MIPModDB
 
STRUCTURE BASED ALIGNMENT
  A conserved positions at helix-helix interface     A Ar/R selectivity filter

Protein
Helix 1
Helix 2
1J4N
FWRAVVAEFLAMILFIFISIGSALGF
DNVKVSLAFGLSIATLAQSVGH
1FX8
LKGQCIAEFLGTGLLIFFGVGCVAAL
GQWEISVIWGLGVAMAIYLTAG
1RC2
MFRKLAAECFGTFWLVFGGCGSAVLA
GFAGVALAFGLTVLTMAFAVGH
1Z98
FWRAAIAEFIATLLFLYITVATVIGH
GLLGIAWAFGGMIFVLVYCTAG
2B60
FWRAIFAEFFATLFYVFFGLGASLRW
HVLQVALAFGLALATLVQAVGH
2F2B
LTKRCIAEFIGTFILVFFGAGSAAVT
DWVAIGLAFGFAIAASIYALGN
ORSATI0223FIQKIIAEIFGTYFLIFAGCGAVTINGVLGIAWAFGGMIFILVYCTAG
ORSATI0224KNLLILAEILGTYFMIFAGCGAVVVNGLLGISWAFGGMIFILVYCTAG
ORSATI0225FAQKVIAEILGTFFLIFAGCAAVAVNGLLGIAWAFGGMIFVLVYCTAG
ORSATI0226FLQMLLAEFLATFFLMFAGLGAITVEGLLGIAWAFGGMIFVLVYCTAG
ORSATI0227FMQKILTEILGTYFMIFAGCGAVVVNGLIAAAVAHAFALFVAVSVGAN
ORSATI0228LLKKVVSEVVATFLLVFMTCGAAGISGLIAASLAHALALFVAVAVGAN
ORSATI0229LLKKVISEVVATFLLVFVTCGAASIYGLVAIAIAHALALFVGVSVAAN
ORSATI0230LHVCLGAEFVGTFILIFFATAAPIVNGLVAVAVCHGFGLFVAVAIGAN
ORSATI0231LVKKVGAEFFGTFTLIFTVLSTIIMDGLVAIAIAHAFALFVGVSMAAN
ORSATI0232LLKKVSAEFFGTFILIFTVLSTIIMDGLVAVSLAHALALAVAVAVAVN
ORSATI0233LAKKAAAEFVGTFILIFAMLSTIVTDGLLVVAVAHALALAAAVAVSRN
ORSATI0234LVKKAAAEFIGTFILVFTVLSTVVMDALAGVAIATALAAGVLVTAGFH
ORSATI0235LIREVMVEGLASFLVVFWSCVAALMQAVTAAAMAQALVVAVLATAGFH
ORSATI0236FYRAGIAEFVATFLFLYITILTVMGVGLTAVAAAHALVVAVMVSAGLH
ORSATI0237FYRAGIAEFMATFLFLYITVLTVMGVSLMATAVAQAFGLFAAVFIAAD
ORSATI0238FYRAGIAEFVATFLFLYISILTVMGVGLIAAAVAHAFALFVAVSVGAN
ORSATI0239FYRAGIADFVATFLFLYITILTVMGVGLIAASLAHALALFVAVSVGAN
ORSATI0240FYRAGIAEFMATFLFLYITVLTVMGVGLVAIAIAHALALFVGVSVAAN
ORSATI0241LYRAVIAEFIATLLFLYITVATVIGYGLVAIAVAHALALFVGVSVAAN
ORSATI0242LYRAVIAEFIATLLFLYITVATVIGYGLVAIAIAHAFALFVGVSMAAN
ORSATI0243LYRAVIAEFVATLLFLYITVATVIGYGLVAVALAHALALAVAVAVAVN
ORSATI0244LYRALIAEFVATLLFLYVTVATVIGYTLAAVAIAHALAAGVLVTAGFH
ORSATI0245LYRAVIAEFVATLLFLYVTVATVIGYTLAAVAIAHALAAGVLVTAGFH
ORSATI0246FYRALIAEFIATLLFLYITVATVIGYDLTAVALGQALVVAVIATAGFH
ORSATI0247LYRALIAEFMATLIFLYVSIATVIGYGLTAVALAHTLVVAVMVSAGLH
