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STRUCTURE BASED ALIGNMENT |
| |
A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| LASAKE0047 | ~MRRYAAEFIGTFMLVFLGTGAVVIA | DTLTIGLAFGLTVTVMAYAFGG | | LASAKE0048 | IMVQALGELVGTFILVLLGDGVVAGV | GWIAITLGWGFAVTLGVYASAF | | LASAKE0049 | LTTRLAAEFIGTAIMIIFGNGAVANV | DWFLIAFGYGCGVMIPAVMFGS | | LASAKE0167 | MVHQLLAEFMGTALMIIFGVGVHSDE | GHLFAITTWGFGITVALFIFGD |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
|
| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| LASAKE0047 | EAKDGVFYIVAQFLGAIVASGLLSV | AGVAFLVEVIVTFSFILVILMTT | | LASAKE0048 | SWSVVLPFIIAQMIGAFLGAVVVWI | PFANLMSEIIGTFVLVFALLALT | | LASAKE0049 | PWENVLPYIIVQFLGAMVGQLLLVA | RMNGFVNEFLGTLILVFGALAIG | | LASAKE0167 | SWAMFIPYSVAEVLGGVVGAIIVYI | LPRNFFVEFFATFVFISSIIAIT |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
|
WIFWVGPFIGAALAVLIYDFI
|
| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| LASAKE0047 | MAPLAIGITLSLLIIVALN | WVYLAAPIVGAILAAFTGRLL | | LASAKE0048 | LNPLVVGVIITAIGLSLGG | WIPVIGPFVGGILGALLFVLL | | LASAKE0049 | AGHIVVGLLVMTLVASLGG | WVPVVAPIIGAICGAGIYQFI | | LASAKE0167 | IAPIAVGLLVWAIGMGMGG | IVPGIAPFVGGLCAALFMRSF |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| LASAKE0047 | GHFNPAVSIAMMIN | GGSLNPARSFGPAIFA | | LASAKE0048 | AHLNPAVTLAFAII | GYAINPARDLGPRIAH | | LASAKE0049 | NHLNPAVTLSFAVM | GPALNPARDLGPRLVH | | LASAKE0167 | VSINPAMVLAQCVL | GFAMNLARDMGPRIAH |
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