|
STRUCTURE BASED ALIGNMENT |
| |
A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| DARERI0358 | FWRAVFAEFYGTMFFVFFGLGAALRW | NVLQVAFCFGLAAATFIQSIGH | | DARERI0359 | FWRAVFAEFFGTMFFVFFGMGAALRW | HVFHTALCFGFAAATLIQSIGH | | DARERI0360 | FWRAVLAEFVGMTIFVFIGIASAIGN | QEVKVALAFGLAIATLAQSLGH | | DARERI0361 | FWRAVSGEFLAMIIFVLLSLGSTINW | DLVLISLCFGLSIATLVQCFGH | | DARERI0362 | FWRAVLAELLGMTLFIFLSITAAVGN | QEIKVALAFGLSIATLAQSLGH | | DARERI0363 | YIQPCLAEVVGSFLFMFVGCVSVMGN | GSIQPALAHGLALAIAIAIFGE | | DARERI0364 | LVQPCMAELVGTAFFVLMGCLCVIES | HTLQAALVHGLALAVVIGCMVE | | DARERI0365 | IIREFLAELLGTFVLILFGCGSVAQT | QLLTIHFGFTLGVMLAVYMAGG | | DARERI0366 | YIRVALAESLCTFIMMVFGLGTVAQV | EYLSINIGFGLAVAMGVHVGGK | | DARERI0367 | LLRQGLAECLGTLILVMFGCGSLAQL | LFLTANLAFGFGATLGILVCGQ | | DARERI0368 | LMRQALAECLGTLILVMFGCGALAQH | MFLTVNFAFGFAATLGILVCGQ | | DARERI0369 | LFKEFLAEFLGTFVLVLFGCGSVAQT | EPLTIHIGFSTGLMMGVYVSGG | | DARERI0370 | LARQIMGEILGTFVLLLFGCAAAAQV | QFLSGNIAFSVGVMSAMYLCRA | | DARERI0371 | LARQIMGEILGTFVLLLFGCAAAAQV | QFLSGNIAFSVGVMSAMYLCRA | | DARERI0372 | LPRECLAEFFGVYVLILFGCGSVAQV | EYLSINLGFALGTTFGIYIAKG | | DARERI0373 | EWIIYMLEFISTFQLCACTHELKLL- | GGLDPQTGLTLTFIISVVHGFS |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
|
| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| DARERI0358 | SLFRAFFYICAQCLGALAGAAVLYG | MGMATTIEIFLTLQLVVCVFAVT | | DARERI0359 | SVFRAFFYICAQCLGAMAGAAALYG | LGMATTVEVFLTMQLVVCVFAVT | | DARERI0360 | SFFRAFMYIIAQMLGAVLASGIMFK | VGQGFAIELFATFQLVLCVLATT | | DARERI0361 | SLAKGVFYLLAQCLGAVVGAAILYG | AGHAIVIELIITFELVFTVFATC | | DARERI0362 | SLLRAVMYILAQMIGATVASAIVLG | AGQGVGIELLATFQLVLCVLATT | | DARERI0363 | EVILLVPYIISQMLGGVIAASLAKA | IGAATMAEMIMTLFLTIVVSMGA | | DARERI0364 | ELKMVLPYLISQVSGGLLGAVMAKG | IMKALFAEAAMTCLATLAVLLSA | | DARERI0365 | PLKKFPVYVLAQFLGAFFGSCAVYC | LLNGFIDQVIGAGALVLCILAVV | | DARERI0366 | RWKMLPLYVFAQFLGSFLAAGTIFS | VYTGFFDQVAGTGLLLLCLMALS | | DARERI0367 | KWRKFPVYFLFQTLGSFLGAAIIFA | PLNGFFDQVIGTASLIVCILAIV | | DARERI0368 | PWRKFPVYFLAQTVGAFLGAGIIFG | LLNGFFDQMIGTAALIVCILAIV | | DARERI0369 | KIWKFPVYVIAQMLGAFAGAAAVFG | VLGGFVDQVVGTGMLVLCILAIV | | DARERI0370 | AWIKLLPYSLAQILGAYLASGLVYL | VQTNFLDQVVGTAMLMLCILPLN | | DARERI0371 | AWIKLLPYSLAQILGAYLASGLVYL | VQTNFLDQVVGTAMLMLCILPLN | | DARERI0372 | SWTRLPFYVCSQLFGAFLAAATVAL | LWGGVVDQIIGTAALLVCVLALG | | DARERI0373 | PWGCALARVSCQLTAAVVSRWVMPV | VLQAAAVELSCPFVMHTAVNNAE |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
