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STRUCTURE BASED ALIGNMENT |
| |
A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| MECRYS0605 | TLKQALAEFISTLIFVFAGEGSGMAF | GLVAASVAHAFALFVAVSVGAN | | MECRYS0606 | FYRAVIAEFIATLLFLYITVLTVIGY | GILGIAWAFGGMIFILVYCTAG | | MECRYS0607 | FYRALIAEFIATLLFLYVTIATVVGN | GLLGIAWSFGGMIFILVYCTAG | | MECRYS0652 | FYRAGLAEFIATFFFLYVSVLTVMGV | GIQGIAWAFGGMIFALVYCTAG | | MECRYS0653 | FYRAGIAEFIATFLFLYISILTVMGV | GIQGIAWSFGGMIFALVYCTAG | | MECRYS0654 | FWRAGIAEFVATFLFLYITVLTVMGV | GIQGIAWAFGGMIFALVYCTAG | | MECRYS0795 | FYRALIAEFIATLLFLYITVLTVIGY | GILGIAWAFGGMIFILVYCTAG | | MECRYS0796 | ALKAALAEFISMLIFVFAGQGSGMAF | GLVAASLSHGFALFVAVSVGAN | | MECRYS0797 | SIKAYIAEFISTLLFVFAGVGSCIAF | GLVAVAVCHAFALFVAVSVGAN |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
|
| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| MECRYS0605 | SLLRGIVYWIAQLAGSSVACLLLKF | VWNALVFEIVMTFGLVYTVYATA | | MECRYS0606 | SLIKAVLYMVAQCLGAICGVGFVKA | KGTGLGAEIIGTFVLVYTVFAAT | | MECRYS0607 | SLIRAVSYMIAQCLGAICGVGLVKA | KGTALGAEIIGTFVLVYTVFSAT | | MECRYS0652 | SLTRAVFYMIMQCLGAICGAGVVKG | KGDGLGAEIIGTFVLVYTVFSAT | | MECRYS0653 | SLTRAVFYMVMQCLGAICGAGVVKG | KGSGLGAEIIGTFVLVYTVFSAT | | MECRYS0654 | SLSRAVFYMIMQCLGAICGAGVVKG | KGSGLGAEIVGTFVLVYTVFSAT | | MECRYS0795 | SLIRAIMYMVAQCLGAICGVGFVKA | KGTGLAAEIIGTFVLVYTVFSAT | | MECRYS0796 | SLPRTILYWIAQCLGAVVACLLLSF | VWNALVFEIVMTFGLVYTVYATA | | MECRYS0797 | TILTGVLYWIAQLAGSVAGCFLLKA | AIEAVVMEIIITFALVYTVYATA |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
|
WIFWVGPFIGAALAVLIYDFI
|
| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| MECRYS0605 | IAPIAIGFIVGANILVGGA | WVYWVGPLIGGGLAGVIYETI | | MECRYS0606 | LAPLPIGFAVFMVHLATIP | WIFWVGPFIGAAIAAFYHQYI | | MECRYS0607 | LAPLPIGFAVFMVHLATIP | WIFWVGPMVGALAAAAYHQYI | | MECRYS0652 | LAPLPIGFAVFLVHLATIP | WIFWVGPFIGAALAAVYHQIV | | MECRYS0653 | LAPLPIGFAVFLVHLATIP | WIFWVGPFIGAALAALYHVVV | | MECRYS0654 | LAPLPIGFAVFLVHLATIP | WIFWVGPFIGAALAALYHTIV | | MECRYS0795 | LAPLPIGFAVFMVHLATIP | WIFWVGPFIGAAIAAIYHQYI | | MECRYS0796 | IAPLAIGLIVAANILAGGA | WVYWLGPFAGAGIAALLYHIV | | MECRYS0797 | IAPIAIGFIVGANILAAGP | WVYWVGPLIGGGLAGLTYSNV |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| MECRYS0605 | GHVNPAVTFGAFIG | GASMNPAVSFGPALVS | | MECRYS0606 | GHINPAVTFGLFLA | GTGINPARSFGAAVIY | | MECRYS0607 | GHINPAVTFGLFLA | GTGINPARSFGAAVIF | | MECRYS0652 | GHINPAVTFGLLLA | GTGINPARSLGAAIIY | | MECRYS0653 | GHINPAVTFGLFLA | GTGINPARSLGAAIIY | | MECRYS0654 | GHINPAVTFGLLLA | GTGINPARSLGAAIIF | | MECRYS0795 | GHINPAVTFGLFLA | GTGINPARSLGAAVIY | | MECRYS0796 | GHVNPAVTFGAFLG | GASMNPAVSFGPAVVS | | MECRYS0797 | GHVNPAVTFGLAVG | GGSMNPARSFGPALAS |
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