (TM5) |
Channel facing |
Ile (Aliphatic hydrophobic) -> Lys (Charged) |
- |
| 973 |
|
AQP4 |
rs1351028155 |
NP_001641.1 - 189 (TM5) |
Channel facing |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 974 |
|
AQP4 |
rs760110983 |
NP_001641.1 - 190 (TM5) |
Helix - helix interface (TM5 - TM2) |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 975 |
|
AQP4 |
rs61731037 |
NP_001641.1 - 193 (TM5) |
Channel facing |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 976 |
|
AQP4 |
rs1420359363 |
NP_001641.1 - 196 (TM5) |
Helix - helix interface (TM5 - TM2) |
Ser (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 977 |
|
AQP4 |
rs145495511 |
NP_001641.1 - 197 (TM5) |
Channel facing |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 978 |
|
AQP4 |
rs371959559 |
NP_001641.1 - 201 (TM5 - Ar/R Selectivity filter) |
Channel facing |
His (Charged) -> Arg (Charged) |
- |
| 979 |
|
AQP4 |
rs772697365 |
NP_001641.1 - 201 (TM5 - Ar/R Selectivity filter) |
Channel facing |
His (Charged) -> Tyr (Aromatic) |
- |
| 980 |
|
AQP4 |
rs72557974 |
NP_001641.1 - 205 (TM5) |
Channel facing |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 981 |
|
AQP4 |
rs72557974 |
NP_001641.1 - 205 (TM5) |
Channel facing |
Ile (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 982 |
|
AQP4 |
rs1225203582 |
NP_001641.1 - 205 (TM5) |
Channel facing;Helix - helix interface (TM5 - TM2) |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 983 |
|
AQP4 |
rs760164324 |
NP_001641.1 - 206 (TM5) |
Exposed to the extracellular environment |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 984 |
|
AQP4 |
rs371550687 |
NP_001641.1 - 207 (TM5) |
Monomer - monomer interface |
Tyr (Aromatic) -> His (Charged) |
- |
| 985 |
|
AQP4 |
rs765939032 |
NP_001641.1 - 207 (TM5) |
Monomer - monomer interface |
Tyr (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 986 |
|
AQP4 |
rs760034094 |
NP_001641.1 - 209 (TM5) |
Channel facing |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 987 |
|
AQP4 |
rs1195287695 |
NP_001641.1 - 210 (Loop region after TM5 - Ar/R Selectivity filter) |
Loop E |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 988 |
|
AQP4 |
rs1166313518 |
NP_001641.1 - 214 (LE - NPA2) |
Helix - helix interface (LE - LB, LE - TM6) |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 989 |
|
AQP4 |
rs148498248 |
NP_001641.1 - 215 (LE - NPA2) |
Helix - helix interface (LE - TM3) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 990 |
|
AQP4 |
rs777406434 |
NP_001641.1 - 216 (LE - Ar/R Selectivity filter) |
Channel facing |
Arg (Charged) -> Leu (Aliphatic hydrophobic) |
- |
| 991 |
|
AQP4 |
rs777406434 |
NP_001641.1 - 216 (LE - Ar/R Selectivity filter) |
Channel facing |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 992 |
|
AQP4 |
rs1433982336 |
NP_001641.1 - 221 (LE) |
Helix - helix interface (LE - TM6) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 993 |
|
AQP4 |
rs72557975 |
NP_001641.1 - 224 (LE) |
Exposed to the extracellular environment |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 994 |
|
AQP4 |
rs371557672 |
NP_001641.1 - 224 (LE) |
Exposed to the extracellular environment |
Met (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 995 |
|
AQP4 |
rs747003795 |
NP_001641.1 - 224 (LE) |
Exposed to the extracellular environment |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 996 |
|
AQP4 |
rs1457851657 |
NP_001641.1 - 226 (Loop region after LE) |
Loop E |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 997 |
|
AQP4 |
rs72557976 |
NP_001641.1 - 230 (Loop region after LE) |
Loop E |
His (Charged) -> Gln (Neutral polar) |
- |
| 998 |
|
AQP4 |
rs537674134 |
NP_001641.1 - 231 (TM6) |
Lipid facing |
Trp (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 999 |
|
AQP4 |
rs779472607 |
NP_001641.1 - 231 (TM6) |
Lipid facing |
Trp (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 1000 |
|
AQP4 |
rs1323983891 |
NP_001641.1 - 232 (TM6) |
Helix - helix interface (TM6 - TM4) |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1001 |
|
AQP4 |
rs1232778112 |
NP_001641.1 - 235 (TM6) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 1002 |
|
AQP4 |
rs372829102 |
NP_001641.1 - 238 (TM6) |
Lipid facing |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1003 |
|
AQP4 |
rs368184643 |
NP_001641.1 - 239 (TM6) |
Lipid facing |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1004 |
|
AQP4 |
rs1436473121 |
NP_001641.1 - 240 (TM6) |
Helix - helix interface (TM6 - TM4) |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 1005 |
|
AQP4 |
rs200115882 |
NP_001641.1 - 242 (TM6) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 1006 |
|
AQP4 |
rs1319117107 |
NP_001641.1 - 243 (TM6) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 1007 |
|
AQP4 |
rs374302276 |
NP_001641.1 - 244 (TM6) |
Helix - helix interface (TM6 - TM4) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1008 |
|
AQP4 |
rs1394322779 |
NP_001641.1 - 244 (TM6) |
Helix - helix interface (TM6 - TM4) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1009 |
|
AQP4 |
rs201162228 |
NP_001641.1 - 245 (TM6) |
Helix - helix interface (TM6 - TM4, TM6 - LB) |
Gly (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 1010 |
|
AQP4 |
rs765053126 |
NP_001641.1 - 248 (TM6) |
Helix - helix interface (TM6 - TM4) |
Tyr (Aromatic) -> Phe (Aromatic) |
- |
| 1011 |
|
AQP4 |
rs1448332095 |
NP_001641.1 - 252 (C terminus) |
C terminal domain |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 1012 |
|
AQP4 |
rs1454526733 |
NP_001641.1 - 254 (C terminus) |
C terminal domain |
Pro (Proline) -> Thr (Small and Weakly Polar) |
- |
| 1013 |
|
AQP4 |
rs1246183799 |
NP_001641.1 - 256 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Asp (Charged) |
- |
| 1014 |
|
AQP4 |
rs371339472 |
NP_001641.1 - 257 (C terminus) |
Absent in the structure |
Glu (Charged) -> Gln (Neutral polar) |
- |
| 1015 |
|
AQP4 |
rs201862553 |
NP_001641.1 - 260 (C terminus) |
Absent in the structure |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 1016 |
|
AQP4 |
rs774006470 |
NP_001641.1 - 260 (C terminus) |
Absent in the structure |
Arg (Charged) -> His (Charged) |
- |
| 1017 |
|
AQP4 |
rs149529726 |
NP_001641.1 - 261 (C terminus) |
Absent in the structure |
Arg (Charged) -> Leu (Aliphatic hydrophobic) |
- |
| 1018 |
|
AQP4 |
rs149529726 |
NP_001641.1 - 261 (C terminus) |
Absent in the structure |
Arg (Charged) -> His (Charged) |
- |
| 1019 |
|
AQP4 |
rs528517012 |
NP_001641.1 - 261 (C terminus) |
Absent in the structure |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 1020 |
|
AQP4 |
rs749491894 |
NP_001641.1 - 262 (C terminus) |
Absent in the structure |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 1021 |
|
AQP4 |
rs200121613 |
NP_001641.1 - 265 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1022 |
|
AQP4 |
rs200121613 |
NP_001641.1 - 265 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 1023 |
|
AQP4 |
rs200121613 |
NP_001641.1 - 265 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 1024 |
|
AQP4 |
rs372185576 |
NP_001641.1 - 265 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1025 |
|
AQP4 |
rs746404258 |
NP_001641.1 - 267 (C terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 1026 |
|
AQP4 |
rs781611001 |
NP_001641.1 - 269 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Pro (Proline) |
- |
| 1027 |
|
AQP4 |
rs886513761 |
NP_001641.1 - 271 (C terminus) |
Absent in the structure |
Gln (Neutral polar) -> Arg (Charged) |
- |
| 1028 |
|
AQP4 |
rs1393937756 |
NP_001641.1 - 275 (C terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1029 |
|
AQP4 |
rs3906956 |
NP_001641.1 - 278 (C terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1030 |
|
AQP4 |
rs199882615 |
NP_001641.1 - 279 (C terminus) |
Absent in the structure |
Glu (Charged) -> Gly (Small and Weakly Polar) |
- |
| 1031 |
|
AQP4 |
rs199882615 |
NP_001641.1 - 279 (C terminus) |
Absent in the structure |
Glu (Charged) -> Ala (Small and Weakly Polar) |
- |
| 1032 |
|
AQP4 |
rs749849201 |
NP_001641.1 - 280 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Gly (Small and Weakly Polar) |
- |
| 1033 |
|
AQP4 |
rs1387758698 |
NP_001641.1 - 282 (C terminus) |
Absent in the structure |
Asp (Charged) -> Asn (Neutral polar) |
- |
| 1034 |
|
AQP4 |
rs575542462 |
NP_001641.1 - 285 (C terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Asn (Neutral polar) |
- |
| 1035 |
|
AQP4 |
rs759368377 |
NP_001641.1 - 288 (C terminus) |
Absent in the structure |
Glu (Charged) -> Gly (Small and Weakly Polar) |
- |
| 1036 |
|
AQP4 |
rs759368377 |
NP_001641.1 - 288 (C terminus) |
Absent in the structure |
Glu (Charged) -> Ala (Small and Weakly Polar) |
- |
| 1037 |
|
AQP4 |
rs930787688 |
NP_001641.1 - 288 (C terminus) |
Absent in the structure |
Glu (Charged) -> Gln (Neutral polar) |
- |
| 1038 |
|
AQP4 |
rs563427443 |
NP_001641.1 - 289 (C terminus) |
Absent in the structure |
Thr (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1039 |
|
AQP4 |
rs766479946 |
NP_001641.1 - 289 (C terminus) |
Absent in the structure |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 1040 |
|
AQP4 |
rs774609951 |
NP_001641.1 - 291 (C terminus) |
Absent in the structure |
Asp (Charged) -> Glu (Charged) |
- |
| 1041 |
|
AQP4 |
rs1482801855 |
NP_001641.1 - 291 (C terminus) |
Absent in the structure |
Asp (Charged) -> Gly (Small and Weakly Polar) |
- |
| 1042 |
|
AQP4 |
rs767059912 |
NP_001641.1 - 293 (C terminus) |
Absent in the structure |
Ile (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 1043 |
|
AQP4 |
rs1468768005 |
NP_001641.1 - 293 (C terminus) |
Absent in the structure |
Ile (Aliphatic hydrophobic) -> Ser (Small and Weakly Polar) |
- |
| 1044 |
|
AQP4 |
rs768757331 |
NP_001641.1 - 296 (C terminus) |
Absent in the structure |
Pro (Proline) -> Arg (Charged) |
- |
| 1045 |
|
AQP4 |
rs1195221169 |
NP_001641.1 - 296 (C terminus) |
Absent in the structure |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 1046 |
|
AQP4 |
rs763105992 |
NP_001641.1 - 297 (C terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1047 |
|
AQP4 |
rs1325525301 |
NP_001641.1 - 298 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1048 |
|
AQP4 |
rs1325525301 |
NP_001641.1 - 298 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1049 |
|
AQP4 |
rs141721622 |
NP_001641.1 - 300 (C terminus) |
Absent in the structure |
His (Charged) -> Gln (Neutral polar) |
- |
| 1050 |
|
AQP4 |
rs781524733 |
NP_001641.1 - 300 (C terminus) |
Absent in the structure |
His (Charged) -> Arg (Charged) |
- |
| 1051 |
|
AQP4 |
rs781524733 |
NP_001641.1 - 300 (C terminus) |
Absent in the structure |
His (Charged) -> Pro (Proline) |
- |
| 1052 |
|
AQP4 |
rs1467217194 |
NP_001641.1 - 300 (C terminus) |
Absent in the structure |
His (Charged) -> Asn (Neutral polar) |
- |
| 1053 |
|
AQP4 |
rs996603532 |
NP_001641.1 - 301 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Gly (Small and Weakly Polar) |
- |
| 1054 |
|
AQP4 |
rs893806406 |
NP_001641.1 - 302 (C terminus) |
Absent in the structure |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1055 |
|
AQP4 |
rs1389987040 |
NP_001641.1 - 304 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Asp (Charged) |
- |
| 1056 |
|
AQP4 |
rs1405904864 |
NP_001641.1 - 304 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1057 |
|
AQP4 |
rs777201205 |
NP_001641.1 - 305 (C terminus) |
Absent in the structure |
Asp (Charged) -> Glu (Charged) |
- |
| 1058 |
|
AQP4 |
rs1032875508 |
NP_001641.1 - 305 (C terminus) |
Absent in the structure |
Asp (Charged) -> Gly (Small and Weakly Polar) |
- |
| 1059 |
|
AQP4 |
rs577742718 |
NP_001641.1 - 306 (C terminus) |
Absent in the structure |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 1060 |
|
AQP4 |
rs757879775 |
NP_001641.1 - 306 (C terminus) |
Absent in the structure |
Arg (Charged) -> Trp (Aromatic) |
- |
| 1061 |
|
AQP4 |
rs1046619582 |
NP_001641.1 - 309 (C terminus) |
Absent in the structure |
Glu (Charged) -> Lys (Charged) |
- |
| 1062 |
|
AQP4 |
rs1224886579 |
NP_001641.1 - 311 (C terminus) |
Absent in the structure |
Lys (Charged) -> Arg (Charged) |
- |
| 1063 |
|
AQP4 |
rs753748633 |
NP_001641.1 - 312 (C terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Trp (Aromatic) |
- |
| 1064 |
|
AQP4 |
rs1289880293 |
NP_001641.1 - 316 (C terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 1065 |
|
AQP4 |
rs200498749 |
NP_001641.1 - 319 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1066 |
|
AQP4 |
rs534381952 |
NP_001641.1 - 321 (C terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Pro (Proline) |
- |
| 1067 |
|
AQP4 |
rs534381952 |
NP_001641.1 - 321 (C terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1068 |
|
AQP5 |
rs1264202277 |
NP_001642.1 - 1 (N terminus) |
N terminal domain |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1069 |
|
AQP5 |
rs1414511990 |
NP_001642.1 - 4 (N terminus) |
N terminal domain |
Glu (Charged) -> Gly (Small and Weakly Polar) |
- |
| 1070 |
|
AQP5 |
rs1414511990 |
NP_001642.1 - 4 (N terminus) |
N terminal domain |
Glu (Charged) -> Val (Aliphatic hydrophobic) |
- |
| 1071 |
|
AQP5 |
rs747845858 |
NP_001642.1 - 6 (N terminus) |
N terminal domain |
Cys (Small and Weakly Polar) -> Trp (Aromatic) |
- |
| 1072 |
|
AQP5 |
rs1359109751 |
NP_001642.1 - 6 (N terminus) |
N terminal domain |
Cys (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 1073 |
|
AQP5 |
rs758120085 |
NP_001642.1 - 8 (TM1) |
Exposed to cytoplasm |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1074 |
|
AQP5 |
rs1434712483 |
NP_001642.1 - 10 (TM1) |
Helix - helix interface (TM1 - TM3) |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 1075 |
|
AQP5 |
rs575071552 |
NP_001642.1 - 11 (TM1) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 1076 |
|
AQP5 |
rs746804140 |
NP_001642.1 - 12 (TM1) |
Monomer - monomer interface |
Lys (Charged) -> Arg (Charged) |
- |
| 1077 |
|
AQP5 |
rs770591290 |
NP_001642.1 - 13 (TM1) |
Helix - helix interface (TM1 - TM2, TM1 - TM3) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1078 |
|
AQP5 |
rs776651494 |
NP_001642.1 - 14 (TM1) |
Helix - helix interface (TM1 - TM3) |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1079 |
|
AQP5 |
rs776651494 |
NP_001642.1 - 14 (TM1) |
Helix - helix interface (TM1 - TM3) |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1080 |
|
AQP5 |
rs745767685 |
NP_001642.1 - 15 (TM1) |
Monomer - monomer interface |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 1081 |
|
AQP5 |
rs745767685 |
NP_001642.1 - 15 (TM1) |
Monomer - monomer interface |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 1082 |
|
AQP5 |
rs138665659 |
NP_001642.1 - 16 (TM1) |
Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Glu (Charged) |
- |
| 1083 |
|
AQP5 |
rs138665659 |
NP_001642.1 - 16 (TM1) |
Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1084 |
|
AQP5 |
rs532533853 |
NP_001642.1 - 16 (TM1) |
Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1085 |
|
AQP5 |
rs532533853 |
NP_001642.1 - 16 (TM1) |
Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1086 |
|
AQP5 |
rs540509756 |
NP_001642.1 - 18 (TM1) |
Helix - helix interface (TM1 - TM3); Lipid facing |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 1087 |
|
AQP5 |
rs1464257093 |
NP_001642.1 - 18 (TM1) |
Helix - helix interface (TM1 - TM3); Lipid facing |
Phe (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 1088 |
|
AQP5 |
rs762076378 |
NP_001642.1 - 19 (TM1) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Ser (Small and Weakly Polar) |
- |
| 1089 |
|
AQP5 |
rs762076378 |
NP_001642.1 - 19 (TM1) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Trp (Aromatic) |
- |
| 1090 |
|
AQP5 |
rs568521335 |
NP_001642.1 - 22 (TM1) |
Helix - helix interface (TM1 - TM3) |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 1091 |
|
AQP5 |
rs142676062 |
NP_001642.1 - 24 (TM1) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Phe (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 1092 |
|
AQP5 |
rs139623970 |
NP_001642.1 - 30 (TM1) |
Helix - helix interface (TM1 - TM3);Monomer - monomer interface |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1093 |
|
AQP5 |
rs139623970 |
NP_001642.1 - 30 (TM1) |
Helix - helix interface (TM1 - TM3);Monomer - monomer interface |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1094 |
|
AQP5 |
rs139623970 |
NP_001642.1 - 30 (TM1) |
Helix - helix interface (TM1 - TM3);Monomer - monomer interface |
Gly (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 1095 |
|
AQP5 |
rs754419280 |
NP_001642.1 - 30 (TM1) |
Helix - helix interface (TM1 - TM3);Monomer - monomer interface |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 1096 |
|
AQP5 |
rs1351853699 |
NP_001642.1 - 34 (Loop region after TM1) |
Loop A |
Lys (Charged) -> Arg (Charged) |
- |
| 1097 |
|
AQP5 |
rs146740002 |
NP_001642.1 - 36 (Loop region after TM1) |
Loop A |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 1098 |
|
AQP5 |
rs757913702 |
NP_001642.1 - 36 (Loop region after TM1) |
Loop A |
Pro (Proline) -> Gln (Neutral polar) |
- |
| 1099 |
|
AQP5 |
rs1328341018 |
NP_001642.1 - 37 (Loop region after TM1) |
Loop A |
Ser (Small and Weakly Polar) -> Leu (Aliphatic hydrophobic) |
- |
| 1100 |
|
AQP5 |
rs398123054 |
NP_001642.1 - 38 (Loop region after TM1) |
Loop A |
Ala (Small and Weakly Polar) -> Glu (Charged) |
Palmoplantar Keratoderma |
| 1101 |
|
AQP5 |
rs398123054 |
NP_001642.1 - 38 (Loop region after TM1) |
Loop A |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1102 |
|
AQP5 |
rs1244523495 |
NP_001642.1 - 42 (TM2) |
Helix - helix interface (TM2 - TM5) |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1103 |
|
AQP5 |
rs745880687 |
NP_001642.1 - 43 (TM2) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 1104 |
|
AQP5 |
rs398123055 |
NP_001642.1 - 45 (TM2) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Ile (Aliphatic hydrophobic) -> Ser (Small and Weakly Polar) |
Palmoplantar Keratoderma |
| 1105 |
|
AQP5 |
rs199524477 |
NP_001642.1 - 46 (TM2) |
Helix - helix interface (TM2 - TM5) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1106 |
|
AQP5 |
rs1481308684 |
NP_001642.1 - 46 (TM2) |
Helix - helix interface (TM2 - TM5) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1107 |
|
AQP5 |
rs779906043 |
NP_001642.1 - 48 (TM2) |
Helix - helix interface (TM1 - TM2);Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1108 |
|
AQP5 |
rs1157410332 |
NP_001642.1 - 51 (TM2) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1109 |
|
AQP5 |
rs139174720 |
NP_001642.1 - 52 (TM2) |
Monomer - monomer interface;Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1110 |
|
AQP5 |
rs1446033559 |
NP_001642.1 - 52 (TM2) |
Monomer - monomer interface;Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 1111 |
|
AQP5 |
rs748233977 |
NP_001642.1 - 53 (TM2) |
Channel facing |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1112 |
|
AQP5 |
rs1406235581 |
NP_001642.1 - 53 (TM2) |
Channel facing |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1113 |
|
AQP5 |
rs1416410538 |
NP_001642.1 - 53 (TM2) |
Channel facing |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1114 |
|
AQP5 |
rs1348251687 |
NP_001642.1 - 55 (TM2) |
Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 1115 |
|
AQP5 |
rs1226491229 |
NP_001642.1 - 59 (TM2) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 1116 |
|
AQP5 |
rs1285794353 |
NP_001642.1 - 60 (TM2) |
Helix - helix interface (TM1 - TM2);Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1117 |
|
AQP5 |
rs771368210 |
NP_001642.1 - 62 (TM2) |
Monomer - monomer interface |
Pro (Proline) -> Thr (Small and Weakly Polar) |
- |
| 1118 |
|
AQP5 |
rs771368210 |
NP_001642.1 - 62 (TM2) |
Monomer - monomer interface |
Pro (Proline) -> Ala (Small and Weakly Polar) |
- |
| 1119 |
|
AQP5 |
rs993506836 |
NP_001642.1 - 63 (TM2) |
Helix - helix interface (TM1 - TM2);Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1120 |
|
AQP5 |
rs993506836 |
NP_001642.1 - 63 (TM2) |
Helix - helix interface (TM1 - TM2);Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1121 |
|
AQP5 |
rs147337355 |
NP_001642.1 - 65 (TM2) |
Channel facing |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1122 |
|
AQP5 |
rs147337355 |
NP_001642.1 - 65 (TM2) |
Channel facing |
Gly (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 1123 |
|
AQP5 |
rs1483056077 |
NP_001642.1 - 66 (Loop region after TM2) |
Loop B |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1124 |
|
AQP5 |
rs751297059 |
NP_001642.1 - 68 (Loop region after TM2) |
Loop B |
Ile (Aliphatic hydrophobic) -> Ser (Small and Weakly Polar) |
- |
| 1125 |
|
AQP5 |
rs1473313840 |
NP_001642.1 - 69 (LB - NPA1) |
Channel facing;Helix - helix interface (LB - LE, LB - TM3) |
Asn (Neutral polar) -> Thr (Small and Weakly Polar) |
- |
| 1126 |
|
AQP5 |
rs144062328 |
NP_001642.1 - 70 (LB - NPA1) |
Helix - helix interface (LB - LE, LB - TM3) |
Pro (Proline) -> His (Charged) |
- |
| 1127 |
|
AQP5 |
rs781095987 |
NP_001642.1 - 71 (LB - NPA1) |
Helix - helix interface (LB - TM4, LB - LE, LB - TM6) |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1128 |
|
AQP5 |
rs1431789695 |
NP_001642.1 - 73 (LB) |
Helix - helix interface (LB - TM3) |
Thr (Small and Weakly Polar) -> Asn (Neutral polar) |
- |
| 1129 |
|
AQP5 |
rs755874805 |
NP_001642.1 - 84 (TM3) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 1130 |
|
AQP5 |
rs372058000 |
NP_001642.1 - 86 (TM3) |
Channel facing |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 1131 |
|
AQP5 |
rs375720885 |
NP_001642.1 - 86 (TM3) |
Channel facing |
Arg (Charged) -> Trp (Aromatic) |
- |
| 1132 |
|
AQP5 |
rs867642609 |
NP_001642.1 - 87 (TM3) |
Helix - helix interface (LB - TM3) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1133 |
|
AQP5 |
rs1051745908 |
NP_001642.1 - 87 (TM3) |
Helix - helix interface (LB - TM3) |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 1134 |
|
AQP5 |
rs912464121 |
NP_001642.1 - 88 (TM3) |
Lipid facing |
Phe (Aromatic) -> Val (Aliphatic hydrophobic) |
- |
| 1135 |
|
AQP5 |
rs1282149881 |
NP_001642.1 - 91 (TM3) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1136 |
|
AQP5 |
rs777799527 |
NP_001642.1 - 92 (TM3) |
Lipid facing |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1137 |
|
AQP5 |
rs925731999 |
NP_001642.1 - 92 (TM3) |
Lipid facing |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1138 |
|
AQP5 |
rs747324053 |
NP_001642.1 - 95 (TM3) |
Lipid facing;Helix - helix interface (TM3 - LE) |
Leu (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1139 |
|
AQP5 |
rs747324053 |
NP_001642.1 - 95 (TM3) |
Lipid facing;Helix - helix interface (TM3 - LE) |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1140 |
|
AQP5 |
rs1281388026 |
NP_001642.1 - 97 (TM3) |
Helix - helix interface (TM1 - TM3) |
Gly (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 1141 |
|
AQP5 |
rs746249395 |
NP_001642.1 - 98 (TM3) |
Helix - helix interface (TM1 - TM3, TM3 - LE) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1142 |
|
AQP5 |
rs776856913 |
NP_001642.1 - 98 (TM3) |
Helix - helix interface (TM1 - TM3, TM3 - LE) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1143 |
|
AQP5 |
rs373259927 |
NP_001642.1 - 99 (TM3) |
Lipid facing;Helix - helix interface (TM3 - LE) |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1144 |
|
AQP5 |
rs770232536 |
NP_001642.1 - 99 (TM3) |
Lipid facing;Helix - helix interface (TM3 - LE) |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1145 |
|
AQP5 |
rs770232536 |
NP_001642.1 - 99 (TM3) |
Lipid facing;Helix - helix interface (TM3 - LE) |
Ile (Aliphatic hydrophobic) -> Ser (Small and Weakly Polar) |
- |
| 1146 |
|
AQP5 |
rs1236082203 |
NP_001642.1 - 100 (TM3) |
Lipid facing |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1147 |
|
AQP5 |
rs866339903 |
NP_001642.1 - 103 (TM3) |
Lipid facing |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 1148 |
|
AQP5 |
rs1451626196 |
NP_001642.1 - 103 (TM3) |
Lipid facing |
Gly (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 1149 |
|
AQP5 |
rs1189429849 |
NP_001642.1 - 105 (TM3) |
Helix - helix interface (TM1 - TM3) |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 1150 |
|
AQP5 |
rs776187324 |
NP_001642.1 - 106 (TM3) |
Helix - helix interface (TM3 - LE) |
Tyr (Aromatic) -> Asn (Neutral polar) |
- |
| 1151 |
|
AQP5 |
rs763760977 |
NP_001642.1 - 107 (TM3) |
Lipid facing |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1152 |
|
AQP5 |
rs763760977 |
NP_001642.1 - 107 (TM3) |
Lipid facing |
Gly (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 1153 |
|
AQP5 |
rs761326596 |
NP_001642.1 - 110 (Loop region after TM3) |
Loop C |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 1154 |
|
AQP5 |
rs1332028400 |
NP_001642.1 - 111 (Loop region after TM3) |
Loop C |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 1155 |
|
AQP5 |
rs755928749 |
NP_001642.1 - 112 (Loop region after TM3) |
Loop C |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 1156 |
|
AQP5 |
rs766144362 |
NP_001642.1 - 114 (Loop region after TM3) |
Loop C |
Arg (Charged) -> Trp (Aromatic) |
- |
| 1157 |
|
AQP5 |
rs1234813760 |
NP_001642.1 - 114 (Loop region after TM3) |
Loop C |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 1158 |
|
AQP5 |
rs1446684991 |
NP_001642.1 - 116 (Loop region after TM3) |
Loop C |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 1159 |
|
AQP5 |
rs747075251 |
NP_001642.1 - 119 (Loop region after TM3) |
Loop C |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1160 |
|
AQP5 |
rs1209704895 |
NP_001642.1 - 120 (Loop region after TM3) |
Loop C |
Asn (Neutral polar) -> Ile (Aliphatic hydrophobic) |
- |
| 1161 |
|
AQP5 |
rs757296927 |
NP_001642.1 - 121 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 1162 |
|
AQP5 |
rs757296927 |
NP_001642.1 - 121 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1163 |
|
AQP5 |
rs1247665816 |
NP_001642.1 - 121 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1164 |
|
AQP5 |
rs1170009300 |
NP_001642.1 - 122 (Loop region after TM3) |
Loop C |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 1165 |
|
AQP5 |
rs398123057 |
NP_001642.1 - 123 (Loop region after TM3) |
Loop C |
Asn (Neutral polar) -> Asp (Charged) |
Palmoplantar Keratoderma |
| 1166 |
|
AQP5 |
rs756193040 |
NP_001642.1 - 123 (Loop region after TM3) |
Loop C |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 1167 |
|
AQP5 |
rs555923120 |
NP_001642.1 - 124 (Loop region after TM3) |
Loop C |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 1168 |
|
AQP5 |
rs771274265 |
NP_001642.1 - 127 (TM4) |
Exposed to the extracellular environment |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 1169 |
|
AQP5 |
rs1434205786 |
NP_001642.1 - 128 (TM4) |
Exposed to the extracellular environment |
Gln (Neutral polar) -> His (Charged) |
- |
| 1170 |
|
AQP5 |
rs151105020 |
NP_001642.1 - 129 (TM4) |
Lipid facing |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1171 |
|
AQP5 |
rs1340102657 |
NP_001642.1 - 130 (TM4) |
Exposed to the extracellular environment |
Gln (Neutral polar) -> Pro (Proline) |
- |
| 1172 |
|
AQP5 |
rs779308907 |
NP_001642.1 - 132 (TM4) |
Helix - helix interface (TM4 - TM6); Lipid facing |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1173 |
|
AQP5 |
rs1380974407 |
NP_001642.1 - 133 (TM4) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 1174 |
|
AQP5 |
rs142666049 |
NP_001642.1 - 134 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1175 |
|
AQP5 |
rs142666049 |
NP_001642.1 - 134 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1176 |
|
AQP5 |
rs142666049 |
NP_001642.1 - 134 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1177 |
|
AQP5 |
rs200469009 |
NP_001642.1 - 136 (TM4) |
Helix - helix interface (TM4 - TM6); Lipid facing |
Leu (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1178 |
|
AQP5 |
rs1248222841 |
NP_001642.1 - 136 (TM4) |
Helix - helix interface (TM4 - TM6); Lipid facing |
Leu (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 1179 |
|
AQP5 |
rs1009007988 |
NP_001642.1 - 139 (TM4) |
Helix - helix interface (TM4 - TM6) |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 1180 |
|
AQP5 |
rs1040491324 |
NP_001642.1 - 142 (TM4) |
Channel facing |
Leu (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1181 |
|
AQP5 |
rs776312791 |
NP_001642.1 - 144 (TM4) |
Helix - helix interface (TM4 - TM6);Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 1182 |
|
AQP5 |
rs759155675 |
NP_001642.1 - 145 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Cys (Small and Weakly Polar) -> Tyr (Aromatic) |
- |
| 1183 |
|
AQP5 |
rs775341539 |
NP_001642.1 - 148 (TM4) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1184 |
|
AQP5 |
rs762593807 |
NP_001642.1 - 150 (TM4) |
Channel facing |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 1185 |
|
AQP5 |
rs535080363 |
NP_001642.1 - 151 (TM4) |
Helix - helix interface (TM4 - TM6) |
Asp (Charged) -> Ala (Small and Weakly Polar) |
- |
| 1186 |
|
AQP5 |
rs535080363 |
NP_001642.1 - 151 (TM4) |
Helix - helix interface (TM4 - TM6) |
Asp (Charged) -> Gly (Small and Weakly Polar) |
- |
| 1187 |
|
AQP5 |
rs751499633 |
NP_001642.1 - 152 (Loop region after TM4) |
Loop D |
Ser (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1188 |
|
AQP5 |
rs751499633 |
NP_001642.1 - 152 (Loop region after TM4) |
Loop D |
Ser (Small and Weakly Polar) -> Pro (Proline) |
- |
| 1189 |
|
AQP5 |
rs146762965 |
NP_001642.1 - 153 (Loop region after TM4) |
Loop D |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 1190 |
|
AQP5 |
rs754156758 |
NP_001642.1 - 153 (Loop region after TM4) |
Loop D |
Arg (Charged) -> His (Charged) |
- |
| 1191 |
|
AQP5 |
rs754156758 |
NP_001642.1 - 153 (Loop region after TM4) |
Loop D |
Arg (Charged) -> Pro (Proline) |
- |
| 1192 |
|
AQP5 |
rs139276257 |
NP_001642.1 - 154 (Loop region after TM4) |
Loop D |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 1193 |
|
AQP5 |
rs541231363 |
NP_001642.1 - 154 (Loop region after TM4) |
Loop D |
Arg (Charged) -> His (Charged) |
- |
| 1194 |
|
AQP5 |
rs541231363 |
NP_001642.1 - 154 (Loop region after TM4) |
Loop D |
Arg (Charged) -> Pro (Proline) |
- |
| 1195 |
|
AQP5 |
rs541231363 |
NP_001642.1 - 154 (Loop region after TM4) |
Loop D |
Arg (Charged) -> Leu (Aliphatic hydrophobic) |
- |
| 1196 |
|
AQP5 |
rs753119460 |
NP_001642.1 - 155 (Loop region after TM4) |
Loop D |
Thr (Small and Weakly Polar) -> Asn (Neutral polar) |
- |
| 1197 |
|
AQP5 |
rs1313945276 |
NP_001642.1 - 157 (Loop region after TM4) |
Loop D |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 1198 |
|
AQP5 |
rs1361325689 |
NP_001642.1 - 158 (Loop region after TM4) |
Loop D |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1199 |
|
AQP5 |
rs1210705708 |
NP_001642.1 - 159 (Loop region after TM4) |
Loop D |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1200 |
|
AQP5 |
rs1286497367 |
NP_001642.1 - 159 (Loop region after TM4) |
Loop D |
Gly (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 1201 |
|
AQP5 |
rs1208305198 |
NP_001642.1 - 160 (TM5) |
Monomer - monomer interface |
Ser (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 1202 |
|
AQP5 |
rs1451649777 |
NP_001642.1 - 161 (TM5) |
Helix - helix interface (TM4 - TM5) |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 1203 |
|
AQP5 |
rs778284854 |
NP_001642.1 - 162 (TM5) |
Helix - helix interface (TM2 - TM5) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1204 |
|
AQP5 |
rs777174489 |
NP_001642.1 - 165 (TM5) |
Channel facing;Helix - helix interface (TM4 - TM5) |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1205 |
|
AQP5 |
rs1426661802 |
NP_001642.1 - 166 (TM5) |
Helix - helix interface (TM2 - TM5) |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 1206 |
|
AQP5 |
rs578029378 |
NP_001642.1 - 168 (TM5) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Ser (Small and Weakly Polar) -> Tyr (Aromatic) |
- |
| 1207 |
|
AQP5 |
rs147053469 |
NP_001642.1 - 169 (TM5) |
Channel facing |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1208 |
|
AQP5 |
rs1429152052 |
NP_001642.1 - 170 (TM5) |
Helix - helix interface (TM2 - TM5) |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 1209 |
|
AQP5 |
rs144294640 |
NP_001642.1 - 172 (TM5) |
Helix - helix interface (TM4 - TM5) |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1210 |
|
AQP5 |
rs1389659407 |
NP_001642.1 - 173 (TM5 - Ar/R Selectivity filter) |
Channel facing |
His (Charged) -> Arg (Charged) |
- |
| 1211 |
|
AQP5 |
rs543679570 |
NP_001642.1 - 174 (TM5) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1212 |
|
AQP5 |
rs1430268901 |
NP_001642.1 - 174 (TM5) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 1213 |
|
AQP5 |
rs745563552 |
NP_001642.1 - 176 (TM5) |
Helix - helix interface (TM4 - TM5) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1214 |
|
AQP5 |
rs769499282 |
NP_001642.1 - 176 (TM5) |
Helix - helix interface (TM4 - TM5) |
Gly (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 1215 |
|
AQP5 |
rs769499282 |
NP_001642.1 - 176 (TM5) |
Helix - helix interface (TM4 - TM5) |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1216 |
|
AQP5 |
rs398123056 |
NP_001642.1 - 177 (TM5) |
Channel facing |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1217 |
|
AQP5 |
rs398123056 |
NP_001642.1 - 177 (TM5) |
Channel facing |
Ile (Aliphatic hydrophobic) -> Phe (Aromatic) |
Palmoplantar Keratoderma |
| 1218 |
|
AQP5 |
rs1400711542 |
NP_001642.1 - 177 (TM5) |
Channel facing |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1219 |
|
AQP5 |
rs1416253239 |
NP_001642.1 - 179 (TM5) |
Exposed to the extracellular environment |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 1220 |
|
AQP5 |
rs768614872 |
NP_001642.1 - 181 (TM5) |
Channel facing |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1221 |
|
AQP5 |
rs774286980 |
NP_001642.1 - 182 (Loop region after TM5 - Ar/R Selectivity filter) |
Loop E |
