Translation initiation using alternative codons
is one of the important mechanisms by which single
mRNA gives rise to multiple proteins. Several examples have been found in which mRNAs
naturally support initiation from non-canonical codons. nonAUG database contains mRNA
sequences with non-canonical start codons collected from
Currently, coding regions of 876 mRNA sequences from 51 species
start from a non-AUG codon. This is about 0.04% of the
total mRNA sequences available in
database. 95 sequences are
highly curated and explicitly annotated to have non-AUG start sites.
This database will serve as a repository for mRNA sequences that use
alternate codons for translation initiation.
RefSeq release 44 totals nonAUG
sequences to 876.