ORSATI0248LYRAAIAEFTATLLLVCISVSTVIGEPLVATAVAQAFGLFAAVLIAAD
ORSATI0249AVRAAAADAAVTFLWVLCVSTLGASTGLVAAAVAHAFGLFVAVSVGAN
ORSATI0250RPWLVVGDLVVAAMWVCAGALVKLAVGLVAAALAHAFGLFVAVSVGAN
ORSATI0251ALKAALAEFISTLIFVFAGQGSGMAFGLVAASLSHAFALFVAVSVGAN
ORSATI0252TAKAAVAEFISMLIFVFAGSGSGMAFGLVAIAVCHGFALFVAVAIGAN
ORSATI0253SVKAYVAEFIATLLFVFAGVGSAIAYGLVAVAVAHAFALFVGVSIAAN
ORSATI0254SLKAYVAEFISTLVFVFAGVGSAIAYGLVAIAIAHAFALFVGVSIAAN
ORSATI0255SIKAYVAEFIATLLFVFAGVGSAIAYGLILVALAHAFALFAAVSAAIN
ORSATI0256TIRAAISEFLATAIFVFAAEGSILSLGLVLVALAHALALFAAVSAAIN
ORSATI0257ATRAALSEFVATAVFVFAAEGSVYGLGLFAVAVAHAFVVAVMISAG-H
ORSATI0258CVRAVLAELVLTFVFVFTGVAATMAAGVLIPAIANALALSSSVYISWN
ORSATI0259CLRAVAGELLFTFLFVFIGVASTITATFPGVAIVWGLAVMVMVYAVGH
ORSATI0260CLRAVVAELLLTFLFVFSGVGSAMAATFPGICAVWGLVVMVLVYTVSH
ORSATI0261ALRAYFAEFFSTFLFVFIAVGSTISATFPGICITWGLAVMVMVYSVGH

Protein
Helix 3
Helix 4
1J4N
SVLRAIMYIIAQCVGAIVATAILSG
SGQGLGIEIIGTLQLVLCVLATT
1FX8
DKRKVIPFIVSQVAGAFCAAALVYG
FVQAFAVEMVITAILMGLILALT
1RC2
PAKEVVGYVIAQVVGGIVAAALLYL
MLSALVVELVLSAGFLLVIHGAT
1Z98
SLLRALVYMIAQCLGAICGVGLVKA
KGTALGAEIIGTFVLVYTVFSAT
2B60
SLLRAICYVVAQLLGAVAGAAVLYS
VGQATIVEIFLTLQFVLCIFATY
2F2B
PGREVVPYIIAQLLGAAFGSFIFLQ
YWQAMLAEVVGTFLLMITIMGIA
ORSATI0223PWRQVPAYAAAQMLGATLAAGTLRLDVQSLVLEFIITFYLMFVISGVA
ORSATI0224RWKQVPSYVVAQVLGSTMASLTLRVMAQAAALEFVISFFLMFVVSGVA
ORSATI0225PWRRVPAYAAAQVAGSAAASAALRADVQSLAMEFIITFYLMFVVSGVA
ORSATI0226PWRRAPAYALAQTAAATAASVVLRLHAQSLVIEFVITFYLMFVIMAVA
ORSATI0227VVINVPSYVVAQVLGSTMASLTLRVMAQAAALEFVISFFLMFVVSSVA
ORSATI0228PWIQVPFYWAAQFTGAICASFVLKAHWHSLVVEVIVTFNMMFVTLAVA
ORSATI0229PWIQVPFYWAAQFTGAMCAAFVLRAHWHALVIEIVVTFNMMFVTCAVA
ORSATI0230PWLQVPAYVAVQVLGSICAGFALKGTAQAFFTEFIITFNLLFVVTAVA
ORSATI0231PPAHLLPYIAAQILGSITASFAVKGTVEAFFLEFVTTFVLLFIITALA
ORSATI0232PSAHLLPYISSQILGAVAASFAVKGTVEAFFVEFIITFFLLFIITALA
ORSATI0233QPAHLLPYAAAQVLGAVAAAAAVDGVKELIAVAVGGTAMMNVLVAG--
ORSATI0234PPAHLLPYAAVQTAASLAAAFLAKGAGEAFVVEVALTFVLSKELVAI-
ORSATI0235VWPKLPLYVAAQLAGSLLACLSVNATRLPFLMEFLASAVLMIVIATVA
ORSATI0236SLTRAIFYIVMQCLGAICGAGVVKGKGDGLGAEIVGTFILVYTVFSAT
