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STRUCTURE BASED ALIGNMENT
  A conserved positions at helix-helix interface     A Ar/R selectivity filter

Protein
Helix 1
Helix 2
1J4N
FWRAVVAEFLAMILFIFISIGSALGF
DNVKVSLAFGLSIATLAQSVGH
1FX8
LKGQCIAEFLGTGLLIFFGVGCVAAL
GQWEISVIWGLGVAMAIYLTAG
1RC2
MFRKLAAECFGTFWLVFGGCGSAVLA
GFAGVALAFGLTVLTMAFAVGH
1Z98
FWRAAIAEFIATLLFLYITVATVIGH
GLLGIAWAFGGMIFVLVYCTAG
2B60
FWRAIFAEFFATLFYVFFGLGASLRW
HVLQVALAFGLALATLVQAVGH
2F2B
LTKRCIAEFIGTFILVFFGAGSAAVT
DWVAIGLAFGFAIAASIYALGN
CAGLAB0340HVIAFFGELVGTFMFLWCAYVIANIAQLIMIALGFGFSVMFSIWCFAG
CAGLAB0341HVIAFMGELCGTFMFLWCAYVIANIAQLIMIALGFGFSVMFSIWCFVG
CAGLAB0342YLKEFLAEFLGTMMMVFFGQCIDIQVTADNVPKNWAAAVVMGYFAAGG
CAGLAB0343VLKEFLAEFMGTMVMIIFGSAVVIQVTFDDIALGWAAAVVMGYFCAGG
CAGLAB0881HVIAFMGELCGTFMFLWCAYVIANIAQLIMIALGFGFSVMFSIWCFVG
CAGLAB0887HVIAFFGELVGTFMFLWCAYVIANIAQLIMIALGFGFSVMFSIWCFAG

Protein
Helix 3
Helix 4
1J4N
SVLRAIMYIIAQCVGAIVATAILSG
SGQGLGIEIIGTLQLVLCVLATT
1FX8
DKRKVIPFIVSQVAGAFCAAALVYG
FVQAFAVEMVITAILMGLILALT
1RC2
PAKEVVGYVIAQVVGGIVAAALLYL
MLSALVVELVLSAGFLLVIHGAT
1Z98
SLLRALVYMIAQCLGAICGVGLVKA
KGTALGAEIIGTFVLVYTVFSAT
2B60
SLLRAICYVVAQLLGAVAGAAVLYS
VGQATIVEIFLTLQFVLCIFATY
2F2B
PGREVVPYIIAQLLGAAFGSFIFLQ
YWQAMLAEVVGTFLLMITIMGIA
CAGLAB0340TPMRCIVMWVAQMLGGMAAGGAASGRTRGLFLEMFGTTILCLTVLMTA
CAGLAB0341TPTRCVVMWIAQILGGMAAGGAASARTRGLFLEMFGTAILCLTVLMTA
CAGLAB0342PARKMPFYFAGQLLGGFMACLLSYITERQITSEFMCTAAMQLCVFALT
CAGLAB0343PAKKIPFYFFGQLFGAYVGGLIAYGSARQFVSEFLCGAMLVACTFALT
CAGLAB0881TPTRCVVMWIAQILGGMAAGGAASARTRGLFLEMFGTAILCLTVLMTA
CAGLAB0887TPMRCIVMWVAQMLGGMAAGGAASGRTRGLFLEMFGTTILCLTVLMTA

Protein
Helix 5
Helix 6
1J4N
SGPLAIGFSVALGHLLAID
WIFWVGPFIGAALAVLIYDFI
1FX8
LAPLLIGLLIAVIGASMGP
LVPLFGPIVGAIVGAFAYRKL
1RC2
FAPIAIGLALTLIHLISIP
WFFWVVPIVGGIIGGLIYRTL
1Z98
LAPLPIGFAVFMVHLATIP
WIFWVGPFIGAAVAAAYHQYV
2B60
SVALAVGFSLTLGHLFGMY
WVYWVGPVIGAGLGSLLYDFL
2F2B
FAGIIIGLTVAGIITTLGN
SIYVIGPIVGAVLAALTYQYL
CAGLAB0340MCALPIGISLFIGHLALTGWIYWIGPLLGAILAWFVWQVL
CAGLAB0341MCALPIGISLFIGHLALTAWIYWIGPLLGAILAWFVWQVL
CAGLAB0342IFPLLLFLMALVVNSSMSFWVPMIVPFWGSMTGALLYDFC
CAGLAB0343VFPLMLFLLIFMCNSGLGYWVPICAPFIGALTGGLVYDIF
CAGLAB0881MCALPIGISLFIGHLALTAWIYWIGPLLGAILAWFVWQVL
CAGLAB0887MCALPIGISLFIGHLALTGWIYWIGPLLGAILAWFVWQVL

Protein
Loop B
Loop E
1J4N
AHLNPAVTLGLLLS
GCGINPARSFGSSVIT
1FX8
AHLNPAVTIALWLF
GFAMNPARDFGPKVFA
1RC2
GHFNPAVTIGLWAG
NTSVNPARSTAVAI-F
1Z98
GHINPAVTFGLFLA
GTGINPARSFGAAVIF
2B60
AHVNPAVTFAFLVG
GAGMNPARSFAPAILT
2F2B
CHINPAVTIGLWSV
GSSLNPARTFGPYLND
CAGLAB0340GALNPAVSLSLALSGTGVNPARSFGAALAA
CAGLAB0341GALNPAVSLSLALAGTGVNPARSFGAALAK
CAGLAB0342AHLNPAATVTTFFFGSAMNAARDLGPRLAL
CAGLAB0343GHLNPIITLANFVYGTAMNMARDLGPRMAL
CAGLAB0881GALNPAVSLSLALAGTGVNPARSFGAALAK
CAGLAB0887GALNPAVSLSLALSGTGVNPARSFGAALAA
 
 
Last Updated: Monday, April 7, 2025
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Bioinformatics and Biomolecular Simulation Laboratory, Department of Biological Sciences and Bioengineering,
Indian Institute of Technology, Kanpur, INDIA-208016
Copyright (c) 2007 All rights reserved, IIT Kanpur