|
STRUCTURE BASED ALIGNMENT |
| |
A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| LEMACU1024 | ELAAFFGEFIGTFMFLSLAFSGTQIA | KLLYISFAFGVSLAINVAIFAD | | LEMACU1025 | QYPQAPAEFLATFVYLFIGICVNLSV | SFETQAWGWCFAVMIGIYVAGG | | LEMACU1026 | VLREPFAEFWGVAIMVMFGDGSVAQV | SYQSINWGWGLGVMLGVYVAGD | | LEMACU1027 | HFVAFVGEFVGTTMFLFFSFSGTQVA | ~LLYIALVFAFSLMVNVWVFFR | | LEMACU1028 | HIVACVGELVGTFMFLLFALGGTNVV | KIMYIALVFGFSLTVNAWVYFR |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
|
| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| LEMACU1024 | HWHRAAQTILAQLIAGMAAAGFVEA | VTRGLFLEAFVTSQLVLTILMLK | | LEMACU1025 | PWKMAIVYICMQMLAGLCAGGLAYA | TSSGFFNDFVYMAVYVCIAFALG | | LEMACU1026 | PWRRFPLYFLAQLLGGFVGSGIVYA | KSSQFFSEFIASALLMFVIFALK | | LEMACU1027 | SPLRGFLLLAAQISGSIFASYLVSV | LARGFFIEMVLTAELVFTIFMLA | | LEMACU1028 | GYRRGFLIILAQIIGGIAASGVVSA | VVQGLFIEMFLTAQLVFTIFMLA |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
|
WIFWVGPFIGAALAVLIYDFI
|
| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| LEMACU1024 | SKPMYIGFSLFIAHICSVY | WIYWLGPLLGAVVASGAYALI | | LEMACU1025 | MTALIFGFTVFVTMIALGY | YGSWGASISGALVGGFMYDLC | | LEMACU1026 | WFPLCLFFLIFGLGSCFGW | WIPMVAPFLGCNFGAFLYDVF | | LEMACU1027 | IAPVGIGLALFIGELVGVY | WIYWIGPGAGAIFAVGFYQFI | | LEMACU1028 | IAPVGIGLSLFVAELMGVF | WIYWVGPILGALLASVFYMFI |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| LEMACU1024 | GKFNPAVTTALFIT | GASLNPARSFGPAVVI | | LEMACU1025 | AHLSPTISISLSVY | GLGISPARDLGPRLIA | | LEMACU1026 | AYLNPAVTFCSCLF | GYAINIARDFGPRLMS | | LEMACU1027 | GLFNPAVTFAMLLC | GGSLNPARSFGPCVVT | | LEMACU1028 | GLFNPAVTLGMMVV | GGSVNPARSFGPAVVT |
|
