|
STRUCTURE BASED ALIGNMENT |
| |
A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| HOSAPI0399 | FWRAIFAEFFATLFYVFFGLGSSLRW | HVLQVAMAFGLALATLVQSVGH | | HOSAPI0400 | FSRAVFAEFLATLLFVFFGLGSALNW | SVLQIAMAFGLGIGTLVQALGH | | HOSAPI0401 | FLKAVFAEFLATLIFVFFGLGSALKW | TILQIALAFGLAIGTLAQALGP | | HOSAPI0402 | ISRALFAEFLATGLYVFFGVGSVMRW | SVLQIAITFNLVTAMAVQVTWK | | HOSAPI0403 | FWKAVTAEFLAMLIFVLLSLGSTINW | DMVLISLCFGLSIATMVQCFGH | | HOSAPI0404 | FWKAVTAEFLAMLIFVLLSLGSTINW | DMVLISLCFGLSIATMVQCFGH | | HOSAPI0405 | FWRAVVAEFLATTLFVFISIGSALGF | DNVKVSLAFGLSIATLAQSVGH | | HOSAPI0406 | FVQPCLVELLGSALFIFIGCLSVIEN | GLLQPALAHGLALGLVIATLGN | | HOSAPI0407 | MVREFLAEFMSTYVMMVFGLGSVAHM | SYLGVNLGFGFGVTMGVHVAGR | | HOSAPI0408 | LLRQALAECLGTLILVMFGCGSVAQV | GFLTINLAFGFAVTLGILIAGQ | | HOSAPI0409 | LARQCLAEFLGVFVLMLLTQGAVAQA | NFFTMFLAGSLAVTIAIYVGGN | | HOSAPI0410 | VAHAFVLEFLATFQLCCCTHELQLLS | PTWTLTLVYFFSLVHGLTL--- | | HOSAPI0411 | AYEVFAREAMRTLVELGPWAGDFG-- | ~DFGPDLLLTLLFLLFLAHGVT | | HOSAPI0486 | LAKETLSEFLGTFILIVLGCGCVAQA | GVITINVGFSMAVAMAIYVAGG | | HOSAPI0559 | ISRALFAEFLATGLYVFFGVGSVMRW | SVLQIAITFNLVTAMAVQVTWK | | HOSAPI0722 | MVREFLAEFMSTYVMMVFGLGSVAHM | SYLGVNLGFGFGVTMGVHVAGR |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
|
| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| HOSAPI0399 | SLLRAFCYMAAQLLGAVAGAAVLYS | VGQATTVEIFLTLQFVLCIFATY | | HOSAPI0400 | SVLRAAFYVAAQLLGAVAGAALLHE | AGQAVTVELFLTLQLVLCIFAST | | HOSAPI0401 | SLLRAFFYVAAQLVGAIAGAGILYG | QGQAMVVELILTFQLALCIFAST | | HOSAPI0402 | SLPRAVAYVAAQLVGATVGAALLYG | TGQAVAVELLLTLQLVLCVFAST | | HOSAPI0403 | SIAKSVFYIAAQCLGAIIGAGILYL | AGHGLLVELIITFQLVFTIFASC | | HOSAPI0404 | SIAKSVFYIAAQCLGAIIGAGILYL | AGHGLLVELIITFQLVFTIFASC | | HOSAPI0405 | SIFRALMYIIAQCVGAIVATAILSG | SGQGLGIEIIGTLQLVLCVLATT | | HOSAPI0406 | NLVMLLPYWVSQLLGGMLGAALAKA | VAGALVAEIILTTLLALAVCMGA | | HOSAPI0407 | PWRKFPVYVLGQFLGSFLAAATIYS | LWRGFLNEAWLTGMLQLCLFAIT | | HOSAPI0408 | PWIKLPIYTLAQTLGAFLGAGIVFG | MINGFFDQFIGTASLIVCVLAIV | | HOSAPI0409 | PWVKLPIYILVQLLSAFCASGATYV | LNNGFLDQVLGTGMLIVGLLAIL | | HOSAPI0410 | SPETGAVRLLAQLVSALCSRYCTSA | LLKAVITEAVCSFLFHSALLHFQ | | HOSAPI0411 | SLPGTLLKLAAQGLGMQAACTLMRL | VPHGALVEAACAFCFHLTLLHLR | | HOSAPI0486 | KWFKLPFYVGAQFLGAFVGAATVFG | LANAFADQVVATMILLIIVFAIF | | HOSAPI0559 | SLPRAVAYVAAQLVGATVGAALLYG | TGQAVAVELLLTLQLVLCVFAST | | HOSAPI0722 | PWRKFPVHVLGQFLGSFLAAATIYS | LWRGFLNEEWLTRMLQLCLFTIT |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
