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STRUCTURE BASED ALIGNMENT |
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A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| DRMELA0380 | IWRMLLGELVGTFFLIFVGVGSTTSG | SVPQIAFTFGLTVATIAQGLGH | | DRMELA0381 | LWQALIGEFLGNLILNFFACGACTQI | DGTFKALAFGLAIFMAITIVGH | | DRMELA0382 | LWQALIGEFLGNLILNFFACGACTQI | DGTFKALAFGLAIFMAITIVGH | | DRMELA0383 | KISAFLGELIGTGILVFLGCMGCVKT | NHLQIVLNFGFAVLIAIQCFGC | | DRMELA0384 | SITTVLAEMIATAMLMFLGCMGSVEN | SDFQSALNFGFVVLICIQCFGC | | DRMELA0385 | AIACFFGELAATAVFVFIACMGCVET | SHFRSGLTFGLAILIAIQCFGS | | DRMELA0386 | TFIRGATEFSATALLILLGCMGDSTN | KFLVASVHYGLTVMVVMHVFGF | | DRMELA0387 | LVPILINEAIAAAELCACCFELIIV- | ADNFGVSMYAVCLFLLTIWWGR | | DRMELA0707 | SITTVLAEMIATAMLMFLGCMGSVEN | SDFQSALNFGFVVLICIQCFGC |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
|
| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| DRMELA0380 | SILKAAFYIIVQCVGAIAGAAVIKV | CAQAVLIEALITFILVFVVKAVS | | DRMELA0381 | SLIRAFFYVVFQCLGAIAGTAAVKI | ELQGLGIEFFLGLLLVLVVFGAC | | DRMELA0382 | SLIRAFFYVVFQCLGAIAGTAAVKI | ELQGLGIEFFLGLLLVLVVFGAC | | DRMELA0383 | TLRMAFAYFAAQMLGAFIGYGLLMV | TGQALGIEFVITSILVIVCCGVW | | DRMELA0384 | SLPMALAYFVAQMVGAFIGYGLLKA | PWQGLAVEFLITCVLISVCCGVW | | DRMELA0385 | GWIRAIAYFVAQAAGALIGYGLLVA | VLQGVFIEFLITCCLVMVACSVW | | DRMELA0386 | ALEVMMMYVVCQMAGAFLGYFLLMQ | TYQVVIIECLLTAVLVLGWCSLW | | DRMELA0387 | SFKEMALRSWAELMGGCCVYRVVQV | PYLGAVIEGVATLLCRLASKT-- | | DRMELA0707 | SLPMALAYFVAQMVGAFIGYGLLKA | PWQGLAVEFLITCVLISVCCGVW |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
|
WIFWVGPFIGAALAVLIYDFI
|
| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| DRMELA0380 | SAPLAVGLAIAAGHLCAIK | WVYWVGPIAGGLLAGIIYRLI | | DRMELA0381 | TAPLAIGMAVTLGHLGTIR | WVYWVGPVLGGVAAALLYTQV | | DRMELA0382 | TAPLAIGMAVTLGHLGTIR | WVYWVGPVLGGVAAALLYTQV | | DRMELA0383 | SVGIRFGLAIACLACAAGP | WIYWLAPLSSSAITAYAYKVV | | DRMELA0384 | SLPVRFGLAIACLSLTAGQ | WIYWVGPMAAALITSVIYKHA | | DRMELA0385 | SVPVRFGLTVSCLILTAVG | WIYWVGPLVAGAVTSLIYRMA | | DRMELA0386 | SVAIRMGLLVIACSFAGIQ | LAAIMVPFVWNHAYTPPYKPL | | DRMELA0387 | YIDSFIGTSLVVAVYAFNY | IVYWIGACAGAVLSIPVFKVP | | DRMELA0707 | SLPVRFGLAIACLSLTAGQ | WIYWVGPMAAALITSVIYKHA |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| DRMELA0380 | CHINPAVTLGFLIV | GASMNPARSFGPAVVQ | | DRMELA0381 | GHVNPAVTAGMLVA | GASMNPARTVGTAFAT | | DRMELA0382 | GHVNPAVTAGMLVA | GASMNPARTVGTAFAT | | DRMELA0383 | AHLNPAVTVAAYIY | GGSMNPARSFAPALWN | | DRMELA0384 | AHLNPAVTLATYVY | GASMNPVRSFAPAIWN | | DRMELA0385 | AHLNPAITLAAWLY | GASMNPTRSLGPAVWN | | DRMELA0386 | AHSNPCISISCYLM | GASMNPAKTLVPAIFY | | DRMELA0387 | DASACPYTHMEDVV | LAAFNFSGGYFNPVLA | | DRMELA0707 | AHLNPAVTLATYVY | GASMNPVRSFAPAIWN |
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