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STRUCTURE BASED ALIGNMENT |
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A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| PHPATE0822 | FWRAGIAEFIATLLFLYITIQTVMGH | GIQGIAWAFGGMIFALVYCTAG | | PHPATE0823 | FWRAGIAEFFATLLFLYITIQTVMGH | GIQGIAWAFGGMIFALVYCTAG | | PHPATE0824 | FWRAGIAEFFASFLFLYITVQTVMGH | GIQGIAWAFGGMIFTLVYCTAG | | PHPATE0825 | FYRAIIAEFVATLLFLYITISTVIGA | GLLGIAWAFGGMIFVLVYCTAG | | PHPATE0826 | FYRAVIAEFVATLLFLYITIATVIGA | GLLGIAWAFGGMIFVLVYCTAG | | PHPATE0827 | FYRAIIAEFVATLLFLYITIATVIGA | GTLGIAWAFGGMIFVLVYCTAG | | PHPATE0828 | FYRAIITEFISTLLFLYIAIGTVVGA | GILGIAWAFGGMIFVLVYCTAG | | PHPATE0829 | FYRAIIAEFIATLLFLYVSLTTLMGT | GLIETAWAFGGMIFILVYCTAG | | PHPATE0830 | AIKGAVAEFISLFLFVFIGVGSVMAY | GLLMIAIAHGLAIAVLVAATAN | | PHPATE0831 | ALKGALAEFISLFLFVFIGVGSVMSY | GLLIIAIAHGLAIAILVAATAN | | PHPATE0832 | ALKGALAEFISLFLFVFIGVGSVMSY | GLLMIAIAHGLAIAILVAATAN | | PHPATE0833 | ALKGAFAEFLALFLFVFIGVGSVMSY | GLLVIAIAHGLAIAVLVSATAN | | PHPATE0834 | LTRKFATELIGTFVLIFAATATPIVN | TLLGNAATAGLAIMIVIFATGH | | PHPATE0835 | LARKAVADASITFLWVFAMASLGAVS | KMYIVFSLVSFLIFFFSFLGQA | | PHPATE0836 | LARKAVADASITFLWVFAMASLGAAS | KMYIVFALVSFLVFFFSFLGHA | | PHPATE0837 | VWRAGVFECVASFAATFVGILCTIST | PVAVIACLQGLVLSLCIFAAAP |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
|
| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| PHPATE0822 | SLNRALFYMIMQCLGAMCGAEIVKG | KGDGLGAEIVGTFVLVYTVFSAT | | PHPATE0823 | SLNRALYYMIMQCLGAMAGAGIVKG | KGDGLGAEIVGTFVLVYTVFSAT | | PHPATE0824 | TFPRTVLYIVCQCLGAICGAGAVKG | KGDGLGAEIVGTFVLVYTVFSAT | | PHPATE0825 | SLPRALTYMIAQCLGAICGAGLAKG | TGTGLAAEIIGTFVLVYTVFSAT | | PHPATE0826 | SLPRALAYMIAQCLGAICGAGLVKG | IGTGLAAEIIGTFVLVYTVFSAT | | PHPATE0827 | SLPRALAYMIAQCLGAICGAGLVKG | IGTGLAAEIIGTFVLVYTVFSAT | | PHPATE0828 | SLTRSLAYMVAQCLGAICGAGLVKE | TGTGLAAEIIGTFVLMFTVFSAT | | PHPATE0829 | TLPRASAYIVAQCLGAIVGAAIARG | IGQALAAEIMGTFVLLYTVLSAT | | PHPATE0830 | TIIRLVLYWVAQLLGAVAGAWVLKA | GFSAMLMEIVLTFTLMFVVFATA | | PHPATE0831 | TIIRLVLYWIAQLLGAVAGAWVLKI | TWSATLMEIVLTFTLVFVVFATA | | PHPATE0832 | TVIRLVLYWVAQLLGAVAGAWVLKM | PMSAVLMEIVLTFTLVFVVFATA | | PHPATE0833 | TVIRLVLYWIAQLLGAAAGAWVLKI | PWSAVLMEAVLTFTLVFVVFATA | | PHPATE0834 | PWVQVPFYIAAQVLGSIAASFTLKG | YWPSFLLEFIISFNLMFVITAVA | | PHPATE0835 | DLFTLGVRLPAQMVGAVGGALTIWE | LETGVAAETILTFTITLIVMWAI | | PHPATE0836 | DLFTLGVRLPAQMVGAVGGALAILE | LQTGVIAEAILTFTITLIVMWAM | | PHPATE0837 | SPVRGVLYIIGQILGSIVGSFMAKI | TGRALVLEIVLAFFVLFISYSVA |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