Cys (Small and Weakly Polar) -> Trp (Aromatic) |
- |
| 1222 |
|
AQP5 |
rs1363775663 |
NP_001642.1 - 183 (Loop region after TM5) |
Loop E |
Ser (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 1223 |
|
AQP5 |
rs1156411143 |
NP_001642.1 - 184 (Loop region after TM5) |
Loop E |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1224 |
|
AQP5 |
rs772153691 |
NP_001642.1 - 186 (LE - NPA2) |
Helix - helix interface (LE - LB, LE - TM6) |
Pro (Proline) -> Arg (Charged) |
- |
| 1225 |
|
AQP5 |
rs772153691 |
NP_001642.1 - 186 (LE - NPA2) |
Helix - helix interface (LE - LB, LE - TM6) |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 1226 |
|
AQP5 |
rs1335045089 |
NP_001642.1 - 186 (LE - NPA2) |
Helix - helix interface (LE - LB, LE - TM6) |
Pro (Proline) -> Ala (Small and Weakly Polar) |
- |
| 1227 |
|
AQP5 |
rs1379527461 |
NP_001642.1 - 187 (LE - NPA2) |
Helix - helix interface (LE - TM3) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1228 |
|
AQP5 |
rs368292687 |
NP_001642.1 - 188 (LE - Ar/R Selectivity filter) |
Channel facing |
Arg (Charged) -> Cys (Small and Weakly Polar) |
Palmoplantar Keratoderma |
| 1229 |
|
AQP5 |
rs765183334 |
NP_001642.1 - 188 (LE - Ar/R Selectivity filter) |
Channel facing |
Arg (Charged) -> His (Charged) |
- |
| 1230 |
|
AQP5 |
rs775832116 |
NP_001642.1 - 190 (LE) |
Lipid facing |
Phe (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 1231 |
|
AQP5 |
rs117761535 |
NP_001642.1 - 193 (LE) |
Lipid facing |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1232 |
|
AQP5 |
rs762099173 |
NP_001642.1 - 194 (LE) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1233 |
|
AQP5 |
rs768038810 |
NP_001642.1 - 194 (LE) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 1234 |
|
AQP5 |
rs1473282713 |
NP_001642.1 - 195 (LE) |
Helix - helix interface (LE - TM3) |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1235 |
|
AQP5 |
rs1240442785 |
NP_001642.1 - 196 (LE) |
Exposed to the extracellular environment |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1236 |
|
AQP5 |
rs1183202230 |
NP_001642.1 - 197 (Loop region after LE) |
Loop E |
Asn (Neutral polar) -> Asp (Charged) |
- |
| 1237 |
|
AQP5 |
rs143584978 |
NP_001642.1 - 198 (Loop region after LE) |
Loop E |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 1238 |
|
AQP5 |
rs143584978 |
NP_001642.1 - 198 (Loop region after LE) |
Loop E |
Arg (Charged) -> Pro (Proline) |
- |
| 1239 |
|
AQP5 |
rs202006860 |
NP_001642.1 - 198 (Loop region after LE) |
Loop E |
Arg (Charged) -> Gly (Small and Weakly Polar) |
- |
| 1240 |
|
AQP5 |
rs202006860 |
NP_001642.1 - 198 (Loop region after LE) |
Loop E |
Arg (Charged) -> Trp (Aromatic) |
- |
| 1241 |
|
AQP5 |
rs1395686918 |
NP_001642.1 - 199 (Loop region after LE) |
Loop E |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 1242 |
|
AQP5 |
rs778654352 |
NP_001642.1 - 201 (Loop region after LE) |
Loop E |
Pro (Proline) -> Thr (Small and Weakly Polar) |
- |
| 1243 |
|
AQP5 |
rs771953539 |
NP_001642.1 - 202 (Loop region after LE) |
Loop E |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1244 |
|
AQP5 |
rs771953539 |
NP_001642.1 - 202 (Loop region after LE) |
Loop E |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1245 |
|
AQP5 |
rs878929047 |
NP_001642.1 - 203 (Loop region after LE) |
Loop E |
His (Charged) -> Gln (Neutral polar) |
- |
| 1246 |
|
AQP5 |
rs1201026229 |
NP_001642.1 - 205 (TM6) |
Helix - helix interface (TM4 - TM6) |
Val (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 1247 |
|
AQP5 |
rs1319855429 |
NP_001642.1 - 206 (TM6) |
Helix - helix interface (TM4 - LE) |
Phe (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 1248 |
|
AQP5 |
rs1269540453 |
NP_001642.1 - 207 (TM6) |
Lipid facing |
Trp (Aromatic) -> Arg (Charged) |
- |
| 1249 |
|
AQP5 |
rs901182462 |
NP_001642.1 - 210 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6, LE - TM6) |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 1250 |
|
AQP5 |
rs75180659 |
NP_001642.1 - 212 (TM6) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1251 |
|
AQP5 |
rs766801870 |
NP_001642.1 - 214 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1252 |
|
AQP5 |
rs1382275648 |
NP_001642.1 - 214 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6) |
Ala (Small and Weakly Polar) -> Pro (Proline) |
- |
| 1253 |
|
AQP5 |
rs1382275648 |
NP_001642.1 - 214 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6) |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1254 |
|
AQP5 |
rs764820617 |
NP_001642.1 - 216 (TM6) |
Helix - helix interface (TM4 - TM6); Lipid facing |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 1255 |
|
AQP5 |
rs144078933 |
NP_001642.1 - 217 (TM6) |
Helix - helix interface (TM4 - TM6) |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 1256 |
|
AQP5 |
rs1349829490 |
NP_001642.1 - 217 (TM6) |
Helix - helix interface (TM4 - TM6) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1257 |
|
AQP5 |
rs1171685231 |
NP_001642.1 - 218 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1258 |
|
AQP5 |
rs752440029 |
NP_001642.1 - 220 (TM6) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 1259 |
|
AQP5 |
rs373813169 |
NP_001642.1 - 222 (TM6) |
Channel facing |
Phe (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 1260 |
|
AQP5 |
rs1331624272 |
NP_001642.1 - 222 (TM6) |
Channel facing |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 1261 |
|
AQP5 |
rs1240153551 |
NP_001642.1 - 223 (TM6) |
Lipid facing |
Tyr (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 1262 |
|
AQP5 |
rs1454866658 |
NP_001642.1 - 225 (C terminus) |
C terminal domain |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 1263 |
|
AQP5 |
rs763741727 |
NP_001642.1 - 227 (C terminus) |
C terminal domain |
Pro (Proline) -> Arg (Charged) |
- |
| 1264 |
|
AQP5 |
rs763741727 |
NP_001642.1 - 227 (C terminus) |
C terminal domain |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 1265 |
|
AQP5 |
rs1211722072 |
NP_001642.1 - 227 (C terminus) |
C terminal domain |
Pro (Proline) -> Ala (Small and Weakly Polar) |
- |
| 1266 |
|
AQP5 |
rs41495048 |
NP_001642.1 - 228 (C terminus) |
C terminal domain |
Asn (Neutral polar) -> Lys (Charged) |
- |
| 1267 |
|
AQP5 |
rs376916607 |
NP_001642.1 - 229 (C terminus) |
C terminal domain |
Ser (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 1268 |
|
AQP5 |
rs961903396 |
NP_001642.1 - 231 (C terminus) |
C terminal domain |
Ser (Small and Weakly Polar) -> Asn (Neutral polar) |
- |
| 1269 |
|
AQP5 |
rs1180766434 |
NP_001642.1 - 232 (C terminus) |
C terminal domain |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 1270 |
|
AQP5 |
rs755088994 |
NP_001642.1 - 233 (C terminus) |
C terminal domain |
Ser (Small and Weakly Polar) -> Asn (Neutral polar) |
- |
| 1271 |
|
AQP5 |
rs778957386 |
NP_001642.1 - 234 (C terminus) |
C terminal domain |
Glu (Charged) -> Asp (Charged) |
- |
| 1272 |
|
AQP5 |
rs1364382865 |
NP_001642.1 - 234 (C terminus) |
C terminal domain |
Glu (Charged) -> Lys (Charged) |
- |
| 1273 |
|
AQP5 |
rs148637740 |
NP_001642.1 - 235 (C terminus) |
C terminal domain |
Arg (Charged) -> His (Charged) |
- |
| 1274 |
|
AQP5 |
rs148637740 |
NP_001642.1 - 235 (C terminus) |
C terminal domain |
Arg (Charged) -> Leu (Aliphatic hydrophobic) |
- |
| 1275 |
|
AQP5 |
rs772197950 |
NP_001642.1 - 235 (C terminus) |
C terminal domain |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 1276 |
|
AQP5 |
rs747365491 |
NP_001642.1 - 236 (C terminus) |
C terminal domain |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1277 |
|
AQP5 |
rs771282441 |
NP_001642.1 - 237 (C terminus) |
C terminal domain |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1278 |
|
AQP5 |
rs200035861 |
NP_001642.1 - 238 (C terminus) |
C terminal domain |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1279 |
|
AQP5 |
rs959035539 |
NP_001642.1 - 238 (C terminus) |
C terminal domain |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1280 |
|
AQP5 |
rs374603563 |
NP_001642.1 - 241 (C terminus) |
C terminal domain |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1281 |
|
AQP5 |
rs764910180 |
NP_001642.1 - 242 (C terminus) |
C terminal domain |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 1282 |
|
AQP5 |
rs145882681 |
NP_001642.1 - 243 (C terminus) |
C terminal domain |
Tyr (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 1283 |
|
AQP5 |
rs978299974 |
NP_001642.1 - 243 (C terminus) |
C terminal domain |
Tyr (Aromatic) -> His (Charged) |
- |
| 1284 |
|
AQP5 |
rs1248132794 |
NP_001642.1 - 245 (C terminus) |
C terminal domain |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 1285 |
|
AQP5 |
rs763681821 |
NP_001642.1 - 246 (C terminus) |
Absent in the structure |
Asp (Charged) -> Glu (Charged) |
- |
| 1286 |
|
AQP5 |
rs150715551 |
NP_001642.1 - 247 (C terminus) |
Absent in the structure |
Glu (Charged) -> Lys (Charged) |
- |
| 1287 |
|
AQP5 |
rs757051423 |
NP_001642.1 - 248 (C terminus) |
Absent in the structure |
Asp (Charged) -> Asn (Neutral polar) |
- |
| 1288 |
|
AQP5 |
rs1274942368 |
NP_001642.1 - 250 (C terminus) |
Absent in the structure |
Glu (Charged) -> Gly (Small and Weakly Polar) |
- |
| 1289 |
|
AQP5 |
rs1274942368 |
NP_001642.1 - 250 (C terminus) |
Absent in the structure |
Glu (Charged) -> Val (Aliphatic hydrophobic) |
- |
| 1290 |
|
AQP5 |
rs1356790425 |
NP_001642.1 - 250 (C terminus) |
Absent in the structure |
Glu (Charged) -> Lys (Charged) |
- |
| 1291 |
|
AQP5 |
rs200088878 |
NP_001642.1 - 253 (C terminus) |
Absent in the structure |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 1292 |
|
AQP5 |
rs756030949 |
NP_001642.1 - 253 (C terminus) |
Absent in the structure |
Arg (Charged) -> Trp (Aromatic) |
- |
| 1293 |
|
AQP5 |
rs1177778724 |
NP_001642.1 - 255 (C terminus) |
Absent in the structure |
Glu (Charged) -> Lys (Charged) |
- |
| 1294 |
|
AQP5 |
rs139421403 |
NP_001642.1 - 256 (C terminus) |
Absent in the structure |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 1295 |
|
AQP5 |
rs748231984 |
NP_001642.1 - 256 (C terminus) |
Absent in the structure |
Arg (Charged) -> Trp (Aromatic) |
- |
| 1296 |
|
AQP5 |
rs1243890701 |
NP_001642.1 - 260 (C terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1297 |
|
AQP5 |
rs777885456 |
NP_001642.1 - 262 (C terminus) |
Absent in the structure |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1298 |
|
AQP5 |
rs879362168 |
NP_001642.1 - 264 (C terminus) |
Absent in the structure |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 1299 |
|
AQP5 |
rs150292051 |
NP_001642.1 - 265 (C terminus) |
Absent in the structure |
Arg (Charged) -> His (Charged) |
- |
| 1300 |
|
AQP5 |
rs150292051 |
NP_001642.1 - 265 (C terminus) |
Absent in the structure |
Arg (Charged) -> Leu (Aliphatic hydrophobic) |
- |
| 1301 |
|
AQP5 |
rs747236328 |
NP_001642.1 - 265 (C terminus) |
Absent in the structure |
Arg (Charged) -> Gly (Small and Weakly Polar) |
- |
| 1302 |
|
AQP5 |
rs747236328 |
NP_001642.1 - 265 (C terminus) |
Absent in the structure |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 1303 |
|
AQP6 |
rs199824424 |
NP_001643.2 - 1 (N terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1304 |
|
AQP6 |
rs780751367 |
NP_001643.2 - 1 (N terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1305 |
|
AQP6 |
rs1282454403 |
NP_001643.2 - 2 (N terminus) |
Absent in the structure |
Asp (Charged) -> Val (Aliphatic hydrophobic) |
- |
| 1306 |
|
AQP6 |
rs35413161 |
NP_001643.2 - 3 (N terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1307 |
|
AQP6 |
rs35413161 |
NP_001643.2 - 3 (N terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1308 |
|
AQP6 |
rs1229958334 |
NP_001643.2 - 4 (N terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1309 |
|
AQP6 |
rs761169565 |
NP_001643.2 - 6 (N terminus) |
Absent in the structure |
Pro (Proline) -> Thr (Small and Weakly Polar) |
- |
| 1310 |
|
AQP6 |
rs761169565 |
NP_001643.2 - 6 (N terminus) |
Absent in the structure |
Pro (Proline) -> Ala (Small and Weakly Polar) |
- |
| 1311 |
|
AQP6 |
rs761169565 |
NP_001643.2 - 6 (N terminus) |
Absent in the structure |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 1312 |
|
AQP6 |
rs142918049 |
NP_001643.2 - 8 (N terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1313 |
|
AQP6 |
rs150677602 |
NP_001643.2 - 9 (N terminus) |
Absent in the structure |
Arg (Charged) -> His (Charged) |
- |
| 1314 |
|
AQP6 |
rs761162542 |
NP_001643.2 - 9 (N terminus) |
Absent in the structure |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 1315 |
|
AQP6 |
rs149436032 |
NP_001643.2 - 10 (N terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1316 |
|
AQP6 |
rs961571139 |
NP_001643.2 - 10 (N terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 1317 |
|
AQP6 |
rs961571139 |
NP_001643.2 - 10 (N terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 1318 |
|
AQP6 |
rs139772677 |
NP_001643.2 - 11 (N terminus) |
Absent in the structure |
Trp (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 1319 |
|
AQP6 |
rs149806227 |
NP_001643.2 - 12 (N terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1320 |
|
AQP6 |
rs144813201 |
NP_001643.2 - 14 (N terminus) |
N terminal domain |
Met (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 1321 |
|
AQP6 |
rs759516234 |
NP_001643.2 - 16 (N terminus) |
N terminal domain |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1322 |
|
AQP6 |
rs1179261074 |
NP_001643.2 - 16 (N terminus) |
N terminal domain |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1323 |
|
AQP6 |
rs570185132 |
NP_001643.2 - 22 (TM1) |
Exposed to cytoplasm |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1324 |
|
AQP6 |
rs554173591 |
NP_001643.2 - 23 (TM1) |
Helix - helix interface (TM1 - TM3) |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1325 |
|
AQP6 |
rs35872290 |
NP_001643.2 - 24 (TM1) |
Lipid facing |
Ser (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 1326 |
|
AQP6 |
rs1363586681 |
NP_001643.2 - 24 (TM1) |
Lipid facing |
Ser (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 1327 |
|
AQP6 |
rs756585868 |
NP_001643.2 - 27 (TM1) |
Helix - helix interface (TM1 - TM3) |
Leu (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 1328 |
|
AQP6 |
rs950526862 |
NP_001643.2 - 28 (TM1) |
Monomer - monomer interface |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 1329 |
|
AQP6 |
rs780461912 |
NP_001643.2 - 31 (TM1) |
Helix - helix interface (TM1 - TM3); Lipid facing |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 1330 |
|
AQP6 |
rs369326240 |
NP_001643.2 - 32 (TM1) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1331 |
|
AQP6 |
rs779223765 |
NP_001643.2 - 32 (TM1) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 1332 |
|
AQP6 |
rs147630546 |
NP_001643.2 - 34 (TM1) |
Helix - helix interface (TM1 - TM3) |
Thr (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1333 |
|
AQP6 |
rs1207145859 |
NP_001643.2 - 34 (TM1) |
Helix - helix interface (TM1 - TM3) |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 1334 |
|
AQP6 |
rs1339945212 |
NP_001643.2 - 35 (TM1) |
Helix - helix interface (TM1 - TM3) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1335 |
|
AQP6 |
rs770782793 |
NP_001643.2 - 36 (TM1) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 1336 |
|
AQP6 |
rs759196030 |
NP_001643.2 - 38 (TM1) |
Helix - helix interface (TM1 - TM3) |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1337 |
|
AQP6 |
rs765249088 |
NP_001643.2 - 39 (TM1) |
Helix - helix interface (TM1 - TM3);Monomer - monomer interface |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 1338 |
|
AQP6 |
rs1184986603 |
NP_001643.2 - 41 (TM1) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1339 |
|
AQP6 |
rs373075912 |
NP_001643.2 - 42 (TM1) |
Helix - helix interface (TM1 - TM3, TM1 - LE) |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1340 |
|
AQP6 |
rs373075912 |
NP_001643.2 - 42 (TM1) |
Helix - helix interface (TM1 - TM3, TM1 - LE) |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1341 |
|
AQP6 |
rs750740886 |
NP_001643.2 - 42 (TM1) |
Helix - helix interface (TM1 - TM3, TM1 - LE) |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 1342 |
|
AQP6 |
rs138957590 |
NP_001643.2 - 46 (TM1) |
Exposed to the extracellular environment |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1343 |
|
AQP6 |
rs377408973 |
NP_001643.2 - 46 (TM1) |
Exposed to the extracellular environment |
Met (Aliphatic hydrophobic) -> Lys (Charged) |
- |
| 1344 |
|
AQP6 |
rs377408973 |
NP_001643.2 - 46 (TM1) |
Exposed to the extracellular environment |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1345 |
|
AQP6 |
rs151202401 |
NP_001643.2 - 47 (TM1) |
Exposed to the extracellular environment |
Arg (Charged) -> His (Charged) |
- |
| 1346 |
|
AQP6 |
rs151202401 |
NP_001643.2 - 47 (TM1) |
Exposed to the extracellular environment |
Arg (Charged) -> Pro (Proline) |
- |
| 1347 |
|
AQP6 |
rs200724517 |
NP_001643.2 - 47 (TM1) |
Exposed to the extracellular environment |
Arg (Charged) -> Gly (Small and Weakly Polar) |
- |
| 1348 |
|
AQP6 |
rs200724517 |
NP_001643.2 - 47 (TM1) |
Exposed to the extracellular environment |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 1349 |
|
AQP6 |
rs897309973 |
NP_001643.2 - 49 (TM1) |
Exposed to the extracellular environment |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 1350 |
|
AQP6 |
rs1348620940 |
NP_001643.2 - 49 (TM1) |
Exposed to the extracellular environment |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 1351 |
|
AQP6 |
rs201467517 |
NP_001643.2 - 51 (Loop region after TM1) |
Loop A |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1352 |
|
AQP6 |
rs1216807502 |
NP_001643.2 - 53 (Loop region after TM1) |
Loop A |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 1353 |
|
AQP6 |
rs1274200010 |
NP_001643.2 - 54 (Loop region after TM1) |
Loop A |
Ser (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1354 |
|
AQP6 |
rs369863737 |
NP_001643.2 - 55 (TM2) |
Helix - helix interface (TM2 - TM5) |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1355 |
|
AQP6 |
rs775735800 |
NP_001643.2 - 57 (TM2) |
Monomer - monomer interface |
Gln (Neutral polar) -> His (Charged) |
- |
| 1356 |
|
AQP6 |
rs776104415 |
NP_001643.2 - 58 (TM2) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Ile (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1357 |
|
AQP6 |
rs1468777152 |
NP_001643.2 - 58 (TM2) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1358 |
|
AQP6 |
rs1183142191 |
NP_001643.2 - 59 (TM2) |
Helix - helix interface (TM2 - TM5) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1359 |
|
AQP6 |
rs769450395 |
NP_001643.2 - 60 (TM2) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1360 |
|
AQP6 |
rs775533716 |
NP_001643.2 - 61 (TM2) |
Helix - helix interface (TM2 - TM1);Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 1361 |
|
AQP6 |
rs767762926 |
NP_001643.2 - 64 (TM2) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1362 |
|
AQP6 |
rs1408010282 |
NP_001643.2 - 66 (TM2) |
Channel facing |
Thr (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1363 |
|
AQP6 |
rs1408010282 |
NP_001643.2 - 66 (TM2) |
Channel facing |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 1364 |
|
AQP6 |
rs766657221 |
NP_001643.2 - 67 (TM2) |
Helix - helix interface (TM2 - TM5) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1365 |
|
AQP6 |
rs753959722 |
NP_001643.2 - 69 (TM2) |
Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1366 |
|
AQP6 |
rs1327643616 |
NP_001643.2 - 70 (TM2) |
Channel facing;Helix - helix interface (TM2 - TM5) |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 1367 |
|
AQP6 |
rs1334176993 |
NP_001643.2 - 70 (TM2) |
Channel facing;Helix - helix interface (TM2 - TM5) |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1368 |
|
AQP6 |
rs1555167004 |
NP_001643.2 - 71 (TM2) |
Monomer - monomer interface |
Gln (Neutral polar) -> Pro (Proline) |
- |
| 1369 |
|
AQP6 |
rs1425956477 |
NP_001643.2 - 72 (TM2) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 1370 |
|
AQP6 |
rs755419694 |
NP_001643.2 - 73 (TM2) |
Helix - helix interface (TM1 - TM2);Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Asn (Neutral polar) |
- |
| 1371 |
|
AQP6 |
rs755419694 |
NP_001643.2 - 73 (TM2) |
Helix - helix interface (TM1 - TM2);Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 1372 |
|
AQP6 |
rs994470947 |
NP_001643.2 - 74 (TM2) |
Channel facing |
Trp (Aromatic) -> Arg (Charged) |
- |
| 1373 |
|
AQP6 |
rs140178530 |
NP_001643.2 - 76 (TM2) |
Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1374 |
|
AQP6 |
rs140178530 |
NP_001643.2 - 76 (TM2) |
Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1375 |
|
AQP6 |
rs150314044 |
NP_001643.2 - 76 (TM2) |
Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1376 |
|
AQP6 |
rs778196962 |
NP_001643.2 - 78 (Loop region after TM2) |
Loop B |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1377 |
|
AQP6 |
rs140752695 |
NP_001643.2 - 79 (Loop region after TM2) |
Loop B |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1378 |
|
AQP6 |
rs140752695 |
NP_001643.2 - 79 (Loop region after TM2) |
Loop B |
Ala (Small and Weakly Polar) -> Pro (Proline) |
- |
| 1379 |
|
AQP6 |
rs145050895 |
NP_001643.2 - 80 (Loop region after TM2) |
Loop B |
His (Charged) -> Gln (Neutral polar) |
- |
| 1380 |
|
AQP6 |
rs756669886 |
NP_001643.2 - 80 (Loop region after TM2) |
Loop B |
His (Charged) -> Pro (Proline) |
- |
| 1381 |
|
AQP6 |
rs116856189 |
NP_001643.2 - 81 (Loop region after TM2) |
Loop B |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1382 |
|
AQP6 |
rs116856189 |
NP_001643.2 - 81 (Loop region after TM2) |
Loop B |
Ala (Small and Weakly Polar) -> Pro (Proline) |
- |
| 1383 |
|
AQP6 |
rs202163475 |
NP_001643.2 - 82 (LB - NPA1) |
Channel facing;Helix - helix interface (LB - LE, LB - TM3) |
Asn (Neutral polar) -> Thr (Small and Weakly Polar) |
- |
| 1384 |
|
AQP6 |
rs144408327 |
NP_001643.2 - 84 (LB - NPA1) |
Helix - helix interface (LB - TM4, LB - LE, LB - TM6) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1385 |
|
AQP6 |
rs1173853768 |
NP_001643.2 - 84 (LB - NPA1) |
Helix - helix interface (LB - TM4, LB - LE, LB - TM6) |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 1386 |
|
AQP6 |
rs542164923 |
NP_001643.2 - 85 (LB) |
Channel facing |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1387 |
|
AQP6 |
rs542164923 |
NP_001643.2 - 85 (LB) |
Channel facing |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1388 |
|
AQP6 |
rs200570924 |
NP_001643.2 - 86 (LB) |
Helix - helix interface (LB - TM3) |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 1389 |
|
AQP6 |
rs143331466 |
NP_001643.2 - 88 (LB) |
Helix - helix interface (LB - TM4, LB - TM6) |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 1390 |
|
AQP6 |
rs143331466 |
NP_001643.2 - 88 (LB) |
Helix - helix interface (LB - TM4, LB - TM6) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1391 |
|
AQP6 |
rs1353027750 |
NP_001643.2 - 90 (LB) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 1392 |
|
AQP6 |
rs764605030 |
NP_001643.2 - 91 (Loop region after LB) |
Loop B |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1393 |
|
AQP6 |
rs764605030 |
NP_001643.2 - 91 (Loop region after LB) |
Loop B |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1394 |
|
AQP6 |
rs943708924 |
NP_001643.2 - 92 (Loop region after LB) |
Loop B |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1395 |
|
AQP6 |
rs756828233 |
NP_001643.2 - 93 (Loop region after LB) |
Loop B |
Ser (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 1396 |
|
AQP6 |
rs1269460909 |
NP_001643.2 - 94 (Loop region after LB) |
Loop B |
His (Charged) -> Tyr (Aromatic) |
- |
| 1397 |
|
AQP6 |
rs1187355615 |
NP_001643.2 - 96 (Loop region after LB) |
Loop B |
Ser (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 1398 |
|
AQP6 |
rs148360286 |
NP_001643.2 - 98 (TM3) |
Lipid facing |
Pro (Proline) -> Ala (Small and Weakly Polar) |
- |
| 1399 |
|
AQP6 |
rs148360286 |
NP_001643.2 - 98 (TM3) |
Lipid facing |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 1400 |
|
AQP6 |
rs779784128 |
NP_001643.2 - 99 (TM3) |
Channel facing |
Arg (Charged) -> His (Charged) |
- |
| 1401 |
|
AQP6 |
rs1365188304 |
NP_001643.2 - 99 (TM3) |
Channel facing |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 1402 |
|
AQP6 |
rs1267433004 |
NP_001643.2 - 100 (TM3) |
Helix - helix interface (LB - TM3) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1403 |
|
AQP6 |
rs1485974811 |
NP_001643.2 - 100 (TM3) |
Helix - helix interface (LB - TM3) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1404 |
|
AQP6 |
rs749124996 |
NP_001643.2 - 103 (TM3) |
Helix - helix interface (TM1 - TM3, LB - TM3) |
Tyr (Aromatic) -> His (Charged) |
- |
| 1405 |
|
AQP6 |
rs1382116056 |
NP_001643.2 - 103 (TM3) |
Helix - helix interface (TM1 - TM3, LB - TM3) |
Tyr (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 1406 |
|
AQP6 |
rs768523216 |
NP_001643.2 - 105 (TM3) |
Lipid facing |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1407 |
|
AQP6 |
rs768523216 |
NP_001643.2 - 105 (TM3) |
Lipid facing |
Ala (Small and Weakly Polar) -> Pro (Proline) |
- |
| 1408 |
|
AQP6 |
rs1366668753 |
NP_001643.2 - 107 (TM3) |
Helix - helix interface (TM1 - TM3, LB - TM3, TM3 - LE) |
Gln (Neutral polar) -> Lys (Charged) |
- |
| 1409 |
|
AQP6 |
rs989418350 |
NP_001643.2 - 109 (TM3) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1410 |
|
AQP6 |
rs1299635384 |
NP_001643.2 - 109 (TM3) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 1411 |
|
AQP6 |
rs370418802 |
NP_001643.2 - 110 (TM3) |
Helix - helix interface (TM1 - TM3) |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 1412 |
|
AQP6 |
rs370418802 |
NP_001643.2 - 110 (TM3) |
Helix - helix interface (TM1 - TM3) |
Gly (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 1413 |
|
AQP6 |
rs1279076990 |
NP_001643.2 - 111 (TM3) |
Helix - helix interface (TM1 - TM3, TM3 - LE) |
Ala (Small and Weakly Polar) -> Pro (Proline) |
- |
| 1414 |
|
AQP6 |
rs1279076990 |
NP_001643.2 - 111 (TM3) |
Helix - helix interface (TM1 - TM3, TM3 - LE) |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1415 |
|
AQP6 |
rs748005233 |
NP_001643.2 - 112 (TM3) |
Lipid facing;Helix - helix interface (TM3 - LE) |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 1416 |
|
AQP6 |
rs771110605 |
NP_001643.2 - 112 (TM3) |
Lipid facing;Helix - helix interface (TM3 - LE) |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 1417 |
|
AQP6 |
rs1490146970 |
NP_001643.2 - 113 (TM3) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1418 |
|
AQP6 |
rs1490146970 |
NP_001643.2 - 113 (TM3) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1419 |
|
AQP6 |
rs1207912927 |
NP_001643.2 - 114 (TM3) |
Helix - helix interface (TM1 - TM3) |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 1420 |
|
AQP6 |
rs776563266 |
NP_001643.2 - 116 (TM3) |
Lipid facing |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1421 |
|
AQP6 |
rs1180611772 |
NP_001643.2 - 116 (TM3) |
Lipid facing |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 1422 |
|
AQP6 |
rs759606356 |
NP_001643.2 - 117 (TM3) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1423 |
|
AQP6 |
rs775653516 |
NP_001643.2 - 119 (TM3) |
Helix - helix interface (TM3 - LE) |
Tyr (Aromatic) -> His (Charged) |
- |
| 1424 |
|
AQP6 |
rs1386474455 |
NP_001643.2 - 121 (TM3) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1425 |
|
AQP6 |
rs763354703 |
NP_001643.2 - 122 (Loop region after TM3) |
Loop C |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1426 |
|
AQP6 |
rs764408991 |
NP_001643.2 - 123 (Loop region after TM3) |
Loop C |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 1427 |
|
AQP6 |
rs912061785 |
NP_001643.2 - 124 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 1428 |
|
AQP6 |
rs1328459523 |
NP_001643.2 - 124 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1429 |
|
AQP6 |
rs762210162 |
NP_001643.2 - 125 (Loop region after TM3) |
Loop C |
Asp (Charged) -> Asn (Neutral polar) |
- |
| 1430 |
|
AQP6 |
rs1248271173 |
NP_001643.2 - 126 (Loop region after TM3) |
Loop C |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1431 |
|
AQP6 |
rs139985595 |
NP_001643.2 - 127 (Loop region after TM3) |
Loop C |
Arg (Charged) -> Gly (Small and Weakly Polar) |
- |
| 1432 |
|
AQP6 |
rs1039226530 |
NP_001643.2 - 127 (Loop region after TM3) |
Loop C |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 1433 |
|
AQP6 |
rs1166966774 |
NP_001643.2 - 128 (Loop region after TM3) |
Loop C |
Glu (Charged) -> Gln (Neutral polar) |
- |
| 1434 |
|
AQP6 |
rs374093263 |
NP_001643.2 - 133 (Loop region after TM3) |
Loop C |
Asn (Neutral polar) -> Lys (Charged) |
- |
| 1435 |
|
AQP6 |
rs140661599 |
NP_001643.2 - 134 (Loop region after TM3) |
Loop C |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1436 |
|
AQP6 |
rs144604786 |
NP_001643.2 - 136 (Loop region after TM3) |
Loop C |
Arg (Charged) -> Trp (Aromatic) |
- |
| 1437 |
|
AQP6 |
rs780089765 |
NP_001643.2 - 136 (Loop region after TM3) |
Loop C |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 1438 |
|
AQP6 |
rs780089765 |
NP_001643.2 - 136 (Loop region after TM3) |
Loop C |
Arg (Charged) -> Pro (Proline) |
- |
| 1439 |
|
AQP6 |
rs943933751 |
NP_001643.2 - 139 (Loop region after TM3) |
Loop C |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1440 |
|
AQP6 |
rs138476618 |
NP_001643.2 - 144 (TM4) |
Helix - helix interface (TM4 - TM5) |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 1441 |
|
AQP6 |
rs138476618 |
NP_001643.2 - 144 (TM4) |
Helix - helix interface (TM4 - TM5) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1442 |
|
AQP6 |
rs1296287089 |
NP_001643.2 - 145 (TM4) |
Lipid facing;Helix - helix interface (TM4 - TM6) |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1443 |
|
AQP6 |
rs889154259 |
NP_001643.2 - 146 (TM4) |
Lipid facing |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1444 |
|
AQP6 |
rs1255337805 |
NP_001643.2 - 147 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1445 |
|
AQP6 |
rs1426973426 |
NP_001643.2 - 148 (TM4) |
Helix - helix interface (TM4 - TM5, TM4 - TM6) |
Glu (Charged) -> Asp (Charged) |
- |
| 1446 |
|
AQP6 |
rs1405332446 |
NP_001643.2 - 150 (TM4) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 1447 |
|
AQP6 |
rs761260090 |
NP_001643.2 - 155 (TM4) |
Channel facing;Helix - helix interface (LB - TM4, TM4 - TM5) |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 1448 |
|
AQP6 |
rs766046804 |
NP_001643.2 - 160 (TM4) |
Helix - helix interface (LB - TM4, TM4 - TM6) |
Phe (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 1449 |
|
AQP6 |
rs996142985 |
NP_001643.2 - 161 (TM4) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1450 |
|
AQP6 |
rs80104550 |
NP_001643.2 - 162 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Ser (Small and Weakly Polar) -> Pro (Proline) |
- |
| 1451 |
|
AQP6 |
rs1260998687 |
NP_001643.2 - 163 (TM4) |
Channel facing |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 1452 |
|
AQP6 |
rs764831146 |
NP_001643.2 - 164 (TM4) |
Channel facing |
Asp (Charged) -> Asn (Neutral polar) |
- |
| 1453 |
|
AQP6 |
rs1049092728 |
NP_001643.2 - 164 (TM4) |
Channel facing |
Asp (Charged) -> Gly (Small and Weakly Polar) |
- |
| 1454 |
|
AQP6 |
rs752349131 |
NP_001643.2 - 165 (Loop region after TM4) |
Loop D |
Ser (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1455 |
|
AQP6 |
rs752349131 |
NP_001643.2 - 165 (Loop region after TM4) |
Loop D |
Ser (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 1456 |
|
AQP6 |
rs114066000 |
NP_001643.2 - 166 (Loop region after TM4) |
Loop D |
Arg (Charged) -> Gly (Small and Weakly Polar) |
- |
| 1457 |
|
AQP6 |
rs114066000 |
NP_001643.2 - 166 (Loop region after TM4) |
Loop D |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 1458 |
|
AQP6 |
rs201943822 |
NP_001643.2 - 166 (Loop region after TM4) |
Loop D |
Arg (Charged) -> His (Charged) |
- |
| 1459 |
|
AQP6 |
rs201943822 |
NP_001643.2 - 166 (Loop region after TM4) |
Loop D |
Arg (Charged) -> Leu (Aliphatic hydrophobic) |
- |
| 1460 |
|
AQP6 |
rs757197615 |
NP_001643.2 - 168 (Loop region after TM4) |
Loop D |
Thr (Small and Weakly Polar) -> Lys (Charged) |
- |
| 1461 |
|
AQP6 |
rs146781368 |
NP_001643.2 - 170 (Loop region after TM4) |
Loop D |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1462 |
|
AQP6 |
rs753948412 |
NP_001643.2 - 171 (Loop region after TM4) |
Loop D |
Ser (Small and Weakly Polar) -> Tyr (Aromatic) |
- |
| 1463 |
|
AQP6 |
rs755001261 |
NP_001643.2 - 172 (TM5) |
Helix - helix interface (TM4 - TM5) |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 1464 |
|
AQP6 |
rs1347872600 |
NP_001643.2 - 172 (TM5) |
Helix - helix interface (TM4 - TM5) |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 1465 |
|
AQP6 |
rs1298418309 |
NP_001643.2 - 173 (TM5) |
Helix - helix interface (TM2 - TM5) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1466 |
|
AQP6 |
rs141412916 |
NP_001643.2 - 174 (TM5) |
Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 1467 |
|
AQP6 |
rs549230039 |
NP_001643.2 - 175 (TM5) |
Monomer - monomer interface |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1468 |
|
AQP6 |
rs1302604596 |
NP_001643.2 - 175 (TM5) |
Monomer - monomer interface |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1469 |
|
AQP6 |
rs772385525 |
NP_001643.2 - 176 (TM5) |
Channel facing |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1470 |
|
AQP6 |
rs778189444 |
NP_001643.2 - 180 (TM5) |
Channel facing |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1471 |
|
AQP6 |
rs747321183 |
NP_001643.2 - 185 (TM5) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 1472 |
|
AQP6 |
rs747321183 |
NP_001643.2 - 185 (TM5) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 1473 |
|
AQP6 |
rs1229359116 |
NP_001643.2 - 185 (TM5) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 1474 |
|
AQP6 |
rs565761341 |
