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STRUCTURE BASED ALIGNMENT |
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A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| MAMULA0428 | FWRAIFAEFFATLFYVFFGLGSSLRW | HVLQVAMAFGLALATLVQSVGH | | MAMULA0429 | FSRAVFAEFLATLLFVFFGLGSALNW | SVLQIAMAFGLGIGTLVQALGH | | MAMULA0430 | FLKAVFAEFLATLIFVFFGLGSALKW | TILQIALAFGLAIGTLAQALGP | | MAMULA0431 | FWKAVTAEFLAMLIFVLLSLGSTINW | DMVLISLCFGLSIATMVQCFGH | | MAMULA0432 | FWKAVTAEFLAMLIFVLLSLGSTINW | DMVLISLCFGLSIATMVQCFGH | | MAMULA0433 | FWRAVVAEFLATTLFVFISIGSALGF | DNVKVSLAFGLSIATLAQSVGH | | MAMULA0434 | FVQPCLVELLGSALFIFIGCLSVIEN | GLLQPALAHGLALGLVIATLGN | | MAMULA0435 | MVREFLAEFMSTYVMMVFGLGSVAHM | SYLGVNLGFGFGVTMGVHVAGH | | MAMULA0436 | LAKETLSEFLGTFIMIVLGCGSVAQA | GIITINVGFSMAVAMAIYVTGG | | MAMULA0437 | VAHAFVLEFLATFQLCCCTHELQLLS | ~PAHPTWTLTLVYFFSLVHGLT | | MAMULA0438 | LLRQALAECLGTLILVMFGCGSVAQV | GFLTINLAFGFAVTLGILIAGQ | | MAMULA0490 | LARQCLAEFLGVFVLMLLTQGAVAQA | NFFTMFLAGSLAVVIAIYVGGN | | MAMULA0491 | LARQCLAEFLGVFVLMLLTQGAVAQA | NFFTMFLAGSLAVVIAIYVGGN |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
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| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| MAMULA0428 | SLLRAFCYMAAQLLGAVAGAAVLYS | VAQATTVEIFLTLQFVLCIFATY | | MAMULA0429 | SFLRATFYVAAQLLGAVAGAALLHE | AGQAVTVELFLTLQLVLCIFAST | | MAMULA0430 | SLLRAFFYVAAQLVGAIAGAGILYG | QGQAMVVELILTFQLALCIFAST | | MAMULA0431 | SIAKSVFYIAAQCLGAIIGAGILYL | AGHGLLVELIITFQLVFTIFASC | | MAMULA0432 | SIAKSVFYIAAQCLGAIIGAGILYL | AGHGLLVELIITFQLVFTIFASC | | MAMULA0433 | SIFRALMYIIAQCVGAIVAAAILSG | SGQGLGIEIIGTLQLVLCVLATT | | MAMULA0434 | NLVMLLPYWVSQLLGGMLGAALAKA | VAGALGAEIILTTLLALAVCMGA | | MAMULA0435 | PWRKFPVYVLGQFLGSFLAAATIYT | LWRGFLNEAWLTGMLQLCLFAIT | | MAMULA0436 | KWFKLPFYVGAQFLGAFVGAATLFG | LANAFADQVVATTILLMIVFAIF | | MAMULA0437 | SPETGAVRLLAQLVSALCSRYCTSA | LFKAVITEAVCSFLFHSALLHFQ | | MAMULA0438 | PWIKLPVYTLAQTLGAFLGAGIVFG | MINGFFDQFIGTASLIVCVLAIV | | MAMULA0490 | PWVKLPIYILVQLLSAFCASGATYV | LNNGFLDQVLGTGMLMVGLLAIL | | MAMULA0491 | PWVKLPIYILVQLLSAFCASGATYV | LNNGFLDQVLGTGMLMVGLLAIL |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
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WIFWVGPFIGAALAVLIYDFI
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| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| MAMULA0428 | SVALAVGFSLALGHLFGMY | WVYWVGPIIGGGLGSLLYDFL | | MAMULA0429 | TPALSIGFSVALGHLLGIH | WVFWIGPLVGAILGSLLYNYV | | MAMULA0430 | SPALSIGLSVTLGHLVGIY | AILYFYLLFPNSLSLSERVDI | | MAMULA0431 | SIALAIGFSVAIGHLFAIN | WIYWVGPIIGAVLAGGLYEYV | | MAMULA0432 | SIALAIGFSVAIGHLFAIN | WIYWVGPIIGAVLAGGLYEYV | | MAMULA0433 | SAPLAIGLSVALGHLLAID | WIFWVGPFIGGALAVLIYDFI | | MAMULA0434 | LAPFSIGFAVIVDILAGGT | WIYWLGPLLAGLLVGLLIRCF | | MAMULA0435 | TQALVIGILVVIIGVSLGM | WVPVVAPLLGACLGGIIYLVF | | MAMULA0436 | LEPIVIGLLIIVISSSLGL | WIPVVGPLVGAVIGGLIYVLV | | MAMULA0437 | LRIHLLAALITFLVYAGGS | IVYWLAPSLGILLMILMFSFF | | MAMULA0438 | LEAFTVGLVVLVIGTSMGF | WVPIVSPLLGSIAGVFVYQLM | | MAMULA0490 | LEPVVVGMLILAIGLSMGA | GLHSPSSAKGSVPGSTALSL- | | MAMULA0491 | LEPVVVGMLILAIGLSMGA | WVPVVAPLVGATLGTATYQLL |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| MAMULA0428 | AHVNPAVTFAFLVG | GAGMNPARSFAPAILT | | MAMULA0429 | AHINPAVTVACLVG | GCSMNPARSLAPAVVT | | MAMULA0430 | GHINPAITLALLVG | GCSMNPARSFGPAVVM | | MAMULA0431 | GHINPAVTVAMVCT | GASMNPARSFGPAVIM | | MAMULA0432 | GHINPAVTVAMVCT | GASMNPARSFGPAVIM | | MAMULA0433 | AHLNPAVTVGLLLS | GCGINPARSFGSAVIT | | MAMULA0434 | GHFNPAVSLAATLI | GGCMNPARAFGPAVVA | | MAMULA0435 | AHMNAAVTFANCAL | GYAINPSRDLPPRVFT | | MAMULA0436 | GHINPAVSFAMCLF | GCAMNPARDLSPRLFT | | MAMULA0437 | TFSNPCGVMMQMML | GAVFNPALALSLHFMC | | MAMULA0438 | AHLNPAVTFAMCFL | GYAVNPARDFGPRLFT | | MAMULA0490 | AHLNPAFSLAMCIV | GFPLNPARDLGPRLFT | | MAMULA0491 | AHLNPAFSLAMCIV | GFPLNPARDLGPRLFT |
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