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STRUCTURE BASED ALIGNMENT |
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A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| MODOME0439 | FWKAVAAEFLAMLIFVLLSLGSTINW | DMVLISLCFGLSIATMVQCFGH | | MODOME0440 | YFQPCIVELLGSALFIFIGCLSVIEN | GRLQPALAHGLALGLTIAILGN | | MODOME0441 | LLRQALAECLGTLILVMFGCGSVAQV | GFLTINLAFGFAVTLGILIAGQ | | MODOME0442 | LVKEMIAELIGTFVMVVLGCGSIAQA | QIITINAGFSAAVALGVYVSGG | | MODOME0443 | VTRTFVAELLATFQLCCCSHELQVLV | GPSNPSWPLTIIYFLSLVHGLT | | MODOME0444 | IYSSFAGELASAFQLCACCLELRMLV | GGFGPDVVLTLLFLLFLVHGLS |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
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| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| MODOME0439 | SLAKSVFYIAAQCLGAIIGAGILYL | AGHGLLVELIITFQLVFTIFASC | | MODOME0440 | NYMMLIPYCISQLCGGIIGAALAKA | VGGAVVAETIMTLFLILTVCMGA | | MODOME0441 | PWIKLPIYALAQTLGAFLGSGIVFG | MVNGFFDQFIGTAALIICVLAIV | | MODOME0442 | KWFKLPFYVAAQFLGAFLGAAALFG | VPNAFGEQVLSSMFLLLIVFAIF | | MODOME0443 | PVGMSILKILAQMLGAWFSRTFMLW | LPEAFLVEMFCSFIFHSTMMHFQ | | MODOME0444 | SLPATTVKLSAQFVGMKASCVLTRL | VGQGTLVEAACSFFFHLTLLHFQ |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
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WIFWVGPFIGAALAVLIYDFI
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| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| MODOME0439 | SIALAIGFSVAIGHLFAIN | WIYWVGPIIGAVLAGGLYEYV | | MODOME0440 | LAPLCIGFTVTVDILAGGA | WVYWLGPLAASLIAGTLIRIL | | MODOME0441 | LEAFTVGFVVLVIGTSMGF | WVPIVSPLLGAVAGILVYQLM | | MODOME0442 | LEPFAIFMLILVLTCALG- | WIPVLGPVVGGVLGGFIYIYG | | MODOME0443 | FRIHLQAALITFLVFAGGS | IVYCLGPSLGIMLMVLMFSHF | | MODOME0444 | YRVTAVALLVTILAYTGGP | QVYCLGSLAGMVVAVLLYQGN |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| MODOME0439 | GHINPAVTVAMVCT | GASMNPARSFGPAVIM | | MODOME0440 | GHFNPAVSLAAVLI | GACMNPARAFGPAVMS | | MODOME0441 | AHLNPAVTFAMCLL | GYAVNPARDFGPRLFT | | MODOME0442 | GHINPAVSFTMCFF | GAAMNPARDLGPRLFT | | MODOME0443 | AVSNPCGVLEQLAL | GAVFNPVLALSLHFQC | | MODOME0444 | ASANPAVSIREFLM | SAFFNPALASSVTCHC |
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