NP_001643.2 - 186 (TM5) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1475 |
|
AQP6 |
rs148811050 |
NP_001643.2 - 192 (Loop region after TM5) |
Loop E |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 1476 |
|
AQP6 |
rs148811050 |
NP_001643.2 - 192 (Loop region after TM5) |
Loop E |
Gly (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 1477 |
|
AQP6 |
rs752350341 |
NP_001643.2 - 192 (Loop region after TM5) |
Loop E |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1478 |
|
AQP6 |
rs760648119 |
NP_001643.2 - 193 (Loop region after TM5 - Ar/R Selectivity filter) |
Loop E |
Cys (Small and Weakly Polar) -> Trp (Aromatic) |
- |
| 1479 |
|
AQP6 |
rs77450760 |
NP_001643.2 - 195 (Loop region after TM5) |
Loop E |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1480 |
|
AQP6 |
rs766171829 |
NP_001643.2 - 195 (Loop region after TM5) |
Loop E |
Met (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1481 |
|
AQP6 |
rs766171829 |
NP_001643.2 - 195 (Loop region after TM5) |
Loop E |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1482 |
|
AQP6 |
rs751812963 |
NP_001643.2 - 199 (LE - Ar/R Selectivity filter) |
Channel facing |
Arg (Charged) -> His (Charged) |
- |
| 1483 |
|
AQP6 |
rs764436074 |
NP_001643.2 - 199 (LE - Ar/R Selectivity filter) |
Channel facing |
Arg (Charged) -> Ser (Small and Weakly Polar) |
- |
| 1484 |
|
AQP6 |
rs764436074 |
NP_001643.2 - 199 (LE - Ar/R Selectivity filter) |
Channel facing |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 1485 |
|
AQP6 |
rs757739948 |
NP_001643.2 - 200 (LE) |
Helix - helix interface (LE - TM6) |
Ser (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1486 |
|
AQP6 |
rs781677564 |
NP_001643.2 - 200 (LE) |
Helix - helix interface (LE - TM6) |
Ser (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 1487 |
|
AQP6 |
rs534559791 |
NP_001643.2 - 202 (LE) |
Helix - helix interface (TM3 - LE) |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1488 |
|
AQP6 |
rs780382050 |
NP_001643.2 - 205 (LE) |
Lipid facing |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1489 |
|
AQP6 |
rs748850847 |
NP_001643.2 - 207 (LE) |
Exposed to the extracellular environment |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1490 |
|
AQP6 |
rs768027849 |
NP_001643.2 - 208 (Loop region after LE) |
Loop E |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1491 |
|
AQP6 |
rs1201227114 |
NP_001643.2 - 209 (Loop region after LE) |
Loop E |
Lys (Charged) -> Arg (Charged) |
- |
| 1492 |
|
AQP6 |
rs771913203 |
NP_001643.2 - 212 (Loop region after LE) |
Loop E |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 1493 |
|
AQP6 |
rs773004608 |
NP_001643.2 - 213 (TM6) |
Lipid facing |
His (Charged) -> Arg (Charged) |
- |
| 1494 |
|
AQP6 |
rs760322147 |
NP_001643.2 - 214 (TM6) |
Lipid facing |
Trp (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 1495 |
|
AQP6 |
rs949800801 |
NP_001643.2 - 215 (TM6) |
Helix - helix interface (TM4 - TM6) |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1496 |
|
AQP6 |
rs949800801 |
NP_001643.2 - 215 (TM6) |
Helix - helix interface (TM4 - TM6) |
Val (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 1497 |
|
AQP6 |
rs1423132212 |
NP_001643.2 - 215 (TM6) |
Helix - helix interface (TM4 - TM6) |
Val (Aliphatic hydrophobic) -> Asp (Charged) |
- |
| 1498 |
|
AQP6 |
rs1337687287 |
NP_001643.2 - 217 (TM6) |
Lipid facing |
Trp (Aromatic) -> Arg (Charged) |
- |
| 1499 |
|
AQP6 |
rs1431604862 |
NP_001643.2 - 218 (TM6) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 1500 |
|
AQP6 |
rs1308608856 |
NP_001643.2 - 219 (TM6) |
Helix - helix interface (TM4 - TM6) |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 1501 |
|
AQP6 |
rs1447697732 |
NP_001643.2 - 219 (TM6) |
Helix - helix interface (TM4 - TM6) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1502 |
|
AQP6 |
rs1351482410 |
NP_001643.2 - 220 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6, LE - TM6) |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 1503 |
|
AQP6 |
rs1355409001 |
NP_001643.2 - 223 (TM6) |
Helix - helix interface (TM4 - TM6) |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 1504 |
|
AQP6 |
rs746845642 |
NP_001643.2 - 224 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6) |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1505 |
|
AQP6 |
rs1457933743 |
NP_001643.2 - 229 (TM6) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1506 |
|
AQP6 |
rs17124220 |
NP_001643.2 - 234 (C terminus) |
C terminal domain |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1507 |
|
AQP6 |
rs17124220 |
NP_001643.2 - 234 (C terminus) |
C terminal domain |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1508 |
|
AQP6 |
rs998897078 |
NP_001643.2 - 234 (C terminus) |
C terminal domain |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 1509 |
|
AQP6 |
rs1457721889 |
NP_001643.2 - 236 (C terminus) |
Absent in the structure |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 1510 |
|
AQP6 |
rs766648516 |
NP_001643.2 - 238 (C terminus) |
Absent in the structure |
Asp (Charged) -> Asn (Neutral polar) |
- |
| 1511 |
|
AQP6 |
rs1466317771 |
NP_001643.2 - 240 (C terminus) |
Absent in the structure |
Lys (Charged) -> Asn (Neutral polar) |
- |
| 1512 |
|
AQP6 |
rs952444032 |
NP_001643.2 - 242 (C terminus) |
Absent in the structure |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1513 |
|
AQP6 |
rs112783768 |
NP_001643.2 - 243 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Pro (Proline) |
- |
| 1514 |
|
AQP6 |
rs373331272 |
NP_001643.2 - 243 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1515 |
|
AQP6 |
rs139145931 |
NP_001643.2 - 245 (C terminus) |
Absent in the structure |
Arg (Charged) -> Trp (Aromatic) |
- |
| 1516 |
|
AQP6 |
rs757856161 |
NP_001643.2 - 245 (C terminus) |
Absent in the structure |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 1517 |
|
AQP6 |
rs149339956 |
NP_001643.2 - 247 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1518 |
|
AQP6 |
rs149339956 |
NP_001643.2 - 247 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1519 |
|
AQP6 |
rs1195229265 |
NP_001643.2 - 248 (C terminus) |
Absent in the structure |
Ile (Aliphatic hydrophobic) -> Ser (Small and Weakly Polar) |
- |
| 1520 |
|
AQP6 |
rs1197591844 |
NP_001643.2 - 250 (C terminus) |
Absent in the structure |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 1521 |
|
AQP6 |
rs770828964 |
NP_001643.2 - 251 (C terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 1522 |
|
AQP6 |
rs769879813 |
NP_001643.2 - 253 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1523 |
|
AQP6 |
rs199975780 |
NP_001643.2 - 254 (C terminus) |
Absent in the structure |
Glu (Charged) -> Val (Aliphatic hydrophobic) |
- |
| 1524 |
|
AQP6 |
rs555724572 |
NP_001643.2 - 257 (C terminus) |
Absent in the structure |
Thr (Small and Weakly Polar) -> Lys (Charged) |
- |
| 1525 |
|
AQP6 |
rs566077374 |
NP_001643.2 - 259 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1526 |
|
AQP6 |
rs144701154 |
NP_001643.2 - 260 (C terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1527 |
|
AQP6 |
rs144701154 |
NP_001643.2 - 260 (C terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1528 |
|
AQP6 |
rs144701154 |
NP_001643.2 - 260 (C terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Trp (Aromatic) |
- |
| 1529 |
|
AQP6 |
rs1303497781 |
NP_001643.2 - 260 (C terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 1530 |
|
AQP6 |
rs1340500836 |
NP_001643.2 - 261 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 1531 |
|
AQP6 |
rs766565532 |
NP_001643.2 - 263 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 1532 |
|
AQP6 |
rs766565532 |
NP_001643.2 - 263 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1533 |
|
AQP6 |
rs765757557 |
NP_001643.2 - 264 (C terminus) |
Absent in the structure |
Glu (Charged) -> Gly (Small and Weakly Polar) |
- |
| 1534 |
|
AQP6 |
rs991454896 |
NP_001643.2 - 264 (C terminus) |
Absent in the structure |
Glu (Charged) -> Lys (Charged) |
- |
| 1535 |
|
AQP6 |
rs753183355 |
NP_001643.2 - 265 (C terminus) |
Absent in the structure |
Pro (Proline) -> Ala (Small and Weakly Polar) |
- |
| 1536 |
|
AQP6 |
rs753183355 |
NP_001643.2 - 265 (C terminus) |
Absent in the structure |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 1537 |
|
AQP6 |
rs1217723890 |
NP_001643.2 - 265 (C terminus) |
Absent in the structure |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 1538 |
|
AQP6 |
rs1210278814 |
NP_001643.2 - 271 (C terminus) |
Absent in the structure |
Gln (Neutral polar) -> Leu (Aliphatic hydrophobic) |
- |
| 1539 |
|
AQP6 |
rs142788752 |
NP_001643.2 - 272 (C terminus) |
Absent in the structure |
Pro (Proline) -> Arg (Charged) |
- |
| 1540 |
|
AQP6 |
rs142788752 |
NP_001643.2 - 272 (C terminus) |
Absent in the structure |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 1541 |
|
AQP6 |
rs745677036 |
NP_001643.2 - 273 (C terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1542 |
|
AQP6 |
rs760593320 |
NP_001643.2 - 274 (C terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Leu (Aliphatic hydrophobic) |
- |
| 1543 |
|
AQP6 |
rs749232622 |
NP_001643.2 - 277 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1544 |
|
AQP6 |
rs772251291 |
NP_001643.2 - 277 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 1545 |
|
AQP6 |
rs773177473 |
NP_001643.2 - 279 (C terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1546 |
|
AQP6 |
rs1464578427 |
NP_001643.2 - 281 (C terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 1547 |
|
AQP7 |
rs1176553780 |
NP_001161.1 - 1 (N terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1548 |
|
AQP7 |
rs1458881244 |
NP_001161.1 - 2 (N terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 1549 |
|
AQP7 |
rs143956595 |
NP_001161.1 - 4 (N terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1550 |
|
AQP7 |
rs763009579 |
NP_001161.1 - 5 (N terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 1551 |
|
AQP7 |
rs148119598 |
NP_001161.1 - 6 (N terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1552 |
|
AQP7 |
rs374964943 |
NP_001161.1 - 7 (N terminus) |
Absent in the structure |
His (Charged) -> Gln (Neutral polar) |
- |
| 1553 |
|
AQP7 |
rs959914653 |
NP_001161.1 - 7 (N terminus) |
Absent in the structure |
His (Charged) -> Asn (Neutral polar) |
- |
| 1554 |
|
AQP7 |
rs143724569 |
NP_001161.1 - 9 (N terminus) |
Absent in the structure |
Arg (Charged) -> Trp (Aromatic) |
- |
| 1555 |
|
AQP7 |
rs776777658 |
NP_001161.1 - 9 (N terminus) |
Absent in the structure |
Arg (Charged) -> Pro (Proline) |
- |
| 1556 |
|
AQP7 |
rs776777658 |
NP_001161.1 - 9 (N terminus) |
Absent in the structure |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 1557 |
|
AQP7 |
rs1308054467 |
NP_001161.1 - 11 (N terminus) |
Absent in the structure |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 1558 |
|
AQP7 |
rs139297434 |
NP_001161.1 - 12 (N terminus) |
Absent in the structure |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 1559 |
|
AQP7 |
rs777690481 |
NP_001161.1 - 12 (N terminus) |
Absent in the structure |
Arg (Charged) -> His (Charged) |
- |
| 1560 |
|
AQP7 |
rs758186124 |
NP_001161.1 - 15 (N terminus) |
Absent in the structure |
Lys (Charged) -> Glu (Charged) |
- |
| 1561 |
|
AQP7 |
rs201166466 |
NP_001161.1 - 16 (N terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1562 |
|
AQP7 |
rs752676074 |
NP_001161.1 - 16 (N terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1563 |
|
AQP7 |
rs1421013136 |
NP_001161.1 - 16 (N terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1564 |
|
AQP7 |
rs185204201 |
NP_001161.1 - 19 (N terminus) |
Absent in the structure |
Trp (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 1565 |
|
AQP7 |
rs1477831537 |
NP_001161.1 - 19 (N terminus) |
Absent in the structure |
Trp (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 1566 |
|
AQP7 |
rs766484596 |
NP_001161.1 - 21 (N terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1567 |
|
AQP7 |
rs1450363188 |
NP_001161.1 - 21 (N terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 1568 |
|
AQP7 |
rs760862357 |
NP_001161.1 - 22 (N terminus) |
Absent in the structure |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1569 |
|
AQP7 |
rs1206150599 |
NP_001161.1 - 22 (N terminus) |
Absent in the structure |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1570 |
|
AQP7 |
rs1317523871 |
NP_001161.1 - 22 (N terminus) |
Absent in the structure |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1571 |
|
AQP7 |
rs750700265 |
NP_001161.1 - 25 (N terminus) |
Absent in the structure |
Ile (Aliphatic hydrophobic) -> Asn (Neutral polar) |
- |
| 1572 |
|
AQP7 |
rs767860854 |
NP_001161.1 - 26 (N terminus) |
Absent in the structure |
Gln (Neutral polar) -> His (Charged) |
- |
| 1573 |
|
AQP7 |
rs145775825 |
NP_001161.1 - 27 (N terminus) |
Absent in the structure |
Glu (Charged) -> Lys (Charged) |
- |
| 1574 |
|
AQP7 |
rs1232662359 |
NP_001161.1 - 27 (N terminus) |
Absent in the structure |
Glu (Charged) -> Asp (Charged) |
- |
| 1575 |
|
AQP7 |
rs774787164 |
NP_001161.1 - 28 (N terminus) |
Absent in the structure |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1576 |
|
AQP7 |
rs1341168484 |
NP_001161.1 - 28 (N terminus) |
Absent in the structure |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1577 |
|
AQP7 |
rs2381005 |
NP_001161.1 - 29 (N terminus) |
Absent in the structure |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1578 |
|
AQP7 |
rs2381005 |
NP_001161.1 - 29 (N terminus) |
Absent in the structure |
Leu (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1579 |
|
AQP7 |
rs192851993 |
NP_001161.1 - 29 (N terminus) |
Absent in the structure |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 1580 |
|
AQP7 |
rs776252656 |
NP_001161.1 - 31 (N terminus) |
Absent in the structure |
Arg (Charged) -> Ser (Small and Weakly Polar) |
- |
| 1581 |
|
AQP7 |
rs2381004 |
NP_001161.1 - 34 (TM1) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 1582 |
|
AQP7 |
rs2381004 |
NP_001161.1 - 34 (TM1) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Glu (Charged) |
- |
| 1583 |
|
AQP7 |
rs543495409 |
NP_001161.1 - 34 (TM1) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1584 |
|
AQP7 |
rs747841241 |
NP_001161.1 - 35 (TM1) |
Monomer - monomer interface |
Arg (Charged) -> Gly (Small and Weakly Polar) |
- |
| 1585 |
|
AQP7 |
rs763689078 |
NP_001161.1 - 35 (TM1) |
Monomer - monomer interface |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 1586 |
|
AQP7 |
rs1170273419 |
NP_001161.1 - 37 (TM1) |
Helix - helix interface (TM1 - TM3) |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 1587 |
|
AQP7 |
rs2381003 |
NP_001161.1 - 38 (TM1) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1588 |
|
AQP7 |
rs2381003 |
NP_001161.1 - 38 (TM1) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1589 |
|
AQP7 |
rs780091659 |
NP_001161.1 - 38 (TM1) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 1590 |
|
AQP7 |
rs1457558837 |
NP_001161.1 - 39 (TM1) |
Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1591 |
|
AQP7 |
rs2381002 |
NP_001161.1 - 40 (TM1) |
Helix - helix interface (TM1 - TM2, TM1 - TM3) |
Glu (Charged) -> Lys (Charged) |
- |
| 1592 |
|
AQP7 |
rs558128835 |
NP_001161.1 - 42 (TM1) |
Monomer - monomer interface |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1593 |
|
AQP7 |
rs1278071704 |
NP_001161.1 - 42 (TM1) |
Monomer - monomer interface |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1594 |
|
AQP7 |
rs764563140 |
NP_001161.1 - 43 (TM1) |
Helix - helix interface (TM1 - TM2) |
Ser (Small and Weakly Polar) -> Asn (Neutral polar) |
- |
| 1595 |
|
AQP7 |
rs776199160 |
NP_001161.1 - 44 (TM1) |
Helix - helix interface (TM1 - TM3) |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 1596 |
|
AQP7 |
rs776199160 |
NP_001161.1 - 44 (TM1) |
Helix - helix interface (TM1 - TM3) |
Thr (Small and Weakly Polar) -> Pro (Proline) |
- |
| 1597 |
|
AQP7 |
rs1333082206 |
NP_001161.1 - 46 (TM1) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1598 |
|
AQP7 |
rs1447127817 |
NP_001161.1 - 47 (TM1) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1599 |
|
AQP7 |
rs1411612556 |
NP_001161.1 - 48 (TM1) |
Helix - helix interface (TM1 - TM3) |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1600 |
|
AQP7 |
rs768771734 |
NP_001161.1 - 49 (TM1) |
Helix - helix interface (TM1 - TM3);Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1601 |
|
AQP7 |
rs575153087 |
NP_001161.1 - 51 (TM1) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Gly (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 1602 |
|
AQP7 |
rs575153087 |
NP_001161.1 - 51 (TM1) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1603 |
|
AQP7 |
rs756610430 |
NP_001161.1 - 51 (TM1) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1604 |
|
AQP7 |
rs1196769580 |
NP_001161.1 - 52 (TM1) |
Helix - helix interface (TM1 - TM3, TM1 - LE) |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1605 |
|
AQP7 |
rs1267813063 |
NP_001161.1 - 52 (TM1) |
Helix - helix interface (TM1 - TM3, TM1 - LE) |
Leu (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 1606 |
|
AQP7 |
rs750945114 |
NP_001161.1 - 53 (TM1) |
Helix - helix interface (TM1 - TM3);Monomer - monomer interface |
Gly (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 1607 |
|
AQP7 |
rs538923905 |
NP_001161.1 - 55 (TM1) |
Channel facing |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1608 |
|
AQP7 |
rs1263139303 |
NP_001161.1 - 56 (TM1) |
Exposed to the extracellular environment |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1609 |
|
AQP7 |
rs752210629 |
NP_001161.1 - 57 (TM1) |
Monomer - monomer interface |
His (Charged) -> Arg (Charged) |
- |
| 1610 |
|
AQP7 |
rs764813738 |
NP_001161.1 - 58 (TM1) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1611 |
|
AQP7 |
rs764813738 |
NP_001161.1 - 58 (TM1) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Met (Aliphatic hydrophobic) -> Lys (Charged) |
- |
| 1612 |
|
AQP7 |
rs4008659 |
NP_001161.1 - 59 (TM1) |
Exposed to the extracellular environment |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1613 |
|
AQP7 |
rs1209613166 |
NP_001161.1 - 59 (TM1) |
Exposed to the extracellular environment |
Val (Aliphatic hydrophobic) -> Gly (Small and Weakly Polar) |
- |
| 1614 |
|
AQP7 |
rs1209613166 |
NP_001161.1 - 59 (TM1) |
Exposed to the extracellular environment |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 1615 |
|
AQP7 |
rs753629469 |
NP_001161.1 - 62 (Loop region after TM1) |
Loop A |
Lys (Charged) -> Arg (Charged) |
- |
| 1616 |
|
AQP7 |
rs4008658 |
NP_001161.1 - 63 (Loop region after TM1) |
Loop A |
Lys (Charged) -> Thr (Small and Weakly Polar) |
- |
| 1617 |
|
AQP7 |
rs199711780 |
NP_001161.1 - 64 (Loop region after TM1) |
Loop A |
Tyr (Aromatic) -> Phe (Aromatic) |
- |
| 1618 |
|
AQP7 |
rs1276354660 |
NP_001161.1 - 64 (Loop region after TM1) |
Loop A |
Tyr (Aromatic) -> His (Charged) |
- |
| 1619 |
|
AQP7 |
rs368849644 |
NP_001161.1 - 65 (Loop region after TM1) |
Loop A |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1620 |
|
AQP7 |
rs1384802325 |
NP_001161.1 - 66 (TM2) |
Exposed to the extracellular environment |
Ser (Small and Weakly Polar) -> Asn (Neutral polar) |
- |
| 1621 |
|
AQP7 |
rs775905309 |
NP_001161.1 - 68 (TM2) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 1622 |
|
AQP7 |
rs746373896 |
NP_001161.1 - 71 (TM2) |
Helix - helix interface (TM2 - TM5) |
Asn (Neutral polar) -> Ile (Aliphatic hydrophobic) |
- |
| 1623 |
|
AQP7 |
rs746373896 |
NP_001161.1 - 71 (TM2) |
Helix - helix interface (TM2 - TM5) |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 1624 |
|
AQP7 |
rs781616926 |
NP_001161.1 - 71 (TM2) |
Helix - helix interface (TM2 - TM5) |
Asn (Neutral polar) -> Lys (Charged) |
- |
| 1625 |
|
AQP7 |
rs781616926 |
NP_001161.1 - 71 (TM2) |
Helix - helix interface (TM2 - TM5) |
Asn (Neutral polar) -> Lys (Charged) |
- |
| 1626 |
|
AQP7 |
rs757776208 |
NP_001161.1 - 72 (TM2) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Trp (Aromatic) |
- |
| 1627 |
|
AQP7 |
rs1198614474 |
NP_001161.1 - 73 (TM2) |
Helix - helix interface (TM2 - TM1);Monomer - monomer interface |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 1628 |
|
AQP7 |
rs1374071314 |
NP_001161.1 - 73 (TM2) |
Helix - helix interface (TM2 - TM1);Monomer - monomer interface |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1629 |
|
AQP7 |
rs140405277 |
NP_001161.1 - 75 (TM2) |
Helix - helix interface (TM2 - TM5) |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1630 |
|
AQP7 |
rs747608427 |
NP_001161.1 - 75 (TM2) |
Helix - helix interface (TM2 - TM5) |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1631 |
|
AQP7 |
rs146743129 |
NP_001161.1 - 76 (TM2) |
Monomer - monomer interface |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 1632 |
|
AQP7 |
rs536416831 |
NP_001161.1 - 76 (TM2) |
Monomer - monomer interface |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 1633 |
|
AQP7 |
rs766191156 |
NP_001161.1 - 77 (TM2) |
Monomer - monomer interface;Helix - helix interface (TM1 - TM2) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1634 |
|
AQP7 |
rs1354676296 |
NP_001161.1 - 77 (TM2) |
Monomer - monomer interface;Helix - helix interface (TM1 - TM2) |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1635 |
|
AQP7 |
rs1270218464 |
NP_001161.1 - 78 (TM2) |
Channel facing |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1636 |
|
AQP7 |
rs750256339 |
NP_001161.1 - 79 (TM2) |
Helix - helix interface (TM2 - TM5) |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 1637 |
|
AQP7 |
rs1215848555 |
NP_001161.1 - 79 (TM2) |
Helix - helix interface (TM2 - TM5) |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 1638 |
|
AQP7 |
rs761869327 |
NP_001161.1 - 80 (TM2) |
Monomer - monomer interface |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1639 |
|
AQP7 |
rs767509430 |
NP_001161.1 - 80 (TM2) |
Monomer - monomer interface |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1640 |
|
AQP7 |
rs774538753 |
NP_001161.1 - 81 (TM2) |
Helix - helix interface (TM1 - TM2) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1641 |
|
AQP7 |
rs763225810 |
NP_001161.1 - 82 (TM2) |
Channel facing;Helix - helix interface (TM2 - TM5) |
Val (Aliphatic hydrophobic) -> Gly (Small and Weakly Polar) |
- |
| 1642 |
|
AQP7 |
rs764126290 |
NP_001161.1 - 82 (TM2) |
Channel facing;Helix - helix interface (TM2 - TM5) |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1643 |
|
AQP7 |
rs375803801 |
NP_001161.1 - 83 (TM2) |
Monomer - monomer interface |
His (Charged) -> Gln (Neutral polar) |
- |
| 1644 |
|
AQP7 |
rs567492290 |
NP_001161.1 - 84 (TM2) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1645 |
|
AQP7 |
rs567492290 |
NP_001161.1 - 84 (TM2) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1646 |
|
AQP7 |
rs1182364775 |
NP_001161.1 - 84 (TM2) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Gly (Small and Weakly Polar) |
- |
| 1647 |
|
AQP7 |
rs747557155 |
NP_001161.1 - 85 (TM2) |
Helix - helix interface (TM1 - TM2);Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1648 |
|
AQP7 |
rs1397868274 |
NP_001161.1 - 85 (TM2) |
Helix - helix interface (TM1 - TM2);Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1649 |
|
AQP7 |
rs754511517 |
NP_001161.1 - 86 (TM2) |
Channel facing |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1650 |
|
AQP7 |
rs754511517 |
NP_001161.1 - 86 (TM2) |
Channel facing |
Gly (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 1651 |
|
AQP7 |
rs754511517 |
NP_001161.1 - 86 (TM2) |
Channel facing |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 1652 |
|
AQP7 |
rs143391243 |
NP_001161.1 - 87 (Loop region after TM2) |
Loop B |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 1653 |
|
AQP7 |
rs371783551 |
NP_001161.1 - 87 (Loop region after TM2) |
Loop B |
Arg (Charged) -> His (Charged) |
- |
| 1654 |
|
AQP7 |
rs569224546 |
NP_001161.1 - 88 (Loop region after TM2) |
Loop B |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1655 |
|
AQP7 |
rs767456180 |
NP_001161.1 - 88 (Loop region after TM2) |
Loop B |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1656 |
|
AQP7 |
rs767456180 |
NP_001161.1 - 88 (Loop region after TM2) |
Loop B |
Ile (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1657 |
|
AQP7 |
rs762878686 |
NP_001161.1 - 89 (Loop region after TM2) |
Loop B |
Ser (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 1658 |
|
AQP7 |
rs762878686 |
NP_001161.1 - 89 (Loop region after TM2) |
Loop B |
Ser (Small and Weakly Polar) -> Tyr (Aromatic) |
- |
| 1659 |
|
AQP7 |
rs1198707602 |
NP_001161.1 - 89 (Loop region after TM2) |
Loop B |
Ser (Small and Weakly Polar) -> Pro (Proline) |
- |
| 1660 |
|
AQP7 |
rs1349541243 |
NP_001161.1 - 90 (Loop region after TM2) |
Loop B |
Gly (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 1661 |
|
AQP7 |
rs767970054 |
NP_001161.1 - 92 (Loop region after TM2) |
Loop B |
His (Charged) -> Arg (Charged) |
- |
| 1662 |
|
AQP7 |
rs762210355 |
NP_001161.1 - 93 (Loop region after TM2) |
Loop B |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1663 |
|
AQP7 |
rs1243127641 |
NP_001161.1 - 93 (Loop region after TM2) |
Loop B |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1664 |
|
AQP7 |
rs374393354 |
NP_001161.1 - 95 (LB - NPA1 Deviation) |
Helix - helix interface (LB - LE, LB - TM3) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1665 |
|
AQP7 |
rs1238821337 |
NP_001161.1 - 96 (LB - NPA1) |
Helix - helix interface (LB - TM4, LB - LE, LB - TM6) |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 1666 |
|
AQP7 |
rs759061075 |
NP_001161.1 - 97 (LB) |
Channel facing |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1667 |
|
AQP7 |
rs770671678 |
NP_001161.1 - 98 (LB) |
Helix - helix interface (LB - TM3) |
Thr (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1668 |
|
AQP7 |
rs776307581 |
NP_001161.1 - 98 (LB) |
Helix - helix interface (LB - TM3) |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 1669 |
|
AQP7 |
rs941138025 |
NP_001161.1 - 99 (LB) |
Lipid facing |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 1670 |
|
AQP7 |
rs77962308 |
NP_001161.1 - 100 (LB) |
Helix - helix interface (LB - TM4, LB - TM6) |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1671 |
|
AQP7 |
rs77962308 |
NP_001161.1 - 100 (LB) |
Helix - helix interface (LB - TM4, LB - TM6) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1672 |
|
AQP7 |
rs1468629772 |
NP_001161.1 - 102 (LB) |
Helix - helix interface (LB - TM3); Lipid facing |
Cys (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1673 |
|
AQP7 |
rs1468629772 |
NP_001161.1 - 102 (LB) |
Helix - helix interface (LB - TM3); Lipid facing |
Cys (Small and Weakly Polar) -> Tyr (Aromatic) |
- |
| 1674 |
|
AQP7 |
rs140976103 |
NP_001161.1 - 103 (LB) |
Lipid facing |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1675 |
|
AQP7 |
rs1256940846 |
NP_001161.1 - 103 (LB) |
Lipid facing |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1676 |
|
AQP7 |
rs1298308230 |
NP_001161.1 - 105 (Loop region after LB) |
Loop B |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1677 |
|
AQP7 |
rs140411243 |
NP_001161.1 - 106 (Loop region after LB) |
Loop B |
Arg (Charged) -> His (Charged) |
- |
| 1678 |
|
AQP7 |
rs778763120 |
NP_001161.1 - 106 (Loop region after LB) |
Loop B |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 1679 |
|
AQP7 |
rs778763120 |
NP_001161.1 - 106 (Loop region after LB) |
Loop B |
Arg (Charged) -> Ser (Small and Weakly Polar) |
- |
| 1680 |
|
AQP7 |
rs142586635 |
NP_001161.1 - 107 (Loop region after LB) |
Loop B |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1681 |
|
AQP7 |
rs142586635 |
NP_001161.1 - 107 (Loop region after LB) |
Loop B |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1682 |
|
AQP7 |
rs1324502794 |
NP_001161.1 - 107 (Loop region after LB) |
Loop B |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 1683 |
|
AQP7 |
rs750711308 |
NP_001161.1 - 108 (Loop region after LB) |
Loop B |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 1684 |
|
AQP7 |
rs750711308 |
NP_001161.1 - 108 (Loop region after LB) |
Loop B |
Pro (Proline) -> Ala (Small and Weakly Polar) |
- |
| 1685 |
|
AQP7 |
rs1241930172 |
NP_001161.1 - 109 (Loop region after LB) |
Loop B |
Trp (Aromatic) -> Arg (Charged) |
- |
| 1686 |
|
AQP7 |
rs767765778 |
NP_001161.1 - 110 (TM3) |
Lipid facing |
Arg (Charged) -> Gly (Small and Weakly Polar) |
- |
| 1687 |
|
AQP7 |
rs373004742 |
NP_001161.1 - 113 (TM3) |
Lipid facing |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 1688 |
|
AQP7 |
rs373004742 |
NP_001161.1 - 113 (TM3) |
Lipid facing |
Pro (Proline) -> Arg (Charged) |
- |
| 1689 |
|
AQP7 |
rs74668961 |
NP_001161.1 - 115 (TM3) |
Helix - helix interface (TM1 - TM3, LB - TM3) |
Tyr (Aromatic) -> His (Charged) |
- |
| 1690 |
|
AQP7 |
rs868498427 |
NP_001161.1 - 115 (TM3) |
Helix - helix interface (TM1 - TM3, LB - TM3) |
Tyr (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 1691 |
|
AQP7 |
rs1166925278 |
NP_001161.1 - 116 (TM3) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1692 |
|
AQP7 |
rs148428903 |
NP_001161.1 - 118 (TM3) |
Helix - helix interface (TM1 - TM3) |
Gly (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 1693 |
|
AQP7 |
rs148428903 |
NP_001161.1 - 118 (TM3) |
Helix - helix interface (TM1 - TM3) |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 1694 |
|
AQP7 |
rs988869324 |
NP_001161.1 - 118 (TM3) |
Helix - helix interface (TM1 - TM3) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1695 |
|
AQP7 |
rs1251354215 |
NP_001161.1 - 120 (TM3) |
Lipid facing;Helix - helix interface (TM3 - LE) |
Phe (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 1696 |
|
AQP7 |
rs1236871781 |
NP_001161.1 - 122 (TM3) |
Helix - helix interface (TM1 - TM3) |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 1697 |
|
AQP7 |
rs1306505924 |
NP_001161.1 - 125 (TM3) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 1698 |
|
AQP7 |
rs577783586 |
NP_001161.1 - 126 (TM3) |
Helix - helix interface (TM1 - TM3) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1699 |
|
AQP7 |
rs577783586 |
NP_001161.1 - 126 (TM3) |
Helix - helix interface (TM1 - TM3) |
Ala (Small and Weakly Polar) -> Glu (Charged) |
- |
| 1700 |
|
AQP7 |
rs756281506 |
NP_001161.1 - 129 (TM3) |
Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 1701 |
|
AQP7 |
rs1033231484 |
NP_001161.1 - 131 (TM3) |
Helix - helix interface (TM3 - LE) |
Tyr (Aromatic) -> Asp (Charged) |
- |
| 1702 |
|
AQP7 |
rs1373479176 |
NP_001161.1 - 132 (TM3) |
Lipid facing |
Ser (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1703 |
|
AQP7 |
rs745937443 |
NP_001161.1 - 134 (TM3) |
Exposed to the extracellular environment |
Phe (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 1704 |
|
AQP7 |
rs199840488 |
NP_001161.1 - 136 (Loop region after TM3) |
Loop C |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 1705 |
|
AQP7 |
rs978997160 |
NP_001161.1 - 136 (Loop region after TM3) |
Loop C |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 1706 |
|
AQP7 |
rs763685025 |
NP_001161.1 - 137 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1707 |
|
AQP7 |
rs1213358838 |
NP_001161.1 - 137 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1708 |
|
AQP7 |
rs1213358838 |
NP_001161.1 - 137 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 1709 |
|
AQP7 |
rs1322003615 |
NP_001161.1 - 138 (Loop region after TM3) |
Loop C |
Ile (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1710 |
|
AQP7 |
rs1246565722 |
NP_001161.1 - 139 (Loop region after TM3) |
Loop C |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 1711 |
|
AQP7 |
rs758080799 |
NP_001161.1 - 140 (Loop region after TM3) |
Loop C |
His (Charged) -> Tyr (Aromatic) |
- |
| 1712 |
|
AQP7 |
rs752508547 |
NP_001161.1 - 142 (Loop region after TM3) |
Loop C |
Ser (Small and Weakly Polar) -> Leu (Aliphatic hydrophobic) |
- |
| 1713 |
|
AQP7 |
rs759504102 |
NP_001161.1 - 143 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 1714 |
|
AQP7 |
rs776499439 |
NP_001161.1 - 143 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 1715 |
|
AQP7 |
rs79172651 |
NP_001161.1 - 145 (Loop region after TM3) |
Loop C |
Gln (Neutral polar) -> Glu (Charged) |
- |
| 1716 |
|
AQP7 |
rs748367118 |
NP_001161.1 - 147 (Loop region after TM3) |
Loop C |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1717 |
|
AQP7 |
rs774764353 |
NP_001161.1 - 148 (Loop region after TM3) |
Loop C |
Val (Aliphatic hydrophobic) -> Gly (Small and Weakly Polar) |
- |
| 1718 |
|
AQP7 |
rs144445015 |
NP_001161.1 - 150 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 1719 |
|
AQP7 |
rs144445015 |
NP_001161.1 - 150 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1720 |
|
AQP7 |
rs1396450420 |
NP_001161.1 - 150 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1721 |
|
AQP7 |
rs1396450420 |
NP_001161.1 - 150 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 1722 |
|
AQP7 |
rs756634075 |
NP_001161.1 - 151 (Loop region after TM3) |
Loop C |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 1723 |
|
AQP7 |
rs76608797 |
NP_001161.1 - 152 (Loop region after TM3) |
Loop C |
Val (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 1724 |
|
AQP7 |
rs76608797 |
NP_001161.1 - 152 (Loop region after TM3) |
Loop C |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1725 |
|
AQP7 |
rs765077284 |
NP_001161.1 - 152 (Loop region after TM3) |
Loop C |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 1726 |
|
AQP7 |
rs144159502 |
NP_001161.1 - 153 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1727 |
|
AQP7 |
rs766372675 |
NP_001161.1 - 153 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1728 |
|
AQP7 |
rs760732558 |
NP_001161.1 - 154 (Loop region after TM3) |
Loop C |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 1729 |
|
AQP7 |
rs1355833339 |
NP_001161.1 - 157 (Loop region after TM3) |
