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STRUCTURE BASED ALIGNMENT |
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A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| SCSCLE0892 | DEWSLSSEEAMQYIQEEKDNSNALAS | NYQSTNWAWGLGITIGIYIAGG | | SCSCLE0896 | LRFREPLAELLAVTCQLTLGFCADLV | NEVTTDWAWGLASMLGIYIAGG | | SCSCLE0919 | HFVATVGEFVGTTMFLFFAFAGTQVA | VELYIAIIFGFSLMVNVWIFFR | | SCSCLE0925 | HFVATTAEFAGTTLFLFFAFAGTQVA | QLLYIALSFGFSLAVNVWVFFR | | SCSCLE0934 | HIVAVIGELIGTTLFLFFGYAGIEVT | VLFYISATFGASLMVTAWIFFR | | SCSCLE0943 | HVVAVIGELIGTTAFLFIAFSAAEVA | QILFIAFGAGISLVVNAWTFFR | | SCSCLE0954 | LLVSMIGEFVGTFLFLFFAFGAAQTA | KLLFIALAFSASLAANVWIFFR |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
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| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| SCSCLE0892 | PIRKAFIYVLAQILGGFLAGLIAYG | PSSSFFNELVATGILACTILALG | | SCSCLE0896 | PLRKVPMYVLAQILGAFIAALIAFG | ASTSFFTEFVGTAILAVAVLALG | | SCSCLE0919 | PIVRAICLFFAQILGGIAASAMVLG | TVQGVFIEAILTAELVFTIFMLA | | SCSCLE0925 | PYLRGLFLFIAQIVGGITAAALVSA | IVRGLFIEMFLTAQLALTIFMLA | | SCSCLE0934 | SPVRAVLLVITQLGASCLAAILVKE | TAQGFVIEAITTAALIFTIIMLA | | SCSCLE0943 | DLTRCILLCIAQCAGGIAASAMAYG | TAQGVIVEMILTCQLCFTVLMLA | | SCSCLE0954 | SPLKALVLIPAQLAGGSLAAAAVKG | HVQGLFIELLLTFMLVITILMLV |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
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WIFWVGPFIGAALAVLIYDFI
|
| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| SCSCLE0892 | MHALIVGLVVTVLTMAFGY | YGAWGATISGALIGGLFYDVA | | SCSCLE0896 | MSAFVMGLVITVLSMAFGY | WGNWCAPISGAIFGAFLYDVA | | SCSCLE0919 | IAPVGIGLALFIAEMVGVF | WIYWIGPIMGTCIAVFFYKFI | | SCSCLE0925 | IAPIGIGLALFIAELTGLY | WIYWLGPFLGAILASAFYKFI | | SCSCLE0934 | VAPIGIGLALFVAHMVAVP | WIYWVGPLLGAGLAVLFFRLI | | SCSCLE0943 | LAPLGIGLSVFIGELAGVF | WIYWVGPIAGAGLASIIYKLI | | SCSCLE0954 | LAPIGIGFSLFIGHLVGIF | WIYWLGPALGSCLAAAVYLGL |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| SCSCLE0892 | AHLNPAISLMLCIY | GACLNPARDFGPRLAT | | SCSCLE0896 | AHLNPAISIMLWIY | GAALNPSRDLGPRLAL | | SCSCLE0919 | GLFNPAVTLGMVLV | GGSLNPARSFGPCVVS | | SCSCLE0925 | GLFNPAVTVGMCLV | GGSVNPARSFGPSVVS | | SCSCLE0934 | GLFNPAVTLALALL | GASLNPARSFGPSAIV | | SCSCLE0943 | GLFDPAVSIALFFV | GGSMNPARSLGPAVIT | | SCSCLE0954 | GQFNPAVTLALVII | GAGINPARAFSPALVQ |
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