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STRUCTURE BASED ALIGNMENT |
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A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| GAGALL0392 | FWRAVVAEFLAMILFIFISIGSALGF | DNVKVSLAFGLSIATMAQSVGH | | GAGALL0393 | FWKAVSAEFLVMLIFVLLSLGSTINW | DMVLISLCFGLSIATMVQCFGH | | GAGALL0394 | YVLPCLAELLGSAAFVFIGCLSVVED | GLLQPALVHGLSIVPIVVSLGN | | GAGALL0395 | SVRELLAEALGMYILMVLGLSSVAQT | QYLSINLGFGIGVTMGIHAAGG | | GAGALL0396 | LVRQALAECLGTLILVLFGCGSVAQI | GFLTVNLAFGFAVMLGILIAGQ | | GAGALL0397 | LVKEALSEFLGTFIMITLGCGCVGQA | GPMTISVGFAMAVTTAVYVSGG | | GAGALL0398 | HLCSFLLELLSTFQVCACTNELSLLG | PHTALTLTYGFTVLHGL----T | | GAGALL0703 | FWRAILAEFLGSLLYTLLGLGASLRW | GVLGSALAFGLAQATLVQALGH |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
|
| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| GAGALL0392 | SIFKALMYILAQCLGAVVATAILSG | AGQGLGIEIIATLQLVLCVLATT | | GAGALL0393 | SLAKSVFYILAQCLGAIVGAGILYL | AGHGLLVELIITFQLVFTIFASC | | GAGALL0394 | KLIMLIPYCIAQLCGGILGAALTKA | IGPALGNEIILTTFLLLVVCMTA | | GAGALL0395 | PWRKLPVYLLGQFLGSFLAAATIFG | LTGGFFTEFIATVMLLLGILVIH | | GAGALL0396 | PWIKLPVYALAQTLGAFLGAGIVFG | VVNGFFDQFIGTASLIVCVLAIV | | GAGALL0397 | KWTKLPIYILAQFLGAFVGAAAVFG | LINGFADQVMSTAVLLLVIFAIF | | GAGALL0398 | SARAGGLKIWAQFAAAVLARVFMHF | EVQAFCIELLFSVVFQLTILQVE | | GAGALL0703 | SLPRALGYLLAQLLGALAGAGVLYG | PGQGTVVELLLTAQFILCVFASF |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
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WIFWVGPFIGAALAVLIYDFI
|
| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| GAGALL0392 | SAPLAIGLSVALGHLLAID | WIFWVGPIIGGAGAALIYDFI | | GAGALL0393 | SVALAIGFSVAIGHLFAIN | WVYWVGPIIGAVLAGALYEYV | | GAGALL0394 | LAPVCIALTVVINIIVGGS | WVYWVGPLIGCLISSLLIRFV | | GAGALL0395 | THALLTGILVLGIGMGMGM | WVPVVAPTLGSLAGGLIHKLL | | GAGALL0396 | LEAFTVGFVVLVIGTSMGF | WVPIVAPFLGAIAGVIVYQLM | | GAGALL0397 | LEPVVVGLLIIVLTCSLGM | WVPIVAPMLGGVLGALTYIIF | | GAGALL0398 | YRVHAVALLITMLVFAGGN | LVYWIAPCLGTVLVAFVWKSF | | GAGALL0703 | SAALPVGFSLALGHLFGIP | WVFWAGPLLGAALAALLYELA |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| GAGALL0392 | AHLNPAVTLGLLLS | GCGINPARSFGSALIA | | GAGALL0393 | GHINPAVTVAMVCT | GASMNPARSFGPAVIM | | GAGALL0394 | AHINPVVSLGIWLV | GPCMNPARAFGPAVIA | | GAGALL0395 | AHLNAAITLTHCMF | GYAINPSRDLPPRIFT | | GAGALL0396 | GHLNPAVTFAMCFL | GYAVNPARDFGPRLFT | | GAGALL0397 | GHINPAVSLAMCVA | GCAMNPARDLGPRLFT | | GAGALL0398 | STCNPCGTLQPLWG | GAIFNPALAFSLHPHC | | GAGALL0703 | GHINPAITLAFLLA | GAGMNPARSFAPAVIT |
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