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STRUCTURE BASED ALIGNMENT |
| |
A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| GLMAXx0593 | FLQKLVAEAVGTYFLIFAGCASLVVN | TFPGIAIVWGLVLTVLVYTVGH | | GLMAXx0644 | FYRALIAEFIATLLFLYITVLTVIGY | GILGIAWAFGGMIFILVYCTAG | | GLMAXx0645 | TLKAGLAEFISTLIFVFAGSGSGIAY | GLISASIAHAFALFVAVSVGPN | | GLMAXx0646 | ALKAALAEFISMLIFVFAGEGSGMAY | GLVAASLSHAFALFVAVSVGAN |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
|
| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| GLMAXx0593 | PLIQVPAYVVAQLLGSILASGTLRL | NLQAFVFEFIMTFFLMFVICGVA | | GLMAXx0644 | SLIRAIMYMVAQCLGAICGVGLVKA | TGVGLGAEIIGTSGGVYTVFSAT | | GLMAXx0645 | SPSRGIVYVIAQLLGSIVASLLLAF | VGNALVLEIVMTFGLVYTVYATA | | GLMAXx0646 | TLFRSILYWIAQLLGSVVACLLLKF | AGNALVFEIVMTFGLVYTVYATA |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
|
WIFWVGPFIGAALAVLIYDFI
|
| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| GLMAXx0593 | FAGIAIGSTLLLNVIIGGP | WIYLLAPVVGAIAGAWVYNIV | | GLMAXx0644 | LAPLPIGFAVFMVHLANIP | WIFWVGPFIGAAIAAFYHQFI | | GLMAXx0645 | IAPIAIGFIVGANILLGGA | WIYWAGPLIGGGIAGLIYEVV | | GLMAXx0646 | IAPIAIGFIVGANILAGGA | WVYWVGPFAGAAIAAIVYEIF |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| GLMAXx0593 | GHFNPAVTIAFAST | GASMNPARSLGPAFVH | | GLMAXx0644 | GHINPAVTFGLFLA | GTGINPARSLGAAVMY | | GLMAXx0645 | GHVNPAVTFGAFVG | GAAMNPAVTFGPAVVS | | GLMAXx0646 | GHVNPAVTFGAFVG | GASMNPAVSFGPAVVS |
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