|
STRUCTURE BASED ALIGNMENT |
| |
A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| PIABIE0608 | FWRAGIAEFMATFLFLYITILTVMGV | GIQGIAWAFGGMIFCLVYCTAG | | PIABIE0614 | FYRALIAEFVATLLFLYITIATVIGH | GVLGIAWSFGGMIFVLVYCTAG | | PIABIE0620 | AFKAALAELISTLIFVFAGEGSGMAF | GLVAVALAHGLGLFVAVAVGAN | | PIABIE0799 | SIRAALAEFFSTLIFVFAGEGSVMAY | GLVAVALAHALGLFVAVAVAIN |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
|
| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| PIABIE0608 | SLPRAVFYMICQCLGAICGAGVVKG | KGDGLGAEIVGTFVLVYTVFSAT | | PIABIE0614 | SLPRAILYMIAQCLGAICGTGLAIC | KGVGLAAEIIGTFVLVYTVFSAT | | PIABIE0620 | TLLRGILYWIAQLLGAIVACLLLKF | TGEGVVMEIVITFALIYTVYATA | | PIABIE0799 | SILRGILYWIAQLLGAVVASLLLKF | SWNAVVLEIVMTFGLVYTVYATA |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
|
WIFWVGPFIGAALAVLIYDFI
|
| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| PIABIE0608 | LAPLPIGFAVFLVHLATIP | WIFWVGPFLGAGLAAFYHQMI | | PIABIE0614 | LAPLPIGFAVFMVHLATIP | WIFWVGPFAGAALAAAYHQYI | | PIABIE0620 | IAPIAIGFIVGANILAAGP | WVYWVGPLIGGGLAGIVYRGI | | PIABIE0799 | IAPLAIGFIVGANILAGGA | WIYWVGPLIGGGFAGLLYEWL |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| PIABIE0608 | GHINPAVTFGLFLA | GTGINPARSLGAAIIY | | PIABIE0614 | GHINPAVTFGLFLA | GTGINPARSFGAAVIY | | PIABIE0620 | GHVNPAVTFGALVG | GGSMNPARSFDPAVVS | | PIABIE0799 | GHVNPAVTFGALMG | GASMNPARAFGPALVS |
|
