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STRUCTURE BASED ALIGNMENT |
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A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| LEBRAZ0413 | FLSQLVAEFVGTFLFVLTIILASVGV | ~GSLAPIPIGFMLAAMCFTFGY | | LEBRAZ0414 | WIREYVAEFFGSFFLLSFGIGVTATT | SYLAITLGWGFGLAIALFITMG | | LEBRAZ0415 | LLGTYFAELVGTFGWVLTLALASVRN | DTNMTSLSIGFMLMSMIFTFGY | | LEBRAZ0416 | YQAKFMCEGLGTFIFSLTIALAEMNC | TRNLAPIAGGLMLCVLIFTFGY | | LEBRAZ0417 | LTSAAVVEFIGTFLLVLTVSLSTVQ- | NTEMAPISIGFLFMSLVFSFGY | | LEBRAZ0987 | WIREYVAEFFGSFFLLSFGIGVTATT | SYLAITLGWGFGLAIALFITMG | | LEBRAZ1002 | FLSQLVAEFVGTFLFVLTIILASVG- | VGSLAPIPIGFMLAAMCFTFGY | | LEBRAZ1007 | LTSAAVVEFIGTFLLVLTVSLSTVQ- | NTEMAPISIGFLFMSLVFSFGY |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
|
| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| LEBRAZ0413 | TLRQTVLYVMMQLGGSFCASLYASA | TWQALLCELVYTFALTSVVLHVY | | LEBRAZ0414 | PWRKAPGFMLAQLLGAILGAANVYG | NVFAVWSEIFNTMVLMMGILAIN | | LEBRAZ0415 | KLAQCCAYILCQLAASLAAGVVAMV | VSSGIFSELVFTFAMCLVVLNSA | | LEBRAZ0416 | RVEEAMSYWVAQVVGALIGAGLSIL | IFSAFIAEAVFTMLLVTVVLHVV | | LEBRAZ0417 | SMRRLIMYVVAQMVGGMIAAFICAA | MLRGFLAESVFTFVLCSVFLHVA | | LEBRAZ0987 | PWRKAPGFMLAQLLGAILGAANVYG | NVFAVWSEIFNTMVLMMGILAIN | | LEBRAZ1002 | TLRQTVLYVMMQLGGSFCASLYASA | TWQALLCELVYTFALTSVVLHVY | | LEBRAZ1007 | SMRRLIMYVVAQMVGGMIAAFICAA | MLRGFLAESVFTFVLCSVFLHVA |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
|
WIFWVGPFIGAALAVLIYDFI
|
| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| LEBRAZ0413 | FYGFAIGMMLMAAGFSVGG | WVYWIAPIGGAVIASIVYQLL | | LEBRAZ0414 | YKPVAVGLLLFVIGITTGI | WIPIVGPIAGALLGMFLYVFC | | LEBRAZ0415 | FYGFAVGMTISAGSASVGH | WIYWLAPVVGAILAALLFSQM | | LEBRAZ0416 | YYGLAIGMCFLASQYAIGG | WLYWAAPACGAVGAAFLFTMT | | LEBRAZ0417 | FYGFAIGFSVLCGGLTCDS | LVYWVSEAIGAMCASIVYVAL | | LEBRAZ0987 | YKPVAVGLLLFVIGITTGI | WIPIVGPIAGALLGMFLYVFC | | LEBRAZ1002 | FYGFAIGMMLMAAGFSVGG | WVYWIAPIGGAVIASIVYQLL | | LEBRAZ1007 | FYGFAIGFSVLCGGLTCDS | LVYWVSEAIGAMCASIVYVAL |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| LEBRAZ0413 | AHFNPAISFAIFIN | GGAFNPAVATGTQLVL | | LEBRAZ0414 | GHLNPAVTLANCAF | GYALNPTRDLGPRIFT | | LEBRAZ0415 | SHLNPAVSITVFLV | GGAFNPAAASGLQVAM | | LEBRAZ0416 | GHFNPAVTFAVVMI | GGAFNPAVATGLQVAK | | LEBRAZ0417 | GHINPMVTISVWLA | GGVFNPAVTTPLMIVR | | LEBRAZ0987 | GHLNPAVTLANCAF | GYALNPTRDLGPRIFT | | LEBRAZ1002 | AHFNPAISFAIFIN | GGAFNPAVATGTQLVL | | LEBRAZ1007 | GHINPMVTISVWLA | GGVFNPAVTTLMIVRC |
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