Loop C |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1730 |
|
AQP7 |
rs767762794 |
NP_001161.1 - 163 (Loop region after TM3) |
Loop C |
Pro (Proline) -> Arg (Charged) |
- |
| 1731 |
|
AQP7 |
rs762090573 |
NP_001161.1 - 165 (Loop region after TM3) |
Loop C |
His (Charged) -> Asn (Neutral polar) |
- |
| 1732 |
|
AQP7 |
rs774369511 |
NP_001161.1 - 166 (Loop region after TM3) |
Loop C |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1733 |
|
AQP7 |
rs201415718 |
NP_001161.1 - 170 (TM4) |
Lipid facing |
Arg (Charged) -> Pro (Proline) |
- |
| 1734 |
|
AQP7 |
rs201415718 |
NP_001161.1 - 170 (TM4) |
Lipid facing |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 1735 |
|
AQP7 |
rs1412196070 |
NP_001161.1 - 170 (TM4) |
Lipid facing |
Arg (Charged) -> Trp (Aromatic) |
- |
| 1736 |
|
AQP7 |
rs775861945 |
NP_001161.1 - 171 (TM4) |
Helix - helix interface (TM4 - TM5) |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1737 |
|
AQP7 |
rs1397156045 |
NP_001161.1 - 173 (TM4) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 1738 |
|
AQP7 |
rs1259886341 |
NP_001161.1 - 175 (TM4) |
Helix - helix interface (TM4 - TM5, TM4 - TM6) |
Glu (Charged) -> Lys (Charged) |
- |
| 1739 |
|
AQP7 |
rs62542746 |
NP_001161.1 - 176 (TM4) |
Helix - helix interface (TM4 - TM6) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1740 |
|
AQP7 |
rs62542746 |
NP_001161.1 - 176 (TM4) |
Helix - helix interface (TM4 - TM6) |
Ala (Small and Weakly Polar) -> Glu (Charged) |
- |
| 1741 |
|
AQP7 |
rs1028216797 |
NP_001161.1 - 177 (TM4) |
Monomer - monomer interface |
Trp (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 1742 |
|
AQP7 |
rs1162875098 |
NP_001161.1 - 178 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 1743 |
|
AQP7 |
rs775225196 |
NP_001161.1 - 179 (TM4) |
Helix - helix interface (LB - TM4, TM4 - TM6) |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 1744 |
|
AQP7 |
rs202183465 |
NP_001161.1 - 180 (TM4) |
Helix - helix interface (TM4 - TM6);Monomer - monomer interface |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1745 |
|
AQP7 |
rs202183465 |
NP_001161.1 - 180 (TM4) |
Helix - helix interface (TM4 - TM6);Monomer - monomer interface |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1746 |
|
AQP7 |
rs747027644 |
NP_001161.1 - 181 (TM4) |
Monomer - monomer interface |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1747 |
|
AQP7 |
rs757121649 |
NP_001161.1 - 181 (TM4) |
Monomer - monomer interface |
Met (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1748 |
|
AQP7 |
rs1467746411 |
NP_001161.1 - 182 (TM4) |
Channel facing;Helix - helix interface (LB - TM4, TM4 - TM5) |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 1749 |
|
AQP7 |
rs1236362055 |
NP_001161.1 - 186 (TM4) |
Channel facing |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 1750 |
|
AQP7 |
rs73478963 |
NP_001161.1 - 188 (TM4) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Pro (Proline) |
- |
| 1751 |
|
AQP7 |
rs73478963 |
NP_001161.1 - 188 (TM4) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1752 |
|
AQP7 |
rs755227850 |
NP_001161.1 - 190 (TM4) |
Channel facing |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 1753 |
|
AQP7 |
rs766822910 |
NP_001161.1 - 191 (TM4) |
Exposed to cytoplasm |
Asp (Charged) -> Glu (Charged) |
- |
| 1754 |
|
AQP7 |
rs62542745 |
NP_001161.1 - 192 (Loop region after TM4) |
Loop D |
Gln (Neutral polar) -> Arg (Charged) |
- |
| 1755 |
|
AQP7 |
rs62542745 |
NP_001161.1 - 192 (Loop region after TM4) |
Loop D |
Gln (Neutral polar) -> Pro (Proline) |
- |
| 1756 |
|
AQP7 |
rs62542744 |
NP_001161.1 - 194 (Loop region after TM4) |
Loop D |
Asn (Neutral polar) -> Lys (Charged) |
- |
| 1757 |
|
AQP7 |
rs904642382 |
NP_001161.1 - 195 (Loop region after TM4) |
Loop D |
Asn (Neutral polar) -> His (Charged) |
- |
| 1758 |
|
AQP7 |
rs767919525 |
NP_001161.1 - 196 (Loop region after TM4) |
Loop D |
Pro (Proline) -> Thr (Small and Weakly Polar) |
- |
| 1759 |
|
AQP7 |
rs1350436935 |
NP_001161.1 - 196 (Loop region after TM4) |
Loop D |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 1760 |
|
AQP7 |
rs762503156 |
NP_001161.1 - 197 (Loop region after TM4) |
Loop D |
Ala (Small and Weakly Polar) -> Glu (Charged) |
- |
| 1761 |
|
AQP7 |
rs549789029 |
NP_001161.1 - 199 (Loop region after TM4) |
Loop D |
Pro (Proline) -> Arg (Charged) |
- |
| 1762 |
|
AQP7 |
rs775170288 |
NP_001161.1 - 200 (Loop region after TM4) |
Loop D |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1763 |
|
AQP7 |
rs76908057 |
NP_001161.1 - 202 (TM5) |
Helix - helix interface (TM4 - TM5) |
Glu (Charged) -> Gln (Neutral polar) |
- |
| 1764 |
|
AQP7 |
rs114937176 |
NP_001161.1 - 202 (TM5) |
Helix - helix interface (TM4 - TM5) |
Glu (Charged) -> Asp (Charged) |
- |
| 1765 |
|
AQP7 |
rs776278674 |
NP_001161.1 - 203 (TM5) |
Helix - helix interface (TM2 - TM5) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1766 |
|
AQP7 |
rs746785282 |
NP_001161.1 - 204 (TM5) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1767 |
|
AQP7 |
rs1163234551 |
NP_001161.1 - 204 (TM5) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 1768 |
|
AQP7 |
rs201507439 |
NP_001161.1 - 205 (TM5) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1769 |
|
AQP7 |
rs777708430 |
NP_001161.1 - 205 (TM5) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Gly (Small and Weakly Polar) |
- |
| 1770 |
|
AQP7 |
rs748190708 |
NP_001161.1 - 206 (TM5) |
Channel facing;Helix - helix interface (TM4 - TM5) |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1771 |
|
AQP7 |
rs758358831 |
NP_001161.1 - 206 (TM5) |
Channel facing;Helix - helix interface (TM4 - TM5) |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1772 |
|
AQP7 |
rs117663392 |
NP_001161.1 - 207 (TM5) |
Helix - helix interface (TM2 - TM5) |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1773 |
|
AQP7 |
rs755176890 |
NP_001161.1 - 209 (TM5) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 1774 |
|
AQP7 |
rs201192248 |
NP_001161.1 - 210 (TM5) |
Channel facing |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1775 |
|
AQP7 |
rs201192248 |
NP_001161.1 - 210 (TM5) |
Channel facing |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1776 |
|
AQP7 |
rs1301481920 |
NP_001161.1 - 210 (TM5) |
Channel facing |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 1777 |
|
AQP7 |
rs1368420100 |
NP_001161.1 - 212 (TM5) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1778 |
|
AQP7 |
rs1489175259 |
NP_001161.1 - 212 (TM5) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1779 |
|
AQP7 |
rs1297620069 |
NP_001161.1 - 213 (TM5) |
Helix - helix interface (TM4 - TM5) |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1780 |
|
AQP7 |
rs114484742 |
NP_001161.1 - 214 (TM5 - Ar/R Selectivity filter) |
Channel facing |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1781 |
|
AQP7 |
rs1169041382 |
NP_001161.1 - 214 (TM5 - Ar/R Selectivity filter) |
Channel facing |
Gly (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 1782 |
|
AQP7 |
rs768096479 |
NP_001161.1 - 215 (TM5) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1783 |
|
AQP7 |
rs768096479 |
NP_001161.1 - 215 (TM5) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1784 |
|
AQP7 |
rs199936776 |
NP_001161.1 - 216 (TM5) |
Monomer - monomer interface |
Ser (Small and Weakly Polar) -> Tyr (Aromatic) |
- |
| 1785 |
|
AQP7 |
rs201773300 |
NP_001161.1 - 217 (TM5) |
Helix - helix interface (TM4 - TM5) |
Leu (Aliphatic hydrophobic) -> His (Charged) |
- |
| 1786 |
|
AQP7 |
rs1174969247 |
NP_001161.1 - 218 (TM5) |
Channel facing |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1787 |
|
AQP7 |
rs201117022 |
NP_001161.1 - 219 (Loop region after TM5) |
Loop E |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1788 |
|
AQP7 |
rs1169866396 |
NP_001161.1 - 222 (Loop region after TM5) |
Loop E |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1789 |
|
AQP7 |
rs770503247 |
NP_001161.1 - 224 (Loop region after TM5) |
Loop E |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1790 |
|
AQP7 |
rs770503247 |
NP_001161.1 - 224 (Loop region after TM5) |
Loop E |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 1791 |
|
AQP7 |
rs776281487 |
NP_001161.1 - 224 (Loop region after TM5) |
Loop E |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1792 |
|
AQP7 |
rs760474263 |
NP_001161.1 - 226 (LE - NPA2) |
Channel facing;Helix - helix interface (TM1 - LE, LB - LE) |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 1793 |
|
AQP7 |
rs760474263 |
NP_001161.1 - 226 (LE - NPA2) |
Channel facing;Helix - helix interface (TM1 - LE, LB - LE) |
Asn (Neutral polar) -> Thr (Small and Weakly Polar) |
- |
| 1794 |
|
AQP7 |
rs138290992 |
NP_001161.1 - 227 (LE - NPA2) |
Helix - helix interface (LB - LE, LE - TM6) |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 1795 |
|
AQP7 |
rs377195045 |
NP_001161.1 - 228 (LE - NPA2 deviation) |
Helix - helix interface (LB - LE, TM3 - LE) |
Ser (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 1796 |
|
AQP7 |
rs373501318 |
NP_001161.1 - 229 (LE - Ar/R Selectivity filter) |
Channel facing |
Arg (Charged) -> Leu (Aliphatic hydrophobic) |
- |
| 1797 |
|
AQP7 |
rs373501318 |
NP_001161.1 - 229 (LE - Ar/R Selectivity filter) |
Channel facing |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 1798 |
|
AQP7 |
rs780270047 |
NP_001161.1 - 229 (LE - Ar/R Selectivity filter) |
Channel facing |
Arg (Charged) -> Trp (Aromatic) |
- |
| 1799 |
|
AQP7 |
rs559393989 |
NP_001161.1 - 230 (LE) |
Helix - helix interface (LE - TM6) |
Asp (Charged) -> Asn (Neutral polar) |
- |
| 1800 |
|
AQP7 |
rs757823924 |
NP_001161.1 - 230 (LE) |
Helix - helix interface (LE - TM6) |
Asp (Charged) -> Glu (Charged) |
- |
| 1801 |
|
AQP7 |
rs145516206 |
NP_001161.1 - 231 (LE) |
Helix - helix interface (LE - TM6, TM3 - LE); Lipid facing |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 1802 |
|
AQP7 |
rs753311168 |
NP_001161.1 - 232 (LE) |
Helix - helix interface (TM3 - LE) |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 1803 |
|
AQP7 |
rs753311168 |
NP_001161.1 - 232 (LE) |
Helix - helix interface (TM3 - LE) |
Pro (Proline) -> His (Charged) |
- |
| 1804 |
|
AQP7 |
rs759029108 |
NP_001161.1 - 232 (LE) |
Helix - helix interface (TM3 - LE) |
Pro (Proline) -> Thr (Small and Weakly Polar) |
- |
| 1805 |
|
AQP7 |
rs766018958 |
NP_001161.1 - 233 (LE) |
Helix - helix interface (TM3 - LE) |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 1806 |
|
AQP7 |
rs766018958 |
NP_001161.1 - 233 (LE) |
Helix - helix interface (TM3 - LE) |
Pro (Proline) -> Arg (Charged) |
- |
| 1807 |
|
AQP7 |
rs139024279 |
NP_001161.1 - 234 (LE) |
Exposed to the extracellular environment |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 1808 |
|
AQP7 |
rs139024279 |
NP_001161.1 - 234 (LE) |
Exposed to the extracellular environment |
Arg (Charged) -> Gly (Small and Weakly Polar) |
- |
| 1809 |
|
AQP7 |
rs139024279 |
NP_001161.1 - 234 (LE) |
Exposed to the extracellular environment |
Arg (Charged) -> Ser (Small and Weakly Polar) |
- |
| 1810 |
|
AQP7 |
rs369644615 |
NP_001161.1 - 234 (LE) |
Exposed to the extracellular environment |
Arg (Charged) -> His (Charged) |
- |
| 1811 |
|
AQP7 |
rs768599373 |
NP_001161.1 - 235 (LE) |
Lipid facing |
Ile (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 1812 |
|
AQP7 |
rs768599373 |
NP_001161.1 - 235 (LE) |
Lipid facing |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1813 |
|
AQP7 |
rs1423757766 |
NP_001161.1 - 235 (LE) |
Lipid facing |
Ile (Aliphatic hydrophobic) -> Asn (Neutral polar) |
- |
| 1814 |
|
AQP7 |
rs1202534815 |
NP_001161.1 - 237 (LE) |
Exposed to the extracellular environment |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 1815 |
|
AQP7 |
rs1255848704 |
NP_001161.1 - 237 (LE) |
Exposed to the extracellular environment |
Thr (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1816 |
|
AQP7 |
rs543757751 |
NP_001161.1 - 241 (LE) |
Exposed to the extracellular environment |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 1817 |
|
AQP7 |
rs770033710 |
NP_001161.1 - 241 (LE) |
Exposed to the extracellular environment |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1818 |
|
AQP7 |
rs781688387 |
NP_001161.1 - 243 (Loop region after LE) |
Loop E |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 1819 |
|
AQP7 |
rs1331348216 |
NP_001161.1 - 243 (Loop region after LE) |
Loop E |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1820 |
|
AQP7 |
rs751986180 |
NP_001161.1 - 245 (Loop region after LE) |
Loop E |
Gln (Neutral polar) -> Leu (Aliphatic hydrophobic) |
- |
| 1821 |
|
AQP7 |
rs778376340 |
NP_001161.1 - 246 (Loop region after LE) |
Loop E |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1822 |
|
AQP7 |
rs758864520 |
NP_001161.1 - 247 (Loop region after LE) |
Loop E |
Phe (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 1823 |
|
AQP7 |
rs758864520 |
NP_001161.1 - 247 (Loop region after LE) |
Loop E |
Phe (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 1824 |
|
AQP7 |
rs753362587 |
NP_001161.1 - 248 (Loop region after LE) |
Loop E |
Ser (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 1825 |
|
AQP7 |
rs74557595 |
NP_001161.1 - 249 (Loop region after LE) |
Loop E |
Asn (Neutral polar) -> Asp (Charged) |
- |
| 1826 |
|
AQP7 |
rs760977156 |
NP_001161.1 - 250 (Loop region after LE) |
Loop E |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1827 |
|
AQP7 |
rs773244652 |
NP_001161.1 - 250 (Loop region after LE) |
Loop E |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 1828 |
|
AQP7 |
rs375356467 |
NP_001161.1 - 252 (Loop region after LE) |
Loop E |
Asn (Neutral polar) -> Lys (Charged) |
- |
| 1829 |
|
AQP7 |
rs769128601 |
NP_001161.1 - 253 (Loop region after LE) |
Loop E |
Trp (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 1830 |
|
AQP7 |
rs1554714474 |
NP_001161.1 - 256 (TM6) |
Helix - helix interface (TM4 - TM6) |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1831 |
|
AQP7 |
rs780673396 |
NP_001161.1 - 260 (TM6) |
Helix - helix interface (TM4 - TM6) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1832 |
|
AQP7 |
rs770359710 |
NP_001161.1 - 262 (TM6) |
Helix - helix interface (LB - TM6); Lipid facing |
Leu (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1833 |
|
AQP7 |
rs62542743 |
NP_001161.1 - 264 (TM6) |
Helix - helix interface (TM4 - TM6) |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
Diminished glycerol uptake |
| 1834 |
|
AQP7 |
rs184118433 |
NP_001161.1 - 264 (TM6) |
Helix - helix interface (TM4 - TM6) |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1835 |
|
AQP7 |
rs202043723 |
NP_001161.1 - 266 (TM6) |
Helix - helix interface (LB - TM6); Lipid facing |
Tyr (Aromatic) -> Phe (Aromatic) |
- |
| 1836 |
|
AQP7 |
rs202043723 |
NP_001161.1 - 266 (TM6) |
Helix - helix interface (LB - TM6); Lipid facing |
Tyr (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 1837 |
|
AQP7 |
rs561584740 |
NP_001161.1 - 268 (TM6) |
Helix - helix interface (TM4 - TM6) |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1838 |
|
AQP7 |
rs561584740 |
NP_001161.1 - 268 (TM6) |
Helix - helix interface (TM4 - TM6) |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 1839 |
|
AQP7 |
rs753896238 |
NP_001161.1 - 269 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6) |
Gly (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 1840 |
|
AQP7 |
rs753896238 |
NP_001161.1 - 269 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6) |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1841 |
|
AQP7 |
rs1289616046 |
NP_001161.1 - 274 (TM6) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1842 |
|
AQP7 |
rs1289616046 |
NP_001161.1 - 274 (TM6) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1843 |
|
AQP7 |
rs1376273760 |
NP_001161.1 - 276 (TM6) |
Exposed to cytoplasm |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1844 |
|
AQP7 |
rs760785390 |
NP_001161.1 - 277 (TM6) |
Exposed to cytoplasm |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 1845 |
|
AQP7 |
rs766426189 |
NP_001161.1 - 277 (TM6) |
Exposed to cytoplasm |
Gly (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 1846 |
|
AQP7 |
rs370340757 |
NP_001161.1 - 278 (TM6) |
Exposed to cytoplasm |
Ser (Small and Weakly Polar) -> Pro (Proline) |
- |
| 1847 |
|
AQP7 |
rs190625868 |
NP_001161.1 - 279 (TM6) |
Exposed to cytoplasm |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 1848 |
|
AQP7 |
rs1446242768 |
NP_001161.1 - 280 (C terminus) |
Absent in the structure |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1849 |
|
AQP7 |
rs768393072 |
NP_001161.1 - 282 (C terminus) |
Absent in the structure |
Arg (Charged) -> Trp (Aromatic) |
- |
| 1850 |
|
AQP7 |
rs774564666 |
NP_001161.1 - 282 (C terminus) |
Absent in the structure |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 1851 |
|
AQP7 |
rs763311844 |
NP_001161.1 - 284 (C terminus) |
Absent in the structure |
Pro (Proline) -> Ala (Small and Weakly Polar) |
- |
| 1852 |
|
AQP7 |
rs202003063 |
NP_001161.1 - 285 (C terminus) |
Absent in the structure |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 1853 |
|
AQP7 |
rs770308564 |
NP_001161.1 - 286 (C terminus) |
Absent in the structure |
Lys (Charged) -> Thr (Small and Weakly Polar) |
- |
| 1854 |
|
AQP7 |
rs1219152528 |
NP_001161.1 - 288 (C terminus) |
Absent in the structure |
Glu (Charged) -> Asp (Charged) |
- |
| 1855 |
|
AQP7 |
rs1179941138 |
NP_001161.1 - 289 (C terminus) |
Absent in the structure |
Asp (Charged) -> Ala (Small and Weakly Polar) |
- |
| 1856 |
|
AQP7 |
rs1237788650 |
NP_001161.1 - 290 (C terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Tyr (Aromatic) |
- |
| 1857 |
|
AQP7 |
rs201527236 |
NP_001161.1 - 292 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1858 |
|
AQP7 |
rs542757882 |
NP_001161.1 - 294 (C terminus) |
Absent in the structure |
Glu (Charged) -> Gly (Small and Weakly Polar) |
- |
| 1859 |
|
AQP7 |
rs376205588 |
NP_001161.1 - 296 (C terminus) |
Absent in the structure |
His (Charged) -> Arg (Charged) |
- |
| 1860 |
|
AQP7 |
rs749112658 |
NP_001161.1 - 297 (C terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1861 |
|
AQP7 |
rs780095371 |
NP_001161.1 - 298 (C terminus) |
Absent in the structure |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1862 |
|
AQP7 |
rs1430363924 |
NP_001161.1 - 299 (C terminus) |
Absent in the structure |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 1863 |
|
AQP7 |
rs61073250 |
NP_001161.1 - 300 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1864 |
|
AQP7 |
rs1432944647 |
NP_001161.1 - 300 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 1865 |
|
AQP7 |
rs767693529 |
NP_001161.1 - 302 (C terminus) |
Absent in the structure |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 1866 |
|
AQP7 |
rs757414925 |
NP_001161.1 - 303 (C terminus) |
Absent in the structure |
Lys (Charged) -> Glu (Charged) |
- |
| 1867 |
|
AQP7 |
rs371523158 |
NP_001161.1 - 304 (C terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1868 |
|
AQP7 |
rs751738116 |
NP_001161.1 - 304 (C terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1869 |
|
AQP7 |
rs764313048 |
NP_001161.1 - 304 (C terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Lys (Charged) |
- |
| 1870 |
|
AQP7 |
rs1249475411 |
NP_001161.1 - 306 (C terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 1871 |
|
AQP7 |
rs1447342994 |
NP_001161.1 - 306 (C terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1872 |
|
AQP7 |
rs541770524 |
NP_001161.1 - 310 (C terminus) |
Absent in the structure |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 1873 |
|
AQP7 |
rs772587113 |
NP_001161.1 - 315 (C terminus) |
Absent in the structure |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 1874 |
|
AQP7 |
rs771682923 |
NP_001161.1 - 316 (C terminus) |
Absent in the structure |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 1875 |
|
AQP7 |
rs1291113394 |
NP_001161.1 - 316 (C terminus) |
Absent in the structure |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 1876 |
|
AQP7 |
rs199594532 |
NP_001161.1 - 317 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1877 |
|
AQP7 |
rs868186854 |
NP_001161.1 - 318 (C terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 1878 |
|
AQP7 |
rs796349423 |
NP_001161.1 - 319 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1879 |
|
AQP7 |
rs1436024401 |
NP_001161.1 - 319 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Gly (Small and Weakly Polar) |
- |
| 1880 |
|
AQP7 |
rs201424877 |
NP_001161.1 - 321 (C terminus) |
Absent in the structure |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 1881 |
|
AQP7 |
rs749056562 |
NP_001161.1 - 321 (C terminus) |
Absent in the structure |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 1882 |
|
AQP7 |
rs755989154 |
NP_001161.1 - 322 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1883 |
|
AQP7 |
rs745882902 |
NP_001161.1 - 326 (C terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Leu (Aliphatic hydrophobic) |
- |
| 1884 |
|
AQP7 |
rs113571472 |
NP_001161.1 - 327 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 1885 |
|
AQP7 |
rs1245079837 |
NP_001161.1 - 328 (C terminus) |
Absent in the structure |
His (Charged) -> Gln (Neutral polar) |
- |
| 1886 |
|
AQP7 |
rs78431873 |
NP_001161.1 - 329 (C terminus) |
Absent in the structure |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 1887 |
|
AQP7 |
rs1168854859 |
NP_001161.1 - 329 (C terminus) |
Absent in the structure |
Pro (Proline) -> Arg (Charged) |
- |
| 1888 |
|
AQP7 |
rs1264739226 |
NP_001161.1 - 330 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 1889 |
|
AQP7 |
rs199871527 |
NP_001161.1 - 331 (C terminus) |
Absent in the structure |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 1890 |
|
AQP7 |
rs199871527 |
NP_001161.1 - 331 (C terminus) |
Absent in the structure |
Pro (Proline) -> Arg (Charged) |
- |
| 1891 |
|
AQP7 |
rs1192417714 |
NP_001161.1 - 331 (C terminus) |
Absent in the structure |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 1892 |
|
AQP7 |
rs758660571 |
NP_001161.1 - 332 (C terminus) |
Absent in the structure |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 1893 |
|
AQP7 |
rs758660571 |
NP_001161.1 - 332 (C terminus) |
Absent in the structure |
Pro (Proline) -> His (Charged) |
- |
| 1894 |
|
AQP7 |
rs1438298065 |
NP_001161.1 - 332 (C terminus) |
Absent in the structure |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 1895 |
|
AQP7 |
rs1205026401 |
NP_001161.1 - 334 (C terminus) |
Absent in the structure |
His (Charged) -> Arg (Charged) |
- |
| 1896 |
|
AQP7 |
rs368432936 |
NP_001161.1 - 338 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1897 |
|
AQP7 |
rs958540175 |
NP_001161.1 - 338 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1898 |
|
AQP7 |
rs1229416384 |
NP_001161.1 - 339 (C terminus) |
Absent in the structure |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 1899 |
|
AQP7 |
rs1299353226 |
NP_001161.1 - 340 (C terminus) |
Absent in the structure |
Glu (Charged) -> Gln (Neutral polar) |
- |
| 1900 |
|
AQP8 |
rs146610605 |
NP_001160.2 - 1 (N terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1901 |
|
AQP8 |
rs771106662 |
NP_001160.2 - 2 (N terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Pro (Proline) |
- |
| 1902 |
|
AQP8 |
rs1328291356 |
NP_001160.2 - 3 (N terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 1903 |
|
AQP8 |
rs1308659812 |
NP_001160.2 - 6 (N terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 1904 |
|
AQP8 |
rs769366843 |
NP_001160.2 - 7 (N terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1905 |
|
AQP8 |
rs369810183 |
NP_001160.2 - 8 (N terminus) |
Absent in the structure |
Cys (Small and Weakly Polar) -> Tyr (Aromatic) |
- |
| 1906 |
|
AQP8 |
rs762604533 |
NP_001160.2 - 9 (N terminus) |
Absent in the structure |
Glu (Charged) -> Lys (Charged) |
- |
| 1907 |
|
AQP8 |
rs1360980702 |
NP_001160.2 - 10 (N terminus) |
Absent in the structure |
Pro (Proline) -> Arg (Charged) |
- |
| 1908 |
|
AQP8 |
rs766391001 |
NP_001160.2 - 11 (N terminus) |
Absent in the structure |
Glu (Charged) -> Lys (Charged) |
- |
| 1909 |
|
AQP8 |
rs774493823 |
NP_001160.2 - 13 (N terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1910 |
|
AQP8 |
rs752434452 |
NP_001160.2 - 20 (N terminus) |
Absent in the structure |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 1911 |
|
AQP8 |
rs201271698 |
NP_001160.2 - 22 (N terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1912 |
|
AQP8 |
rs368580582 |
NP_001160.2 - 23 (N terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1913 |
|
AQP8 |
rs780528008 |
NP_001160.2 - 23 (N terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 1914 |
|
AQP8 |
rs747459028 |
NP_001160.2 - 24 (N terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1915 |
|
AQP8 |
rs192649983 |
NP_001160.2 - 25 (N terminus) |
Absent in the structure |
Arg (Charged) -> Met (Aliphatic hydrophobic) |
- |
| 1916 |
|
AQP8 |
rs1350169846 |
NP_001160.2 - 26 (N terminus) |
N terminal domain |
Trp (Aromatic) -> Arg (Charged) |
- |
| 1917 |
|
AQP8 |
rs61733055 |
NP_001160.2 - 27 (N terminus) |
N terminal domain |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 1918 |
|
AQP8 |
rs777612586 |
NP_001160.2 - 28 (TM1) |
Exposed to cytoplasm |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1919 |
|
AQP8 |
rs140471716 |
NP_001160.2 - 32 (TM1) |
Exposed to cytoplasm |
Glu (Charged) -> Lys (Charged) |
- |
| 1920 |
|
AQP8 |
rs140471716 |
NP_001160.2 - 32 (TM1) |
Exposed to cytoplasm |
Glu (Charged) -> Gln (Neutral polar) |
- |
| 1921 |
|
AQP8 |
rs147031036 |
NP_001160.2 - 33 (TM1) |
Exposed to cytoplasm |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 1922 |
|
AQP8 |
rs557244284 |
NP_001160.2 - 33 (TM1) |
Exposed to cytoplasm |
Arg (Charged) -> Trp (Aromatic) |
- |
| 1923 |
|
AQP8 |
rs760436309 |
NP_001160.2 - 38 (TM1) |
Helix - helix interface (TM1 - TM3) |
Cys (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1924 |
|
AQP8 |
rs1489825155 |
NP_001160.2 - 39 (TM1) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 1925 |
|
AQP8 |
rs1446648688 |
NP_001160.2 - 42 (TM1) |
Helix - helix interface (TM1 - TM3); Lipid facing |
Leu (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 1926 |
|
AQP8 |
rs763176599 |
NP_001160.2 - 43 (TM1) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 1927 |
|
AQP8 |
rs751622264 |
NP_001160.2 - 45 (TM1) |
Helix - helix interface (TM1 - TM3) |
Ser (Small and Weakly Polar) -> Pro (Proline) |
- |
| 1928 |
|
AQP8 |
rs1426895529 |
NP_001160.2 - 45 (TM1) |
Helix - helix interface (TM1 - TM3) |
Ser (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 1929 |
|
AQP8 |
rs781601347 |
NP_001160.2 - 49 (TM1) |
Helix - helix interface (TM1 - TM3) |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1930 |
|
AQP8 |
rs1407897720 |
NP_001160.2 - 51 (TM1) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1931 |
|
AQP8 |
rs766942366 |
NP_001160.2 - 52 (TM1) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1932 |
|
AQP8 |
rs573342798 |
NP_001160.2 - 55 (TM1) |
Helix - helix interface (TM1 - TM2) |
Ser (Small and Weakly Polar) -> Leu (Aliphatic hydrophobic) |
- |
| 1933 |
|
AQP8 |
rs772022609 |
NP_001160.2 - 56 (TM1) |
Channel facing |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 1934 |
|
AQP8 |
rs1223319546 |
NP_001160.2 - 57 (TM1) |
Helix - helix interface (TM1 - TM3) |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 1935 |
|
AQP8 |
rs1022630516 |
NP_001160.2 - 58 (TM1) |
Monomer - monomer interface |
Glu (Charged) -> Asp (Charged) |
- |
| 1936 |
|
AQP8 |
rs1415798702 |
NP_001160.2 - 59 (TM1) |
Helix - helix interface (TM1 - TM2) |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 1937 |
|
AQP8 |
rs1325997102 |
NP_001160.2 - 60 (Loop region after TM1) |
Loop A |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1938 |
|
AQP8 |
rs111572783 |
NP_001160.2 - 61 (Loop region after TM1) |
Loop A |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 1939 |
|
AQP8 |
rs1486253760 |
NP_001160.2 - 62 (Loop region after TM1) |
Loop A |
Asp (Charged) -> His (Charged) |
- |
| 1940 |
|
AQP8 |
rs199576560 |
NP_001160.2 - 63 (Loop region after TM1) |
Loop A |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 1941 |
|
AQP8 |
rs776417844 |
NP_001160.2 - 63 (Loop region after TM1) |
Loop A |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 1942 |
|
AQP8 |
rs200560569 |
NP_001160.2 - 68 (TM2) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 1943 |
|
AQP8 |
rs1398523897 |
NP_001160.2 - 69 (TM2) |
Helix - helix interface (TM2 - TM5) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1944 |
|
AQP8 |
rs759578291 |
NP_001160.2 - 71 (TM2) |
Helix - helix interface (TM2 - TM1);Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 1945 |
|
AQP8 |
rs759578291 |
NP_001160.2 - 71 (TM2) |
Helix - helix interface (TM2 - TM1);Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1946 |
|
AQP8 |
rs138117795 |
NP_001160.2 - 72 (TM2 - Ar/R Selectivity filter) |
Channel facing |
His (Charged) -> Gln (Neutral polar) |
- |
| 1947 |
|
AQP8 |
rs1345212740 |
NP_001160.2 - 72 (TM2 - Ar/R Selectivity filter) |
Channel facing |
His (Charged) -> Tyr (Aromatic) |
- |
| 1948 |
|
AQP8 |
rs764825543 |
NP_001160.2 - 73 (TM2) |
Helix - helix interface (TM2 - TM5) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1949 |
|
AQP8 |
rs1022427921 |
NP_001160.2 - 75 (TM2) |
Monomer - monomer interface;Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1950 |
|
AQP8 |
rs552099899 |
NP_001160.2 - 79 (TM2) |
Helix - helix interface (TM1 - TM2) |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 1951 |
|
AQP8 |
rs552099899 |
NP_001160.2 - 79 (TM2) |
Helix - helix interface (TM1 - TM2) |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1952 |
|
AQP8 |
rs778477614 |
NP_001160.2 - 81 (TM2) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 1953 |
|
AQP8 |
rs745351844 |
NP_001160.2 - 82 (TM2) |
Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 1954 |
|
AQP8 |
rs746856769 |
NP_001160.2 - 84 (TM2) |
Channel facing |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1955 |
|
AQP8 |
rs746856769 |
NP_001160.2 - 84 (TM2) |
Channel facing |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1956 |
|
AQP8 |
rs776362370 |
NP_001160.2 - 86 (Loop region after TM2) |
Loop B |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1957 |
|
AQP8 |
rs1169002853 |
NP_001160.2 - 88 (Loop region after TM2) |
Loop B |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1958 |
|
AQP8 |
rs1233082277 |
NP_001160.2 - 90 (Loop region after TM2) |
Loop B |
His (Charged) -> Tyr (Aromatic) |
- |
| 1959 |
|
AQP8 |
rs758076165 |
NP_001160.2 - 92 (LB - NPA1) |
Channel facing;Helix - helix interface (LB - LE, LB - TM3) |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 1960 |
|
AQP8 |
rs746545322 |
NP_001160.2 - 94 (LB - NPA1) |
Helix - helix interface (LB - TM4, LB - LE, LB - TM6) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1961 |
|
AQP8 |
rs1008226244 |
NP_001160.2 - 96 (LB) |
Helix - helix interface (LB - TM3) |
Ser (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 1962 |
|
AQP8 |
rs781151382 |
NP_001160.2 - 97 (LB) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Gln (Neutral polar) |
- |
| 1963 |
|
AQP8 |
rs747937289 |
NP_001160.2 - 99 (LB) |
Channel facing |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 1964 |
|
AQP8 |
rs769538217 |
NP_001160.2 - 100 (LB) |
Lipid facing |
Met (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1965 |
|
AQP8 |
rs746008216 |
NP_001160.2 - 101 (LB) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 1966 |
|
AQP8 |
rs773075713 |
NP_001160.2 - 101 (LB) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 1967 |
|
AQP8 |
rs1246849945 |
NP_001160.2 - 103 (Loop region after LB) |
Loop B |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1968 |
|
AQP8 |
rs1285873126 |
NP_001160.2 - 103 (Loop region after LB) |
Loop B |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 1969 |
|
AQP8 |
rs1213933966 |
NP_001160.2 - 104 (Loop region after LB) |
Loop B |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 1970 |
|
AQP8 |
rs1337431198 |
NP_001160.2 - 104 (Loop region after LB) |
Loop B |
Gly (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 1971 |
|
AQP8 |
rs775378783 |
NP_001160.2 - 109 (TM3) |
Channel facing |
Met (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 1972 |
|
AQP8 |
rs760883458 |
NP_001160.2 - 110 (TM3) |
Helix - helix interface (LB - TM3) |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 1973 |
|
AQP8 |
rs555280665 |
NP_001160.2 - 112 (TM3) |
Helix - helix interface (LB - TM3); Lipid facing |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 1974 |
|
AQP8 |
rs762253546 |
NP_001160.2 - 115 (TM3) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Asp (Charged) |
- |
| 1975 |
|
AQP8 |
rs141164855 |
NP_001160.2 - 120 (TM3) |
Helix - helix interface (TM1 - TM3) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1976 |
|
AQP8 |
rs141164855 |
NP_001160.2 - 120 (TM3) |
Helix - helix interface (TM1 - TM3) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1977 |
|
AQP8 |
rs141164855 |
NP_001160.2 - 120 (TM3) |
Helix - helix interface (TM1 - TM3) |
Gly (Small and Weakly Polar) -> Trp (Aromatic) |
- |
| 1978 |
|
AQP8 |
rs766105122 |
NP_001160.2 - 120 (TM3) |
Helix - helix interface (TM1 - TM3) |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 1979 |
|
AQP8 |
rs1025966548 |
NP_001160.2 - 123 (TM3) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 1980 |
|
AQP8 |
rs139054676 |
NP_001160.2 - 124 (TM3) |
Helix - helix interface (TM1 - TM3) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1981 |
|
AQP8 |
rs139054676 |
NP_001160.2 - 124 (TM3) |
Helix - helix interface (TM1 - TM3) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1982 |
|
AQP8 |
rs1484517546 |
NP_001160.2 - 126 (TM3) |