ORSATI0237SLTRALFYMVMQCLGAICGAGVVKGKGDGLGAEIVGTFILVYTVFSAT
ORSATI0238SLTRAVFYMAMQCLGAICGAGVVKGKGDGLGAEIVGTFVLVYTVFSAT
ORSATI0239SLSRAIFYILMQCLGAICRTGFVKGKGDGLGAEIVGTFILVYTVFSAT
ORSATI0240SLTRALFYMVMQCLGAICGAGVVKGKGDRLGAEIVGTFILVYTVFSAT
ORSATI0241SLVRAILYIVAQCLGAICGVGLVKAKGTGLAAEIIGTFVLVYTVFSAT
ORSATI0242SLIRAVLYIIAQCLGAICGVGLVKGKGTGLGAEIIGTFVLVYTVFSAT
ORSATI0243SLVRAVLYIVAQSLGAICGVGLVKGKGTGLAAEIIGTFVLVYTVFSAT
ORSATI0244SLVRALLYMAAQCLGAICGVALVKGTGTGLAAEIIGTFVLVYTVFSAT
ORSATI0245SLVRAILYIVAQCLGAVCGVALVKGKGTGLAAEIIGTFVLVYTVFSAT
ORSATI0246SVIRAVMYIVAQCLGGIVGVGIVKGTGTALGAEIIGTFVLVYTVFSAT
ORSATI0247SLVRTVLYVVAQCLGAIAGAGIVKGAAGALGAEIVGTFILVYTVFSAT
ORSATI0248SLPRAALYTMAQCVGAVCGAGLARAAGAGVVAEMVGTFVLVYTVFSAT
ORSATI0249SLFPLALRFPAQAAGAVGGAMAISELHTGAAAELVLTFVITLAVLWII
ORSATI0250YLFAAFVRMPAQVFGSILGVKLIRAVHHGALAEGLATFMVVIVSVTLK
ORSATI0251TLFRGLLYWIAQLLGSTVACFLLRFVWEALVLEIVMTFGLVYTVYATA
ORSATI0252SLVKAVVYWVAQLLGSVVACLLLKIAWNAVVFEIVMTFGLVYTVYATA
ORSATI0253TILTGLFYWIAQLLGASIACLLLKFELEGVVMEIVITFALVYTVYATA
ORSATI0254TILTGVFYWIAQLLGAIVGAVLVQFAFEGVVMEIIVTFGLVYTVYATA
ORSATI0255TILTGIFYWVAQLLGASVACLLCSSEIEGMVMEIVITFALVYTVYATA
ORSATI0256SLIRALFYWLAQLLGAVVATLLLRLDWHAVLLEATMTFGLMYAYYATV
ORSATI0257SFARAALYWAAQLLGAVLAVLLLRLERHALLLEVVMTFGLVYTVYATA
ORSATI0258TAFRSALYVAAQLLASSLACILLRYPMQGLVMEIILTFSLLFVVYATI
ORSATI0259TLFRSALYVAAQLAGSSLACLLLRCPVQGVAAEAVFTFTLLLVICATI
ORSATI0260TLFRSALYAAAQLLGSSLACLLLAAAARAVAMEAVLTFSLLFAVYATV
ORSATI0261TVPSAIFYWASQMLGSTFACLVLHYGFGAGILEGVLTFMVVYTVHVAG

Protein
Helix 5
Helix 6
1J4N
SGPLAIGFSVALGHLLAID
WIFWVGPFIGAALAVLIYDFI
1FX8
LAPLLIGLLIAVIGASMGP
LVPLFGPIVGAIVGAFAYRKL
1RC2
FAPIAIGLALTLIHLISIP
WFFWVVPIVGGIIGGLIYRTL
1Z98
LAPLPIGFAVFMVHLATIP
WIFWVGPFIGAAVAAAYHQYV
2B60
SVALAVGFSLTLGHLFGMY
WVYWVGPVIGAGLGSLLYDFL
2F2B
FAGIIIGLTVAGIITTLGN
SIYVIGPIVGAVLAALTYQYL
ORSATI0223LAGLAVGATILLNVLIAGPWVYIVGPVAGAVAGAWAYNII
ORSATI0224LAGLAVGATVAVNVLFAGPWVYVAAPVSGTVCGAWAYNLL
ORSATI0225LAGLAVGATVLVNVLFAGPWVYIAGPVFGAVAGAWAYNLI
