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STRUCTURE BASED ALIGNMENT |
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A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| GLGRAM1016 | HLVAASAEFVGTFFFLFFGYGGQLMV | GVVFIALTYGFSLLVNVWTFYR | | GLGRAM1017 | TWREEFAEFWGTFMILLFGAGVECET | DFLQCRLAWAAGVSMAVWISGG | | GLGRAM1018 | HFVASLGELVGTTMFLFFAFAGTEVA | TLLYISIIFGFSLMVNVWIFFR | | GLGRAM1019 | NIVAVLGEFVGTFLFLLFSFAGTQVA | CIIFIALAFGVSLTANVWAFYR | | GLGRAM1020 | HLQDGFSEFFGTMVLVLFGDGVVAQV | DYQSISWGWGLGVMLGVYCSKK |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
|
| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| GLGRAM1016 | PWMRSLFLIPAQLLASMCAGGLVEV | VAQGLFLEMFFTAQLVIVVFMLA | | GLGRAM1017 | PWRKVPGFLAAQVLGAAFASLAVYL | YAGAFYTEFLASATLVAIVFALA | | GLGRAM1018 | NAARAVYLFIAQLLGGMLASLIVRF | LVQGVFIEAILTAELVFTIFMLA | | GLGRAM1019 | SPLRALLIMPTQIIAGLCAAGVASA | VAQGFFIETFLTTQLVFVILMVA | | GLGRAM1020 | PWRKFPVYFIGQLLGAMVAALIVYG | RTGMFFSELIASCILQFVIFALA |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
|
WIFWVGPFIGAALAVLIYDFI
|
| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| GLGRAM1016 | LAPIGIGLALFMIMIPGTF | WIYWLGPTLGAALAAAYYSWL | | GLGRAM1017 | TQPFAMFLALLAIGSALGI | WAPWVAAIAGGVAGASVYDAF | | GLGRAM1018 | IAPVGIGLTLFIAELVGVQ | WIYWIGPFFGTLIAVVFYKFI | | GLGRAM1019 | LAPVAIGLSFFLAELTGVY | WIYWLGPIFGSMMACGFYLLL | | GLGRAM1020 | LMPLALFFLIFGIGACWGW | WIPMVAPFFGTLLGGFLYDVF |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| GLGRAM1016 | GLFNPAVSIGLSLG | GGSLNPARSFGCAVAG | | GLGRAM1017 | GHCNPTVTVVLALF | GYAMNGARDTGPRIAL | | GLGRAM1018 | GLFNPAVTLGMYLV | GGSLNPARSFGPCVIT | | GLGRAM1019 | GMFNPVVTLALVVC | GGSLNPARSLGPAVVA | | GLGRAM1020 | GHLNPAVTLANCVF | GYAINLARDFGPRLVS |
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