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STRUCTURE BASED ALIGNMENT |
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A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| LEINFA0418 | FLSQLVAEFVGTFLLVLTITLASVGV | ~GTLAPIPIGFMLAAMCFTFGY | | LEINFA0419 | WLREYVAEFFGTFFLVTFGTGVIATT | SYMAITFGWGFGLTIGLFLSMA | | LEINFA0420 | LLGTYFAELVGTFGWVLTLALVSVRN | ATNMMPLPIGFMFTSMIFTFGY | | LEINFA0421 | YQAKFVCEGIGTFIFLMTTSLAEMNC | TRNLAPIAEGFMLCVLIFMFGY | | LEINFA0422 | LMSAAVVEFIGTFLLVLTVPLSVIQ- | NAEMAPISIGFLLMSLVFSFGY | | LEINFA0982 | WLREYVAEFFGTFFLVTFGTGVIATT | SYMAITFGWGFGLTIGLFLSMA | | LEINFA0988 | LLGTYFAELVGTFGWVLTLALVSVRN | DATNMMLPIGFMFTSMIFTFGY |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
|
| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| LEINFA0418 | TLRRTVMYIVVQLAGSFCASLYASA | TWQVLLCELVYTFALTSVVLHVC | | LEINFA0419 | PWIKLPGYFLAQFLGGLVGAANTYG | NTYAVWSEVFNTMALMMGILAIT | | LEINFA0420 | KVAQCCAYILCQLTGGLAAGVVAMI | VSSGIFSELIFTFAMCLVVLNIA | | LEINFA0421 | RVEEAISYWVAQVVGALVGAGLSIL | VFSAFVAEAVFTMLLVTVVLHAA | | LEINFA0422 | NKRRLIMYLVAQMAGGVTAAFYCMM | MLRGFLAESVFTFVLCSVVLHVA | | LEINFA0982 | PWIKLPGYFLAQFLGGLVGAANTYG | NTYAVWSEVFNTMALMMGILAIT | | LEINFA0988 | KVAQCCAYILCQLTGGLAAGVVAMI | VSSGIFSELIFTFAMCLVVLNIA |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
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WIFWVGPFIGAALAVLIYDFI
|
| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| LEINFA0418 | FYGFAIGMTLMAAGFSVGG | WVYWIAPICGAFVASVIFQLL | | LEINFA0419 | YKPVAIGLLLFVIGITTGI | WIPLVAPFVGALLGMFLYVFF | | LEINFA0420 | FYGFAVGMTISAGSASAGR | WVYWLAPVVGAILAAVLFSQM | | LEINFA0421 | FYGLAVGMCLLASQYAVGG | WLYWAAPACGAVAAAFLFMMT | | LEINFA0422 | FYGFAIGFSVLCGGLTCGP | WVYWASEAVGAVCASIMYLAL | | LEINFA0982 | YKPVAIGLLLFVIGITTGI | FWILVAPFVGALLGMFLYVFF | | LEINFA0988 | FYGFAVGMTISAGSASAGR | WVYWLAPVVGAILAAVLFSQM |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| LEINFA0418 | AHFNPAISFAVFIN | GGAFNPAVATGTQLVL | | LEINFA0419 | GHLNPAVTLANCVF | SYGLNPARDLSPRILS | | LEINFA0420 | SHFNPAVSIAVFLV | GGAFNPAAASGLQVAM | | LEINFA0421 | GHFNPAVTFAVVMI | GGAFNPAVATGLQVTK | | LEINFA0422 | GHINPMVTVSVWLA | GGVFNPAVATPLIVVR | | LEINFA0982 | GHLNPAVTLANCVF | SYGLNPARDLSPRILS | | LEINFA0988 | SHFNPAVSIAVFLV | GGAFNPAAASGLQVAM |
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