|
WIFWVGPFIGAALAVLIYDFI
|
| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| PHPATE0822 | LAPLPIGFAVFLVHLATIP | WIFWIGPMLGAALAAAYHTLV | | PHPATE0823 | LAPLPIGFAVFLVHLATIP | WIFWVGPFIGAALAAAYHTLV | | PHPATE0824 | LAPLPIGFAVFLVHLATIP | WIFWVGPILGATLAAMYHTLV | | PHPATE0825 | LAPLPIGFAVFMVHLATIP | WIFWVGPFLGAALAASYHQYI | | PHPATE0826 | LAPLPIGFAVFMVHLATIP | WIYWVGPFLGAALAAAYHQYV | | PHPATE0827 | LAPLPIGFAVFMVHLATIP | WIFWVGPFVGAALAAAYHQYV | | PHPATE0828 | LAPLPIGFAVFVVHCATIP | WIFWVGPFLGAALAAAYHQYI | | PHPATE0829 | LAPLPIGFAIFVVHLATIP | WIFWVGPIVGSTCAAIYYTYV | | PHPATE0830 | IAPLAIGFTVLAQIFVGAP | WVYWVGPLVGAALAALIYDGV | | PHPATE0831 | IAPLAIGFTVLAQIFVGAP | WVYWVGPFIGAALAALIYDGV | | PHPATE0832 | IAPLAIGFTVLAQIFVGAP | WVYWVGPFIGAALAAVIYDGV | | PHPATE0833 | IAPLAIGFTVLAQIFVGAP | WVYWVGPFIGAALAALIYDGV | | PHPATE0834 | LAGIAVGACVMMNIMIAGS | WLYMLGPVLGMLAGATAYTAV | | PHPATE0835 | SRTFIIIGATIALVIAGGA | AVYWAGPMIGTICAVLTFNLI | | PHPATE0836 | AKTFIIIGATIALVTAGGA | AVYWAGPMIGTIFAVWAFNLL | | PHPATE0837 | MIGGIVGLCIFAGAGLFSG | WVFWVGPGLSGALMAALYRNI |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| PHPATE0822 | GHINPAVTFGLFLA | GTGINPARSLGAAVVF | | PHPATE0823 | GHINPAVTFGLFLA | GTGINPARSLGAATIY | | PHPATE0824 | GHINPAVTFGLFLA | GTSINPARSLGAAVI- | | PHPATE0825 | GHINPAVTFGLLMA | GTGINPARSFGAAVIY | | PHPATE0826 | GHINPAVTFGLLLA | GTGINPARSFGAAVIY | | PHPATE0827 | GHINPAVTFGLLLA | GTGINPARSFGAAVIY | | PHPATE0828 | GHINPAVTFGLLLA | GTGINPARSFGAAVIF | | PHPATE0829 | GHINPAVTFGLFLA | GTGINPARSLGA---- | | PHPATE0830 | GHVNPAVSLGLALA | GASMNPGRSFGPAVVA | | PHPATE0831 | GHVNPAVSLGLALA | GASMNPGRSFGPAVVA | | PHPATE0832 | GHVNPAVSLGLALA | GASMNPGRSFGPAVIA | | PHPATE0833 | GHINPAVSLGLALA | GASMNPGRSFGPALVA | | PHPATE0834 | AHVNPAITIAFASL | GASMNPVRTLGPAIAV | | PHPATE0835 | ASWNPTTIVAFSFA | GPAMNPANAFGWAFVS | | PHPATE0836 | ASWNPTAIVAFSYA | GPAMNPANAFGWAFVS | | PHPATE0837 | GHVNPCITWTEMLT | GAGINPGRCIGPAVVL |
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