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STRUCTURE BASED ALIGNMENT |
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A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| MUMUSC0446 | FFKAVFAEFLATLIFVFFGLGSALKW | TILQISIAFGLAIGTLAQALGP | | MUMUSC0447 | ISKALFAEFLATGLYVFFGVGSVLPW | SVLQIAITFNLATATAVQISWK | | MUMUSC0448 | FWRAVVAEFLAMTLFVFISIGSALGF | DNVKVSLAFGLSIATLAQSVGH | | MUMUSC0449 | YVQPCIVELVGSALFIFIGCLSVIEN | GLLQPALAHGLALGLIIATLGN | | MUMUSC0450 | MVREFLAEFLSTYVMMVFGLGSVAHM | SYLGVNLGFGFGVTMGVHVAGG | | MUMUSC0451 | LAKETLSEFLGTFIMIVLGCGSIAQA | GIITINIGFATAVVMALYATFG | | MUMUSC0452 | LLRQALAECLGTLILVMFGCGSVAQV | GFLTINLAFGFAVTLGILVAGQ | | MUMUSC0453 | VVHAFVLEFLATFQLCCCTHELQVLS | DSAHPTWTLTLIYFFSLVHGLT | | MUMUSC0454 | TYASFARGAVGAAQLAACCLEMRVLV | GGFGPDLLLTLVFLLFLVHGVT | | MUMUSC0492 | FSRAVLAEFLATLLFVFFGLGSALQW | SVLQIAVAFGLGIGTLVQALGH | | MUMUSC0493 | FWKAVSAEFLATLIFVLLGVGSTINW | DMVLISLCFGLSIATMVQCFGH | | MUMUSC0560 | MVREFLAEFLSTYVMMVFGLGSVAHM | SYLGVNLGFGFGVTMGVHVAGG |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
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| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| MUMUSC0446 | SLLRAIFYVAAQLVGAIAGAGILYW | PGKAVVVELILTFQLALCIFSST | | MUMUSC0447 | SLPRAMAYIAAQLAGATAGAALLYG | TGQAVAVELVLTLQLVLCVFASM | | MUMUSC0448 | SILRAVMYIIAQCVGAIVATAILSG | SGQGLGIEIIGTLQLVLCVLATT | | MUMUSC0449 | KTMLLIPYWISQLFGGLIGAALAKV | VAEALGIEIILTMLLVLAVCMGA | | MUMUSC0450 | TWKKFPVYVLGQFLGSFSAAATTYL | LWRGFLDEAFVTGMLQLCLFAIT | | MUMUSC0451 | EWFKFPFYVGAQLLGAFVGAATVFG | VPGAFVDQVVSTMFLLLIVFAIF | | MUMUSC0452 | PWIKLPIYALAQTLGAFLGAGIVFG | MVNGFFDQFIGTAALIVCVLAIV | | MUMUSC0453 | SPEMGAVRLLAQLVSALCSRYCISA | MSKAIIIEAICSFIFHSALLHFQ | | MUMUSC0454 | SLPNTLLKLSAQVLGAQAACALTQR | VLQGMLVEGACTFFFHLSLLHLQ | | MUMUSC0492 | SFLRAAFYVAAQLLGAVAGAAILHE | AGQAVTVELFLTMQLVLCIFAST | | MUMUSC0493 | SIAKSVFYIIAQCLGAIIGAGILYL | AGHGLLVELIITFQLVFTIFASC | | MUMUSC0560 | TWKKFPVYVLGQFLGSFSAAATTYL | LWRGFLDEAFVTGMLQLCLFAIT |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
|
WIFWVGPFIGAALAVLIYDFI
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| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| MUMUSC0446 | SPALSIGLSVTLGHLVGIY | WVFWVGPIVGAVLAAILYFYL | | MUMUSC0447 | SPAAMIGTSVALGHLIGIY | WIFWVGPLTGAVLASLIYNFI | | MUMUSC0448 | SAPLAIGLSVALGHLLAID | WIFWVGPFIGGALAVLIYDFI | | MUMUSC0449 | LAPFSIGFSVIVDILAGGS | WIYWLGPLLAGLFVGLLIRLL | | MUMUSC0450 | TEPLVIGILVTVLGVSLGM | WVPVVAPLLGAYLGGIVYLGL | | MUMUSC0451 | LEPIVIGLLIIVISCSLGL | WIPVVGPMIGAVLGGLIYVLF | | MUMUSC0452 | LEAFTVGLVVLVIGTSMGF | WVPIVSPLLGSIAGVFVYQLM | | MUMUSC0453 | LRIHLLAALITFLAYAGGS | VVYWLAPSVGVLMMILMFSFF | | MUMUSC0454 | YRVPALALLVTLMAYTAGP | HVYCLGPVAGMILAVLLHQGH | | MUMUSC0492 | SPALSIGFSVTLGHLLGIY | WVFWIGPLVGAVIGSLLYNYL | | MUMUSC0493 | SIALAIGFSVAIGHLFAIN | WIYWVGPIMGAVLAGALYEYV | | MUMUSC0560 | TEPLVIGILVTVLGVSLGM | WVPVVAPLLGAYLGGIVYLGL |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| MUMUSC0446 | GHINPAITLALLIG | GCSMNPARSFGPAVVM | | MUMUSC0447 | AHANPAVTLAYLVG | GCSMNPARSFGPAVIV | | MUMUSC0448 | AHLNPAVTLGLLLS | GCGINPARSFGSAVLT | | MUMUSC0449 | GHFNPAVSLAVTVI | GACMNPARAFGPAVMA | | MUMUSC0450 | AHMNAAVTFTNCAL | GYAINPSRDLPPRLFT | | MUMUSC0451 | GHINPAVSFAMCTF | GCAMNPARDLSPRLFT | | MUMUSC0452 | AHLNPAVTFAMCFL | GYAVNPARDFGPRLFT | | MUMUSC0453 | TASNPCGVMMQMIL | GALFNPALALSLHFPC | | MUMUSC0454 | ASANPTVALQEFLM | SAFFNPALAASVTFHC | | MUMUSC0492 | AHINPAVTVACLVG | GCSMNPARSLAPAVVT | | MUMUSC0493 | GHINPAVTVAMVCT | GASMNPARSFGPAVIM | | MUMUSC0560 | AHMNAAVTFTNCAL | GYAINPSRDLPPRLFT |
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