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STRUCTURE BASED ALIGNMENT |
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A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| PYTRIT0913 | KYPQAPAEFLATFIYLLIGLCVNLSV | NFETQAWGWGFAVMIGIYLGGG | | PYTRIT0931 | HFVAFVGEFVGTTMFLFFAFSGTQVA | VLLYIAIVFAFSLMVNVWVFFR | | PYTRIT0936 | HLISFLGEYVGTFLFLFFAFAATQVA | TLLYISLAFGCSLAITVWVFFR | | PYTRIT0947 | ELIAATSEFAGTFMFLFFAFGGTSIA | VLLYISLIFGFSLMVNVWIFFR | | PYTRIT0953 | HIVAASSEFVGSFMFLFFSFSGHLMI | QNIFIALVYGFSLLVNSWAFFR |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
|
| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| PYTRIT0913 | PWRMALVYIAMQLLAGLCAGAVAYA | TATGFFNDFVYMAIFVCVIFALG | | PYTRIT0931 | SPIRAFLLLAAQILGSIFASWLVSI | LVQGVFIEAILTAELVFTIFMLA | | PYTRIT0936 | GWVKVLLLILAQTLGAITAAAIVSG | VTRGLFIEMFLTFMLLLTIFMLA | | PYTRIT0947 | PLPRAIFLTISQLLAGIAAAAVVSA | PAQGVFLEMFMTSFLVFTIFMLA | | PYTRIT0953 | PTIRAIFLFPAQLLGAICAAALVEA | IVQGVFIEAFMTAELVFVVLMLA |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
|
WIFWVGPFIGAALAVLIYDFI
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| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| PYTRIT0913 | MTAFIVGLTGMVTMIGLGY | GASISGALCGGLLYDLCIFVG | | PYTRIT0931 | IAPVGIGLALFIAELVGVY | WIYWIGPGMGAIIAVVFYRSS | | PYTRIT0936 | IAPLGIGLALFIAELAGVY | WIYWLGPLLGAAMAAGFYRLL | | PYTRIT0947 | LAPIGIGLSLFVAELLGAF | YVYWAGPVMGTLLAWAVYKLV | | PYTRIT0953 | IAPIGIGLALFVAMMGGVY | WIYWIGPILGALFAALYYRFV |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| PYTRIT0913 | SHLSPTISISLSVY | GLGISPARDLGPRLIA | | PYTRIT0931 | GLFNPAVTFAMLLC | GGSLNPARSFGPCVIT | | PYTRIT0936 | GLFNPAVTFAMGLV | GGSLNPARSFGPALIT | | PYTRIT0947 | GLFNPTVSLGLYLI | GGSLNPARSLGPAVVT | | PYTRIT0953 | GLFNPAVTFGMVVA | GASLNPARSFGPAVAS |
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