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STRUCTURE BASED ALIGNMENT |
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A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| RANORV0469 | FSRAVLAEFLATLLFVFFGLGSALQW | SVLQIAVAFGLGIGILVQALGH | | RANORV0470 | FFKAVFAEFLATLIFVFFGLGSALKW | TILQISIAFGLAIGTLAQALGP | | RANORV0471 | ISKALFAEFLATGLYVFFGVGSVLPW | SVLQVAITFNLATATAVQISWK | | RANORV0472 | FWKAVTAEFLAMLIFVLLSVGSTINW | DMVLISLCFGLSIATMVQCFGH | | RANORV0473 | FWRAVVAEFLAMTLFVFISIGSALGF | DNVKVSLAFGLSIATLAQSVGH | | RANORV0474 | YIQPCVVELLGSALFIFIGCLSVIEN | GLLQPALAHGLALGLIIATLGN | | RANORV0475 | WVREFLAEFLSTYVLMVFGLGSVAHM | SYLGVNLGFGFGVTMGIHVAGG | | RANORV0476 | LLRQALAECLGTLILVMFGCGSVAQV | GFLTINLAFGFAVTLAILVAGQ | | RANORV0477 | IAKETLSEFLGTFIMIVLGCSSIAQA | GIITINIGFASAVVMALYVTFG | | RANORV0478 | MVHAFVLEFLATFQLCYCTHELQLLS | DSGHPTWTLTLIYFFSLVHGLT | | RANORV0494 | FWRAIFAEFFATLFYVFFGLGSSLRW | HVLQVALAFGLALATLVQTVGH |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
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| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| RANORV0469 | SFLRAAFYVAAQLLGAVAGAAILHE | AGQAVTVELFLTMQLVLCIFAST | | RANORV0470 | SLLRAVFYVAAQLVGAIAGAGILYW | PGKAMVVELILTFQLALCIFSST | | RANORV0471 | SLPRAVAYIAAQLAGATVGAALLYG | TGQAVAVELVLTLQLVLCVFASM | | RANORV0472 | SIAKSVFYITAQCLGAIIGAGILYL | AGHGLLVELIITFQLVFTIFASC | | RANORV0473 | SILRAVMYIIAQCVGAIVASAILSG | SGQGLGIEIIGTLQLVLCVLATT | | RANORV0474 | KTMLLIPYWVSQLFGGMIGAALAKV | VAEALGVEIVMTMLLVLAVCMGA | | RANORV0475 | AWKKFPIYVLGQFLGSFLAAATTYL | LWRGFVDEVFVTGMLQLCIFAIT | | RANORV0476 | PWIKLPIYTLAQTLGAFLGAGIVFG | MVNGFFDQFIGTAALIVCVLAIV | | RANORV0477 | EWFKFPFYVGAQFLGAFVGAATVFG | TPGAFVDQVVSTMFLLLIVFAMF | | RANORV0478 | SPEMGAVRLMAQLVSALCSRYCISA | ISKAIIIEAICSFIFHSALLHFQ | | RANORV0494 | SLLRAFCYIAAQLLGAVAGAAVLYS | VGQATTVEIFLTLQFVLCIFATY |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
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WIFWVGPFIGAALAVLIYDFI
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| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| RANORV0469 | SPALSIGFSVTLGHLLGIY | WVFWIGPLVGAIIGSLLYNYL | | RANORV0470 | SPALSIGLSVTLGHLVGIY | WVFWVGPIVGAMLAAILYFYL | | RANORV0471 | SPAAMIGTSVALGHLIGIY | WIFWVGPLTGAVLASLIYNFI | | RANORV0472 | SVALAIGFSVAIGHLFAIN | WIYWVGPIIGAVLAGALYEYV | | RANORV0473 | SAPLAIGLSVALGHLLAID | WIFWVGPFIGSALAVLIYDFI | | RANORV0474 | LAPFSIGFSVIVDILAGGG | WIYWLGPLLAGLFVGLLIRLF | | RANORV0475 | TEPLMIGILVCVLGVSLGM | WVPVVAPLLGAYLGGIVYLGL | | RANORV0476 | LEAFTVGLVVLVIGTSMGF | WVPIVSPLLGSIGGVFVYQLM | | RANORV0477 | LEPVVIGLLIIVLSCSLGL | WIPVVGPMIGAFLGGLIYILF | | RANORV0478 | LRIHVLAALITFLAYAGGS | VVYWVAPSLGVLLMILMFSFF | | RANORV0494 | SVALAVGFSLTLGHLFGMY | WVYWVGPIIGGGLGSLLYDFL |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| RANORV0469 | AHINPAVTVACLVG | GCSMNPARSLAPAVVT | | RANORV0470 | GHINPAITLALLIG | GCSMNPARSFGPAVVM | | RANORV0471 | AHANPAVTLAYLVG | GCSMNPARSFGPAVIV | | RANORV0472 | GHINPAVTVAMVCT | GASMNPARSFGPAVIM | | RANORV0473 | AHLNPAVTLGLLLS | GCGINPARSFGSAVLT | | RANORV0474 | GHFNPAVSLAVTLV | GACMNPARAFGPAVMA | | RANORV0475 | AHMNAAVTFTNCAL | GYAINPSRDLPPRFFT | | RANORV0476 | AHLNPAVTFAMCFL | GYAVNPARDFGPRLFT | | RANORV0477 | GHINPAVSFAMCAF | GCAMNPARDLSPRLFT | | RANORV0478 | TASNPCGVMMQMIL | GALFNPALALSLHFPC | | RANORV0494 | AHVNPAVTFAFLVG | GAGMNPARSFAPAILT |
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