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STRUCTURE BASED ALIGNMENT |
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A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| CAFAMI0344 | FSRAVFAEFLATLLFVFFGLGSALNW | SVLQIAMAFGLGIGTLVQALGH | | CAFAMI0345 | ASRALFAEFLATGLYVFFGVGSALPW | TVLQMAITFNLATAVAVQITWK | | CAFAMI0346 | ASRALFAEFLATGLYVFFGVGSALPW | TVLQMAITFNLATAVAVQITWK | | CAFAMI0347 | FWKAVTAEFLAMLIFVLLSLGSTINW | DMVLISLCFGLSIATMVQCFGH | | CAFAMI0348 | FWRAVVAEFLAMILFVFISIGSALGF | DNVKVSLAFGLSIATLAQSVGH | | CAFAMI0349 | SSRGVVSETLSDCASPWFSDFFILAE | LLVVNTGCSLYLEYTLAQALGP | | CAFAMI0350 | FLQPCLVELLGSALFIFIGCLSVIEN | GRLQPALAHGLALGLIIATLGN | | CAFAMI0351 | MVREFLAEFMSTYVMMVFGLGSVAHM | SYLGVNLGFGFGVTMGVHVAGN | | CAFAMI0352 | LLRQALAECLGTLILVMFGCGSVAQV | GFLTINLAFGFAVTLGILVAGQ | | CAFAMI0353 | LAKETISEFLGTFIMIVLGCGSVAQA | GIITINVGFAMAVVMAIYVTGG | | CAFAMI0354 | LVRQCLAEFLGVFVLMILTQGAVAQA | NFFTMFLAASLAVTIAIYVSGN | | CAFAMI0355 | MAHTFVLEFLATFQLCCCTHELQLLS | QEPVHPTWPLTLTYFFSLVHGL | | CAFAMI0489 | FWRAIFAEFFATLFYVFFGLGASLRW | HVLQVALAFGLALATLVQAVGH |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
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| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| CAFAMI0344 | SFLRAAFYVAAQLLGAVAGAALLHE | AGQAVTVELFLTLQLVLCIFAST | | CAFAMI0345 | SLPRAMAYVAAQLAGATLGAAVLYG | TGQAVAVELVLTLQLVLCIFAST | | CAFAMI0346 | SLPRAMAYVAAQLAGATLGAAVLYG | TGQAVAVELVLTLQLVLCIFAST | | CAFAMI0347 | SIAKSVFYVAAQCLGAIIGAGILYL | AGHGLLVELIITFQLVFTIFASC | | CAFAMI0348 | SILRAVMYIIAQCVGAIVATAILSG | SGQGLGIEIIGTLQLVLCVLATT | | CAFAMI0349 | SLLRAAFYVAAQLAGAIAGAGILYG | QGQAMVVELILTFQLALCIFSST | | CAFAMI0350 | NLVMLLPYWIAQLCGGLIGAALAKA | VVGAVVAELILTTLLALAVCMGA | | CAFAMI0351 | SWKKFPVYILGQFLGSFLAAATIYL | LWMGFLDEVIVTGILQLCLFAIT | | CAFAMI0352 | PWIKLPVYALAQTLGAFLGAGIVFG | MVNGFFDQFIGTASLIVCVLAIV | | CAFAMI0353 | KWFKFPFYVGAQFLGAFAGAATLFG | LTNAFADQVVATMFLLMIVFAIF | | CAFAMI0354 | PWAKLPIYCLVQLLSAFCASGATYA | LNNGFLDQVLGTGILIVGILAIL | | CAFAMI0355 | SPETGAIRLLAQLIGALCSRYCISA | LPKAVITEAICSFIFHSALLHFQ | | CAFAMI0489 | SLLRAFCYMAAQLLGAVAGAAVLYS | VGQATTVEIFLTLQFVLCIFATY |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
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WIFWVGPFIGAALAVLIYDFI
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| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| CAFAMI0344 | TPALSIGFSVALGHLLGIH | WVFWIGPLVGAILGSLLYNYV | | CAFAMI0345 | SPATMIGISLSLGHLIGIY | WVFWVGPLTGAVLASLIYNFI | | CAFAMI0346 | SPATMIGISLSLGHLIGIY | WVFWVGPLTGAVLASLIYNFI | | CAFAMI0347 | SVALAIGFSVAIGHLFAIN | WIYWVGPIIGAVLAGGLYEYV | | CAFAMI0348 | SGPLAIGLSVALGHLLAID | WIFWVGPFIGGALAVLIYDFI | | CAFAMI0349 | SPALSIGLSVTLGHLVGIY | WVFWVGPIVGAILAAILYFYL | | CAFAMI0350 | LAPFSIGFAVTVDILAGGA | WIYWLGPLLASLLVGLLIRLF | | CAFAMI0351 | TQALVIGVLIIVIGVSLGM | WVPVVAPLLGAYLGGIIYLVF | | CAFAMI0352 | LEAFTVGLVVLVIGTSMGF | WVPIVSPLLGSIAGVFVYQLM | | CAFAMI0353 | LEPIAIGLLIIVISSSLGL | WIPVVGPLVGAVIGGLIYVLV | | CAFAMI0354 | LEPVAVGLLILAIGLSMGA | WVPVVAPLVGATLGTATYQLL | | CAFAMI0355 | LRIHLLAALITFLVYAGGS | IVYWLAPSLGILLMILMFSFF | | CAFAMI0489 | SVALAVGFSLTLGHLFGMY | WVYWVGPIIGGGLGSLLYDFL |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| CAFAMI0344 | AHINPAVTVACLVG | GCSMNPARSLAPAVVT | | CAFAMI0345 | GHINPAVTLAFLVG | GCSMNPARSFGPAIIV | | CAFAMI0346 | GHINPAVTLAFLVG | GCSMNPARSFGPAIIV | | CAFAMI0347 | GHINPAVTVAMVCT | GASMNPARSFGPAVIM | | CAFAMI0348 | AHLNPAVTLGLLLS | GCGINPARSFGSSVIT | | CAFAMI0349 | GHINPAITLALLVG | GCSMNPARSFGPAVVM | | CAFAMI0350 | GHFNPAVSLAATLI | GACMNPARAFGPAVVA | | CAFAMI0351 | AHMNAAVTFTNCAL | GYAMNPSRDLPPRFFT | | CAFAMI0352 | AHLNPAVTFAMCFL | GYAVNPARDFGPRLFT | | CAFAMI0353 | GHINPAVSLAMCLF | GCAMNPARDLSPRLFT | | CAFAMI0354 | AHLNPAFSLAMCLL | GFPLNPARDLGPRLFT | | CAFAMI0355 | TSTNPCGVMMQMLL | GAVFNPALALSLHFTC | | CAFAMI0489 | AHVNPAVTFAFLVG | GAGMNPARSFAPAILT |
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