|
WIFWVGPFIGAALAVLIYDFI
|
| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| DARERI0358 | SAALSIGFSVLVGHLLGMY | WVYWVGPMIGAAMGALLYDFM | | DARERI0359 | SAALSIGFSVTMGHLMGMY | WVYWVGPMIGAAMGAIFYDFF | | DARERI0360 | SAPLAIGLSVGLGHLVAIS | WIYWIAPMCGGVAAALIYDFL | | DARERI0361 | SAALAIGLSVCIGHLFAIP | WVYWVGPLIGGILAAAVYEYL | | DARERI0362 | SAPLAIGLSVCLGHLTAIS | WVYWVGPMCGGVAAALIYDFL | | DARERI0363 | LAPFCIGLTVTANILAGGG | WIYWVGPLTGALVTVSIVRLV | | DARERI0364 | MFPFLVGCTVMVNVLAGAN | WIYWVGPITGGLIAAALVRLF | | DARERI0365 | MEPLLVGLSILAIGVSMAL | WVPVVGPMVGGVVGAAIYFLM | | DARERI0366 | GEAVGVGLLVMLIGVSMGS | WVPLVAPFIGGVLGALIYKAL | | DARERI0367 | LEAFTVGFSVLIIGLSMGF | LVPIFAPFIGAVIGVIVYQLM | | DARERI0368 | LEAFTVGFVVLVIGLSMGF | FVPVFAPFIGAVFGVMVYQLM | | DARERI0369 | VEPLAVGVVLLGISVSMGL | WIPVAGPLVGGVVGAVIYFLL | | DARERI0370 | LLPPIVATVVLGISISMSA | WIPLVAPMVGGVLGSIIYLVF | | DARERI0371 | LLPPIVATVVLGISISMSA | WIPLVAPMVGGVLGSIIYLVF | | DARERI0372 | LEPVLVGAAVLVIGISMGS | WVPIIVTCVGALLGSLLYELL | | DARERI0373 | GAASISVMFPCVVFCEGGH | FVYWMGPILGMSASLLLSDKL |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| DARERI0358 | GHINPAVTFAYLIG | GAGMNPARSFAPAVLY | | DARERI0359 | GHINPAVTFAYLVG | GAGMNPARSFAPAVIT | | DARERI0360 | AHLNPAITLGLLVS | GCGINPARSFGPAVVL | | DARERI0361 | AHINPAVTVAMVAT | GASMNPARSFGPAVIM | | DARERI0362 | AHLNPAVTLGLLAS | GCGINPARTFGPAMIR | | DARERI0363 | GHFNPAVSVCVYLI | GACMNPARAFGPAVVS | | DARERI0364 | SHFNPSFTIAVFLS | GACLNPVRALGPAVLT | | DARERI0365 | GHVNPAVSLAMVVL | GYPINPARDLGPRLFT | | DARERI0366 | AHMNAAVSFTMCVF | GYAINPTRDLGPRLFT | | DARERI0367 | GHLNPAVTFALCLL | GYAVNPARDFGPRLFT | | DARERI0368 | GHINPTVTFSLCLL | GYAVNPARDLGPRIFT | | DARERI0369 | GHLNPAVSLAMVIL | GYPLNPARDLGPRLFT | | DARERI0370 | AHLNPAVSLSFCVL | GAAINPARDLGPRLFT | | DARERI0371 | AHLNPAVSLSFCVL | GAAINPARDLGPRLFT | | DARERI0372 | AHLNPAVSVSLCVL | GYAINPARDFGPRLFS | | DARERI0373 | AICNPTGALELLSR | GAVFNPALAFSIQFPC |
|
