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STRUCTURE BASED ALIGNMENT |
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A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| PATROG0457 | FLKAVFAEFLATLIFVFFGLGSALKW | TILQIALAFGLAIGTLAQALGP | | PATROG0458 | FSRAVFAEFLATLLFVFFGLGSALNW | SVLQIAMAFGLGIGTLVQALGH | | PATROG0459 | ISRALFAEFLATGLYVFFGVGSVMRW | SVLQIAIAFNLVTAMAVQVTWK | | PATROG0460 | FWKAVTAEFLAMLIFVLLSLGSTINW | DMVLISLCFGLSIATMVQCFGH | | PATROG0461 | FWRAVVAEFLATTLFVFISIGSALGF | DNVKVSLAFGLSIATLAQSVGH | | PATROG0462 | FWRAVVAEFLATTLFVFISIGSALGF | DNVKVSLAFGLSIATLAQSVGH | | PATROG0463 | FVQPCLVELLGSTLFIFIGCLSVIEN | GLLQPALAHGLALGLVIATLGN | | PATROG0464 | LLRQALAECLGTLILVMFGCGSVAQV | GFLTINLAFGFAVTLGILIAGQ | | PATROG0465 | LAKETLSEFLGTFILIVLGCGCVAQA | GVITINVGFSMAVAMAIYVAGG | | PATROG0466 | LARQCLAEFLGVFVLMLLTQGAVAQA | NFFTMFLAGSLAVTIAIYVGGN | | PATROG0467 | VAHAFVLEFLATFQLCCCTHELQLLS | HPAHPTWTLTLVYFFSLVHGLT |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
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| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| PATROG0457 | SLLRAFFYVAAQLVGAIAGASILYG | QGQAMVVELILTFQLALCIFAST | | PATROG0458 | SFLRAAFYVAAQLLGAVAGAALLHE | AGQAVTVELFLTLQLVLCIFAST | | PATROG0459 | SLPRAVAYVAAQLVGATVGAALLYG | TGQAVAVELLLTLQLVLCVFAST | | PATROG0460 | SIAKSVFYIAAQCLGAIIGAGILYL | AGHGLLVELIITFQLVFTIFASC | | PATROG0461 | SIFRALMYIIAQCVGAIVATAILSG | SGQGLGIEIIGTLQLVLCVLATT | | PATROG0462 | SIFRALMYIIAQCVGAIVATAILSG | SGQGLGIEIIGTLQLVLCVLATT | | PATROG0463 | NLVMLLPYWVSQLLGGMLGAALAKA | VAGALVAEIILTTLLALAVCMGA | | PATROG0464 | PWIKLPIYTLAQTLGAFLGAGIVFG | MINGFFDQFIGTASLIVCVLAIV | | PATROG0465 | KWFKLPFYVGAQFLGAFVGAATVFG | LANAFADQVVATMILLIIVFAIF | | PATROG0466 | PWVKLPIYILVQLLSAFCASGATYV | LNNGFLDQVLGTGMLIVGLLAIL | | PATROG0467 | SPETGAVRLLAQLVSALCSRYCTSA | LLKAVITEAVCSFLFHSALLHFQ |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
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WIFWVGPFIGAALAVLIYDFI
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| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| PATROG0457 | SPALSIGLSVTLGHLVGIY | WVFWVGPIVGAVLAAILYFYL | | PATROG0458 | TPALSIGFSVALGHLLGVG | QVFWIGPLVGAILGSLLYNYV | | PATROG0459 | SPATMIGISVALGHLIGIH | WVFWVGPLMGALLASLIYNFV | | PATROG0460 | SIALAIGFSVAIGHLFAIN | WIYWVGPIIGAVLAGGLYEYV | | PATROG0461 | SAPLAIGLSVALGHLLAID | WIFWVGPFIGGALAVLIYDFI | | PATROG0462 | SAPLAIGLSVALGHLLAID | WIFWVGPFIGGALAVLIYDFI | | PATROG0463 | LAPFSIGFAVTVDILAGGT | WIYWLGPLLAGLLVGLLIRCF | | PATROG0464 | LEAFTVGLVVLVIGTSMGF | WVPIVSPLLGSIAGVFVYQLM | | PATROG0465 | LEPIAIGLLIIVIASSLGL | WIPVVGPLVGAVIGGLIYVLV | | PATROG0466 | LEPVVVGMLILALGLSMGA | WVPVVAPLVGATVGTATYQLL | | PATROG0467 | LRIHLLAALITFLVYAGGS | IVYWLAPSLGILLMILMFSFF |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| PATROG0457 | GHINPAITLALLVG | GCSMNPARSFGPAVVM | | PATROG0458 | AHINPAVTVACLVG | GVPPEPAGSGCGRGC | | PATROG0459 | AHANPAVTLAFLVG | GCSMNPARSFGPAIII | | PATROG0460 | GHINPAVTVAMVCT | GASMNPARSFGPAVIM | | PATROG0461 | AHLNPAVTLGLLLS | GCGINPARSFGSAVIT | | PATROG0462 | AHLNPAVTLGLLLS | GCGINPARSFGSAVIT | | PATROG0463 | GHFNPAVSLAAMLI | GGCMNPARAFGPAVVA | | PATROG0464 | AHLNPAVTFAMCFL | GYAVNPARDFGPRLFT | | PATROG0465 | GHVNPALSLAMCLF | GCAMNPARDLSPRLFT | | PATROG0466 | AHLNPAFSLAMCIV | GIPLNPARDLGPRLFT | | PATROG0467 | TSSNPCGVMMQMML | GAVFNPALALSLHFMC |
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