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STRUCTURE BASED ALIGNMENT |
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A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| PHTRIC0991 | LARELIAEAFGTFLIVNIGTGAVMSA | GLWQIAVVWVIAVTVAISATGS | | PHTRIC0995 | LRSQLTAELIGTAILVQVGCGANCLA | GMWQAAIVWILGATLGLYSSAA | | PHTRIC1000 | ---MLIAEVFGTCMFVQIGCAANAVA | IDWQVGVVWALAMTVAVFLSAA | | PHTRIC1008 | YFKSFRHEFFGTMLMIGATFSAGKWI | GKESLRMAWTSHGLGVIAADYL |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
|
| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| PHTRIC0991 | GWIKVLPYILAQVCGSVLGSAANFF | VTQAFFAEALGTALLAGVIFALT | | PHTRIC0995 | PYANVLPYWAAQLAGAFLGALTNLI | GWHAFLLEAFGTAFLVFCIFMLT | | PHTRIC1000 | RFRKLIPYWAAQLGGALLAGIVNLF | GVHAFFIEAFGTGVLVFCIFAAT | | PHTRIC1008 | SYTEAFVRVAAQLGGGLISFPLYHA | ATEAFLSEYVATMLLMFTIYILN |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
|
WIFWVGPFIGAALAVLIYDFI
|
| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| PHTRIC0991 | GLVPLIGLTVGALVCVVA- | WLYILAPMVGAPVGAAFVDRV | | PHTRIC0995 | AAVPLVAIAIGSMVVLLGP | WIVYFTALMGGPIGALIADRL | | PHTRIC1000 | AVPPIIGAMYGVLVVTLGP | LPYLLGPMIGGPIGAFLADKV | | PHTRIC1008 | LIKQSLTAIAIRSLIEGFP | FVYWIAPWMAAITASMLYVIY |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| PHTRIC0991 | AHLNPAISICFALL | QAGFNPARDFGPRIVA | | PHTRIC0995 | GHLNPAVTLSFAVV | GAGINPARDMGPRLAT | | PHTRIC1000 | AHLNPAVSFSFALA | GGSFNPVRDMGPRIVS | | PHTRIC1008 | PHVNPAVTMSMWCL | GPAMNPMLATAWDVFG |
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