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STRUCTURE BASED ALIGNMENT |
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A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| DIDISC0375 | AFKGFFSEFLGTLYLVYFCGGSVCAA | RALLGGLIQGMALAALIWAVSG | | DIDISC0376 | FTRQLLAEFFGTLFVVYIVSGSTLAA | RVCLICLVQGFAFAAIIWSISG | | DIDISC0377 | LIRAVLGELLCTFLFVYVLCATSANF | NPVVGGLSTGFAAVALIYSFAD | | DIDISC0378 | LYRAAITEMVGTALFMFMSIAIFTSS | VPILSGLLHIPLLFLLILACAP | | DIDISC0379 | LYKASVTEMIGSALFLFMSIGIFISS | VPATSAVLHVPLLYLLILTCAP | | DIDISC0999 | FTRQLLAEFFGTLFVVYIVSGSTLAA | RVCLICLVQGFAFAAIIWSISG |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
|
| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| DIDISC0375 | GLIDSLYYVAAQILGCIAGAGILYG | TGQAFLMEMMLTSILCLCVLGTS | | DIDISC0376 | GILNGIAFIIFQCVGALVGAGMMKA | VARGFFLEMVTTSFLVFVVLGVA | | DIDISC0377 | SITKGLMYVGAQLVGSVLASLILLA | IGNAFLTELVLTFILVYVIFAVA | | DIDISC0378 | SFIRCIIYMIAQIVGGVIGSAIIKG | PSGALGLEYMLSLFNLYVSFGTA | | DIDISC0379 | KVIRCLFYIIFQITGGIIGSAIIRG | SGGALGMEFMFSMLNLYIAFGTA | | DIDISC0999 | GILNGIAFIIFQCVGALVGAGMMKA | VARGFFLEMVTTSFLVFVVLGVA |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
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WIFWVGPFIGAALAVLIYDFI
|
| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| DIDISC0375 | IAPFAIGLALFIGVAIGFN | WVYWLGPIVGAILAAFIYRCL | | DIDISC0376 | VAPLAIGCAVIAGVGFLNL | YIYWFGPICGGIIAGLFWRIF | | DIDISC0377 | FAPIAIGFTLGFLCFLGGS | WMYWIADFLGAGLAGFAQKFF | | DIDISC0378 | LGPITGSFFISGMLCLSII | WPYMVGPIMACLTIGVYIHCV | | DIDISC0379 | FISITLGFSIIASSGISPN | WPYMVGPIIACITIGTYIHFV | | DIDISC0999 | RVALAIGCAVIAGVGFLNL | YIYWFGPICGGIIAGLFWRIF |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| DIDISC0375 | CNLNPAVTLANLLS | GGALNPVRVLGPSIIS | | DIDISC0376 | CQLNPAVTVGCVTT | GGSLNPARSFGPAVFS | | DIDISC0377 | AHFNPAVTFATCVT | GGAFNPARVFGTALVG | | DIDISC0378 | GHLNPSITLATFFA | IFGFNIARCLSPAIVL | | DIDISC0379 | GHLNPSITIATFFS | -FGFNMARCLCPAIVT | | DIDISC0999 | CQLNPAVTVGCVTT | GGSLNPARSFGPAVFS |
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