Lipid facing |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1983 |
|
AQP8 |
rs1268579243 |
NP_001160.2 - 130 (TM3) |
Lipid facing |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1984 |
|
AQP8 |
rs777810756 |
NP_001160.2 - 131 (TM3) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 1985 |
|
AQP8 |
rs370539527 |
NP_001160.2 - 133 (Loop region after TM3) |
Loop C |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 1986 |
|
AQP8 |
rs780410063 |
NP_001160.2 - 135 (Loop region after TM3) |
Loop C |
Glu (Charged) -> Lys (Charged) |
- |
| 1987 |
|
AQP8 |
rs747169688 |
NP_001160.2 - 136 (Loop region after TM3) |
Loop C |
Arg (Charged) -> Lys (Charged) |
- |
| 1988 |
|
AQP8 |
rs1444428365 |
NP_001160.2 - 139 (Loop region after TM3) |
Loop C |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 1989 |
|
AQP8 |
rs373232917 |
NP_001160.2 - 140 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1990 |
|
AQP8 |
rs373232917 |
NP_001160.2 - 140 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 1991 |
|
AQP8 |
rs771158498 |
NP_001160.2 - 143 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 1992 |
|
AQP8 |
rs1388337424 |
NP_001160.2 - 144 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 1993 |
|
AQP8 |
rs773838747 |
NP_001160.2 - 148 (Loop region after TM3) |
Loop C |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 1994 |
|
AQP8 |
rs201672056 |
NP_001160.2 - 150 (Loop region after TM3) |
Loop C |
Glu (Charged) -> Lys (Charged) |
- |
| 1995 |
|
AQP8 |
rs1057298202 |
NP_001160.2 - 151 (Loop region after TM3) |
Loop C |
Gln (Neutral polar) -> His (Charged) |
- |
| 1996 |
|
AQP8 |
rs774706475 |
NP_001160.2 - 152 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 1997 |
|
AQP8 |
rs896022100 |
NP_001160.2 - 152 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 1998 |
|
AQP8 |
rs759145311 |
NP_001160.2 - 155 (TM4) |
Lipid facing |
Ala (Small and Weakly Polar) -> Pro (Proline) |
- |
| 1999 |
|
AQP8 |
rs767177408 |
NP_001160.2 - 156 (TM4) |
Monomer - monomer interface |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 2000 |
|
AQP8 |
rs765639523 |
NP_001160.2 - 157 (TM4) |
Helix - helix interface (TM4 - TM5) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2001 |
|
AQP8 |
rs753870432 |
NP_001160.2 - 159 (TM4) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 2002 |
|
AQP8 |
rs1437404777 |
NP_001160.2 - 159 (TM4) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Gly (Small and Weakly Polar) |
- |
| 2003 |
|
AQP8 |
rs1182807009 |
NP_001160.2 - 160 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Glu (Charged) |
- |
| 2004 |
|
AQP8 |
rs1182807009 |
NP_001160.2 - 160 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2005 |
|
AQP8 |
rs757154561 |
NP_001160.2 - 161 (TM4) |
Helix - helix interface (TM4 - TM5, TM4 - TM6) |
Glu (Charged) -> Asp (Charged) |
- |
| 2006 |
|
AQP8 |
rs533891847 |
NP_001160.2 - 165 (TM4) |
Helix - helix interface (LB - TM4, TM4 - TM6) |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 2007 |
|
AQP8 |
rs748173198 |
NP_001160.2 - 166 (TM4) |
Helix - helix interface (TM4 - TM6);Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 2008 |
|
AQP8 |
rs1296175847 |
NP_001160.2 - 166 (TM4) |
Helix - helix interface (TM4 - TM6);Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Pro (Proline) |
- |
| 2009 |
|
AQP8 |
rs1332980013 |
NP_001160.2 - 168 (TM4) |
Channel facing;Helix - helix interface (LB - TM4, TM4 - TM5) |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2010 |
|
AQP8 |
rs777730471 |
NP_001160.2 - 169 (TM4) |
Helix - helix interface (TM4 - TM6) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2011 |
|
AQP8 |
rs1379917083 |
NP_001160.2 - 172 (TM4) |
Channel facing |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2012 |
|
AQP8 |
rs749740434 |
NP_001160.2 - 175 (Loop region after TM4) |
Loop D |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2013 |
|
AQP8 |
rs1451336188 |
NP_001160.2 - 175 (Loop region after TM4) |
Loop D |
Gly (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 2014 |
|
AQP8 |
rs771463196 |
NP_001160.2 - 176 (Loop region after TM4) |
Loop D |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2015 |
|
AQP8 |
rs774645488 |
NP_001160.2 - 178 (Loop region after TM4) |
Loop D |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 2016 |
|
AQP8 |
rs961134108 |
NP_001160.2 - 178 (Loop region after TM4) |
Loop D |
Asn (Neutral polar) -> Lys (Charged) |
- |
| 2017 |
|
AQP8 |
rs746275809 |
NP_001160.2 - 181 (Loop region after TM4) |
Loop D |
Thr (Small and Weakly Polar) -> Lys (Charged) |
- |
| 2018 |
|
AQP8 |
rs746275809 |
NP_001160.2 - 181 (Loop region after TM4) |
Loop D |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 2019 |
|
AQP8 |
rs1199480780 |
NP_001160.2 - 181 (Loop region after TM4) |
Loop D |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 2020 |
|
AQP8 |
rs775276080 |
NP_001160.2 - 182 (Loop region after TM4) |
Loop D |
Lys (Charged) -> Glu (Charged) |
- |
| 2021 |
|
AQP8 |
rs760088990 |
NP_001160.2 - 185 (Loop region after TM4) |
Loop D |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 2022 |
|
AQP8 |
rs776008376 |
NP_001160.2 - 187 (TM5) |
Helix - helix interface (TM2 - TM5) |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 2023 |
|
AQP8 |
rs765315094 |
NP_001160.2 - 188 (TM5) |
Monomer - monomer interface |
Phe (Aromatic) -> Val (Aliphatic hydrophobic) |
- |
| 2024 |
|
AQP8 |
rs1239667609 |
NP_001160.2 - 189 (TM5) |
Monomer - monomer interface |
Ser (Small and Weakly Polar) -> Pro (Proline) |
- |
| 2025 |
|
AQP8 |
rs149824781 |
NP_001160.2 - 191 (TM5) |
Helix - helix interface (TM2 - TM5) |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2026 |
|
AQP8 |
rs767842771 |
NP_001160.2 - 191 (TM5) |
Helix - helix interface (TM2 - TM5) |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2027 |
|
AQP8 |
rs1380716075 |
NP_001160.2 - 192 (TM5) |
Monomer - monomer interface |
Phe (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 2028 |
|
AQP8 |
rs752909014 |
NP_001160.2 - 193 (TM5) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Pro (Proline) |
- |
| 2029 |
|
AQP8 |
rs373200224 |
NP_001160.2 - 194 (TM5) |
Channel facing |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2030 |
|
AQP8 |
rs749345455 |
NP_001160.2 - 194 (TM5) |
Channel facing |
Val (Aliphatic hydrophobic) -> Asp (Charged) |
- |
| 2031 |
|
AQP8 |
rs749345455 |
NP_001160.2 - 194 (TM5) |
Channel facing |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 2032 |
|
AQP8 |
rs780681553 |
NP_001160.2 - 196 (TM5) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 2033 |
|
AQP8 |
rs746224474 |
NP_001160.2 - 197 (TM5) |
Helix - helix interface (TM4 - TM5) |
Asp (Charged) -> Tyr (Aromatic) |
- |
| 2034 |
|
AQP8 |
rs772482279 |
NP_001160.2 - 198 (TM5 - Ar/R Selectivity filter) |
Channel facing;Helix - helix interface (TM2 - TM5) |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 2035 |
|
AQP8 |
rs915179635 |
NP_001160.2 - 198 (TM5 - Ar/R Selectivity filter) |
Channel facing;Helix - helix interface (TM2 - TM5) |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2036 |
|
AQP8 |
rs368371709 |
NP_001160.2 - 200 (TM5) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2037 |
|
AQP8 |
rs1346598332 |
NP_001160.2 - 200 (TM5) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 2038 |
|
AQP8 |
rs765943236 |
NP_001160.2 - 206 (Loop region after TM5) |
Loop E |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2039 |
|
AQP8 |
rs779376629 |
NP_001160.2 - 206 (Loop region after TM5) |
Loop E |
Gly (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 2040 |
|
AQP8 |
rs1334576135 |
NP_001160.2 - 209 (Loop region after TM5) |
Loop E |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2041 |
|
AQP8 |
rs117255669 |
NP_001160.2 - 212 (LE - NPA2) |
Helix - helix interface (LB - LE, TM3 - LE) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2042 |
|
AQP8 |
rs747355466 |
NP_001160.2 - 212 (LE - NPA2) |
Helix - helix interface (LB - LE, TM3 - LE) |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 2043 |
|
AQP8 |
rs149003356 |
NP_001160.2 - 213 (LE - Ar/R Selectivity filter) |
Channel facing |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 2044 |
|
AQP8 |
rs780774514 |
NP_001160.2 - 213 (LE - Ar/R Selectivity filter) |
Channel facing |
Arg (Charged) -> His (Charged) |
- |
| 2045 |
|
AQP8 |
rs780774514 |
NP_001160.2 - 213 (LE - Ar/R Selectivity filter) |
Channel facing |
Arg (Charged) -> Pro (Proline) |
- |
| 2046 |
|
AQP8 |
rs747650236 |
NP_001160.2 - 214 (LE) |
Helix - helix interface (LE - TM6) |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 2047 |
|
AQP8 |
rs536376309 |
NP_001160.2 - 216 (LE) |
Helix - helix interface (TM3 - LE) |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2048 |
|
AQP8 |
rs1166780016 |
NP_001160.2 - 217 (LE) |
Helix - helix interface (TM3 - LE) |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 2049 |
|
AQP8 |
rs762948461 |
NP_001160.2 - 218 (LE) |
Exposed to the extracellular environment |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2050 |
|
AQP8 |
rs1242171768 |
NP_001160.2 - 219 (LE) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 2051 |
|
AQP8 |
rs1441098097 |
NP_001160.2 - 219 (LE) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Gly (Small and Weakly Polar) |
- |
| 2052 |
|
AQP8 |
rs1196958052 |
NP_001160.2 - 221 (Loop region after LE) |
Loop E |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2053 |
|
AQP8 |
rs1289570577 |
NP_001160.2 - 222 (Loop region after LE) |
Loop E |
Asn (Neutral polar) -> Lys (Charged) |
- |
| 2054 |
|
AQP8 |
rs1490123183 |
NP_001160.2 - 223 (Loop region after LE) |
Loop E |
His (Charged) -> Leu (Aliphatic hydrophobic) |
- |
| 2055 |
|
AQP8 |
rs774170496 |
NP_001160.2 - 226 (Loop region after LE) |
Loop E |
Phe (Aromatic) -> Val (Aliphatic hydrophobic) |
- |
| 2056 |
|
AQP8 |
rs759285705 |
NP_001160.2 - 228 (Loop region after LE) |
Loop E |
Trp (Aromatic) -> Gly (Small and Weakly Polar) |
- |
| 2057 |
|
AQP8 |
rs764371026 |
NP_001160.2 - 229 (TM6) |
Helix - helix interface (TM4 - TM6) |
Ile (Aliphatic hydrophobic) -> Asn (Neutral polar) |
- |
| 2058 |
|
AQP8 |
rs1238200436 |
NP_001160.2 - 230 (TM6) |
Helix - helix interface (TM4 - LE) |
Tyr (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 2059 |
|
AQP8 |
rs754114408 |
NP_001160.2 - 233 (TM6) |
Helix - helix interface (TM4 - TM6) |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2060 |
|
AQP8 |
rs754114408 |
NP_001160.2 - 233 (TM6) |
Helix - helix interface (TM4 - TM6) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2061 |
|
AQP8 |
rs765231883 |
NP_001160.2 - 235 (TM6) |
Helix - helix interface (LB - TM6); Lipid facing |
Leu (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2062 |
|
AQP8 |
rs750533191 |
NP_001160.2 - 238 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6) |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2063 |
|
AQP8 |
rs1024664518 |
NP_001160.2 - 238 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6) |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2064 |
|
AQP8 |
rs1165858889 |
NP_001160.2 - 241 (TM6) |
Helix - helix interface (TM4 - TM6) |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 2065 |
|
AQP8 |
rs577380139 |
NP_001160.2 - 246 (TM6) |
Channel facing |
Arg (Charged) -> Ser (Small and Weakly Polar) |
- |
| 2066 |
|
AQP8 |
rs1290510554 |
NP_001160.2 - 246 (TM6) |
Lipid facing |
Arg (Charged) -> Met (Aliphatic hydrophobic) |
- |
| 2067 |
|
AQP8 |
rs189576343 |
NP_001160.2 - 249 (TM6) |
Lipid facing |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2068 |
|
AQP8 |
rs996399426 |
NP_001160.2 - 249 (TM6) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2069 |
|
AQP8 |
rs1212661379 |
NP_001160.2 - 251 (C terminus) |
C terminal domain |
Asp (Charged) -> His (Charged) |
- |
| 2070 |
|
AQP8 |
rs1332468546 |
NP_001160.2 - 252 (C terminus) |
C terminal domain |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2071 |
|
AQP8 |
rs777604685 |
NP_001160.2 - 254 (C terminus) |
C terminal domain |
Thr (Small and Weakly Polar) -> Pro (Proline) |
- |
| 2072 |
|
AQP8 |
rs1269782807 |
NP_001160.2 - 254 (C terminus) |
C terminal domain |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 2073 |
|
AQP8 |
rs893041946 |
NP_001160.2 - 255 (C terminus) |
C terminal domain |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 2074 |
|
AQP8 |
rs1261923666 |
NP_001160.2 - 255 (C terminus) |
C terminal domain |
Arg (Charged) -> His (Charged) |
- |
| 2075 |
|
AQP8 |
rs2287798 |
NP_001160.2 - 260 (C terminus) |
C terminal domain |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2076 |
|
AQP8 |
rs2287798 |
NP_001160.2 - 260 (C terminus) |
C terminal domain |
Ala (Small and Weakly Polar) -> Pro (Proline) |
- |
| 2077 |
|
AQP8 |
rs2287798 |
NP_001160.2 - 260 (C terminus) |
C terminal domain |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2078 |
|
AQP8 |
rs778496185 |
NP_001160.2 - 260 (C terminus) |
C terminal domain |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2079 |
|
AQP8 |
rs111840156 |
NP_001160.2 - 261 (C terminus) |
C terminal domain |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 2080 |
|
AQP8 |
rs370284365 |
NP_001160.2 - 261 (C terminus) |
C terminal domain |
Arg (Charged) -> Trp (Aromatic) |
- |
| 2081 |
|
AQP9 |
rs542588358 |
NP_066190.2 - 6 (N terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2082 |
|
AQP9 |
rs1246475046 |
NP_066190.2 - 8 (N terminus) |
Absent in the structure |
Lys (Charged) -> Asn (Neutral polar) |
- |
| 2083 |
|
AQP9 |
rs1303079140 |
NP_066190.2 - 8 (N terminus) |
Absent in the structure |
Lys (Charged) -> Arg (Charged) |
- |
| 2084 |
|
AQP9 |
rs150714814 |
NP_066190.2 - 9 (N terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2085 |
|
AQP9 |
rs1389846412 |
NP_066190.2 - 10 (N terminus) |
Absent in the structure |
Lys (Charged) -> Glu (Charged) |
- |
| 2086 |
|
AQP9 |
rs752868547 |
NP_066190.2 - 11 (N terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 2087 |
|
AQP9 |
rs1467238345 |
NP_066190.2 - 11 (N terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 2088 |
|
AQP9 |
rs375764372 |
NP_066190.2 - 15 (N terminus) |
Absent in the structure |
Arg (Charged) -> Lys (Charged) |
- |
| 2089 |
|
AQP9 |
rs1259505160 |
NP_066190.2 - 16 (N terminus) |
Exposed to cytoplasm |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 2090 |
|
AQP9 |
rs756348851 |
NP_066190.2 - 17 (TM1) |
Exposed to cytoplasm |
Val (Aliphatic hydrophobic) -> Asp (Charged) |
- |
| 2091 |
|
AQP9 |
rs756348851 |
NP_066190.2 - 17 (TM1) |
Exposed to cytoplasm |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 2092 |
|
AQP9 |
rs780293096 |
NP_066190.2 - 22 (TM1) |
Helix - helix interface (TM1 - TM3) |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2093 |
|
AQP9 |
rs192641731 |
NP_066190.2 - 23 (TM1) |
Lipid facing |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 2094 |
|
AQP9 |
rs192641731 |
NP_066190.2 - 23 (TM1) |
Lipid facing |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2095 |
|
AQP9 |
rs757843275 |
NP_066190.2 - 26 (TM1) |
Helix - helix interface (TM1 - TM3) |
Thr (Small and Weakly Polar) -> Asn (Neutral polar) |
- |
| 2096 |
|
AQP9 |
rs145699280 |
NP_066190.2 - 27 (TM1) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 2097 |
|
AQP9 |
rs370409793 |
NP_066190.2 - 27 (TM1) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2098 |
|
AQP9 |
rs370409793 |
NP_066190.2 - 27 (TM1) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2099 |
|
AQP9 |
rs772510173 |
NP_066190.2 - 29 (TM1) |
Helix - helix interface (TM1 - TM2, TM1 - TM3) |
Glu (Charged) -> Asp (Charged) |
- |
| 2100 |
|
AQP9 |
rs772510173 |
NP_066190.2 - 29 (TM1) |
Helix - helix interface (TM1 - TM2, TM1 - TM3) |
Glu (Charged) -> Asp (Charged) |
- |
| 2101 |
|
AQP9 |
rs1162878848 |
NP_066190.2 - 29 (TM1) |
Helix - helix interface (TM1 - TM2, TM1 - TM3) |
Glu (Charged) -> Gln (Neutral polar) |
- |
| 2102 |
|
AQP9 |
rs768398839 |
NP_066190.2 - 30 (TM1) |
Helix - helix interface (TM1 - TM3); Lipid facing |
Phe (Aromatic) -> Ile (Aliphatic hydrophobic) |
- |
| 2103 |
|
AQP9 |
rs768398839 |
NP_066190.2 - 30 (TM1) |
Helix - helix interface (TM1 - TM3); Lipid facing |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 2104 |
|
AQP9 |
rs768398839 |
NP_066190.2 - 30 (TM1) |
Helix - helix interface (TM1 - TM3); Lipid facing |
Phe (Aromatic) -> Val (Aliphatic hydrophobic) |
- |
| 2105 |
|
AQP9 |
rs374114909 |
NP_066190.2 - 31 (TM1) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2106 |
|
AQP9 |
rs755358483 |
NP_066190.2 - 33 (TM1) |
Helix - helix interface (TM1 - TM3) |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 2107 |
|
AQP9 |
rs1313232545 |
NP_066190.2 - 34 (TM1) |
Helix - helix interface (TM1 - TM3) |
Phe (Aromatic) -> Val (Aliphatic hydrophobic) |
- |
| 2108 |
|
AQP9 |
rs1354423975 |
NP_066190.2 - 34 (TM1) |
Helix - helix interface (TM1 - TM3) |
Phe (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 2109 |
|
AQP9 |
rs762758578 |
NP_066190.2 - 35 (TM1) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2110 |
|
AQP9 |
rs766123835 |
NP_066190.2 - 35 (TM1) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 2111 |
|
AQP9 |
rs1279511159 |
NP_066190.2 - 35 (TM1) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2112 |
|
AQP9 |
rs1228740558 |
NP_066190.2 - 36 (TM1) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Leu (Aliphatic hydrophobic) -> Ser (Small and Weakly Polar) |
- |
| 2113 |
|
AQP9 |
rs749264809 |
NP_066190.2 - 38 (TM1) |
Helix - helix interface (TM1 - TM3);Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 2114 |
|
AQP9 |
rs553727841 |
NP_066190.2 - 40 (TM1) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 2115 |
|
AQP9 |
rs553727841 |
NP_066190.2 - 40 (TM1) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2116 |
|
AQP9 |
rs915261825 |
NP_066190.2 - 42 (TM1) |
Monomer - monomer interface;Helix - helix interface (TM1 - TM3) |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2117 |
|
AQP9 |
rs1260380235 |
NP_066190.2 - 42 (TM1) |
Monomer - monomer interface;Helix - helix interface (TM1 - TM3) |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2118 |
|
AQP9 |
rs77284866 |
NP_066190.2 - 43 (TM1) |
Monomer - monomer interface;Helix - helix interface (TM1 - TM2) |
Cys (Small and Weakly Polar) -> Trp (Aromatic) |
- |
| 2119 |
|
AQP9 |
rs776663420 |
NP_066190.2 - 44 (TM1) |
Channel facing |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 2120 |
|
AQP9 |
rs776663420 |
NP_066190.2 - 44 (TM1) |
Channel facing |
Val (Aliphatic hydrophobic) -> Gly (Small and Weakly Polar) |
- |
| 2121 |
|
AQP9 |
rs1219835683 |
NP_066190.2 - 44 (TM1) |
Channel facing |
Val (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2122 |
|
AQP9 |
rs761978670 |
NP_066190.2 - 46 (TM1) |
Monomer - monomer interface |
Gln (Neutral polar) -> Arg (Charged) |
- |
| 2123 |
|
AQP9 |
rs1317811588 |
NP_066190.2 - 48 (TM1) |
Channel facing |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2124 |
|
AQP9 |
rs1360755742 |
NP_066190.2 - 49 (TM1) |
Exposed to the extracellular environment |
Leu (Aliphatic hydrophobic) -> His (Charged) |
- |
| 2125 |
|
AQP9 |
rs758705317 |
NP_066190.2 - 50 (Loop region after TM1) |
Loop A |
Ser (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 2126 |
|
AQP9 |
rs751975709 |
NP_066190.2 - 51 (Loop region after TM1) |
Loop A |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 2127 |
|
AQP9 |
rs751975709 |
NP_066190.2 - 51 (Loop region after TM1) |
Loop A |
Arg (Charged) -> Pro (Proline) |
- |
| 2128 |
|
AQP9 |
rs755335239 |
NP_066190.2 - 52 (Loop region after TM1) |
Loop A |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2129 |
|
AQP9 |
rs147206102 |
NP_066190.2 - 53 (Loop region after TM1) |
Loop A |
Arg (Charged) -> His (Charged) |
- |
| 2130 |
|
AQP9 |
rs1042353446 |
NP_066190.2 - 53 (Loop region after TM1) |
Loop A |
Arg (Charged) -> Gly (Small and Weakly Polar) |
- |
| 2131 |
|
AQP9 |
rs1042353446 |
NP_066190.2 - 53 (Loop region after TM1) |
Loop A |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 2132 |
|
AQP9 |
rs140513412 |
NP_066190.2 - 55 (Loop region after TM1) |
Loop A |
Gly (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 2133 |
|
AQP9 |
rs1422787892 |
NP_066190.2 - 55 (Loop region after TM1) |
Loop A |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2134 |
|
AQP9 |
rs748783905 |
NP_066190.2 - 56 (Loop region after TM1) |
Loop A |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2135 |
|
AQP9 |
rs1479009132 |
NP_066190.2 - 57 (TM2) |
Helix - helix interface (TM2 - TM5) |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 2136 |
|
AQP9 |
rs201633890 |
NP_066190.2 - 59 (TM2) |
Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 2137 |
|
AQP9 |
rs778758728 |
NP_066190.2 - 59 (TM2) |
Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 2138 |
|
AQP9 |
rs1452564766 |
NP_066190.2 - 60 (TM2) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2139 |
|
AQP9 |
rs776947032 |
NP_066190.2 - 61 (TM2) |
Helix - helix interface (TM2 - TM5) |
Asn (Neutral polar) -> Ile (Aliphatic hydrophobic) |
- |
| 2140 |
|
AQP9 |
rs1180276406 |
NP_066190.2 - 61 (TM2) |
Helix - helix interface (TM2 - TM5) |
Asn (Neutral polar) -> Asp (Charged) |
- |
| 2141 |
|
AQP9 |
rs939599134 |
NP_066190.2 - 62 (TM2) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2142 |
|
AQP9 |
rs1199618548 |
NP_066190.2 - 62 (TM2) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 2143 |
|
AQP9 |
rs750086347 |
NP_066190.2 - 63 (TM2) |
Helix - helix interface (TM2 - TM1);Monomer - monomer interface |
Gly (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 2144 |
|
AQP9 |
rs1156528283 |
NP_066190.2 - 65 (TM2) |
Helix - helix interface (TM2 - TM5) |
Ser (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 2145 |
|
AQP9 |
rs761985517 |
NP_066190.2 - 66 (TM2) |
Monomer - monomer interface |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2146 |
|
AQP9 |
rs770039963 |
NP_066190.2 - 66 (TM2) |
Monomer - monomer interface |
Met (Aliphatic hydrophobic) -> Lys (Charged) |
- |
| 2147 |
|
AQP9 |
rs1327097703 |
NP_066190.2 - 68 (TM2) |
Channel facing |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 2148 |
|
AQP9 |
rs773489828 |
NP_066190.2 - 69 (TM2) |
Helix - helix interface (TM2 - TM5) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2149 |
|
AQP9 |
rs763056632 |
NP_066190.2 - 72 (TM2) |
Channel facing;Helix - helix interface (TM2 - TM5) |
Ile (Aliphatic hydrophobic) -> Ser (Small and Weakly Polar) |
- |
| 2150 |
|
AQP9 |
rs767004480 |
NP_066190.2 - 73 (TM2) |
Monomer - monomer interface |
Tyr (Aromatic) -> Asp (Charged) |
- |
| 2151 |
|
AQP9 |
rs752063676 |
NP_066190.2 - 75 (TM2) |
Helix - helix interface (TM1 - TM2);Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2152 |
|
AQP9 |
rs567455344 |
NP_066190.2 - 76 (Loop region after TM2) |
Loop B |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2153 |
|
AQP9 |
rs536480649 |
NP_066190.2 - 77 (Loop region after TM2) |
Loop B |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2154 |
|
AQP9 |
rs536480649 |
NP_066190.2 - 77 (Loop region after TM2) |
Loop B |
Gly (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 2155 |
|
AQP9 |
rs1272699689 |
NP_066190.2 - 77 (Loop region after TM2) |
Loop B |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2156 |
|
AQP9 |
rs753071847 |
NP_066190.2 - 80 (Loop region after TM2) |
Loop B |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 2157 |
|
AQP9 |
rs753071847 |
NP_066190.2 - 80 (Loop region after TM2) |
Loop B |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2158 |
|
AQP9 |
rs763752290 |
NP_066190.2 - 81 (Loop region after TM2) |
Loop B |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 2159 |
|
AQP9 |
rs763752290 |
NP_066190.2 - 81 (Loop region after TM2) |
Loop B |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2160 |
|
AQP9 |
rs1475094763 |
NP_066190.2 - 82 (Loop region after TM2) |
Loop B |
His (Charged) -> Leu (Aliphatic hydrophobic) |
- |
| 2161 |
|
AQP9 |
rs756795091 |
NP_066190.2 - 83 (Loop region after TM2) |
Loop B |
Ile (Aliphatic hydrophobic) -> Asn (Neutral polar) |
- |
| 2162 |
|
AQP9 |
rs374762465 |
NP_066190.2 - 84 (LB - NPA1) |
Channel facing;Helix - helix interface (LB - LE, LB - TM3) |
Asn (Neutral polar) -> Asp (Charged) |
- |
| 2163 |
|
AQP9 |
rs1353569814 |
NP_066190.2 - 84 (LB - NPA1) |
Channel facing;Helix - helix interface (LB - LE, LB - TM3) |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 2164 |
|
AQP9 |
rs1353569814 |
NP_066190.2 - 84 (LB - NPA1) |
Channel facing;Helix - helix interface (LB - LE, LB - TM3) |
Asn (Neutral polar) -> Ile (Aliphatic hydrophobic) |
- |
| 2165 |
|
AQP9 |
rs528038229 |
NP_066190.2 - 87 (LB) |
Channel facing |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 2166 |
|
AQP9 |
rs1348749454 |
NP_066190.2 - 87 (LB) |
Channel facing |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 2167 |
|
AQP9 |
rs746791248 |
NP_066190.2 - 90 (LB) |
Helix - helix interface (LB - TM4, LB - TM6) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2168 |
|
AQP9 |
rs754752020 |
NP_066190.2 - 91 (LB) |
Channel facing |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2169 |
|
AQP9 |
rs778171615 |
NP_066190.2 - 92 (LB) |
Helix - helix interface (LB - TM3); Lipid facing |
Cys (Small and Weakly Polar) -> Tyr (Aromatic) |
- |
| 2170 |
|
AQP9 |
rs1348362233 |
NP_066190.2 - 93 (LB) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 2171 |
|
AQP9 |
rs771256450 |
NP_066190.2 - 95 (Loop region after LB) |
Loop B |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2172 |
|
AQP9 |
rs200266534 |
NP_066190.2 - 96 (Loop region after LB) |
Loop B |
Arg (Charged) -> Trp (Aromatic) |
- |
| 2173 |
|
AQP9 |
rs745957752 |
NP_066190.2 - 96 (Loop region after LB) |
Loop B |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 2174 |
|
AQP9 |
rs1271031404 |
NP_066190.2 - 98 (Loop region after LB) |
Loop B |
Lys (Charged) -> Glu (Charged) |
- |
| 2175 |
|
AQP9 |
rs200885186 |
NP_066190.2 - 99 (Loop region after LB) |
Loop B |
Trp (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 2176 |
|
AQP9 |
rs200885186 |
NP_066190.2 - 99 (Loop region after LB) |
Loop B |
Trp (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 2177 |
|
AQP9 |
rs776009788 |
NP_066190.2 - 101 (TM3) |
Channel facing |
Lys (Charged) -> Thr (Small and Weakly Polar) |
- |
| 2178 |
|
AQP9 |
rs367800620 |
NP_066190.2 - 102 (TM3) |
Helix - helix interface (LB - TM3) |
Leu (Aliphatic hydrophobic) -> Ser (Small and Weakly Polar) |
- |
| 2179 |
|
AQP9 |
rs764405170 |
NP_066190.2 - 103 (TM3) |
Lipid facing |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 2180 |
|
AQP9 |
rs761507848 |
NP_066190.2 - 105 (TM3) |
Helix - helix interface (TM1 - TM3, LB - TM3) |
Tyr (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 2181 |
|
AQP9 |
rs776953557 |
NP_066190.2 - 105 (TM3) |
Helix - helix interface (TM1 - TM3, LB - TM3) |
Tyr (Aromatic) -> Asn (Neutral polar) |
- |
| 2182 |
|
AQP9 |
rs1263690442 |
NP_066190.2 - 106 (TM3) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 2183 |
|
AQP9 |
rs764860980 |
NP_066190.2 - 107 (TM3) |
Lipid facing |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 2184 |
|
AQP9 |
rs1019361883 |
NP_066190.2 - 108 (TM3) |
Helix - helix interface (TM1 - TM3) |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2185 |
|
AQP9 |
rs1325952020 |
NP_066190.2 - 109 (TM3) |
Helix - helix interface (TM1 - TM3, LB - TM3, TM3 - LE) |
Gln (Neutral polar) -> Pro (Proline) |
- |
| 2186 |
|
AQP9 |
rs1428502898 |
NP_066190.2 - 109 (TM3) |
Helix - helix interface (TM1 - TM3, LB - TM3, TM3 - LE) |
Gln (Neutral polar) -> His (Charged) |
- |
| 2187 |
|
AQP9 |
rs757863863 |
NP_066190.2 - 110 (TM3) |
Lipid facing;Helix - helix interface (TM3 - LE) |
Phe (Aromatic) -> Tyr (Aromatic) |
- |
| 2188 |
|
AQP9 |
rs757863863 |
NP_066190.2 - 110 (TM3) |
Lipid facing;Helix - helix interface (TM3 - LE) |
Phe (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 2189 |
|
AQP9 |
rs1277771462 |
NP_066190.2 - 111 (TM3) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2190 |
|
AQP9 |
rs1319422024 |
NP_066190.2 - 111 (TM3) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2191 |
|
AQP9 |
rs769090915 |
NP_066190.2 - 112 (TM3) |
Helix - helix interface (TM1 - TM3) |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 2192 |
|
AQP9 |
rs1217237468 |
NP_066190.2 - 113 (TM3) |
Helix - helix interface (TM1 - TM3, TM3 - LE) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2193 |
|
AQP9 |
rs1278001887 |
NP_066190.2 - 113 (TM3) |
Helix - helix interface (TM1 - TM3, TM3 - LE) |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 2194 |
|
AQP9 |
rs781181323 |
NP_066190.2 - 116 (TM3) |
Helix - helix interface (TM1 - TM3) |
Gly (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 2195 |
|
AQP9 |
rs1444815089 |
NP_066190.2 - 116 (TM3) |
Helix - helix interface (TM1 - TM3) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2196 |
|
AQP9 |
rs747944362 |
NP_066190.2 - 117 (TM3) |
Helix - helix interface (TM1 - TM3, TM3 - LE) |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 2197 |
|
AQP9 |
rs530320852 |
NP_066190.2 - 118 (TM3) |
Lipid facing |
Ala (Small and Weakly Polar) -> Glu (Charged) |
- |
| 2198 |
|
AQP9 |
rs530320852 |
NP_066190.2 - 118 (TM3) |
Lipid facing |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2199 |
|
AQP9 |
rs200107166 |
NP_066190.2 - 120 (TM3) |
Helix - helix interface (TM1 - TM3) |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2200 |
|
AQP9 |
rs200107166 |
NP_066190.2 - 120 (TM3) |
Helix - helix interface (TM1 - TM3) |
Val (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2201 |
|
AQP9 |
rs747595564 |
NP_066190.2 - 123 (TM3) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2202 |
|
AQP9 |
rs1159395036 |
NP_066190.2 - 123 (TM3) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 2203 |
|
AQP9 |
rs769134578 |
NP_066190.2 - 124 (Loop region after TM3) |
Loop C |
Tyr (Aromatic) -> His (Charged) |
- |
| 2204 |
|
AQP9 |
rs769134578 |
NP_066190.2 - 124 (Loop region after TM3) |
Loop C |
Tyr (Aromatic) -> Asp (Charged) |
- |
| 2205 |
|
AQP9 |
rs1463889319 |
NP_066190.2 - 125 (Loop region after TM3) |
Loop C |
Tyr (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 2206 |
|
AQP9 |
rs151034568 |
NP_066190.2 - 126 (Loop region after TM3) |
Loop C |
Asp (Charged) -> Gly (Small and Weakly Polar) |
- |
| 2207 |
|
AQP9 |
rs760583398 |
NP_066190.2 - 127 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2208 |
|
AQP9 |
rs763977707 |
NP_066190.2 - 127 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 2209 |
|
AQP9 |
rs1196740878 |
NP_066190.2 - 128 (Loop region after TM3) |
Loop C |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2210 |
|
AQP9 |
rs1453852901 |
NP_066190.2 - 129 (Loop region after TM3) |
Loop C |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2211 |
|
AQP9 |
rs1250304680 |
NP_066190.2 - 130 (Loop region after TM3) |
Loop C |
Ser (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2212 |
|
AQP9 |
rs758655755 |
NP_066190.2 - 131 (Loop region after TM3) |
Loop C |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 2213 |
|
AQP9 |
rs1474924571 |
NP_066190.2 - 137 (Loop region after TM3) |
Loop C |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 2214 |
|
AQP9 |
rs1474924571 |
NP_066190.2 - 137 (Loop region after TM3) |
Loop C |
Leu (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 2215 |
|
AQP9 |
rs367676440 |
NP_066190.2 - 139 (Loop region after TM3) |
Loop C |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 2216 |
|
AQP9 |
rs367676440 |
NP_066190.2 - 139 (Loop region after TM3) |
Loop C |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 2217 |
|
AQP9 |
rs984474458 |
NP_066190.2 - 140 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 2218 |
|
AQP9 |
rs984474458 |
NP_066190.2 - 140 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2219 |
|
AQP9 |
rs770151820 |
NP_066190.2 - 143 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Glu (Charged) |
- |
| 2220 |
|
AQP9 |
rs373851179 |
NP_066190.2 - 144 (Loop region after TM3) |
Loop C |
Thr (Small and Weakly Polar) -> Pro (Proline) |
- |
| 2221 |
|
AQP9 |
rs1416194251 |
NP_066190.2 - 145 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Pro (Proline) |
- |
| 2222 |
|
AQP9 |
rs201502001 |
NP_066190.2 - 146 (Loop region after TM3) |
Loop C |
His (Charged) -> Arg (Charged) |
- |
| 2223 |
|
AQP9 |
rs767673037 |
NP_066190.2 - 146 (Loop region after TM3) |
Loop C |
His (Charged) -> Asn (Neutral polar) |
- |
| 2224 |
|
AQP9 |
rs767673037 |
NP_066190.2 - 146 (Loop region after TM3) |
Loop C |
His (Charged) -> Asp (Charged) |
- |
| 2225 |
|
AQP9 |
rs767673037 |
NP_066190.2 - 146 (Loop region after TM3) |
Loop C |
His (Charged) -> Tyr (Aromatic) |
- |
| 2226 |
|
AQP9 |
rs1412366458 |
NP_066190.2 - 148 (Loop region after TM3) |
Loop C |
Phe (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 2227 |
|
AQP9 |
rs1309747190 |
NP_066190.2 - 151 (Loop region after TM3) |
Loop C |
Tyr (Aromatic) -> Asn (Neutral polar) |
- |
| 2228 |
|
AQP9 |
rs759164964 |
NP_066190.2 - 152 (Loop region after TM3) |
Loop C |
Pro (Proline) -> Arg (Charged) |
- |
| 2229 |
|
AQP9 |
rs923172328 |
NP_066190.2 - 153 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2230 |
|
AQP9 |
rs145164884 |
NP_066190.2 - 154 (Loop region after TM3) |
Loop C |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 2231 |
|
AQP9 |
rs760708162 |
NP_066190.2 - 154 (Loop region after TM3) |
Loop C |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 2232 |
|
AQP9 |
rs146866709 |
NP_066190.2 - 159 (TM4) |
Lipid facing |
Ala (Small and Weakly Polar) -> Glu (Charged) |
- |
| 2233 |
|
AQP9 |
rs146866709 |
NP_066190.2 - 159 (TM4) |
Lipid facing |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2234 |
|
AQP9 |
rs562183896 |
NP_066190.2 - 160 (TM4) |
Lipid facing |