ORSATI0226MAGVAVGGTIMLNVLFAGPWVYILGPFAGAAAGAWAYSLI
ORSATI0227LAGLAVGATVAVNVLFAGPWVYVAAPVSGAVCGAWAYNLL
ORSATI0228LAGLAVGSAVCITSIFAGAWIYFLGPVMGTLSGAWTYTFI
ORSATI0229LAGLAVGSAVCITSIFAGPWIYFLGPVVGTLSGAWVYTYI
ORSATI0230LAGIAVGAAVTLNILIAGPWIYLIAPTLGAVAGAGVYTAV
ORSATI0231LIAVAVGATIMMNALVAGPWVYLVATPLGAVAGEGFYFAI
ORSATI0232LIAVAVGATVMMNILVAGPWVYLVATPLGAIAGTGAYVAI
ORSATI0233~~YACEVLLCIYNILVAGPWVYMVSTPLGAIAGTGAYFAI
ORSATI0234~~~~AIAAAIMMNALVGGPWIYLVAPPLGAIAGAATYTLI
ORSATI0235VGGIAIGAAVGGLGLVIGPWIYVVAPVAGMLVAALCNRAV
ORSATI0236LAPLPIGFAVFLVHLATIPWIFWVGPFVGAALAAIYHQVI
ORSATI0237LAPLPIGFAVFLVHLATIPWIFWVGPFIGAALAAIYHQVV
ORSATI0238LAPLPIGFAVFLVHLATIPWIFWVGPFIGAALAAIYHVVV
ORSATI0239LAPLPIGFAVFLVHLATIPWIFWVGPFVGAALVAIYHQVI
ORSATI0240LAPLPIGFAVFLVHLATIPWIFWVGPLMGGALAAIYHQGV
ORSATI0241LAPLPIGFAVFMVHLATIPWIFWVGPFVGAAIAAFYHQYI
ORSATI0242LAPLPIGFAVFMVHLATIPWIFWVGPLIGAAIAAAYHQYV
ORSATI0243LAPLPIGFAVFMVHLATIPWIFWVGPLIGAAIAAAYHQYV
ORSATI0244LAPLPIGFAVFMVHLATIPWIFWVGPFIGAAIAALYHQVI
ORSATI0245LAPLPIGFAVFMVHLATIPWIFWVGPFIGAAIAALYHQIV
ORSATI0246LAPLPIGFAVFMVHLATIPWIFWAGPFIGALAAAAYHQYI
ORSATI0247LVPLPIGFAVFVVHLATIPWIFWVGPVIGAFLAAAYHKLV
ORSATI0248LAPLPIGLAVLVVHLATIPWIFWVGPFAGAAAAMIYHHYI
ORSATI0249VKTWMLSISTVCLVLTGAAYVYWICPFVGAVLGAWVFRAV
ORSATI0250MKTWISSIWKMTFHLLSSDLVYWLAPLQATLLAVWVVTLL
ORSATI0251IAPIAIGFIVGANILVGGAWVYWVGPLIGGGLAGVIYEVL
ORSATI0252IAPIAIGFIVGANILAGGAWVYWLGPFVGAAIAALIYDII
ORSATI0253IAPIAIGFIVGANILAAGPWVYWVGPLIGGGLAGLVYGDV
ORSATI0254IAPIAIGFIVGANILVAGPWIYWVGPLVGGGLAGLVYRYV
ORSATI0255VAPMAIGFIVGANILAAGPWVYWVGPLIGGGLAGLVYDDV
ORSATI0256IAPLAVGFLLGANMLAGGPWVYWLGPFVGAGLAGLLYEYL
ORSATI0257IAPLAIGLVAGANILAGGPWVYWLGPLIGAGMAGALYEFV
ORSATI0258FGPLLTGLIVGANTIAGGNWIYWLGPLIGGPLAGLVYESL
ORSATI0259TGPLLTGLLVGANTVAGGAWVYWVGPLAGGPLAVVAYELL
ORSATI0260LGPLLVGLVVGANILAGGPWIYWVGPLIGGPLAGLVYEGL
ORSATI0261LGALVVGAVTGACVLAAGSAVYWAGPMVGAAVGALVHQAL

Protein
Loop B
Loop E
1J4N
AHLNPAVTLGLLLS
GCGINPARSFGSSVIT
1FX8
AHLNPAVTIALWLF
GFAMNPARDFGPKVFA
1RC2
GHFNPAVTIGLWAG
NTSVNPARSTAVAI-F
1Z98
