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STRUCTURE BASED ALIGNMENT |
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A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| LEMAJO0423 | RLREYVAEFFGTFFLVTFGTGVVATT | SYLAITFGWAFGLAISLFLSMA | | LEMAJO0424 | FLSQLVAEFVGTFLLVLTIALASVGV | ~GALAPIPIGFMLAAMCFTFGY | | LEMAJO0425 | LLGTYFAELVGTFGWVLTLALVSVRN | ATSMTPLPIGFMFTSMIFTFGY | | LEMAJO0426 | YQAKFVCEGIGTFIFLMTTSLAEMNC | TRNLAPIAEGFMLCVLIFMFGY | | LEMAJO0427 | LMSAAVVEFIGTFLLVLTVPLSIIQ- | NAEMAPISIGFLLMSLVFSFGY | | LEMAJO0981 | RLREYVAEFFGTFFLVTFGTGVVATT | SYLAITFGWAFGLAISLFLSMA | | LEMAJO1005 | LMSAAVVEFIGTFLLVLTVLSIIQN- | -AEMAPISIGFLLMSLVFSFGY |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
|
| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| LEMAJO0423 | PWVKLPGYFLAQFLGGFVGAANTYV | NTYAVWSEVFNTMALMMGILAIT | | LEMAJO0424 | TLRRTVMYIVVQLAGSFCASLYASA | TWQVLLCELVYTFALTSVVLHVC | | LEMAJO0425 | KVAQCCAYILCQLAGSLAAGVVAMI | VSSGIFLELIFTFAMCLVVLNIA | | LEMAJO0426 | RVEEAISYWVAQVVGALVGAGLSIL | IFSAFVAEAVFTMLLVTVVLHAA | | LEMAJO0427 | NKRRLIMYVVAQMAGGVAAAFYCMM | MLRGFLAESVFTFVLCSVVLHVA | | LEMAJO0981 | PWVKLPGYFLAQFLGGFVGAANTYV | NTYAVWSEVFNTMALMMGILAIT | | LEMAJO1005 | NKRRLIMYVVAQMAGGVAAAFYCMM | MLRGFLAESVFTFVLCSVVLHVA |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
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WIFWVGPFIGAALAVLIYDFI
|
| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| LEMAJO0423 | YKPVAIGLLLFVIGIASGI | WIPLVVPFVGALFGMFLYVFF | | LEMAJO0424 | FYGFAIGMTLMAAGFSVGG | WVYWIAPICGAFIASVIYQLL | | LEMAJO0425 | FYGFAVGMTISAGSASAGR | WVYWLAPVVGAILAAILFSQM | | LEMAJO0426 | FYGLAVGMCLLASQYAVGG | WLYWAAPACGAIAAAFLFMLT | | LEMAJO0427 | FYGFAIGFSMLCGGLTCGS | WVYWASEAVGAVCASIMYLAL | | LEMAJO0981 | YKPVAIGLLLFVIGIASGI | FWILVVPFVGALFGMFLYVFF | | LEMAJO1005 | FYGFAIGFSMLCGGLTCGS | WVYWASEAVGAVCASIMYLAL |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| LEMAJO0423 | GHLNPAVTLANCVF | SYGLNPARDLSPRILS | | LEMAJO0424 | AHFNPAISFAVFIN | SGAFNPAVATGTQLVL | | LEMAJO0425 | SHFNPAVSIAVFLV | GGAFNPAAASGLQVAM | | LEMAJO0426 | GHFNPAVTFGVVMI | GGAFNPAVATGLQVTK | | LEMAJO0427 | GHINPMVTFSVWLA | GGVFNPAVATPLIVVR | | LEMAJO0981 | GHLNPAVTLANCVF | SYGLNPARDLSPRILS | | LEMAJO1005 | GHINPMVTFSVWLA | GGVFNPAVATLIVVRC |
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