Asn (Neutral polar) -> Lys (Charged) |
- |
| 2235 |
|
AQP9 |
rs752717219 |
NP_066190.2 - 161 (TM4) |
Helix - helix interface (TM4 - TM5) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2236 |
|
AQP9 |
rs752717219 |
NP_066190.2 - 161 (TM4) |
Helix - helix interface (TM4 - TM5) |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2237 |
|
AQP9 |
rs756649939 |
NP_066190.2 - 161 (TM4) |
Helix - helix interface (TM4 - TM5) |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 2238 |
|
AQP9 |
rs530907694 |
NP_066190.2 - 162 (TM4) |
Lipid facing;Helix - helix interface (TM4 - TM6) |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 2239 |
|
AQP9 |
rs530907694 |
NP_066190.2 - 162 (TM4) |
Lipid facing;Helix - helix interface (TM4 - TM6) |
Phe (Aromatic) -> Val (Aliphatic hydrophobic) |
- |
| 2240 |
|
AQP9 |
rs757538160 |
NP_066190.2 - 163 (TM4) |
Lipid facing |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2241 |
|
AQP9 |
rs1290092973 |
NP_066190.2 - 164 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Asp (Charged) -> His (Charged) |
- |
| 2242 |
|
AQP9 |
rs891820591 |
NP_066190.2 - 165 (TM4) |
Helix - helix interface (TM4 - TM5, TM4 - TM6) |
Gln (Neutral polar) -> Pro (Proline) |
- |
| 2243 |
|
AQP9 |
rs150448699 |
NP_066190.2 - 166 (TM4) |
Helix - helix interface (TM4 - TM6) |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 2244 |
|
AQP9 |
rs1408250734 |
NP_066190.2 - 167 (TM4) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 2245 |
|
AQP9 |
rs753424515 |
NP_066190.2 - 168 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2246 |
|
AQP9 |
rs768023705 |
NP_066190.2 - 170 (TM4) |
Helix - helix interface (TM4 - TM6);Monomer - monomer interface |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2247 |
|
AQP9 |
rs1463433764 |
NP_066190.2 - 170 (TM4) |
Helix - helix interface (TM4 - TM6);Monomer - monomer interface |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2248 |
|
AQP9 |
rs754639376 |
NP_066190.2 - 171 (TM4) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 2249 |
|
AQP9 |
rs748060438 |
NP_066190.2 - 172 (TM4) |
Channel facing;Helix - helix interface (LB - TM4, TM4 - TM5) |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2250 |
|
AQP9 |
rs200634549 |
NP_066190.2 - 175 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2251 |
|
AQP9 |
rs142159680 |
NP_066190.2 - 176 (TM4) |
Channel facing |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2252 |
|
AQP9 |
rs1286479256 |
NP_066190.2 - 176 (TM4) |
Channel facing |
Val (Aliphatic hydrophobic) -> Asp (Charged) |
- |
| 2253 |
|
AQP9 |
rs199688809 |
NP_066190.2 - 178 (TM4) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2254 |
|
AQP9 |
rs149268817 |
NP_066190.2 - 179 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2255 |
|
AQP9 |
rs1400358665 |
NP_066190.2 - 180 (TM4) |
Channel facing |
Phe (Aromatic) -> Ile (Aliphatic hydrophobic) |
- |
| 2256 |
|
AQP9 |
rs760847449 |
NP_066190.2 - 181 (Loop region after TM4) |
Loop D |
Asp (Charged) -> Tyr (Aromatic) |
- |
| 2257 |
|
AQP9 |
rs568079867 |
NP_066190.2 - 182 (Loop region after TM4) |
Loop D |
Ser (Small and Weakly Polar) -> Tyr (Aromatic) |
- |
| 2258 |
|
AQP9 |
rs1319918129 |
NP_066190.2 - 184 (Loop region after TM4) |
Loop D |
Asn (Neutral polar) -> Lys (Charged) |
- |
| 2259 |
|
AQP9 |
rs1028882622 |
NP_066190.2 - 185 (Loop region after TM4) |
Loop D |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2260 |
|
AQP9 |
rs1180692615 |
NP_066190.2 - 186 (Loop region after TM4) |
Loop D |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 2261 |
|
AQP9 |
rs17848098 |
NP_066190.2 - 187 (Loop region after TM4) |
Loop D |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 2262 |
|
AQP9 |
rs17848098 |
NP_066190.2 - 187 (Loop region after TM4) |
Loop D |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 2263 |
|
AQP9 |
rs17848098 |
NP_066190.2 - 187 (Loop region after TM4) |
Loop D |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2264 |
|
AQP9 |
rs765768471 |
NP_066190.2 - 189 (Loop region after TM4) |
Loop D |
Arg (Charged) -> Lys (Charged) |
- |
| 2265 |
|
AQP9 |
rs750880003 |
NP_066190.2 - 190 (Loop region after TM4) |
Loop D |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2266 |
|
AQP9 |
rs375430625 |
NP_066190.2 - 192 (TM5) |
Helix - helix interface (TM4 - TM5) |
Glu (Charged) -> Gln (Neutral polar) |
- |
| 2267 |
|
AQP9 |
rs1413695615 |
NP_066190.2 - 193 (TM5) |
Helix - helix interface (TM2 - TM5) |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 2268 |
|
AQP9 |
rs530834755 |
NP_066190.2 - 194 (TM5) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2269 |
|
AQP9 |
rs530834755 |
NP_066190.2 - 194 (TM5) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2270 |
|
AQP9 |
rs1172957356 |
NP_066190.2 - 194 (TM5) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2271 |
|
AQP9 |
rs1355503224 |
NP_066190.2 - 195 (TM5) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2272 |
|
AQP9 |
rs1441698338 |
NP_066190.2 - 195 (TM5) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2273 |
|
AQP9 |
rs201263790 |
NP_066190.2 - 196 (TM5) |
Channel facing;Helix - helix interface (TM4 - TM5) |
Ile (Aliphatic hydrophobic) -> Asn (Neutral polar) |
- |
| 2274 |
|
AQP9 |
rs201263790 |
NP_066190.2 - 196 (TM5) |
Channel facing;Helix - helix interface (TM4 - TM5) |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2275 |
|
AQP9 |
rs201263790 |
NP_066190.2 - 196 (TM5) |
Channel facing;Helix - helix interface (TM4 - TM5) |
Ile (Aliphatic hydrophobic) -> Ser (Small and Weakly Polar) |
- |
| 2276 |
|
AQP9 |
rs527316680 |
NP_066190.2 - 197 (TM5) |
Helix - helix interface (TM2 - TM5) |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2277 |
|
AQP9 |
rs770680734 |
NP_066190.2 - 197 (TM5) |
Helix - helix interface (TM2 - TM5) |
Gly (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 2278 |
|
AQP9 |
rs1446880521 |
NP_066190.2 - 198 (TM5) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 2279 |
|
AQP9 |
rs1306742680 |
NP_066190.2 - 200 (TM5) |
Channel facing |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 2280 |
|
AQP9 |
rs370563891 |
NP_066190.2 - 201 (TM5) |
Helix - helix interface (TM2 - TM5) |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2281 |
|
AQP9 |
rs1202508861 |
NP_066190.2 - 201 (TM5) |
Helix - helix interface (TM2 - TM5) |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 2282 |
|
AQP9 |
rs1226596750 |
NP_066190.2 - 201 (TM5) |
Helix - helix interface (TM2 - TM5) |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2283 |
|
AQP9 |
rs199569670 |
NP_066190.2 - 202 (TM5) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2284 |
|
AQP9 |
rs199569670 |
NP_066190.2 - 202 (TM5) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 2285 |
|
AQP9 |
rs1270853437 |
NP_066190.2 - 202 (TM5) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 2286 |
|
AQP9 |
rs761975633 |
NP_066190.2 - 203 (TM5) |
Helix - helix interface (TM4 - TM5) |
Ile (Aliphatic hydrophobic) -> Asn (Neutral polar) |
- |
| 2287 |
|
AQP9 |
rs761975633 |
NP_066190.2 - 203 (TM5) |
Helix - helix interface (TM4 - TM5) |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2288 |
|
AQP9 |
rs1485831256 |
NP_066190.2 - 203 (TM5) |
Helix - helix interface (TM4 - TM5) |
Ile (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2289 |
|
AQP9 |
rs1235290522 |
NP_066190.2 - 204 (TM5 - Ar/R Selectivity filter) |
Channel facing;Helix - helix interface (TM2 - TM5) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2290 |
|
AQP9 |
rs137909533 |
NP_066190.2 - 206 (Loop region after TM5) |
Loop E |
Ser (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 2291 |
|
AQP9 |
rs193153801 |
NP_066190.2 - 208 (Loop region after TM5) |
Loop E |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 2292 |
|
AQP9 |
rs193153801 |
NP_066190.2 - 208 (Loop region after TM5) |
Loop E |
Gly (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 2293 |
|
AQP9 |
rs1305241527 |
NP_066190.2 - 209 (Loop region after TM5) |
Loop E |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 2294 |
|
AQP9 |
rs866639794 |
NP_066190.2 - 211 (Loop region after TM5) |
Loop E |
Ser (Small and Weakly Polar) -> Asn (Neutral polar) |
- |
| 2295 |
|
AQP9 |
rs1167168400 |
NP_066190.2 - 212 (Loop region after TM5) |
Loop E |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2296 |
|
AQP9 |
rs1377500041 |
NP_066190.2 - 212 (Loop region after TM5) |
Loop E |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2297 |
|
AQP9 |
rs78314281 |
NP_066190.2 - 213 (Loop region after TM5 - Ar/R Selectivity filter) |
Loop E |
Cys (Small and Weakly Polar) -> Trp (Aromatic) |
- |
| 2298 |
|
AQP9 |
rs754593668 |
NP_066190.2 - 214 (Loop region after TM5) |
Loop E |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 2299 |
|
AQP9 |
rs1392220161 |
NP_066190.2 - 214 (Loop region after TM5) |
Loop E |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2300 |
|
AQP9 |
rs201050566 |
NP_066190.2 - 215 (Loop region after TM5) |
Loop E |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2301 |
|
AQP9 |
rs925690889 |
NP_066190.2 - 215 (Loop region after TM5) |
Loop E |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2302 |
|
AQP9 |
rs1163048673 |
NP_066190.2 - 215 (Loop region after TM5) |
Loop E |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2303 |
|
AQP9 |
rs564430904 |
NP_066190.2 - 216 (LE - NPA2) |
Channel facing;Helix - helix interface (TM1 - LE, LB - LE) |
Asn (Neutral polar) -> Lys (Charged) |
- |
| 2304 |
|
AQP9 |
rs1168012945 |
NP_066190.2 - 217 (LE - NPA2) |
Helix - helix interface (LB - LE, LE - TM6) |
Pro (Proline) -> Arg (Charged) |
- |
| 2305 |
|
AQP9 |
rs755597585 |
NP_066190.2 - 218 (LE - NPA2) |
Helix - helix interface (LB - LE, TM3 - LE) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2306 |
|
AQP9 |
rs147222240 |
NP_066190.2 - 219 (LE - Ar/R Selectivity filter) |
Channel facing |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 2307 |
|
AQP9 |
rs147222240 |
NP_066190.2 - 219 (LE - Ar/R Selectivity filter) |
Channel facing |
Arg (Charged) -> Pro (Proline) |
- |
| 2308 |
|
AQP9 |
rs868724333 |
NP_066190.2 - 223 (LE) |
Helix - helix interface (TM3 - LE) |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 2309 |
|
AQP9 |
rs749252837 |
NP_066190.2 - 224 (LE) |
Exposed to the extracellular environment |
Arg (Charged) -> Thr (Small and Weakly Polar) |
- |
| 2310 |
|
AQP9 |
rs374702384 |
NP_066190.2 - 226 (LE) |
Helix - helix interface (LE - TM3) |
Phe (Aromatic) -> Tyr (Aromatic) |
- |
| 2311 |
|
AQP9 |
rs374702384 |
NP_066190.2 - 226 (LE) |
Helix - helix interface (LE - TM3) |
Phe (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 2312 |
|
AQP9 |
rs1275845135 |
NP_066190.2 - 228 (LE) |
Exposed to the extracellular environment |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2313 |
|
AQP9 |
rs377352019 |
NP_066190.2 - 230 (LE) |
Exposed to the extracellular environment |
Ala (Small and Weakly Polar) -> Glu (Charged) |
- |
| 2314 |
|
AQP9 |
rs377352019 |
NP_066190.2 - 230 (LE) |
Exposed to the extracellular environment |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 2315 |
|
AQP9 |
rs988442926 |
NP_066190.2 - 231 (Loop region after LE) |
Loop E |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 2316 |
|
AQP9 |
rs988442926 |
NP_066190.2 - 231 (Loop region after LE) |
Loop E |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2317 |
|
AQP9 |
rs1384894589 |
NP_066190.2 - 231 (Loop region after LE) |
Loop E |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2318 |
|
AQP9 |
rs745606946 |
NP_066190.2 - 232 (Loop region after LE) |
Loop E |
Trp (Aromatic) -> Gly (Small and Weakly Polar) |
- |
| 2319 |
|
AQP9 |
rs1294548747 |
NP_066190.2 - 232 (Loop region after LE) |
Loop E |
Trp (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 2320 |
|
AQP9 |
rs748281967 |
NP_066190.2 - 235 (Loop region after LE) |
Loop E |
Glu (Charged) -> Gln (Neutral polar) |
- |
| 2321 |
|
AQP9 |
rs1187034240 |
NP_066190.2 - 237 (Loop region after LE) |
Loop E |
Phe (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 2322 |
|
AQP9 |
rs1187034240 |
NP_066190.2 - 237 (Loop region after LE) |
Loop E |
Phe (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 2323 |
|
AQP9 |
rs770029077 |
NP_066190.2 - 238 (Loop region after LE) |
Loop E |
Arg (Charged) -> Gly (Small and Weakly Polar) |
- |
| 2324 |
|
AQP9 |
rs773379575 |
NP_066190.2 - 238 (Loop region after LE) |
Loop E |
Arg (Charged) -> Lys (Charged) |
- |
| 2325 |
|
AQP9 |
rs1336191253 |
NP_066190.2 - 240 (Loop region after LE) |
Loop E |
Gly (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 2326 |
|
AQP9 |
rs1209616525 |
NP_066190.2 - 242 (Loop region after LE) |
Loop E |
Asn (Neutral polar) -> Lys (Charged) |
- |
| 2327 |
|
AQP9 |
rs1265764745 |
NP_066190.2 - 244 (Loop region after LE) |
Loop E |
Trp (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 2328 |
|
AQP9 |
rs1439722664 |
NP_066190.2 - 245 (TM6) |
Lipid facing |
Trp (Aromatic) -> Arg (Charged) |
- |
| 2329 |
|
AQP9 |
rs1314772498 |
NP_066190.2 - 247 (TM6) |
Helix - helix interface (TM4 - LE) |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 2330 |
|
AQP9 |
rs371099893 |
NP_066190.2 - 248 (TM6) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 2331 |
|
AQP9 |
rs759858030 |
NP_066190.2 - 248 (TM6) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2332 |
|
AQP9 |
rs774310850 |
NP_066190.2 - 249 (TM6) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 2333 |
|
AQP9 |
rs767955949 |
NP_066190.2 - 250 (TM6) |
Helix - helix interface (TM4 - TM6) |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 2334 |
|
AQP9 |
rs1312962258 |
NP_066190.2 - 250 (TM6) |
Helix - helix interface (TM4 - TM6) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2335 |
|
AQP9 |
rs775782160 |
NP_066190.2 - 251 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6, LE - TM6) |
Pro (Proline) -> Thr (Small and Weakly Polar) |
- |
| 2336 |
|
AQP9 |
rs1457381626 |
NP_066190.2 - 251 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6, LE - TM6) |
Pro (Proline) -> Arg (Charged) |
- |
| 2337 |
|
AQP9 |
rs1389722091 |
NP_066190.2 - 252 (TM6) |
Helix - helix interface (LB - TM6); Lipid facing |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2338 |
|
AQP9 |
rs143394617 |
NP_066190.2 - 253 (TM6) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 2339 |
|
AQP9 |
rs1320139454 |
NP_066190.2 - 253 (TM6) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2340 |
|
AQP9 |
rs763666523 |
NP_066190.2 - 254 (TM6) |
Helix - helix interface (TM4 - TM6) |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 2341 |
|
AQP9 |
rs753410663 |
NP_066190.2 - 255 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2342 |
|
AQP9 |
rs375847778 |
NP_066190.2 - 257 (TM6) |
Helix - helix interface (TM4 - TM6); Lipid facing |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2343 |
|
AQP9 |
rs1348029704 |
NP_066190.2 - 258 (TM6) |
Helix - helix interface (TM4 - TM6) |
Gly (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 2344 |
|
AQP9 |
rs756773366 |
NP_066190.2 - 259 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6) |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2345 |
|
AQP9 |
rs182216973 |
NP_066190.2 - 260 (TM6) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2346 |
|
AQP9 |
rs750410060 |
NP_066190.2 - 262 (TM6) |
Helix - helix interface (TM4 - TM6) |
Tyr (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 2347 |
|
AQP9 |
rs1002894992 |
NP_066190.2 - 264 (TM6) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2348 |
|
AQP9 |
rs374284559 |
NP_066190.2 - 265 (C terminus) |
C terminal domain |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 2349 |
|
AQP9 |
rs142822245 |
NP_066190.2 - 266 (C terminus) |
C terminal domain |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2350 |
|
AQP9 |
rs1274172241 |
NP_066190.2 - 267 (C terminus) |
C terminal domain |
Glu (Charged) -> Asp (Charged) |
- |
| 2351 |
|
AQP9 |
rs749429402 |
NP_066190.2 - 271 (C terminus) |
C terminal domain |
Pro (Proline) -> Ala (Small and Weakly Polar) |
- |
| 2352 |
|
AQP9 |
rs1484776680 |
NP_066190.2 - 272 (C terminus) |
C terminal domain |
Glu (Charged) -> Gln (Neutral polar) |
- |
| 2353 |
|
AQP9 |
rs1423124389 |
NP_066190.2 - 276 (C terminus) |
C terminal domain |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 2354 |
|
AQP9 |
rs778818501 |
NP_066190.2 - 278 (C terminus) |
C terminal domain |
Lys (Charged) -> Asn (Neutral polar) |
- |
| 2355 |
|
AQP9 |
rs1867380 |
NP_066190.2 - 279 (C terminus) |
C terminal domain |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 2356 |
|
AQP9 |
rs1368316607 |
NP_066190.2 - 280 (C terminus) |
C terminal domain |
Glu (Charged) -> Lys (Charged) |
- |
| 2357 |
|
AQP9 |
rs1436248708 |
NP_066190.2 - 281 (C terminus) |
C terminal domain |
Gln (Neutral polar) -> Pro (Proline) |
- |
| 2358 |
|
AQP9 |
rs201914936 |
NP_066190.2 - 284 (C terminus) |
Absent in the structure |
Asp (Charged) -> Gly (Small and Weakly Polar) |
- |
| 2359 |
|
AQP9 |
rs761021408 |
NP_066190.2 - 289 (C terminus) |
Absent in the structure |
Tyr (Aromatic) -> Asn (Neutral polar) |
- |
| 2360 |
|
AQP9 |
rs761021408 |
NP_066190.2 - 289 (C terminus) |
Absent in the structure |
Tyr (Aromatic) -> Asp (Charged) |
- |
| 2361 |
|
AQP9 |
rs768351351 |
NP_066190.2 - 290 (C terminus) |
Absent in the structure |
Glu (Charged) -> Val (Aliphatic hydrophobic) |
- |
| 2362 |
|
AQP9 |
rs868763994 |
NP_066190.2 - 290 (C terminus) |
Absent in the structure |
Glu (Charged) -> Lys (Charged) |
- |
| 2363 |
|
AQP9 |
rs776240993 |
NP_066190.2 - 291 (C terminus) |
Absent in the structure |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2364 |
|
AQP9 |
rs1340272838 |
NP_066190.2 - 293 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 2365 |
|
AQP9 |
rs749847313 |
NP_066190.2 - 294 (C terminus) |
Absent in the structure |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2366 |
|
AQP9 |
rs764829595 |
NP_066190.2 - 294 (C terminus) |
Absent in the structure |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2367 |
|
AQP9 |
rs762955710 |
NP_066190.2 - 295 (C terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 2368 |
|
AQP9 |
rs766415923 |
NP_066190.2 - 295 (C terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2369 |
|
AQP9 |
rs1482970572 |
NP_066190.2 - 295 (C terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2370 |
|
AQP10 |
rs748993302 |
NP_536354.2 - 1 (N terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2371 |
|
AQP10 |
rs773803347 |
NP_536354.2 - 7 (N terminus) |
Absent in the structure |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 2372 |
|
AQP10 |
rs772472650 |
NP_536354.2 - 8 (N terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2373 |
|
AQP10 |
rs759318252 |
NP_536354.2 - 9 (N terminus) |
Absent in the structure |
Glu (Charged) -> Lys (Charged) |
- |
| 2374 |
|
AQP10 |
rs1342563417 |
NP_536354.2 - 13 (N terminus) |
N terminal domain |
His (Charged) -> Gln (Neutral polar) |
- |
| 2375 |
|
AQP10 |
rs6668968 |
NP_536354.2 - 15 (N terminus) |
N terminal domain |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 2376 |
|
AQP10 |
rs538916652 |
NP_536354.2 - 17 (N terminus) |
N terminal domain |
Arg (Charged) -> His (Charged) |
- |
| 2377 |
|
AQP10 |
rs538916652 |
NP_536354.2 - 17 (N terminus) |
N terminal domain |
Arg (Charged) -> Leu (Aliphatic hydrophobic) |
- |
| 2378 |
|
AQP10 |
rs761060478 |
NP_536354.2 - 17 (N terminus) |
N terminal domain |
Arg (Charged) -> Ser (Small and Weakly Polar) |
- |
| 2379 |
|
AQP10 |
rs761060478 |
NP_536354.2 - 17 (N terminus) |
N terminal domain |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 2380 |
|
AQP10 |
rs1224372313 |
NP_536354.2 - 19 (TM1) |
Exposed to cytoplasm |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2381 |
|
AQP10 |
rs1384556904 |
NP_536354.2 - 20 (TM1) |
Helix - helix interface (TM1 - TM3) |
Leu (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 2382 |
|
AQP10 |
rs371762595 |
NP_536354.2 - 22 (TM1) |
Monomer - monomer interface |
Arg (Charged) -> Gly (Small and Weakly Polar) |
- |
| 2383 |
|
AQP10 |
rs371762595 |
NP_536354.2 - 22 (TM1) |
Monomer - monomer interface |
Arg (Charged) -> Trp (Aromatic) |
- |
| 2384 |
|
AQP10 |
rs557796014 |
NP_536354.2 - 22 (TM1) |
Monomer - monomer interface |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 2385 |
|
AQP10 |
rs1237901669 |
NP_536354.2 - 23 (TM1) |
Helix - helix interface (TM1 - TM2, TM1 - TM3) |
Gln (Neutral polar) -> Leu (Aliphatic hydrophobic) |
- |
| 2386 |
|
AQP10 |
rs750483555 |
NP_536354.2 - 24 (TM1) |
Helix - helix interface (TM1 - TM3) |
Cys (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 2387 |
|
AQP10 |
rs765484033 |
NP_536354.2 - 24 (TM1) |
Helix - helix interface (TM1 - TM3) |
Cys (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 2388 |
|
AQP10 |
rs767385572 |
NP_536354.2 - 26 (TM1) |
Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Glu (Charged) |
- |
| 2389 |
|
AQP10 |
rs1270423632 |
NP_536354.2 - 26 (TM1) |
Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2390 |
|
AQP10 |
rs752629904 |
NP_536354.2 - 30 (TM1) |
Helix - helix interface (TM1 - TM2) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2391 |
|
AQP10 |
rs1419212052 |
NP_536354.2 - 30 (TM1) |
Helix - helix interface (TM1 - TM2) |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 2392 |
|
AQP10 |
rs375905475 |
NP_536354.2 - 34 (TM1) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 2393 |
|
AQP10 |
rs756095252 |
NP_536354.2 - 34 (TM1) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2394 |
|
AQP10 |
rs1355583560 |
NP_536354.2 - 35 (TM1) |
Helix - helix interface (TM1 - TM3) |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2395 |
|
AQP10 |
rs1436399550 |
NP_536354.2 - 35 (TM1) |
Helix - helix interface (TM1 - TM3) |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2396 |
|
AQP10 |
rs867380322 |
NP_536354.2 - 40 (TM1) |
Helix - helix interface (TM1 - TM3);Monomer - monomer interface |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 2397 |
|
AQP10 |
rs926311875 |
NP_536354.2 - 47 (TM1) |
Exposed to the extracellular environment |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 2398 |
|
AQP10 |
rs1243637174 |
NP_536354.2 - 47 (TM1) |
Exposed to the extracellular environment |
Thr (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2399 |
|
AQP10 |
rs1317134115 |
NP_536354.2 - 48 (TM1) |
Exposed to the extracellular environment |
Ser (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2400 |
|
AQP10 |
rs534377369 |
NP_536354.2 - 51 (Loop region after TM1) |
Loop A |
Thr (Small and Weakly Polar) -> Asn (Neutral polar) |
- |
| 2401 |
|
AQP10 |
rs1215209840 |
NP_536354.2 - 53 (Loop region after TM1) |
Loop A |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2402 |
|
AQP10 |
rs1473723544 |
NP_536354.2 - 53 (Loop region after TM1) |
Loop A |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 2403 |
|
AQP10 |
rs201824170 |
NP_536354.2 - 54 (TM2) |
Monomer - monomer interface |
Asn (Neutral polar) -> Thr (Small and Weakly Polar) |
- |
| 2404 |
|
AQP10 |
rs201824170 |
NP_536354.2 - 54 (TM2) |
Monomer - monomer interface |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 2405 |
|
AQP10 |
rs757967267 |
NP_536354.2 - 57 (TM2) |
Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 2406 |
|
AQP10 |
rs1243052940 |
NP_536354.2 - 58 (TM2) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2407 |
|
AQP10 |
rs1243052940 |
NP_536354.2 - 58 (TM2) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2408 |
|
AQP10 |
rs201059654 |
NP_536354.2 - 66 (TM2) |
Channel facing |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2409 |
|
AQP10 |
rs1158005561 |
NP_536354.2 - 67 (TM2) |
Helix - helix interface (TM2 - TM5) |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 2410 |
|
AQP10 |
rs201098812 |
NP_536354.2 - 68 (TM2) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 2411 |
|
AQP10 |
rs553145275 |
NP_536354.2 - 68 (TM2) |
Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 2412 |
|
AQP10 |
rs544930612 |
NP_536354.2 - 70 (TM2) |
Channel facing;Helix - helix interface (TM2 - TM5) |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2413 |
|
AQP10 |
rs748490089 |
NP_536354.2 - 70 (TM2) |
Channel facing;Helix - helix interface (TM2 - TM5) |
Ile (Aliphatic hydrophobic) -> Asn (Neutral polar) |
- |
| 2414 |
|
AQP10 |
rs199806224 |
NP_536354.2 - 72 (TM2) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 2415 |
|
AQP10 |
rs1221171133 |
NP_536354.2 - 72 (TM2) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 2416 |
|
AQP10 |
rs773423264 |
NP_536354.2 - 76 (Loop region after TM2) |
Loop B |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2417 |
|
AQP10 |
rs781678853 |
NP_536354.2 - 79 (Loop region after TM2) |
Loop B |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2418 |
|
AQP10 |
rs781678853 |
NP_536354.2 - 79 (Loop region after TM2) |
Loop B |
Ala (Small and Weakly Polar) -> Pro (Proline) |
- |
| 2419 |
|
AQP10 |
rs868287246 |
NP_536354.2 - 80 (Loop region after TM2) |
Loop B |
His (Charged) -> Tyr (Aromatic) |
- |
| 2420 |
|
AQP10 |
rs1182531001 |
NP_536354.2 - 82 (LB - NPA1) |
Channel facing;Helix - helix interface (LB - LE, LB - TM3) |
Asn (Neutral polar) -> Lys (Charged) |
- |
| 2421 |
|
AQP10 |
rs1268287860 |
NP_536354.2 - 83 (LB - NPA1) |
Helix - helix interface (LB - LE, LB - TM3) |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 2422 |
|
AQP10 |
rs1201950180 |
NP_536354.2 - 84 (LB - NPA1) |
Helix - helix interface (LB - TM4, LB - LE, LB - TM6) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2423 |
|
AQP10 |
rs778263215 |
NP_536354.2 - 88 (LB) |
Helix - helix interface (LB - TM6, LB - TM4) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2424 |
|
AQP10 |
rs749598786 |
NP_536354.2 - 89 (LB) |
Channel facing |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2425 |
|
AQP10 |
rs1429077511 |
NP_536354.2 - 89 (LB) |
Channel facing |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2426 |
|
AQP10 |
rs759725317 |
NP_536354.2 - 92 (LB) |
Channel facing |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 2427 |
|
AQP10 |
rs774652913 |
NP_536354.2 - 92 (LB) |
Channel facing |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2428 |
|
AQP10 |
rs774652913 |
NP_536354.2 - 92 (LB) |
Channel facing |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 2429 |
|
AQP10 |
rs761850160 |
NP_536354.2 - 94 (Loop region after LB) |
Loop B |
Arg (Charged) -> His (Charged) |
- |
| 2430 |
|
AQP10 |
rs775690026 |
NP_536354.2 - 94 (Loop region after LB) |
Loop B |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 2431 |
|
AQP10 |
rs372798902 |
NP_536354.2 - 95 (Loop region after LB) |
Loop B |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2432 |
|
AQP10 |
rs980494215 |
NP_536354.2 - 95 (Loop region after LB) |
Loop B |
Leu (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 2433 |
|
AQP10 |
rs374795337 |
NP_536354.2 - 98 (Loop region after LB) |
Loop B |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 2434 |
|
AQP10 |
rs754601574 |
NP_536354.2 - 101 (TM3) |
Lipid facing |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 2435 |
|
AQP10 |
rs1016412418 |
NP_536354.2 - 109 (TM3) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2436 |
|
AQP10 |
rs752139965 |
NP_536354.2 - 111 (TM3) |
Helix - helix interface (TM1 - TM3, TM3 - LE) |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2437 |
|
AQP10 |
rs867709384 |
NP_536354.2 - 114 (TM3) |
Helix - helix interface (TM3 - TM1) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2438 |
|
AQP10 |
rs756699226 |
NP_536354.2 - 115 (TM3) |
Helix - helix interface (TM1 - TM3, TM3 - LE) |
Ser (Small and Weakly Polar) -> Leu (Aliphatic hydrophobic) |
- |
| 2439 |
|
AQP10 |
rs971823507 |
NP_536354.2 - 120 (TM3) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2440 |
|
AQP10 |
rs749670806 |
NP_536354.2 - 121 (TM3) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 2441 |
|
AQP10 |
rs6685323 |
NP_536354.2 - 123 (Loop region after TM3) |
Loop C |
His (Charged) -> Tyr (Aromatic) |
- |
| 2442 |
|
AQP10 |
rs1309912450 |
NP_536354.2 - 125 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 2443 |
|
AQP10 |
rs1316485296 |
NP_536354.2 - 126 (Loop region after TM3) |
Loop C |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2444 |
|
AQP10 |
rs780082562 |
NP_536354.2 - 129 (Loop region after TM3) |
Loop C |
Tyr (Aromatic) -> Asn (Neutral polar) |
- |
| 2445 |
|
AQP10 |
rs1205949010 |
NP_536354.2 - 132 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2446 |
|
AQP10 |
rs1445872604 |
NP_536354.2 - 133 (Loop region after TM3) |
Loop C |
Asn (Neutral polar) -> Lys (Charged) |
- |
| 2447 |
|
AQP10 |
rs934722709 |
NP_536354.2 - 136 (Loop region after TM3) |
Loop C |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 2448 |
|
AQP10 |
rs1001658320 |
NP_536354.2 - 138 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2449 |
|
AQP10 |
rs1249205577 |
NP_536354.2 - 139 (Loop region after TM3) |
Loop C |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 2450 |
|
AQP10 |
rs1232986569 |
NP_536354.2 - 141 (Loop region after TM3) |
Loop C |
Glu (Charged) -> Gln (Neutral polar) |
- |
| 2451 |
|
AQP10 |
rs542543589 |
NP_536354.2 - 145 (Loop region after TM3) |
Loop C |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2452 |
|
AQP10 |
rs1158048574 |
NP_536354.2 - 145 (Loop region after TM3) |
Loop C |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2453 |
|
AQP10 |
rs776750157 |
NP_536354.2 - 148 (Loop region after TM3) |
Loop C |
Thr (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2454 |
|
AQP10 |
rs1404420127 |
NP_536354.2 - 148 (Loop region after TM3) |
Loop C |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 2455 |
|
AQP10 |
rs894944033 |
NP_536354.2 - 150 (Loop region after TM3) |
Loop C |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 2456 |
|
AQP10 |
rs770847978 |
NP_536354.2 - 151 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2457 |
|
AQP10 |
rs774186017 |
NP_536354.2 - 151 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 2458 |
|
AQP10 |
rs774186017 |
NP_536354.2 - 151 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2459 |
|
AQP10 |
rs1014428988 |
NP_536354.2 - 152 (Loop region after TM3) |
Loop C |
Pro (Proline) -> His (Charged) |
- |
| 2460 |
|
AQP10 |
rs1014428988 |
NP_536354.2 - 152 (Loop region after TM3) |
Loop C |
Pro (Proline) -> Arg (Charged) |
- |
| 2461 |
|
AQP10 |
rs1206244863 |
NP_536354.2 - 153 (Loop region after TM3) |
Loop C |
Tyr (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 2462 |
|
AQP10 |
rs1045043554 |
NP_536354.2 - 159 (TM4) |
Helix - helix interface (TM4 - TM5) |
Gly (Small and Weakly Polar) -> Asp (Charged) |
- |
| 2463 |
|
AQP10 |
rs1325502986 |
NP_536354.2 - 161 (TM4) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 2464 |
|
AQP10 |
rs934672125 |
NP_536354.2 - 164 (TM4) |
Helix - helix interface (TM4 - TM6) |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2465 |
|
AQP10 |
rs934672125 |
NP_536354.2 - 164 (TM4) |
Helix - helix interface (TM4 - TM6) |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 2466 |
|
AQP10 |
rs758960762 |
NP_536354.2 - 166 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2467 |
|
AQP10 |
rs751948567 |
NP_536354.2 - 168 (TM4) |
Helix - helix interface (TM4 - TM6);Monomer - monomer interface |
Gly (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 2468 |
|
AQP10 |
rs755209873 |
NP_536354.2 - 169 (TM4) |
Monomer - monomer interface |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2469 |
|
AQP10 |
rs1359651641 |
NP_536354.2 - 169 (TM4) |
Monomer - monomer interface |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2470 |
|
AQP10 |
rs781413989 |
NP_536354.2 - 171 (TM4) |
Helix - helix interface (TM4 - TM6) |
Ile (Aliphatic hydrophobic) -> Asn (Neutral polar) |
- |
| 2471 |
|
AQP10 |
rs781413989 |
NP_536354.2 - 171 (TM4) |
Helix - helix interface (TM4 - TM6) |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2472 |
|
AQP10 |
rs752776491 |
NP_536354.2 - 173 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2473 |
|
AQP10 |
rs1243087590 |
NP_536354.2 - 173 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 2474 |
|
AQP10 |
rs1214685147 |
NP_536354.2 - 175 (TM4) |
Helix - helix interface (LB - TM4, TM4 - TM6) |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2475 |
|
AQP10 |
rs1241887424 |
NP_536354.2 - 177 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2476 |
|
AQP10 |
rs756143604 |
NP_536354.2 - 178 (TM4) |
Channel facing |
Leu (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 2477 |
|
AQP10 |
rs756143604 |
NP_536354.2 - 178 (TM4) |
Channel facing |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2478 |
|
AQP10 |
rs745857248 |
NP_536354.2 - 181 (Loop region after TM4) |
Loop D |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 2479 |
|
AQP10 |
rs778846975 |
NP_536354.2 - 181 (Loop region after TM4) |
Loop D |
Arg (Charged) -> Trp (Aromatic) |
- |
| 2480 |
|
AQP10 |
rs779783182 |
NP_536354.2 - 185 (Loop region after TM4) |
Loop D |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2481 |
|
AQP10 |
rs949215887 |
NP_536354.2 - 186 (Loop region after TM4) |
Loop D |
Pro (Proline) -> Thr (Small and Weakly Polar) |
- |
| 2482 |
|
AQP10 |
rs768207751 |
NP_536354.2 - 187 (Loop region after TM4) |
Loop D |
Ala (Small and Weakly Polar) -> Glu (Charged) |
- |
| 2483 |
|
AQP10 |
rs768207751 |
NP_536354.2 - 187 (Loop region after TM4) |
Loop D |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2484 |
|
AQP10 |
rs747692921 |
NP_536354.2 - 188 (Loop region after TM4) |
Loop D |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2485 |
|
AQP10 |
rs1356662498 |
NP_536354.2 - 190 (TM5) |
Helix - helix interface (TM4 - TM5) |
Glu (Charged) -> Gln (Neutral polar) |
- |
| 2486 |
|
AQP10 |
rs1432561293 |
NP_536354.2 - 191 (TM5) |