GHINPAVTFGLFLA
GTGINPARSFGAAVIF
2B60
AHVNPAVTFAFLVG
GAGMNPARSFAPAILT
2F2B
CHINPAVTIGLWSV
GSSLNPARTFGPYLND
ORSATI0223AHFNPAVTLAF-ATGASMNPARSLGPAMIG
ORSATI0224AHFNPAVTVAFATCGASMNPARSLGPAMVA
ORSATI0225AHLNPAVTLAF-ATGASMNPARTIGPAIIL
ORSATI0226AHLNPAVTLGFAVAGASMNPARSIGPALVG
ORSATI0227THLNPAVTVAFATRGASMNPARSLGPAMVA
ORSATI0228AHMNPAVTLAFAVFGGSMNPARTLGPALAS
ORSATI0229AHMNPAVTLSFAFFGGSMNPARTLAPAVAS
ORSATI0230AHLNPSLTIAFAALGGSMNPVRTLGPAVAA
ORSATI0231CHLNPAVSIAMTVFGASMNPARTLGPAIAT
ORSATI0232CHLNPAISIAMAVFGASMNPARTIGAAIAT
ORSATI0233AHINPAVSVAMAAFGASMNPARTLGTAIVA
ORSATI0234SHLNPAVSLAMAALGPSMNPARTIGAAVAT
ORSATI0235AHFNPAVTITFAAYGGSMNPARTLGPAIVL
ORSATI0236GHINPAVTFGLFLAGTGINPARSLGAAIIY
ORSATI0237GHINPAVTFGLFLAGTGINPARSLGAAIIY
ORSATI0238GHINPAVTFGLFLAGTGINPARSLGAAIVY
ORSATI0239RHINPAVTFGLFLAGTGINPARSLGAAIIY
ORSATI0240GHINPAVTFGLFLAGTGINPRRTWGCHHLQ
ORSATI0241GHINPAVTFGLFLAGTGINPARSIGAAVIF
ORSATI0242GHINPAVTFGLFLAGTGINPARSLGTAVIY
ORSATI0243GHINPAVTFGLFLAGTGINPARSLGAAVIY
ORSATI0244GHINPAVTLGLFLAGTGINPARSLGVAVVY
ORSATI0245GHINPAVTFGLFLAGTGINPARSLGAAVVY
ORSATI0246GHINPAVTFGLLLAGTGINPARSIGAAVIY
ORSATI0247GHINPAVTLGLFFGGTGINPARSLGAAVLY
ORSATI0248GHMNPAVTFAMVLAGTGINPARSLGPALVL
ORSATI0249ASFNPTALAAFHAAGPSMNPANAFGWAYVN
ORSATI0250ASYNPLTVLAGALAGGVMNPASAFAWAYAR
ORSATI0251GHVNPAVTFGAFVGGASMNPAVSFGPALVS
ORSATI0252GHVNPAVTFGAFVGGASMNPAVSFGPAVVT
ORSATI0253GHLNPAVTFGLAVGGGSMNPARSFGPAVAA
ORSATI0254GHVNPAVTFGLALGGGSMNPARSFGPAVAS
ORSATI0255GHLNPVVTFGLAVGGSSMNPARSFGPAVAA
ORSATI0256GHVNPAITFGALLGGAGMNPARVFGPALVG
ORSATI0257GHVNPAVTFGVLVGGAAMNPARAFGPALVG
ORSATI0258GHLNPAVTVALLARGASMNPARSFGPALAT
ORSATI0259GHLNPAVTLSLAVGGASMNPARSFGPALAT
ORSATI0260GHINPAVTLGLAAGGASMNPARSFGPALAA
ORSATI0261GHVNPAVTFAYAIGGASMNPARSFGPAVVS
 
 
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Bioinformatics and Biomolecular Simulation Laboratory, Department of Biological Sciences and Bioengineering,
Indian Institute of Technology, Kanpur, INDIA-208016
Copyright (c) 2007 All rights reserved, IIT Kanpur