|
STRUCTURE BASED ALIGNMENT |
| |
A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| PHINFE0967 | HLRECFAEFLGTFVMILFGMGVNNQV | TWLSINMCWGIGVLIGVYCMEG | | PHINFE0968 | HVRECLAELLGTFVMICFGMGVNNQV | TWLSINVAWGIGILMAVYCSEG | | PHINFE0969 | HLRECFAEFLGTFVMIVFGMGVNNQV | TWLSINMCWGIGVLIGVYCSEG | | PHINFE0970 | LFRECLAEFLGTMVMIMFGDGVVAQV | EYININLCWGLGVLFGIHVSGG | | PHINFE0971 | LFRECMAEFLGMLVFMLFGTGVVAQV | EFLSINLCWGLGILFGIHVCGG | | PHINFE0972 | DMRAYMAEFVGTFILVLIGDGSVAQF | DYLSVNLCWGIALLFGVHFSGG | | PHINFE0973 | HLRECFAEFLGTFVIIVFGMGVNSQV | TWLSINICWGIGVMIGVYCSEG | | PHINFE0974 | HVREIFAEFVAVFVMMSFGLGATCQS | DFTQIVFGWGIGVLFGIHIGGG | | PHINFE0975 | DVRAYLAEFVGTFILVLIGDGSVAQY | HYLSVNLAWGIALLFGIHFSGG | | PHINFE0977 | NFRAYLAEFVGTFILVLIGDGSVAQY | HYLSVNLCWGIALLFGIHFAGG | | PHINFE0978 | FAKEMMAEFLATFVTMLFGLSCMTQV | NFVTIALCWGLAFFFGITVGGG | | PHINFE0980 | FTRQLMAEFFATFIMVSFGLGATAQI | TFITVALTWGIAYFLGITVAGG | | PHINFE0983 | QAHTHGAEHRTGTVATAIHYALTMSA | NLITVALTWGIADFLGITVAGG |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
|
| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| PHINFE0967 | PWWKASGYMISQVLGAFVGAFVIWV | NYTAFYTEVVGTGMLLLGIYAIT | | PHINFE0968 | PWWKMPGYCLSQLIGAFVGAAAIYL | NYTAFYTETLATGMLLLCIYAIT | | PHINFE0969 | PWWKAPGYMISQLLGAFCGAFIIYV | NYTAFYTEFIGTAMLVLSIYAIT | | PHINFE0970 | EWKKVPYYVVSQILGAFVAAFVVWV | VGTCFLTEVVGTALLMGCIFAIG | | PHINFE0971 | KWKKVPYYVAAQLLGAFGASAIVCM | TGTCFLTEVVGTALLVGCLFAIG | | PHINFE0972 | EWRKVPGYIIAQTMGAFAAALVLFI | NWAAFANEVIGTALLVSGIFALC | | PHINFE0973 | PWWKAPVYMISQVFGAFCGAFTIWV | NYTAFYTEFIGTAMLVLSIYAIT | | PHINFE0974 | PWRKVPGYVAAQTLAAYLAALFIYV | NFIAFLTEVFATALLVGGIFAVL | | PHINFE0975 | EWYKLPGYFVAQTLGAFAAAWVVFI | NWCGLANEIVGTALLVSGIFAVG | | PHINFE0977 | EWHKVPGYFVAQTAGAFAAAIIVFI | NWSALANEIIGTALLVSGIFAVG | | PHINFE0978 | PWKKVPFYILNQVVAAYVAALFVYI | NFTCFLTEFVATALLILGILALL | | PHINFE0980 | PWKKVPFYLLAQLLASYIAALVVYI | NFTCFLTEFFAAAVLVVGFLAVQ | | PHINFE0983 | PWKKVPFYLLAQLLASYIAALVVYI | NFTCFLTEFFAAAVLVVGFLAVQ |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
|
WIFWVGPFIGAALAVLIYDFI
|
| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| PHINFE0967 | GAPFAFCLSIMALGMCIGM | WIPIVGLVGGVIGAGLYITLV | | PHINFE0968 | GTPFAFALMIMALGMSFGM | WIPIVGLVGGVIGAGLYTLLV | | PHINFE0969 | GSPFAFCLMIMALGMAFGM | WIPIVADSMGGIAGAGLYRLL | | PHINFE0970 | TQPGAVALLVVAIGMAFGM | WVPIVGLLGGPIGAGIYVGLI | | PHINFE0971 | SQPGAVALLVVAIGMAFGM | WVPIVAPILGGPIGAGMYVVL | | PHINFE0972 | SFPGAVGLLLTGIGMSFGL | WIPILGPFIGAVLGAAMYVGL | | PHINFE0973 | GNAFAFALMIMALGMAFGM | WIPIAADLLGGVAGAGLYRLL | | PHINFE0974 | SAPSAVALLVVGIGMAFSV | WVPIVGPTVGGALGGLVYVAL | | PHINFE0975 | TFPAAVALMLTCVGMAFGL | WIPVVGPFVGGLLGAGLYVGL | | PHINFE0977 | SFPGAVALMLTCIGMAFGL | WIPIVGPFVGGIVGAATYVGL | | PHINFE0978 | AVPPAVGALVSTIAMGFAM | WVPIVAPIMGGAAGGFVYEVL | | PHINFE0980 | AVPAAIGVLVSAIAMAFGM | FWILVAPILGGAVGGIAYEGM | | PHINFE0983 | AVPAAIGVLASAIAMAFGM | FWILVAPILGGAVGGIAYEGM |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| PHINFE0967 | VHLNTAVTLAHCVY | GYAIKPARDFGPRLFT | | PHINFE0968 | AHLNPSVTLAHCVY | GYAMNPARDFGPRLLT | | PHINFE0969 | ANLNTAVTLAHCVY | GYAVNPARDFGPRIFT | | PHINFE0970 | AHLNPAVTTTLAWF | GYAINPARDFGPRFFS | | PHINFE0971 | AHLNPAVTVSLALF | GYAINPARDLGPRLFS | | PHINFE0972 | GHLNPAVSVAMAIF | GYALNPARDFGPRLLT | | PHINFE0973 | ANLNTAVTLAHCVY | GYAVNPARDFGSRLFK | | PHINFE0974 | SHLNPAITTTAALF | GCAINPARDFGPRLMM | | PHINFE0975 | GHLNPAVSLALAAF | GYALNPARDFGPRLFT | | PHINFE0977 | GHLNPAVTLTLALF | GYALNPARDFGPRLFT | | PHINFE0978 | AHLNPAVTTTLALL | GLAINPARDLGPRLFM | | PHINFE0980 | GHLNPTVTVAVAAL | GLAINAARDLGPRLLM | | PHINFE0983 | GHLNPTVTVAVAAL | GLAINAARDLGPRLLM |
|
