|
STRUCTURE BASED ALIGNMENT |
| |
A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| LAPLAN0673 | ~MRKYLAEFLGTFMLVFLGTATVVIA | DVLAIGLAFGLAITVSAYAFGG | | LAPLAN0674 | WEARYAAEFFGTLILVLLGNGAVANA | GWLLVASGYGLGVMLPAMMFGS | | LAPLAN0675 | MIHQLLAEFMGTALMIIFGVGVHCSE | GHIFAITTWGFGITIALFIFG- | | LAPLAN0676 | LALQLLGEFLGTFILILLGDGVVAGV | GWVAITLGWGFAVTMGVYASSF | | LAPLAN0677 | ~MHGFLGEFLGTMVLIVFGVGSGAAM | NWTFICLAWGLAVTFGVYVAGQ | | LAPLAN0678 | MVHQLIAEFMGTALMIIFGVGVHCSS | GHIFAITTWGFGISVALFIFG- |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
|
| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| LAPLAN0673 | DAADAIGYIIAQIIGAIVASAAVKS | SGMAFFVEALVTFLFLMVILNVT | | LAPLAN0674 | PWAHVAPYLIWQFLGAIAGQCLILA | QLNGFVTEMVGTAVLIFGAMGLY | | LAPLAN0675 | SWSLFIPYSVAEVLGGVVGAVIVWI | LPRNFFVEFFDTFIFISGILAIS | | LAPLAN0676 | PWAYVIPYSAAQIAGGVIGGLVVWL | YFWNFISEVIGTFVLVFGLLAFT | | LAPLAN0677 | PMANVWPYLLGQFLGAFIGAVIVII | PVFNFLSETIATFFFIFVLLNLG | | LAPLAN0678 | AWSLFIPYSVAEVLGGVVGSVIVWI | LPRNFFVELFDTFIFISGILAIS |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
|
WIFWVGPFIGAALAVLIYDFI
|
| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| LAPLAN0673 | FAGLTIGVTLAFLIIVALN | WVYILAPEVGAILAAFCARVM | | LAPLAN0674 | IANIGVGLLIAAMVISLGG | WVPVVAPIVGAVIGIWIYKIF | | LAPLAN0675 | IVPIGVGLLVWAIGMGLGG | IVPGIAPFVGAACAALFMHGF | | LAPLAN0676 | LNPIVVGILIIAIGLSLGG | WVPIAGPLVGGALGALLFNVL | | LAPLAN0677 | LKPLMVGLLIVVVGQTLGG | WVPMFGPLLGGILAAGLETII | | LAPLAN0678 | IVPIGVGLLVWAIGMGLGG | IVPGIAPFVGAAIAAWFMHGF |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| LAPLAN0673 | GHFNPAVTTAMLIN | GGSLNPARSIGPAIFA | | LAPLAN0674 | NHLNPAITIGQAVI | GPALNPARDLGPRLVH | | LAPLAN0675 | VCINPAMVLAQCIL | GFAMNLARDMGPRIAH | | LAPLAN0676 | AHLNPAVSLGMAVA | GYAINPARDLGPRIAH | | LAPLAN0677 | GHLNPAVTVGFALF | GFAINPARDWAPRLAY | | LAPLAN0678 | VCINPAMVLAQCLL | GFAMNLARDMGPRIAH |
|