Helix - helix interface (TM2 - TM5) |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 2487 |
|
AQP10 |
rs772816368 |
NP_536354.2 - 200 (TM5) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2488 |
|
AQP10 |
rs1243753250 |
NP_536354.2 - 201 (TM5) |
Helix - helix interface (TM4 - TM5) |
Leu (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 2489 |
|
AQP10 |
rs1356519979 |
NP_536354.2 - 202 (TM5 - Ar/R Selectivity filter) |
Channel facing;Helix - helix interface (TM2 - TM5) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2490 |
|
AQP10 |
rs774589159 |
NP_536354.2 - 210 (Loop region after TM5) |
Loop E |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2491 |
|
AQP10 |
rs759873653 |
NP_536354.2 - 211 (Loop region after TM5 - Ar/R Selectivity filter) |
Loop E |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2492 |
|
AQP10 |
rs1490610336 |
NP_536354.2 - 214 (LE - NPA2) |
Channel facing;Helix - helix interface (TM1 - LE, LB - LE) |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 2493 |
|
AQP10 |
rs752864581 |
NP_536354.2 - 215 (LE - NPA2) |
Helix - helix interface (LB - LE, LE - TM6) |
Pro (Proline) -> Ala (Small and Weakly Polar) |
- |
| 2494 |
|
AQP10 |
rs193133403 |
NP_536354.2 - 216 (LE - NPA2) |
Helix - helix interface (LB - LE, TM3 - LE) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2495 |
|
AQP10 |
rs756309400 |
NP_536354.2 - 217 (LE - Ar/R Selectivity filter) |
Channel facing |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 2496 |
|
AQP10 |
rs1182330307 |
NP_536354.2 - 217 (LE - Ar/R Selectivity filter) |
Channel facing |
Arg (Charged) -> Trp (Aromatic) |
- |
| 2497 |
|
AQP10 |
rs372825269 |
NP_536354.2 - 221 (LE) |
Helix - helix interface (TM3 - LE) |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 2498 |
|
AQP10 |
rs200639079 |
NP_536354.2 - 222 (LE) |
Exposed to the extracellular environment |
Arg (Charged) -> His (Charged) |
- |
| 2499 |
|
AQP10 |
rs200639079 |
NP_536354.2 - 222 (LE) |
Exposed to the extracellular environment |
Arg (Charged) -> Pro (Proline) |
- |
| 2500 |
|
AQP10 |
rs753952871 |
NP_536354.2 - 222 (LE) |
Exposed to the extracellular environment |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 2501 |
|
AQP10 |
rs758326907 |
NP_536354.2 - 223 (LE) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2502 |
|
AQP10 |
rs898792414 |
NP_536354.2 - 225 (LE) |
Exposed to the extracellular environment |
Thr (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2503 |
|
AQP10 |
rs377590602 |
NP_536354.2 - 227 (LE) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 2504 |
|
AQP10 |
rs1440744273 |
NP_536354.2 - 230 (Loop region after LE) |
Loop E |
Trp (Aromatic) -> Gly (Small and Weakly Polar) |
- |
| 2505 |
|
AQP10 |
rs1277298131 |
NP_536354.2 - 231 (Loop region after LE) |
Loop E |
Gly (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 2506 |
|
AQP10 |
rs1375000795 |
NP_536354.2 - 233 (Loop region after LE) |
Loop E |
Glu (Charged) -> Gln (Neutral polar) |
- |
| 2507 |
|
AQP10 |
rs1476473717 |
NP_536354.2 - 233 (Loop region after LE) |
Loop E |
Glu (Charged) -> Val (Aliphatic hydrophobic) |
- |
| 2508 |
|
AQP10 |
rs370728661 |
NP_536354.2 - 234 (Loop region after LE) |
Loop E |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 2509 |
|
AQP10 |
rs144627448 |
NP_536354.2 - 235 (Loop region after LE) |
Loop E |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 2510 |
|
AQP10 |
rs1026061558 |
NP_536354.2 - 236 (Loop region after LE) |
Loop E |
Ser (Small and Weakly Polar) -> Asn (Neutral polar) |
- |
| 2511 |
|
AQP10 |
rs748776019 |
NP_536354.2 - 240 (Loop region after LE) |
Loop E |
Gly (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 2512 |
|
AQP10 |
rs770423797 |
NP_536354.2 - 241 (Loop region after LE) |
Loop E |
Trp (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 2513 |
|
AQP10 |
rs200974498 |
NP_536354.2 - 242 (Loop region after LE) |
Loop E |
Trp (Aromatic) -> Gly (Small and Weakly Polar) |
- |
| 2514 |
|
AQP10 |
rs746430315 |
NP_536354.2 - 243 (TM6) |
Lipid facing |
Trp (Aromatic) -> Gly (Small and Weakly Polar) |
- |
| 2515 |
|
AQP10 |
rs1332110036 |
NP_536354.2 - 245 (TM6) |
Helix - helix interface (TM4 - LE) |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 2516 |
|
AQP10 |
rs148928654 |
NP_536354.2 - 246 (TM6) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 2517 |
|
AQP10 |
rs1295974063 |
NP_536354.2 - 247 (TM6) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 2518 |
|
AQP10 |
rs1024229912 |
NP_536354.2 - 251 (TM6) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 2519 |
|
AQP10 |
rs1229182866 |
NP_536354.2 - 251 (TM6) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Gly (Small and Weakly Polar) |
- |
| 2520 |
|
AQP10 |
rs971809991 |
NP_536354.2 - 253 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6) |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 2521 |
|
AQP10 |
rs760972452 |
NP_536354.2 - 255 (TM6) |
Helix - helix interface (TM4 - TM6); Lipid facing |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2522 |
|
AQP10 |
rs1267785275 |
NP_536354.2 - 256 (TM6) |
Helix - helix interface (TM6 - TM4) |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2523 |
|
AQP10 |
rs1000381897 |
NP_536354.2 - 257 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6) |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 2524 |
|
AQP10 |
rs1391863672 |
NP_536354.2 - 259 (TM6) |
Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 2525 |
|
AQP10 |
rs1383807810 |
NP_536354.2 - 268 (TM6) |
Exposed to cytoplasm |
His (Charged) -> Leu (Aliphatic hydrophobic) |
- |
| 2526 |
|
AQP10 |
rs750463918 |
NP_536354.2 - 269 (C terminus) |
Absent in the structure |
Pro (Proline) -> Ala (Small and Weakly Polar) |
- |
| 2527 |
|
AQP10 |
rs974267438 |
NP_536354.2 - 273 (C terminus) |
Absent in the structure |
Glu (Charged) -> Lys (Charged) |
- |
| 2528 |
|
AQP10 |
rs917274186 |
NP_536354.2 - 277 (C terminus) |
Absent in the structure |
Asp (Charged) -> Asn (Neutral polar) |
- |
| 2529 |
|
AQP10 |
rs917274186 |
NP_536354.2 - 277 (C terminus) |
Absent in the structure |
Asp (Charged) -> His (Charged) |
- |
| 2530 |
|
AQP10 |
rs759603772 |
NP_536354.2 - 278 (C terminus) |
Absent in the structure |
Leu (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 2531 |
|
AQP10 |
rs201240485 |
NP_536354.2 - 279 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Glu (Charged) |
- |
| 2532 |
|
AQP10 |
rs201240485 |
NP_536354.2 - 279 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 2533 |
|
AQP10 |
rs201240485 |
NP_536354.2 - 279 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Gly (Small and Weakly Polar) |
- |
| 2534 |
|
AQP10 |
rs201101129 |
NP_536354.2 - 280 (C terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 2535 |
|
AQP10 |
rs755930334 |
NP_536354.2 - 280 (C terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2536 |
|
AQP10 |
rs1249717189 |
NP_536354.2 - 283 (C terminus) |
Absent in the structure |
His (Charged) -> Tyr (Aromatic) |
- |
| 2537 |
|
AQP10 |
rs1182985955 |
NP_536354.2 - 285 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2538 |
|
AQP10 |
rs756831326 |
NP_536354.2 - 287 (C terminus) |
Absent in the structure |
Glu (Charged) -> Gln (Neutral polar) |
- |
| 2539 |
|
AQP10 |
rs971431630 |
NP_536354.2 - 291 (C terminus) |
Absent in the structure |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 2540 |
|
AQP10 |
rs141365858 |
NP_536354.2 - 292 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 2541 |
|
AQP10 |
rs772586313 |
NP_536354.2 - 296 (C terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2542 |
|
AQP10 |
rs772586313 |
NP_536354.2 - 296 (C terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 2543 |
|
AQP10 |
rs1330664719 |
NP_536354.2 - 299 (C terminus) |
Absent in the structure |
Cys (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2544 |
|
AQP10 |
rs1391703716 |
NP_536354.2 - 299 (C terminus) |
Absent in the structure |
Cys (Small and Weakly Polar) -> Trp (Aromatic) |
- |
| 2545 |
|
AQP10 |
rs1391335910 |
NP_536354.2 - 301 (C terminus) |
Absent in the structure |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2546 |
|
AQP11 |
rs754680380 |
NP_766627.1 - 1 (N terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2547 |
|
AQP11 |
rs764942988 |
NP_766627.1 - 1 (N terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2548 |
|
AQP11 |
rs377635614 |
NP_766627.1 - 3 (N terminus) |
Absent in the structure |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 2549 |
|
AQP11 |
rs1211969773 |
NP_766627.1 - 3 (N terminus) |
Absent in the structure |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 2550 |
|
AQP11 |
rs757754470 |
NP_766627.1 - 4 (N terminus) |
Absent in the structure |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2551 |
|
AQP11 |
rs781687062 |
NP_766627.1 - 5 (N terminus) |
Absent in the structure |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 2552 |
|
AQP11 |
rs1365009572 |
NP_766627.1 - 6 (N terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2553 |
|
AQP11 |
rs1380112032 |
NP_766627.1 - 6 (N terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2554 |
|
AQP11 |
rs566212019 |
NP_766627.1 - 7 (N terminus) |
Absent in the structure |
Leu (Aliphatic hydrophobic) -> His (Charged) |
- |
| 2555 |
|
AQP11 |
rs746428652 |
NP_766627.1 - 7 (N terminus) |
Absent in the structure |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2556 |
|
AQP11 |
rs749290888 |
NP_766627.1 - 8 (N terminus) |
Absent in the structure |
Arg (Charged) -> Pro (Proline) |
- |
| 2557 |
|
AQP11 |
rs756558067 |
NP_766627.1 - 8 (N terminus) |
Absent in the structure |
Arg (Charged) -> Gly (Small and Weakly Polar) |
- |
| 2558 |
|
AQP11 |
rs756558067 |
NP_766627.1 - 8 (N terminus) |
Absent in the structure |
Arg (Charged) -> Trp (Aromatic) |
- |
| 2559 |
|
AQP11 |
rs774502373 |
NP_766627.1 - 10 (N terminus) |
Absent in the structure |
Glu (Charged) -> Lys (Charged) |
- |
| 2560 |
|
AQP11 |
rs1281770119 |
NP_766627.1 - 11 (N terminus) |
Absent in the structure |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2561 |
|
AQP11 |
rs771917262 |
NP_766627.1 - 12 (N terminus) |
Absent in the structure |
Gln (Neutral polar) -> Arg (Charged) |
- |
| 2562 |
|
AQP11 |
rs1214026326 |
NP_766627.1 - 12 (N terminus) |
Absent in the structure |
Gln (Neutral polar) -> His (Charged) |
- |
| 2563 |
|
AQP11 |
rs772848746 |
NP_766627.1 - 14 (N terminus) |
Absent in the structure |
Thr (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2564 |
|
AQP11 |
rs772848746 |
NP_766627.1 - 14 (N terminus) |
Absent in the structure |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 2565 |
|
AQP11 |
rs760713893 |
NP_766627.1 - 15 (N terminus) |
Absent in the structure |
Cys (Small and Weakly Polar) -> Tyr (Aromatic) |
- |
| 2566 |
|
AQP11 |
rs766176138 |
NP_766627.1 - 16 (N terminus) |
Absent in the structure |
Thr (Small and Weakly Polar) -> Asn (Neutral polar) |
- |
| 2567 |
|
AQP11 |
rs766176138 |
NP_766627.1 - 16 (N terminus) |
Absent in the structure |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 2568 |
|
AQP11 |
rs933648280 |
NP_766627.1 - 16 (N terminus) |
Absent in the structure |
Thr (Small and Weakly Polar) -> Pro (Proline) |
- |
| 2569 |
|
AQP11 |
rs776234621 |
NP_766627.1 - 17 (N terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Leu (Aliphatic hydrophobic) |
- |
| 2570 |
|
AQP11 |
rs199510186 |
NP_766627.1 - 21 (N terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2571 |
|
AQP11 |
rs199510186 |
NP_766627.1 - 21 (N terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2572 |
|
AQP11 |
rs199510186 |
NP_766627.1 - 21 (N terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2573 |
|
AQP11 |
rs764994222 |
NP_766627.1 - 21 (N terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2574 |
|
AQP11 |
rs899345983 |
NP_766627.1 - 23 (N terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Leu (Aliphatic hydrophobic) |
- |
| 2575 |
|
AQP11 |
rs1039197705 |
NP_766627.1 - 23 (N terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2576 |
|
AQP11 |
rs1460240298 |
NP_766627.1 - 27 (N terminus) |
Absent in the structure |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2577 |
|
AQP11 |
rs192278505 |
NP_766627.1 - 28 (N terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2578 |
|
AQP11 |
rs780361645 |
NP_766627.1 - 28 (N terminus) |
Absent in the structure |
Met (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 2579 |
|
AQP11 |
rs886733880 |
NP_766627.1 - 30 (N terminus) |
Absent in the structure |
Leu (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 2580 |
|
AQP11 |
rs1323964267 |
NP_766627.1 - 31 (N terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2581 |
|
AQP11 |
rs755105114 |
NP_766627.1 - 32 (N terminus) |
Absent in the structure |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 2582 |
|
AQP11 |
rs1295553049 |
NP_766627.1 - 33 (N terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 2583 |
|
AQP11 |
rs147231654 |
NP_766627.1 - 35 (N terminus) |
N terminal domain |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2584 |
|
AQP11 |
rs147231654 |
NP_766627.1 - 35 (N terminus) |
N terminal domain |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2585 |
|
AQP11 |
rs375329904 |
NP_766627.1 - 35 (N terminus) |
N terminal domain |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 2586 |
|
AQP11 |
rs746740134 |
NP_766627.1 - 36 (N terminus) |
N terminal domain |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 2587 |
|
AQP11 |
rs746740134 |
NP_766627.1 - 36 (N terminus) |
N terminal domain |
Arg (Charged) -> Pro (Proline) |
- |
| 2588 |
|
AQP11 |
rs1252270345 |
NP_766627.1 - 36 (N terminus) |
N terminal domain |
Arg (Charged) -> Trp (Aromatic) |
- |
| 2589 |
|
AQP11 |
rs776373837 |
NP_766627.1 - 37 (N terminus) |
N terminal domain |
Gln (Neutral polar) -> Lys (Charged) |
- |
| 2590 |
|
AQP11 |
rs759542303 |
NP_766627.1 - 38 (N terminus) |
N terminal domain |
Gln (Neutral polar) -> Pro (Proline) |
- |
| 2591 |
|
AQP11 |
rs769469608 |
NP_766627.1 - 39 (N terminus) |
N terminal domain |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2592 |
|
AQP11 |
rs775119169 |
NP_766627.1 - 39 (N terminus) |
N terminal domain |
Leu (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 2593 |
|
AQP11 |
rs762719203 |
NP_766627.1 - 41 (TM1) |
Exposed to cytoplasm |
Arg (Charged) -> Gly (Small and Weakly Polar) |
- |
| 2594 |
|
AQP11 |
rs1245476337 |
NP_766627.1 - 42 (TM1) |
Exposed to cytoplasm |
Pro (Proline) -> Ala (Small and Weakly Polar) |
- |
| 2595 |
|
AQP11 |
rs986374880 |
NP_766627.1 - 48 (TM1) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2596 |
|
AQP11 |
rs1172178766 |
NP_766627.1 - 48 (TM1) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 2597 |
|
AQP11 |
rs1424153794 |
NP_766627.1 - 50 (TM1) |
Helix - helix interface (TM1 - TM2, TM1 - TM3) |
Glu (Charged) -> Lys (Charged) |
- |
| 2598 |
|
AQP11 |
rs1461103321 |
NP_766627.1 - 54 (TM1) |
Helix - helix interface (TM1 - TM3) |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 2599 |
|
AQP11 |
rs942021301 |
NP_766627.1 - 57 (TM1) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2600 |
|
AQP11 |
rs1396755652 |
NP_766627.1 - 59 (TM1) |
Helix - helix interface (TM1 - TM3);Monomer - monomer interface |
Cys (Small and Weakly Polar) -> Tyr (Aromatic) |
- |
| 2601 |
|
AQP11 |
rs1437235697 |
NP_766627.1 - 61 (TM1) |
Channel facing;Helix - helix interface (TM1 - TM2) |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 2602 |
|
AQP11 |
rs1279228856 |
NP_766627.1 - 65 (TM1) |
Channel facing |
Gln (Neutral polar) -> Arg (Charged) |
- |
| 2603 |
|
AQP11 |
rs754364973 |
NP_766627.1 - 69 (Loop region after TM1) |
Loop A |
Glu (Charged) -> Lys (Charged) |
- |
| 2604 |
|
AQP11 |
rs1477214371 |
NP_766627.1 - 76 (TM2) |
Helix - helix interface (TM2 - TM5) |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 2605 |
|
AQP11 |
rs779010359 |
NP_766627.1 - 77 (TM2) |
Monomer - monomer interface |
Trp (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 2606 |
|
AQP11 |
rs1259629963 |
NP_766627.1 - 80 (TM2) |
Helix - helix interface (TM2 - TM5) |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 2607 |
|
AQP11 |
rs375173355 |
NP_766627.1 - 83 (TM2 - Ar/R Selectivity filter) |
Channel facing |
Tyr (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 2608 |
|
AQP11 |
rs777789633 |
NP_766627.1 - 84 (TM2) |
Helix - helix interface (TM2 - TM5) |
Phe (Aromatic) -> Tyr (Aromatic) |
- |
| 2609 |
|
AQP11 |
rs1469814124 |
NP_766627.1 - 84 (TM2) |
Helix - helix interface (TM2 - TM5) |
Phe (Aromatic) -> Ile (Aliphatic hydrophobic) |
- |
| 2610 |
|
AQP11 |
rs770689209 |
NP_766627.1 - 86 (TM2) |
Monomer - monomer interface;Helix - helix interface (TM1 - TM2) |
Ser (Small and Weakly Polar) -> Leu (Aliphatic hydrophobic) |
- |
| 2611 |
|
AQP11 |
rs769806416 |
NP_766627.1 - 87 (TM2) |
Channel facing |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 2612 |
|
AQP11 |
rs557986456 |
NP_766627.1 - 88 (TM2) |
Helix - helix interface (TM2 - TM5) |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 2613 |
|
AQP11 |
rs557986456 |
NP_766627.1 - 88 (TM2) |
Helix - helix interface (TM2 - TM5) |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 2614 |
|
AQP11 |
rs144449509 |
NP_766627.1 - 89 (TM2) |
Monomer - monomer interface |
His (Charged) -> Arg (Charged) |
- |
| 2615 |
|
AQP11 |
rs1455793387 |
NP_766627.1 - 89 (TM2) |
Monomer - monomer interface |
His (Charged) -> Tyr (Aromatic) |
- |
| 2616 |
|
AQP11 |
rs370956057 |
NP_766627.1 - 93 (Loop region after TM2) |
Loop B |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 2617 |
|
AQP11 |
rs1380800397 |
NP_766627.1 - 93 (Loop region after TM2) |
Loop B |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2618 |
|
AQP11 |
rs1305651938 |
NP_766627.1 - 94 (Loop region after TM2) |
Loop B |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 2619 |
|
AQP11 |
rs1218668329 |
NP_766627.1 - 96 (Loop region after TM2) |
Loop B |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 2620 |
|
AQP11 |
rs1238495199 |
NP_766627.1 - 98 (Loop region after TM2) |
Loop B |
Ser (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 2621 |
|
AQP11 |
rs1286604538 |
NP_766627.1 - 98 (Loop region after TM2) |
Loop B |
Ser (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2622 |
|
AQP11 |
rs776955511 |
NP_766627.1 - 99 (LB - NPA1) |
Channel facing;Helix - helix interface (LB - LE, LB - TM3) |
Asn (Neutral polar) -> Thr (Small and Weakly Polar) |
- |
| 2623 |
|
AQP11 |
rs776955511 |
NP_766627.1 - 99 (LB - NPA1) |
Channel facing;Helix - helix interface (LB - LE, LB - TM3) |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 2624 |
|
AQP11 |
rs776955511 |
NP_766627.1 - 99 (LB - NPA1) |
Channel facing;Helix - helix interface (LB - LE, LB - TM3) |
Asn (Neutral polar) -> Ile (Aliphatic hydrophobic) |
- |
| 2625 |
|
AQP11 |
rs752776735 |
NP_766627.1 - 100 (LB - NPA1) |
Helix - helix interface (LB - LE, LB - TM3) |
Pro (Proline) -> Gln (Neutral polar) |
- |
| 2626 |
|
AQP11 |
rs752776735 |
NP_766627.1 - 100 (LB - NPA1) |
Helix - helix interface (LB - LE, LB - TM3) |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 2627 |
|
AQP11 |
rs2276415 |
NP_766627.1 - 102 (LB) |
Channel facing;Helix - helix interface (LB - TM4) |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2628 |
|
AQP11 |
rs751769523 |
NP_766627.1 - 103 (LB) |
Helix - helix interface (LB - TM3) |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 2629 |
|
AQP11 |
rs751769523 |
NP_766627.1 - 103 (LB) |
Helix - helix interface (LB - TM3) |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 2630 |
|
AQP11 |
rs564907519 |
NP_766627.1 - 104 (LB) |
Lipid facing |
Met (Aliphatic hydrophobic) -> Lys (Charged) |
- |
| 2631 |
|
AQP11 |
rs1396637002 |
NP_766627.1 - 105 (LB) |
Helix - helix interface (LB - TM4, LB - TM6) |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2632 |
|
AQP11 |
rs142486413 |
NP_766627.1 - 107 (LB) |
Helix - helix interface (LB - TM3); Lipid facing |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2633 |
|
AQP11 |
rs988643684 |
NP_766627.1 - 107 (LB) |
Helix - helix interface (LB - TM3); Lipid facing |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2634 |
|
AQP11 |
rs1170194235 |
NP_766627.1 - 107 (LB) |
Helix - helix interface (LB - TM3); Lipid facing |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2635 |
|
AQP11 |
rs955324846 |
NP_766627.1 - 110 (Loop region after LB) |
Loop B |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2636 |
|
AQP11 |
rs1470964820 |
NP_766627.1 - 110 (Loop region after LB) |
Loop B |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 2637 |
|
AQP11 |
rs745619792 |
NP_766627.1 - 112 (Loop region after LB) |
Loop B |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2638 |
|
AQP11 |
rs1433405732 |
NP_766627.1 - 113 (Loop region after LB) |
Loop B |
Ser (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 2639 |
|
AQP11 |
rs1360164687 |
NP_766627.1 - 116 (TM3) |
Channel facing |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 2640 |
|
AQP11 |
rs1458126510 |
NP_766627.1 - 119 (TM3) |
Helix - helix interface (LB - TM3); Lipid facing |
Val (Aliphatic hydrophobic) -> Gly (Small and Weakly Polar) |
- |
| 2641 |
|
AQP11 |
rs140743866 |
NP_766627.1 - 120 (TM3) |
Helix - helix interface (TM1 - TM3, LB - TM3) |
Arg (Charged) -> Lys (Charged) |
- |
| 2642 |
|
AQP11 |
rs140743866 |
NP_766627.1 - 120 (TM3) |
Helix - helix interface (TM1 - TM3, LB - TM3) |
Arg (Charged) -> Thr (Small and Weakly Polar) |
- |
| 2643 |
|
AQP11 |
rs1030513222 |
NP_766627.1 - 120 (TM3) |
Helix - helix interface (TM1 - TM3, LB - TM3) |
Arg (Charged) -> Trp (Aromatic) |
- |
| 2644 |
|
AQP11 |
rs1280458551 |
NP_766627.1 - 122 (TM3) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Ser (Small and Weakly Polar) |
- |
| 2645 |
|
AQP11 |
rs777008875 |
NP_766627.1 - 124 (TM3) |
Helix - helix interface (TM1 - TM3, LB - TM3, TM3 - LE) |
Gln (Neutral polar) -> Arg (Charged) |
- |
| 2646 |
|
AQP11 |
rs759827563 |
NP_766627.1 - 126 (TM3) |
Lipid facing |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2647 |
|
AQP11 |
rs201544461 |
NP_766627.1 - 129 (TM3) |
Lipid facing;Helix - helix interface (TM3 - LE) |
Leu (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 2648 |
|
AQP11 |
rs1179260435 |
NP_766627.1 - 129 (TM3) |
Lipid facing;Helix - helix interface (TM3 - LE) |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 2649 |
|
AQP11 |
rs368695449 |
NP_766627.1 - 132 (TM3) |
Helix - helix interface (TM1 - TM3, TM3 - LE) |
Arg (Charged) -> Lys (Charged) |
- |
| 2650 |
|
AQP11 |
rs368695449 |
NP_766627.1 - 132 (TM3) |
Helix - helix interface (TM1 - TM3, TM3 - LE) |
Arg (Charged) -> Met (Aliphatic hydrophobic) |
- |
| 2651 |
|
AQP11 |
rs751609668 |
NP_766627.1 - 134 (TM3) |
Monomer - monomer interface |
Cys (Small and Weakly Polar) -> Tyr (Aromatic) |
- |
| 2652 |
|
AQP11 |
rs1409714364 |
NP_766627.1 - 136 (TM3) |
Helix - helix interface (TM3 - LE) |
Ser (Small and Weakly Polar) -> Asn (Neutral polar) |
- |
| 2653 |
|
AQP11 |
rs767783303 |
NP_766627.1 - 142 (Loop region after TM3) |
Loop C |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2654 |
|
AQP11 |
rs117458417 |
NP_766627.1 - 145 (Loop region after TM3) |
Loop C |
Gln (Neutral polar) -> His (Charged) |
- |
| 2655 |
|
AQP11 |
rs145893530 |
NP_766627.1 - 145 (Loop region after TM3) |
Loop C |
Gln (Neutral polar) -> Pro (Proline) |
- |
| 2656 |
|
AQP11 |
rs145893530 |
NP_766627.1 - 145 (Loop region after TM3) |
Loop C |
Gln (Neutral polar) -> Arg (Charged) |
- |
| 2657 |
|
AQP11 |
rs1184154429 |
NP_766627.1 - 147 (Loop region after TM3) |
Loop C |
His (Charged) -> Asn (Neutral polar) |
- |
| 2658 |
|
AQP11 |
rs759491525 |
NP_766627.1 - 150 (Loop region after TM3) |
Loop C |
Glu (Charged) -> Lys (Charged) |
- |
| 2659 |
|
AQP11 |
rs141340501 |
NP_766627.1 - 152 (Loop region after TM3) |
Loop C |
Ser (Small and Weakly Polar) -> Asn (Neutral polar) |
- |
| 2660 |
|
AQP11 |
rs141340501 |
NP_766627.1 - 152 (Loop region after TM3) |
Loop C |
Ser (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 2661 |
|
AQP11 |
rs1442404559 |
NP_766627.1 - 152 (Loop region after TM3) |
Loop C |
Ser (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2662 |
|
AQP11 |
rs1277947419 |
NP_766627.1 - 154 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 2663 |
|
AQP11 |
rs754917855 |
NP_766627.1 - 155 (Loop region after TM3) |
Loop C |
Cys (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2664 |
|
AQP11 |
rs754917855 |
NP_766627.1 - 155 (Loop region after TM3) |
Loop C |
Cys (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 2665 |
|
AQP11 |
rs1320262703 |
NP_766627.1 - 158 (Loop region after TM3) |
Loop C |
Pro (Proline) -> Thr (Small and Weakly Polar) |
- |
| 2666 |
|
AQP11 |
rs1320262703 |
NP_766627.1 - 158 (Loop region after TM3) |
Loop C |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 2667 |
|
AQP11 |
rs1239860978 |
NP_766627.1 - 159 (Loop region after TM3) |
Loop C |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2668 |
|
AQP11 |
rs906640651 |
NP_766627.1 - 160 (Loop region after TM3) |
Loop C |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 2669 |
|
AQP11 |
rs747650973 |
NP_766627.1 - 162 (Loop region after TM3) |
Loop C |
Asp (Charged) -> Asn (Neutral polar) |
- |
| 2670 |
|
AQP11 |
rs1467225304 |
NP_766627.1 - 163 (Loop region after TM3) |
Loop C |
Leu (Aliphatic hydrophobic) -> Ser (Small and Weakly Polar) |
- |
| 2671 |
|
AQP11 |
rs371423285 |
NP_766627.1 - 164 (Loop region after TM3) |
Loop C |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 2672 |
|
AQP11 |
rs1488795531 |
NP_766627.1 - 165 (Loop region after TM3) |
Loop C |
Lys (Charged) -> Glu (Charged) |
- |
| 2673 |
|
AQP11 |
rs1475384581 |
NP_766627.1 - 166 (TM4) |
Helix - helix interface (TM4 - TM5) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2674 |
|
AQP11 |
rs538116750 |
NP_766627.1 - 168 (TM4) |
Lipid facing |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 2675 |
|
AQP11 |
rs775810795 |
NP_766627.1 - 169 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Pro (Proline) |
- |
| 2676 |
|
AQP11 |
rs559881432 |
NP_766627.1 - 171 (TM4) |
Helix - helix interface (TM4 - TM6) |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 2677 |
|
AQP11 |
rs1157882738 |
NP_766627.1 - 176 (TM4) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2678 |
|
AQP11 |
rs774301866 |
NP_766627.1 - 181 (TM4) |
Channel facing |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2679 |
|
AQP11 |
rs1331540328 |
NP_766627.1 - 183 (TM4) |
Monomer - monomer interface |
His (Charged) -> Asp (Charged) |
- |
| 2680 |
|
AQP11 |
rs1409799349 |
NP_766627.1 - 184 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 2681 |
|
AQP11 |
rs761897009 |
NP_766627.1 - 185 (TM4) |
Channel facing |
Gln (Neutral polar) -> Glu (Charged) |
- |
| 2682 |
|
AQP11 |
rs767695226 |
NP_766627.1 - 186 (Loop region after TM4) |
Loop D |
Glu (Charged) -> Lys (Charged) |
- |
| 2683 |
|
AQP11 |
rs1161418638 |
NP_766627.1 - 187 (Loop region after TM4) |
Loop D |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 2684 |
|
AQP11 |
rs750736920 |
NP_766627.1 - 188 (Loop region after TM4) |
Loop D |
Arg (Charged) -> Pro (Proline) |
- |
| 2685 |
|
AQP11 |
rs1173292943 |
NP_766627.1 - 191 (Loop region after TM4) |
Loop D |
Leu (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 2686 |
|
AQP11 |
rs1001511947 |
NP_766627.1 - 192 (TM5) |
Helix - helix interface (TM4 - TM5) |
Arg (Charged) -> Pro (Proline) |
- |
| 2687 |
|
AQP11 |
rs1332997380 |
NP_766627.1 - 192 (TM5) |
Helix - helix interface (TM4 - TM5) |
Arg (Charged) -> Gly (Small and Weakly Polar) |
- |
| 2688 |
|
AQP11 |
rs753623457 |
NP_766627.1 - 194 (TM5) |
Monomer - monomer interface |
His (Charged) -> Pro (Proline) |
- |
| 2689 |
|
AQP11 |
rs1290692306 |
NP_766627.1 - 194 (TM5) |
Monomer - monomer interface |
His (Charged) -> Tyr (Aromatic) |
- |
| 2690 |
|
AQP11 |
rs754906421 |
NP_766627.1 - 199 (TM5) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2691 |
|
AQP11 |
rs1187718704 |
NP_766627.1 - 202 (TM5) |
Monomer - monomer interface |
Phe (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 2692 |
|
AQP11 |
rs752164439 |
NP_766627.1 - 203 (TM5) |
Helix - helix interface (TM4 - TM5) |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2693 |
|
AQP11 |
rs1054465622 |
NP_766627.1 - 204 (TM5 - Ar/R Selectivity filter) |
Channel facing;Helix - helix interface (TM2 - TM5) |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2694 |
|
AQP11 |
rs374928017 |
NP_766627.1 - 205 (TM5) |
Monomer - monomer interface |
Tyr (Aromatic) -> His (Charged) |
- |
| 2695 |
|
AQP11 |
rs1164489744 |
NP_766627.1 - 205 (TM5) |
Monomer - monomer interface |
Tyr (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 2696 |
|
AQP11 |
rs1164489744 |
NP_766627.1 - 205 (TM5) |
Monomer - monomer interface |
Tyr (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 2697 |
|
AQP11 |
rs893255904 |
NP_766627.1 - 206 (TM5) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2698 |
|
AQP11 |
rs987769949 |
NP_766627.1 - 207 (TM5) |
Helix - helix interface (TM4 - TM5) |
Gly (Small and Weakly Polar) -> Glu (Charged) |
- |
| 2699 |
|
AQP11 |
rs766672199 |
NP_766627.1 - 208 (TM5) |
Channel facing |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2700 |
|
AQP11 |
rs1335150581 |
NP_766627.1 - 210 (Loop region after TM5) |
Loop E |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 2701 |
|
AQP11 |
rs753583276 |
NP_766627.1 - 212 (Loop region after TM5) |
Loop E |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2702 |
|
AQP11 |
rs759319925 |
NP_766627.1 - 214 (Loop region after TM5) |
Loop E |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2703 |
|
AQP11 |
rs764929288 |
NP_766627.1 - 222 (LE) |
Helix - helix interface (TM3 - LE) |
Ser (Small and Weakly Polar) -> Leu (Aliphatic hydrophobic) |
- |
| 2704 |
|
AQP11 |
rs1311560711 |
NP_766627.1 - 222 (LE) |
Helix - helix interface (TM3 - LE) |
Ser (Small and Weakly Polar) -> Pro (Proline) |
- |
| 2705 |
|
AQP11 |
rs914577523 |
NP_766627.1 - 223 (LE) |
Helix - helix interface (TM3 - LE) |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 2706 |
|
AQP11 |
rs1199035333 |
NP_766627.1 - 224 (LE) |
Exposed to the extracellular environment |
His (Charged) -> Tyr (Aromatic) |
- |
| 2707 |
|
AQP11 |
rs1484464031 |
NP_766627.1 - 224 (LE) |
Exposed to the extracellular environment |
His (Charged) -> Arg (Charged) |
- |
| 2708 |
|
AQP11 |
rs528278123 |
NP_766627.1 - 226 (LE) |
Helix - helix interface (LE - TM3) |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2709 |
|
AQP11 |
rs1453243424 |
NP_766627.1 - 226 (LE) |
Helix - helix interface (LE - TM3) |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2710 |
|
AQP11 |
rs1354873470 |
NP_766627.1 - 227 (LE) |
Exposed to the extracellular environment |
Cys (Small and Weakly Polar) -> Tyr (Aromatic) |
- |
| 2711 |
|
AQP11 |
rs780838062 |
NP_766627.1 - 232 (Loop region after LE) |
Loop E |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 2712 |
|
AQP11 |
rs1318373805 |
NP_766627.1 - 232 (Loop region after LE) |
Loop E |
Phe (Aromatic) -> Val (Aliphatic hydrophobic) |
- |
| 2713 |
|
AQP11 |
rs1199812022 |
NP_766627.1 - 233 (Loop region after LE) |
Loop E |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 2714 |
|
AQP11 |
rs1490916389 |
NP_766627.1 - 233 (Loop region after LE) |
Loop E |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 2715 |
|
AQP11 |
rs1172992258 |
NP_766627.1 - 234 (Loop region after LE) |
Loop E |
Gln (Neutral polar) -> His (Charged) |
- |
| 2716 |
|
AQP11 |
rs1220714755 |
NP_766627.1 - 235 (TM6) |
Lipid facing |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 2717 |
|
AQP11 |
rs779112979 |
NP_766627.1 - 237 (TM6) |
Lipid facing |
Ile (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 2718 |
|
AQP11 |
rs1375690943 |
NP_766627.1 - 237 (TM6) |
Lipid facing |
Ile (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2719 |
|
AQP11 |
rs748709229 |
NP_766627.1 - 238 (TM6) |
Helix - helix interface (TM4 - TM6) |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 2720 |
|
AQP11 |
rs746672488 |
NP_766627.1 - 239 (TM6) |
Helix - helix interface (TM4 - LE) |
Tyr (Aromatic) -> His (Charged) |
- |
| 2721 |
|
AQP11 |
rs1333431202 |
NP_766627.1 - 242 (TM6) |
Helix - helix interface (TM4 - TM6) |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 2722 |
|
AQP11 |
rs773461163 |
NP_766627.1 - 245 (TM6) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2723 |
|
AQP11 |
rs537243865 |
NP_766627.1 - 246 (TM6) |
Helix - helix interface (TM4 - TM6) |
Gly (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 2724 |
|
AQP11 |
rs747020932 |
NP_766627.1 - 246 (TM6) |
Helix - helix interface (TM4 - TM6) |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2725 |
|
AQP11 |
rs377545413 |
NP_766627.1 - 250 (TM6) |
Helix - helix interface (TM4 - TM6) |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2726 |
|
AQP11 |
rs749526822 |
NP_766627.1 - 250 (TM6) |
Helix - helix interface (TM4 - TM6) |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2727 |
|
AQP11 |
rs1351749534 |
NP_766627.1 - 251 (TM6) |
Helix - helix interface (LB - TM6, TM4 - TM6) |
Ile (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2728 |
|
AQP11 |
rs149377619 |
NP_766627.1 - 253 (TM6) |
Monomer - monomer interface |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2729 |
|
AQP11 |
rs1030208162 |
NP_766627.1 - 256 (TM6) |
Lipid facing |
Phe (Aromatic) -> Val (Aliphatic hydrophobic) |
- |
| 2730 |
|
AQP11 |
rs762676737 |
NP_766627.1 - 259 (C terminus) |
C terminal domain |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 2731 |
|
AQP11 |
rs201572659 |
NP_766627.1 - 260 (C terminus) |
C terminal domain |
Trp (Aromatic) -> Arg (Charged) |
- |
| 2732 |
|
AQP11 |
rs774337087 |
NP_766627.1 - 260 (C terminus) |
