STRUCTURE BASED ALIGNMENT |
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A conserved positions at helix-helix interface A
Ar/R selectivity filter
Protein |
Helix 1 |
Helix 2 |
1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
SACERE0479 | HFIAAVGEFCGTFMFLWCAYVICNVA | QLIMIAIGFGFSVMFSIWCFAG | SACERE0480 | HMREPFAEFLGTLVLVIFGVGGNLQA | SYESLSFAWGFGCMLGVYVAGG | SACERE0481 | YLKEFLAEFMGTMVMIIFGSAVVCQV | TFDDVALGWAAAVVMGYFCAGG | SACERE0621 | HFIAAVGEFCGTFMFLWCAYVICNVA | QLIMIAIGFGFSVMFSIWCFAG | SACERE0628 | HFIAAVGEFCGTFMFLWCAYVICNVA | QLIMIALGFGFSVMFSIWCFAG | SACERE0879 | HFIAAVGEFCGTFMFLWCAYVICNVA | QLIMIAIGFGFSVMFSIWCFAG | SACERE1009 | HFIAAVGEFCGTFMFLWCAYVICNVA | QLIMIALGFGFSVMFSIWCFAG |
Protein |
Helix 3 |
Helix 4 |
1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
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1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
SACERE0479 | SPTRCVVMWVSQIVAGMAAGGAASA | RTRGLFLEMFGTAILCLTVLMTA | SACERE0480 | PWKKVPVYIVAQIIGAYFGGAMAYG | WRNAFFDEFIGASILVGCLMALL | SACERE0481 | PLKKVPYYFAGQLIGAFTGALILFI | SGRQFFSEFLCGAMLQAGTFALT | SACERE0621 | SPTRCVVMWVSQIVAGMAAGGAASA | RTRGLFLEMFGTAILCLTVLMTA | SACERE0628 | ~PARCVVMWFPQIIAGMAAGGAASA | RSRGLFLEMFGTAVLCLTVLMTA | SACERE0879 | SPTRCVVMWVSQIVAGMAAGGAASA | RTRGLFLEMFGTAILCLTVLMTA | SACERE1009 | SPARCVVMWFSQIIAGMAAGGAASA | RSRGLFLEMFGTAVLCLTVLMTA |
Protein |
Helix 5 |
Helix 6 |
1J4N |
SGPLAIGFSVALGHLLAID
|
WIFWVGPFIGAALAVLIYDFI
|
1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
SACERE0479 | MAALPIGISLFIAHVALTA | WIYWIGTLLGSILAWSVWQLL | SACERE0480 | MTALIIGFLVAAIGMALGY | WGAWGGPIAGGIAGALIYDIF | SACERE0481 | VFPLMMFILIFIINASMAY | WVPMVGPFIGALMGGLVYDVC | SACERE0621 | MAALPIGISLFIAHVALTA | WIYWIGPLLGSILAWSVWQLL | SACERE0628 | MAALPIGISLFMAHMALTG | WIYWIGPLLGAFLAWSVWQLL | SACERE0879 | MAALPIGISLFIAHVALTA | WIYWIGTLLGSILAWSVWQLL | SACERE1009 | MAALPIGISLFMAHMALTG | WIYWIGPLLGAFLAWSVWQLL |
Protein |
Loop B |
Loop E |
1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
SACERE0479 | GALNPAMSLSLCLA | GTGVNPARSLGAAVAA | SACERE0480 | GHINPAVTISMAIF | SFTINPARDLGPRIFA | SACERE0481 | AHLNPSITLANLVY | GTAMNLARDLGPRLAL | SACERE0621 | GALNPAVSLSLCLA | GTGVNPARSLGAAVAA | SACERE0628 | GALNPAVSLSLCLA | GTGVNPARSLGAAVAA | SACERE0879 | GALNPAMSLSLCLA | GTGVNPARSLGAAVAA | SACERE1009 | GALNPAVSLSLCLA | GTGVNPARSLGAAVAA |
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