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STRUCTURE BASED ALIGNMENT |
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A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| CAGLAB0340 | HVIAFFGELVGTFMFLWCAYVIANIA | QLIMIALGFGFSVMFSIWCFAG | | CAGLAB0341 | HVIAFMGELCGTFMFLWCAYVIANIA | QLIMIALGFGFSVMFSIWCFVG | | CAGLAB0342 | YLKEFLAEFLGTMMMVFFGQCIDIQV | TADNVPKNWAAAVVMGYFAAGG | | CAGLAB0343 | VLKEFLAEFMGTMVMIIFGSAVVIQV | TFDDIALGWAAAVVMGYFCAGG | | CAGLAB0881 | HVIAFMGELCGTFMFLWCAYVIANIA | QLIMIALGFGFSVMFSIWCFVG | | CAGLAB0887 | HVIAFFGELVGTFMFLWCAYVIANIA | QLIMIALGFGFSVMFSIWCFAG |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
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| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| CAGLAB0340 | TPMRCIVMWVAQMLGGMAAGGAASG | RTRGLFLEMFGTTILCLTVLMTA | | CAGLAB0341 | TPTRCVVMWIAQILGGMAAGGAASA | RTRGLFLEMFGTAILCLTVLMTA | | CAGLAB0342 | PARKMPFYFAGQLLGGFMACLLSYI | TERQITSEFMCTAAMQLCVFALT | | CAGLAB0343 | PAKKIPFYFFGQLFGAYVGGLIAYG | SARQFVSEFLCGAMLVACTFALT | | CAGLAB0881 | TPTRCVVMWIAQILGGMAAGGAASA | RTRGLFLEMFGTAILCLTVLMTA | | CAGLAB0887 | TPMRCIVMWVAQMLGGMAAGGAASG | RTRGLFLEMFGTTILCLTVLMTA |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
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WIFWVGPFIGAALAVLIYDFI
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| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| CAGLAB0340 | MCALPIGISLFIGHLALTG | WIYWIGPLLGAILAWFVWQVL | | CAGLAB0341 | MCALPIGISLFIGHLALTA | WIYWIGPLLGAILAWFVWQVL | | CAGLAB0342 | IFPLLLFLMALVVNSSMSF | WVPMIVPFWGSMTGALLYDFC | | CAGLAB0343 | VFPLMLFLLIFMCNSGLGY | WVPICAPFIGALTGGLVYDIF | | CAGLAB0881 | MCALPIGISLFIGHLALTA | WIYWIGPLLGAILAWFVWQVL | | CAGLAB0887 | MCALPIGISLFIGHLALTG | WIYWIGPLLGAILAWFVWQVL |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| CAGLAB0340 | GALNPAVSLSLALS | GTGVNPARSFGAALAA | | CAGLAB0341 | GALNPAVSLSLALA | GTGVNPARSFGAALAK | | CAGLAB0342 | AHLNPAATVTTFFF | GSAMNAARDLGPRLAL | | CAGLAB0343 | GHLNPIITLANFVY | GTAMNMARDLGPRMAL | | CAGLAB0881 | GALNPAVSLSLALA | GTGVNPARSFGAALAK | | CAGLAB0887 | GALNPAVSLSLALS | GTGVNPARSFGAALAA |
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