C terminal domain |
Trp (Aromatic) -> Cys (Small and Weakly Polar) |
- |
| 2733 |
|
AQP11 |
rs761704365 |
NP_766627.1 - 262 (C terminus) |
C terminal domain |
His (Charged) -> Pro (Proline) |
- |
| 2734 |
|
AQP11 |
rs761704365 |
NP_766627.1 - 262 (C terminus) |
C terminal domain |
His (Charged) -> Arg (Charged) |
- |
| 2735 |
|
AQP11 |
rs1218430263 |
NP_766627.1 - 264 (C terminus) |
C terminal domain |
Asn (Neutral polar) -> Lys (Charged) |
- |
| 2736 |
|
AQP11 |
rs1487273437 |
NP_766627.1 - 264 (C terminus) |
C terminal domain |
Asn (Neutral polar) -> Ser (Small and Weakly Polar) |
- |
| 2737 |
|
AQP11 |
rs1485461412 |
NP_766627.1 - 266 (C terminus) |
C terminal domain |
Thr (Small and Weakly Polar) -> Lys (Charged) |
- |
| 2738 |
|
AQP11 |
rs200870763 |
NP_766627.1 - 271 (C terminus) |
C terminal domain |
Glu (Charged) -> Ala (Small and Weakly Polar) |
- |
| 2739 |
|
AQP11 |
rs200870763 |
NP_766627.1 - 271 (C terminus) |
C terminal domain |
Glu (Charged) -> Gly (Small and Weakly Polar) |
- |
| 2740 |
|
AQP12 |
rs1336807584 |
NP_945349.1 - 3 (N terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2741 |
|
AQP12 |
rs564922211 |
NP_945349.1 - 4 (N terminus) |
Absent in the structure |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2742 |
|
AQP12 |
rs756179983 |
NP_945349.1 - 4 (N terminus) |
Absent in the structure |
Leu (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 2743 |
|
AQP12 |
rs533085451 |
NP_945349.1 - 6 (N terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 2744 |
|
AQP12 |
rs533085451 |
NP_945349.1 - 6 (N terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 2745 |
|
AQP12 |
rs533085451 |
NP_945349.1 - 6 (N terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 2746 |
|
AQP12 |
rs200502183 |
NP_945349.1 - 7 (N terminus) |
Absent in the structure |
Ser (Small and Weakly Polar) -> Phe (Aromatic) |
- |
| 2747 |
|
AQP12 |
rs1249753663 |
NP_945349.1 - 8 (N terminus) |
Absent in the structure |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2748 |
|
AQP12 |
rs1483306367 |
NP_945349.1 - 8 (N terminus) |
Absent in the structure |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 2749 |
|
AQP12 |
rs373545729 |
NP_945349.1 - 13 (TM1) |
Lipid facing |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2750 |
|
AQP12 |
rs373545729 |
NP_945349.1 - 13 (TM1) |
Lipid facing |
Ala (Small and Weakly Polar) -> Pro (Proline) |
- |
| 2751 |
|
AQP12 |
rs1480260777 |
NP_945349.1 - 13 (TM1) |
Lipid facing |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2752 |
|
AQP12 |
rs1177021899 |
NP_945349.1 - 14 (TM1) |
Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Asn (Neutral polar) |
- |
| 2753 |
|
AQP12 |
rs142830324 |
NP_945349.1 - 15 (TM1) |
Helix - helix interface (TM1 - TM2, TM1 - TM3) |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 2754 |
|
AQP12 |
rs527446942 |
NP_945349.1 - 16 (TM1) |
Helix - helix interface (TM1 - TM3) |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 2755 |
|
AQP12 |
rs566667626 |
NP_945349.1 - 16 (TM1) |
Helix - helix interface (TM1 - TM3) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2756 |
|
AQP12 |
rs770366245 |
NP_945349.1 - 17 (TM1) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2757 |
|
AQP12 |
rs776005562 |
NP_945349.1 - 17 (TM1) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> His (Charged) |
- |
| 2758 |
|
AQP12 |
rs769132099 |
NP_945349.1 - 18 (TM1) |
Helix - helix interface (TM1 - TM2) |
Cys (Small and Weakly Polar) -> Tyr (Aromatic) |
- |
| 2759 |
|
AQP12 |
rs141084461 |
NP_945349.1 - 20 (TM1) |
Helix - helix interface (TM1 - TM3) |
Ala (Small and Weakly Polar) -> Glu (Charged) |
- |
| 2760 |
|
AQP12 |
rs141084461 |
NP_945349.1 - 20 (TM1) |
Helix - helix interface (TM1 - TM3) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2761 |
|
AQP12 |
rs774908729 |
NP_945349.1 - 20 (TM1) |
Helix - helix interface (TM1 - TM3) |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2762 |
|
AQP12 |
rs145322760 |
NP_945349.1 - 21 (TM1) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 2763 |
|
AQP12 |
rs145322760 |
NP_945349.1 - 21 (TM1) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2764 |
|
AQP12 |
rs200814405 |
NP_945349.1 - 21 (TM1) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2765 |
|
AQP12 |
rs752527432 |
NP_945349.1 - 22 (TM1) |
Helix - helix interface (TM1 - TM2);Channel facing |
Arg (Charged) -> Lys (Charged) |
- |
| 2766 |
|
AQP12 |
rs764994622 |
NP_945349.1 - 22 (TM1) |
Helix - helix interface (TM1 - TM2);Channel facing |
Arg (Charged) -> Trp (Aromatic) |
- |
| 2767 |
|
AQP12 |
rs149487583 |
NP_945349.1 - 23 (TM1) |
Helix - helix interface (TM1 - TM3) |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 2768 |
|
AQP12 |
rs375647576 |
NP_945349.1 - 23 (TM1) |
Helix - helix interface (TM1 - TM3) |
Arg (Charged) -> Trp (Aromatic) |
- |
| 2769 |
|
AQP12 |
rs751182309 |
NP_945349.1 - 24 (TM1) |
Helix - helix interface (TM1 - TM3) |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 2770 |
|
AQP12 |
rs751182309 |
NP_945349.1 - 24 (TM1) |
Helix - helix interface (TM1 - TM3) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2771 |
|
AQP12 |
rs1186153268 |
NP_945349.1 - 25 (TM1) |
Monomer - monomer interface |
Ser (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 2772 |
|
AQP12 |
rs1432209571 |
NP_945349.1 - 25 (TM1) |
Monomer - monomer interface |
Ser (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2773 |
|
AQP12 |
rs1365404344 |
NP_945349.1 - 27 (TM1) |
Helix - helix interface (TM1 - TM3) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2774 |
|
AQP12 |
rs71428454 |
NP_945349.1 - 28 (TM1) |
Helix - helix interface (TM1 - TM3);Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Gln (Neutral polar) |
- |
| 2775 |
|
AQP12 |
rs71428454 |
NP_945349.1 - 28 (TM1) |
Helix - helix interface (TM1 - TM3);Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Arg (Charged) |
- |
| 2776 |
|
AQP12 |
rs147441798 |
NP_945349.1 - 29 (TM1) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> His (Charged) |
- |
| 2777 |
|
AQP12 |
rs147441798 |
NP_945349.1 - 29 (TM1) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 2778 |
|
AQP12 |
rs748475971 |
NP_945349.1 - 29 (TM1) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2779 |
|
AQP12 |
rs771028962 |
NP_945349.1 - 32 (TM1) |
Helix - helix interface (TM1 - TM3);Monomer - monomer interface |
Gly (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2780 |
|
AQP12 |
rs776622286 |
NP_945349.1 - 33 (TM1) |
Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2781 |
|
AQP12 |
rs776622286 |
NP_945349.1 - 33 (TM1) |
Helix - helix interface (TM1 - TM2) |
Ala (Small and Weakly Polar) -> Pro (Proline) |
- |
| 2782 |
|
AQP12 |
rs759437692 |
NP_945349.1 - 34 (TM1) |
Channel facing |
Tyr (Aromatic) -> Asn (Neutral polar) |
- |
| 2783 |
|
AQP12 |
rs759437692 |
NP_945349.1 - 34 (TM1) |
Channel facing |
Tyr (Aromatic) -> His (Charged) |
- |
| 2784 |
|
AQP12 |
rs202201302 |
NP_945349.1 - 38 (Loop after TM1) |
Loop A |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2785 |
|
AQP12 |
rs762674665 |
NP_945349.1 - 39 (Loop after TM1) |
Loop A |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 2786 |
|
AQP12 |
rs762674665 |
NP_945349.1 - 39 (Loop after TM1) |
Loop A |
Arg (Charged) -> Pro (Proline) |
- |
| 2787 |
|
AQP12 |
rs1204738295 |
NP_945349.1 - 39 (Loop after TM1) |
Loop A |
Arg (Charged) -> Trp (Aromatic) |
- |
| 2788 |
|
AQP12 |
rs763798528 |
NP_945349.1 - 41 (Loop after TM1) |
Loop A |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2789 |
|
AQP12 |
rs774056915 |
NP_945349.1 - 42 (Loop after TM1) |
Loop A |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2790 |
|
AQP12 |
rs143658178 |
NP_945349.1 - 44 (Loop after TM1) |
Loop A |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 2791 |
|
AQP12 |
rs1160292077 |
NP_945349.1 - 46 (Loop after TM1) |
Loop A |
Val (Aliphatic hydrophobic) -> Asp (Charged) |
- |
| 2792 |
|
AQP12 |
rs766055016 |
NP_945349.1 - 47 (Loop after TM1) |
Loop A |
Glu (Charged) -> Lys (Charged) |
- |
| 2793 |
|
AQP12 |
rs766055016 |
NP_945349.1 - 47 (Loop after TM1) |
Loop A |
Glu (Charged) -> Gln (Neutral polar) |
- |
| 2794 |
|
AQP12 |
rs370765515 |
NP_945349.1 - 48 (Loop after TM1) |
Loop A |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2795 |
|
AQP12 |
rs1358039511 |
NP_945349.1 - 48 (Loop after TM1) |
Loop A |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 2796 |
|
AQP12 |
rs778167168 |
NP_945349.1 - 49 (Loop after TM1) |
Loop A |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2797 |
|
AQP12 |
rs778167168 |
NP_945349.1 - 49 (Loop after TM1) |
Loop A |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2798 |
|
AQP12 |
rs757663186 |
NP_945349.1 - 50 (Loop after TM1) |
Loop A |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 2799 |
|
AQP12 |
rs1371016468 |
NP_945349.1 - 50 (Loop after TM1) |
Loop A |
Pro (Proline) -> Ala (Small and Weakly Polar) |
- |
| 2800 |
|
AQP12 |
rs1288707496 |
NP_945349.1 - 51 (Loop after TM1) |
Loop A |
Trp (Aromatic) -> Arg (Charged) |
- |
| 2801 |
|
AQP12 |
rs1427312823 |
NP_945349.1 - 53 (Loop after TM1) |
Loop A |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2802 |
|
AQP12 |
rs746091243 |
NP_945349.1 - 54 (TM2) |
Helix - helix interface (TM2 - TM5) |
Asp (Charged) -> Tyr (Aromatic) |
- |
| 2803 |
|
AQP12 |
rs769856853 |
NP_945349.1 - 54 (TM2) |
Helix - helix interface (TM2 - TM5) |
Asp (Charged) -> Glu (Charged) |
- |
| 2804 |
|
AQP12 |
rs1212930376 |
NP_945349.1 - 55 (TM2) |
Monomer - monomer interface |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 2805 |
|
AQP12 |
rs1231687621 |
NP_945349.1 - 55 (TM2) |
Monomer - monomer interface |
Phe (Aromatic) -> Ser (Small and Weakly Polar) |
- |
| 2806 |
|
AQP12 |
rs1422147404 |
NP_945349.1 - 56 (TM2) |
Monomer - monomer interface |
Gly (Small and Weakly Polar) -> Trp (Aromatic) |
- |
| 2807 |
|
AQP12 |
rs201804366 |
NP_945349.1 - 62 (TM2) |
Helix - helix interface (TM2 - TM5) |
Thr (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2808 |
|
AQP12 |
rs1171849254 |
NP_945349.1 - 64 (TM2) |
Monomer - monomer interface;Helix - helix interface (TM1 - TM2) |
Leu (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2809 |
|
AQP12 |
rs774372497 |
NP_945349.1 - 70 (TM2) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Glu (Charged) |
- |
| 2810 |
|
AQP12 |
rs774372497 |
NP_945349.1 - 70 (TM2) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2811 |
|
AQP12 |
rs145149435 |
NP_945349.1 - 71 (TM2) |
Monomer - monomer interface |
His (Charged) -> Gln (Neutral polar) |
- |
| 2812 |
|
AQP12 |
rs145149435 |
NP_945349.1 - 71 (TM2) |
Monomer - monomer interface |
His (Charged) -> Gln (Neutral polar) |
- |
| 2813 |
|
AQP12 |
rs765963931 |
NP_945349.1 - 71 (TM2) |
Monomer - monomer interface |
His (Charged) -> Tyr (Aromatic) |
- |
| 2814 |
|
AQP12 |
rs143894146 |
NP_945349.1 - 72 (TM2) |
Helix - helix interface (TM1 - TM2);Monomer - monomer interface |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2815 |
|
AQP12 |
rs143894146 |
NP_945349.1 - 72 (TM2) |
Helix - helix interface (TM1 - TM2);Monomer - monomer interface |
Gly (Small and Weakly Polar) -> Trp (Aromatic) |
- |
| 2816 |
|
AQP12 |
rs757492796 |
NP_945349.1 - 72 (TM2) |
Helix - helix interface (TM1 - TM2);Monomer - monomer interface |
Gly (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 2817 |
|
AQP12 |
rs199880904 |
NP_945349.1 - 73 (TM2) |
Channel facing |
Val (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2818 |
|
AQP12 |
rs140654125 |
NP_945349.1 - 74 (TM2) |
Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 2819 |
|
AQP12 |
rs756370573 |
NP_945349.1 - 76 (TM2) |
Helix - helix interface (TM1 - TM2) |
Asp (Charged) -> Glu (Charged) |
- |
| 2820 |
|
AQP12 |
rs368649686 |
NP_945349.1 - 77 (Loop region after TM2) |
Loop B |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2821 |
|
AQP12 |
rs368649686 |
NP_945349.1 - 77 (Loop region after TM2) |
Loop B |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2822 |
|
AQP12 |
rs749282730 |
NP_945349.1 - 78 (Loop region after TM2) |
Loop B |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2823 |
|
AQP12 |
rs768799804 |
NP_945349.1 - 79 (Loop region after TM2) |
Loop B |
Ser (Small and Weakly Polar) -> Trp (Aromatic) |
- |
| 2824 |
|
AQP12 |
rs768799804 |
NP_945349.1 - 79 (Loop region after TM2) |
Loop B |
Ser (Small and Weakly Polar) -> Leu (Aliphatic hydrophobic) |
- |
| 2825 |
|
AQP12 |
rs867394633 |
NP_945349.1 - 79 (Loop region after TM2) |
Loop B |
Ser (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 2826 |
|
AQP12 |
rs771981901 |
NP_945349.1 - 80 (Loop region after TM2) |
Loop B |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2827 |
|
AQP12 |
rs771981901 |
NP_945349.1 - 80 (Loop region after TM2) |
Loop B |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2828 |
|
AQP12 |
rs760370699 |
NP_945349.1 - 82 (LB - NPA1) |
Helix - helix interface (LB - LE, LB - TM3) |
Pro (Proline) -> Arg (Charged) |
- |
| 2829 |
|
AQP12 |
rs1219102395 |
NP_945349.1 - 82 (LB - NPA1) |
Helix - helix interface (LB - LE, LB - TM3) |
Pro (Proline) -> Thr (Small and Weakly Polar) |
- |
| 2830 |
|
AQP12 |
rs770665889 |
NP_945349.1 - 83 (LB - NPA1 Deviation) |
Helix - helix interface (LB - TM4, LB - LE, LB - TM6) |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 2831 |
|
AQP12 |
rs1429080879 |
NP_945349.1 - 84 (LB) |
Channel facing;Helix - helix interface (LB - TM4) |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 2832 |
|
AQP12 |
rs1429080879 |
NP_945349.1 - 84 (LB) |
Channel facing;Helix - helix interface (LB - TM4) |
Val (Aliphatic hydrophobic) -> Leu (Aliphatic hydrophobic) |
- |
| 2833 |
|
AQP12 |
rs1169137210 |
NP_945349.1 - 85 (LB) |
Helix - helix interface (LB - TM3) |
Ser (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 2834 |
|
AQP12 |
rs1422529979 |
NP_945349.1 - 87 (LB) |
Helix - helix interface (LB - TM4, LB - TM6) |
Gln (Neutral polar) -> Lys (Charged) |
- |
| 2835 |
|
AQP12 |
rs371207290 |
NP_945349.1 - 88 (LB) |
Channel facing |
Glu (Charged) -> Asp (Charged) |
- |
| 2836 |
|
AQP12 |
rs1265691209 |
NP_945349.1 - 92 (Loop region after LB) |
Loop B |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2837 |
|
AQP12 |
rs1438847181 |
NP_945349.1 - 92 (Loop region after LB) |
Loop B |
Ala (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 2838 |
|
AQP12 |
rs200267757 |
NP_945349.1 - 93 (Loop region after LB) |
Loop B |
Glu (Charged) -> Lys (Charged) |
- |
| 2839 |
|
AQP12 |
rs200267757 |
NP_945349.1 - 93 (Loop region after LB) |
Loop B |
Glu (Charged) -> Gln (Neutral polar) |
- |
| 2840 |
|
AQP12 |
rs201212653 |
NP_945349.1 - 93 (Loop region after LB) |
Loop B |
Glu (Charged) -> Asp (Charged) |
- |
| 2841 |
|
AQP12 |
rs754094713 |
NP_945349.1 - 93 (Loop region after LB) |
Loop B |
Glu (Charged) -> Gly (Small and Weakly Polar) |
- |
| 2842 |
|
AQP12 |
rs150513749 |
NP_945349.1 - 94 (Loop region after LB) |
Loop B |
Gln (Neutral polar) -> Glu (Charged) |
- |
| 2843 |
|
AQP12 |
rs779109324 |
NP_945349.1 - 95 (Loop region after LB) |
Loop B |
Ser (Small and Weakly Polar) -> Tyr (Aromatic) |
- |
| 2844 |
|
AQP12 |
rs1451876509 |
NP_945349.1 - 96 (TM3) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 2845 |
|
AQP12 |
rs770862158 |
NP_945349.1 - 97 (TM3) |
Lipid facing |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 2846 |
|
AQP12 |
rs777882637 |
NP_945349.1 - 97 (TM3) |
Lipid facing |
Pro (Proline) -> Ala (Small and Weakly Polar) |
- |
| 2847 |
|
AQP12 |
rs777882637 |
NP_945349.1 - 97 (TM3) |
Lipid facing |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 2848 |
|
AQP12 |
rs1188579352 |
NP_945349.1 - 98 (TM3) |
Channel facing |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2849 |
|
AQP12 |
rs148248008 |
NP_945349.1 - 99 (TM3) |
Helix - helix interface (LB - TM3) |
Thr (Small and Weakly Polar) -> Lys (Charged) |
- |
| 2850 |
|
AQP12 |
rs148248008 |
NP_945349.1 - 99 (TM3) |
Helix - helix interface (LB - TM3) |
Thr (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2851 |
|
AQP12 |
rs148248008 |
NP_945349.1 - 99 (TM3) |
Helix - helix interface (LB - TM3) |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 2852 |
|
AQP12 |
rs557065094 |
NP_945349.1 - 99 (TM3) |
Helix - helix interface (LB - TM3) |
Thr (Small and Weakly Polar) -> Pro (Proline) |
- |
| 2853 |
|
AQP12 |
rs557065094 |
NP_945349.1 - 99 (TM3) |
Helix - helix interface (LB - TM3) |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 2854 |
|
AQP12 |
rs557065094 |
NP_945349.1 - 99 (TM3) |
Helix - helix interface (LB - TM3) |
Thr (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2855 |
|
AQP12 |
rs201167811 |
NP_945349.1 - 104 (TM3) |
Lipid facing |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2856 |
|
AQP12 |
rs548093882 |
NP_945349.1 - 105 (TM3) |
Helix - helix interface (TM1 - TM3) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2857 |
|
AQP12 |
rs758571527 |
NP_945349.1 - 105 (TM3) |
Helix - helix interface (TM1 - TM3) |
Ala (Small and Weakly Polar) -> Glu (Charged) |
- |
| 2858 |
|
AQP12 |
rs758571527 |
NP_945349.1 - 105 (TM3) |
Helix - helix interface (TM1 - TM3) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2859 |
|
AQP12 |
rs1428689902 |
NP_945349.1 - 106 (TM3) |
Helix - helix interface (TM3 - TM1, TM3 - LB, TM3 - LE) |
Gln (Neutral polar) -> Glu (Charged) |
- |
| 2860 |
|
AQP12 |
rs770841484 |
NP_945349.1 - 109 (TM3) |
Helix - helix interface (TM1 - TM3) |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2861 |
|
AQP12 |
rs770841484 |
NP_945349.1 - 109 (TM3) |
Helix - helix interface (TM1 - TM3) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2862 |
|
AQP12 |
rs781095725 |
NP_945349.1 - 110 (TM3) |
Helix - helix interface (TM1 - TM3, TM3 - LE) |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2863 |
|
AQP12 |
rs150061985 |
NP_945349.1 - 111 (TM3) |
Lipid facing;Helix - helix interface (TM3 - LE) |
Gln (Neutral polar) -> Arg (Charged) |
- |
| 2864 |
|
AQP12 |
rs1249318328 |
NP_945349.1 - 111 (TM3) |
Lipid facing;Helix - helix interface (TM3 - LE) |
Gln (Neutral polar) -> His (Charged) |
- |
| 2865 |
|
AQP12 |
rs745485149 |
NP_945349.1 - 112 (TM3) |
Lipid facing |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2866 |
|
AQP12 |
rs745485149 |
NP_945349.1 - 112 (TM3) |
Lipid facing |
Ala (Small and Weakly Polar) -> Pro (Proline) |
- |
| 2867 |
|
AQP12 |
rs1186744053 |
NP_945349.1 - 112 (TM3) |
Lipid facing |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2868 |
|
AQP12 |
rs748738922 |
NP_945349.1 - 113 (TM3) |
Helix - helix interface (TM1 - TM3) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2869 |
|
AQP12 |
rs775028865 |
NP_945349.1 - 113 (TM3) |
Helix - helix interface (TM1 - TM3) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2870 |
|
AQP12 |
rs775028865 |
NP_945349.1 - 113 (TM3) |
Helix - helix interface (TM1 - TM3) |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2871 |
|
AQP12 |
rs773704199 |
NP_945349.1 - 115 (TM3) |
Lipid facing |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 2872 |
|
AQP12 |
rs58604656 |
NP_945349.1 - 117 (TM3) |
Helix - helix interface (TM1 - TM3) |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2873 |
|
AQP12 |
rs141109641 |
NP_945349.1 - 117 (TM3) |
Helix - helix interface (TM1 - TM3) |
Met (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2874 |
|
AQP12 |
rs766634316 |
NP_945349.1 - 118 (TM3) |
Helix - helix interface (TM3 - LE) |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 2875 |
|
AQP12 |
rs777096263 |
NP_945349.1 - 118 (TM3) |
Helix - helix interface (TM3 - LE) |
Arg (Charged) -> His (Charged) |
- |
| 2876 |
|
AQP12 |
rs1288074972 |
NP_945349.1 - 121 (Loop region after TM3) |
Loop C |
Trp (Aromatic) -> Gly (Small and Weakly Polar) |
- |
| 2877 |
|
AQP12 |
rs765448669 |
NP_945349.1 - 122 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 2878 |
|
AQP12 |
rs751528314 |
NP_945349.1 - 129 (Loop region after TM3) |
Loop C |
His (Charged) -> Tyr (Aromatic) |
- |
| 2879 |
|
AQP12 |
rs1179773467 |
NP_945349.1 - 129 (Loop region after TM3) |
Loop C |
His (Charged) -> Pro (Proline) |
- |
| 2880 |
|
AQP12 |
rs757308516 |
NP_945349.1 - 130 (Loop region after TM3) |
Loop C |
Leu (Aliphatic hydrophobic) -> Gln (Neutral polar) |
- |
| 2881 |
|
AQP12 |
rs1184610193 |
NP_945349.1 - 131 (Loop region after TM3) |
Loop C |
Leu (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 2882 |
|
AQP12 |
rs780817136 |
NP_945349.1 - 132 (Loop region after TM3) |
Loop C |
Gln (Neutral polar) -> His (Charged) |
- |
| 2883 |
|
AQP12 |
rs745629262 |
NP_945349.1 - 134 (Loop region after TM3) |
Loop C |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2884 |
|
AQP12 |
rs1405026590 |
NP_945349.1 - 135 (Loop region after TM3) |
Loop C |
Met (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2885 |
|
AQP12 |
rs1408665231 |
NP_945349.1 - 135 (Loop region after TM3) |
Loop C |
Met (Aliphatic hydrophobic) -> Thr (Small and Weakly Polar) |
- |
| 2886 |
|
AQP12 |
rs755876416 |
NP_945349.1 - 136 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2887 |
|
AQP12 |
rs1191048394 |
NP_945349.1 - 136 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2888 |
|
AQP12 |
rs749008298 |
NP_945349.1 - 137 (Loop region after TM3) |
Loop C |
Gln (Neutral polar) -> His (Charged) |
- |
| 2889 |
|
AQP12 |
rs1410111362 |
NP_945349.1 - 137 (Loop region after TM3) |
Loop C |
Gln (Neutral polar) -> Pro (Proline) |
- |
| 2890 |
|
AQP12 |
rs1198116073 |
NP_945349.1 - 138 (Loop region after TM3) |
Loop C |
Ser (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 2891 |
|
AQP12 |
rs1231929395 |
NP_945349.1 - 139 (Loop region after TM3) |
Loop C |
Cys (Small and Weakly Polar) -> Tyr (Aromatic) |
- |
| 2892 |
|
AQP12 |
rs1328930697 |
NP_945349.1 - 139 (Loop region after TM3) |
Loop C |
Cys (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2893 |
|
AQP12 |
rs1328930697 |
NP_945349.1 - 139 (Loop region after TM3) |
Loop C |
Cys (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 2894 |
|
AQP12 |
rs1347096712 |
NP_945349.1 - 141 (Loop region after TM3) |
Loop C |
Ser (Small and Weakly Polar) -> Leu (Aliphatic hydrophobic) |
- |
| 2895 |
|
AQP12 |
rs747485924 |
NP_945349.1 - 142 (Loop region after TM3) |
Loop C |
Ala (Small and Weakly Polar) -> Asp (Charged) |
- |
| 2896 |
|
AQP12 |
rs142225246 |
NP_945349.1 - 144 (Loop region after TM3) |
Loop C |
Arg (Charged) -> His (Charged) |
- |
| 2897 |
|
AQP12 |
rs142225246 |
NP_945349.1 - 144 (Loop region after TM3) |
Loop C |
Arg (Charged) -> Pro (Proline) |
- |
| 2898 |
|
AQP12 |
rs771431612 |
NP_945349.1 - 144 (Loop region after TM3) |
Loop C |
Arg (Charged) -> Ser (Small and Weakly Polar) |
- |
| 2899 |
|
AQP12 |
rs771431612 |
NP_945349.1 - 144 (Loop region after TM3) |
Loop C |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 2900 |
|
AQP12 |
rs1177077265 |
NP_945349.1 - 145 (Loop region after TM3) |
Loop C |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 2901 |
|
AQP12 |
rs1338086288 |
NP_945349.1 - 146 (Loop region after TM3) |
Loop C |
Ser (Small and Weakly Polar) -> Cys (Small and Weakly Polar) |
- |
| 2902 |
|
AQP12 |
rs1379424550 |
NP_945349.1 - 147 (TM4) |
Exposed to the extracellular environment |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 2903 |
|
AQP12 |
rs1448270960 |
NP_945349.1 - 148 (TM4) |
Lipid facing |
Pro (Proline) -> Thr (Small and Weakly Polar) |
- |
| 2904 |
|
AQP12 |
rs763323834 |
NP_945349.1 - 150 (TM4) |
Helix - helix interface (TM4 - TM5) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2905 |
|
AQP12 |
rs764246123 |
NP_945349.1 - 151 (TM4) |
Lipid facing;Helix - helix interface (TM4 - TM6) |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2906 |
|
AQP12 |
rs751727229 |
NP_945349.1 - 152 (TM4) |
Lipid facing |
Leu (Aliphatic hydrophobic) -> Phe (Aromatic) |
- |
| 2907 |
|
AQP12 |
rs757442849 |
NP_945349.1 - 153 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 2908 |
|
AQP12 |
rs1385853916 |
NP_945349.1 - 153 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 2909 |
|
AQP12 |
rs1332316352 |
NP_945349.1 - 155 (TM4) |
Helix - helix interface (TM4 - TM6) |
Ala (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2910 |
|
AQP12 |
rs1182362080 |
NP_945349.1 - 156 (TM4) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2911 |
|
AQP12 |
rs1296800208 |
NP_945349.1 - 156 (TM4) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2912 |
|
AQP12 |
rs12477907 |
NP_945349.1 - 158 (TM4) |
Helix - helix interface (LB - TM4, TM4 - TM6) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2913 |
|
AQP12 |
rs1303346571 |
NP_945349.1 - 159 (TM4) |
Helix - helix interface (TM4 - TM6);Monomer - monomer interface |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 2914 |
|
AQP12 |
rs748920742 |
NP_945349.1 - 164 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 2915 |
|
AQP12 |
rs779770848 |
NP_945349.1 - 164 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Pro (Proline) |
- |
| 2916 |
|
AQP12 |
rs1269628678 |
NP_945349.1 - 165 (TM4) |
Channel facing |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 2917 |
|
AQP12 |
rs754668791 |
NP_945349.1 - 166 (TM4) |
Helix - helix interface (LB - TM4, TM4 - TM6) |
Leu (Aliphatic hydrophobic) -> Val (Aliphatic hydrophobic) |
- |
| 2918 |
|
AQP12 |
rs778570791 |
NP_945349.1 - 166 (TM4) |
Helix - helix interface (LB - TM4, TM4 - TM6) |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 2919 |
|
AQP12 |
rs747606191 |
NP_945349.1 - 167 (TM4) |
Monomer - monomer interface |
His (Charged) -> Pro (Proline) |
- |
| 2920 |
|
AQP12 |
rs747606191 |
NP_945349.1 - 167 (TM4) |
Monomer - monomer interface |
His (Charged) -> Arg (Charged) |
- |
| 2921 |
|
AQP12 |
rs1391358247 |
NP_945349.1 - 167 (TM4) |
Monomer - monomer interface |
His (Charged) -> Tyr (Aromatic) |
- |
| 2922 |
|
AQP12 |
rs1424872845 |
NP_945349.1 - 167 (TM4) |
Monomer - monomer interface |
His (Charged) -> Gln (Neutral polar) |
- |
| 2923 |
|
AQP12 |
rs771492662 |
NP_945349.1 - 168 (TM4) |
Helix - helix interface (TM4 - TM5);Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Pro (Proline) |
- |
| 2924 |
|
AQP12 |
rs576227322 |
NP_945349.1 - 169 (TM4) |
Channel facing |
Arg (Charged) -> Trp (Aromatic) |
- |
| 2925 |
|
AQP12 |
rs746425246 |
NP_945349.1 - 169 (TM4) |
Channel facing |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 2926 |
|
AQP12 |
rs776045536 |
NP_945349.1 - 170 (TM4) |
Exposed to cytoplasm |
His (Charged) -> Tyr (Aromatic) |
- |
| 2927 |
|
AQP12 |
rs763235157 |
NP_945349.1 - 171 (Loop region after TM4) |
Loop D |
Ser (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2928 |
|
AQP12 |
rs1375186480 |
NP_945349.1 - 171 (Loop region after TM4) |
Loop D |
Ser (Small and Weakly Polar) -> Gly (Small and Weakly Polar) |
- |
| 2929 |
|
AQP12 |
rs1396148522 |
NP_945349.1 - 172 (Loop region after TM4) |
Loop D |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 2930 |
|
AQP12 |
rs1432271118 |
NP_945349.1 - 172 (Loop region after TM4) |
Loop D |
Pro (Proline) -> Arg (Charged) |
- |
| 2931 |
|
AQP12 |
rs1432271118 |
NP_945349.1 - 172 (Loop region after TM4) |
Loop D |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 2932 |
|
AQP12 |
rs768958292 |
NP_945349.1 - 173 (Loop region after TM4) |
Loop D |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 2933 |
|
AQP12 |
rs761886843 |
NP_945349.1 - 174 (Loop region after TM4) |
Loop D |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2934 |
|
AQP12 |
rs1159105886 |
NP_945349.1 - 176 (TM5) |
Helix - helix interface (TM4 - TM5) |
Ser (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2935 |
|
AQP12 |
rs1378376549 |
NP_945349.1 - 177 (TM5) |
Helix - helix interface (TM2 - TM5) |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2936 |
|
AQP12 |
rs1320873570 |
NP_945349.1 - 178 (TM5) |
Monomer - monomer interface |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 2937 |
|
AQP12 |
rs766134278 |
NP_945349.1 - 179 (TM5) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2938 |
|
AQP12 |
rs766134278 |
NP_945349.1 - 179 (TM5) |
Monomer - monomer interface |
Ala (Small and Weakly Polar) -> Pro (Proline) |
- |
| 2939 |
|
AQP12 |
rs778476983 |
NP_945349.1 - 181 (TM5) |
Helix - helix interface (TM2 - TM5) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2940 |
|
AQP12 |
rs752347589 |
NP_945349.1 - 182 (TM5) |
Monomer - monomer interface |
Leu (Aliphatic hydrophobic) -> Gln (Neutral polar) |
- |
| 2941 |
|
AQP12 |
rs1248698464 |
NP_945349.1 - 184 (TM5) |
Channel facing |
Val (Aliphatic hydrophobic) -> Asp (Charged) |
- |
| 2942 |
|
AQP12 |
rs746363265 |
NP_945349.1 - 185 (TM5) |
Helix - helix interface (TM2 - TM5) |
Thr (Small and Weakly Polar) -> Asn (Neutral polar) |
- |
| 2943 |
|
AQP12 |
rs746363265 |
NP_945349.1 - 185 (TM5) |
Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2944 |
|
AQP12 |
rs746363265 |
NP_945349.1 - 185 (TM5) |
Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 2945 |
|
AQP12 |
rs777203216 |
NP_945349.1 - 185 (TM5) |
Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 2946 |
|
AQP12 |
rs777203216 |
NP_945349.1 - 185 (TM5) |
Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2947 |
|
AQP12 |
rs769148727 |
NP_945349.1 - 186 (TM5) |
Monomer - monomer interface |
Val (Aliphatic hydrophobic) -> Ile (Aliphatic hydrophobic) |
- |
| 2948 |
|
AQP12 |
rs200467599 |
NP_945349.1 - 187 (TM5) |
Helix - helix interface (TM4 - TM5) |
Thr (Small and Weakly Polar) -> Lys (Charged) |
- |
| 2949 |
|
AQP12 |
rs200467599 |
NP_945349.1 - 187 (TM5) |
Helix - helix interface (TM4 - TM5) |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 2950 |
|
AQP12 |
rs774712231 |
NP_945349.1 - 187 (TM5) |
Helix - helix interface (TM4 - TM5) |
Thr (Small and Weakly Polar) -> Ala (Small and Weakly Polar) |
- |
| 2951 |
|
AQP12 |
rs1455276161 |
NP_945349.1 - 188 (TM5 - Ar/R Selectivity filter) |
Channel facing;Helix - helix interface (TM2 - TM5) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2952 |
|
AQP12 |
rs201497460 |
NP_945349.1 - 190 (TM5) |
Monomer - monomer interface |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 2953 |
|
AQP12 |
rs1423224606 |
NP_945349.1 - 191 (TM5) |
Helix - helix interface (TM4 - TM5) |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2954 |
|
AQP12 |
rs759257510 |
NP_945349.1 - 192 (TM5) |
Channel facing |
Gly (Small and Weakly Polar) -> Arg (Charged) |
- |
| 2955 |
|
AQP12 |
rs1401939125 |
NP_945349.1 - 195 (Loop region after TM5) |
Loop E |
Thr (Small and Weakly Polar) -> Met (Aliphatic hydrophobic) |
- |
| 2956 |
|
AQP12 |
rs200455423 |
NP_945349.1 - 205 (LE) |
Helix - helix interface (LE - TM6, TM3 - LE); Lipid facing |
Ala (Small and Weakly Polar) -> Thr (Small and Weakly Polar) |
- |
| 2957 |
|
AQP12 |
rs1435230888 |
NP_945349.1 - 208 (LE) |
Exposed to the extracellular environment |
Thr (Small and Weakly Polar) -> Ile (Aliphatic hydrophobic) |
- |
| 2958 |
|
AQP12 |
rs1466467006 |
NP_945349.1 - 212 (Loop region after LE) |
Loop E |
Ser (Small and Weakly Polar) -> Leu (Aliphatic hydrophobic) |
- |
| 2959 |
|
AQP12 |
rs1348389109 |
NP_945349.1 - 218 (Loop region after LE) |
Loop E |
Glu (Charged) -> Asp (Charged) |
- |
| 2960 |
|
AQP12 |
rs765080351 |
NP_945349.1 - 220 (TM6) |
Helix - helix interface (LE - TM6); Lipid facing |
Val (Aliphatic hydrophobic) -> Met (Aliphatic hydrophobic) |
- |
| 2961 |
|
AQP12 |
rs1481296171 |
NP_945349.1 - 221 (TM6) |
Lipid facing |
Gln (Neutral polar) -> Arg (Charged) |
- |
| 2962 |
|
AQP12 |
rs1018959419 |
NP_945349.1 - 241 (C terminus) |
C terminal domain |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 2963 |
|
AQP12 |
rs1162389579 |
NP_945349.1 - 241 (C terminus) |
C terminal domain |
Arg (Charged) -> His (Charged) |
- |
| 2964 |
|
AQP12 |
rs201744512 |
NP_945349.1 - 244 (C terminus) |
Absent in the structure |
His (Charged) -> Arg (Charged) |
- |
| 2965 |
|
AQP12 |
rs1323922110 |
NP_945349.1 - 251 (C terminus) |
Absent in the structure |
Phe (Aromatic) -> Leu (Aliphatic hydrophobic) |
- |
| 2966 |
|
AQP12 |
rs1313859990 |
NP_945349.1 - 253 (C terminus) |
Absent in the structure |
Gly (Small and Weakly Polar) -> Ser (Small and Weakly Polar) |
- |
| 2967 |
|
AQP12 |
rs755382140 |
NP_945349.1 - 265 (C terminus) |
Absent in the structure |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 2968 |
|
AQP12 |
rs965577245 |
NP_945349.1 - 266 (C terminus) |
Absent in the structure |
Ala (Small and Weakly Polar) -> Val (Aliphatic hydrophobic) |
- |
| 2969 |
|
AQP12 |
rs1339154977 |
NP_945349.1 - 267 (C terminus) |
Absent in the structure |
Pro (Proline) -> Leu (Aliphatic hydrophobic) |
- |
| 2970 |
|
AQP12 |
rs1165199655 |
NP_945349.1 - 274 (C terminus) |
Absent in the structure |
Thr (Small and Weakly Polar) -> Asn (Neutral polar) |
- |
| 2971 |
|
AQP12 |
rs1383559729 |
NP_945349.1 - 281 (C terminus) |
Absent in the structure |
Val (Aliphatic hydrophobic) -> Ala (Small and Weakly Polar) |
- |
| 2972 |
|
AQP12 |
rs923929489 |
NP_945349.1 - 282 (C terminus) |
Absent in the structure |
Arg (Charged) -> Gln (Neutral polar) |
- |
| 2973 |
|
AQP12 |
rs923929489 |
NP_945349.1 - 282 (C terminus) |
Absent in the structure |
Arg (Charged) -> Pro (Proline) |
- |
| 2974 |
|
AQP12 |
rs976754758 |
NP_945349.1 - 282 (C terminus) |
Absent in the structure |
Arg (Charged) -> Trp (Aromatic) |
- |
| 2975 |
|
AQP12 |
rs1247460838 |
NP_945349.1 - 283 (C terminus) |
Absent in the structure |
Glu (Charged) -> Gln (Neutral polar) |
- |
| 2976 |
|
AQP12 |
rs1223325220 |
NP_945349.1 - 284 (C terminus) |
Absent in the structure |
Pro (Proline) -> Ser (Small and Weakly Polar) |
- |
| 2977 |
|
AQP12 |
rs935442304 |
NP_945349.1 - 286 (C terminus) |
Absent in the structure |
Arg (Charged) -> Cys (Small and Weakly Polar) |
- |
| 2978 |
|
AQP12 |
rs1265773791 |
NP_945349.1 - 286 (C terminus) |
Absent in the structure |
Arg (Charged) -> His (Charged) |
- |