|
WIFWVGPFIGAALAVLIYDFI
|
| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| HOSAPI0399 | SVALAVGFSLALGHLFGMY | WVYWVGPIIGGGLGSLLYDFL | | HOSAPI0400 | TPALSIGFSVALGHLLGIH | WVFWIGPLVGAILGSLLYNYV | | HOSAPI0401 | SPALSIGLSVTLGHLVGIY | WVFWVGPIVGAVLAAILYFYL | | HOSAPI0402 | SPATMIGISVALGHLIGIH | WVFWVGPLMGALLASLIYNFV | | HOSAPI0403 | SIALAIGFSVAIGHLFAIN | WIYWVGPIIGAVLAGGLYEYV | | HOSAPI0404 | SIALAIGFSVAIGHLFAIN | WIYWVGPIIGAVLAGGLYEYV | | HOSAPI0405 | SAPLAIGLSVALGHLLAID | WIFWVGPFIGGALAVLIYDFI | | HOSAPI0406 | LAPFSIGFAVTVDILAGGP | WIYWLGPLLAGLLVGLLIRCF | | HOSAPI0407 | TEALVIGILVVIIGVSLGM | WVPVVAPLLGAYLGGIIYLVF | | HOSAPI0408 | LEAFTVGLVVLVIGTSMGF | WVPIVSPLLGSIAGVFVYQLM | | HOSAPI0409 | LEPVVVGMLILALGLSMGA | WVPVVAPLVGATVGTATYQLL | | HOSAPI0410 | LRIHLLAALITFLVYAGGS | IVYWLAPSLGILLMILMFSFF | | HOSAPI0411 | YSGPAVALLVTVTAYTAGP | QVYWLGPLTGMVLAVLLHQGR | | HOSAPI0486 | LEPIAIGLLIIVIASSLGL | WIPVVGPLVGAVIGGLIYVLV | | HOSAPI0559 | SPATMIGISWALGHLIGIL | WVFWVGPLMGALLASLIYNFV | | HOSAPI0722 | THALVISILVVIIRVSHGI | WVPVVAPLLGASLGGIIYLVF |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| HOSAPI0399 | AHVNPAVTFAFLVG | GAGMNPARSFAPAILT | | HOSAPI0400 | AHINPAVTVACLVG | GCSMNPARSLAPAVVT | | HOSAPI0401 | GHINPAITLALLVG | GCSMNPARSFGPAVVM | | HOSAPI0402 | AHANPAVTLAFLVG | GCSMNPARSFGPAIII | | HOSAPI0403 | GHINPAVTVAMVCT | GASMNPARSFGPAVIM | | HOSAPI0404 | GHINPAVTVAMVCT | GASMNPARSFGPAVIM | | HOSAPI0405 | AHLNPAVTLGLLLS | GCGINPARSFGSAVIT | | HOSAPI0406 | GHFNPAVSLAAMLI | GGCMNPARAFGPAVVA | | HOSAPI0407 | AHMNAAVTFANCAL | GYAINPSRDLPPRIFT | | HOSAPI0408 | AHLNPAVTFAMCFL | GYAVNPARDFGPRLFT | | HOSAPI0409 | AHLNPAFSLAMCIV | GIPLNPARDLGPRLFT | | HOSAPI0410 | TSSNPCGVMMQMML | GAVFNPALALSLHFMC | | HOSAPI0411 | ASANPTVSLQEFLM | SAFFNPALAASVTFAC | | HOSAPI0486 | GHINPAVSLAMCLF | GCAMNPARDLSPRLFT | | HOSAPI0559 | AHANPAVTLAFLVG | GCSMNPARSFGPAIII | | HOSAPI0722 | AHMNAAVTFTNCAL | GYAINPSRDPPPSIFT |
|
