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STRUCTURE BASED ALIGNMENT |
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A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| CAELEG0328 | IYSKCAAEFIAVLLFVYIGSMQAAGV | GVLHAAFAHGVAIFVLAATFGG | | CAELEG0329 | LLTKCVAEFLGDLTFVYVGTMQASLF | GILHAAFAHGFTIFILVTAFGH | | CAELEG0330 | LLRAVLAEFTGTYLLCLIGLSVVAQK | EFIGVNVGFGIAIVFGVAVSAK | | CAELEG0331 | LLRAVLAEFTGTYLLCLIGLSVVAQK | EFIGVNVGFGIAIVFGVAVSAK | | CAELEG0332 | LIRAFLAELFCTGFLVFGGECVNAQY | EWIGISVGWGLVLMLAVLMGSK | | CAELEG0333 | LLRNALSEFFGTFLLLFIGIGIVMQF | TWININLGWGLAIAFTVYTCSK | | CAELEG0334 | LISRCYAEFLGTFIFIFSGTMQANVY | GLTHAALTHGLATIVVIAVFGK | | CAELEG0335 | LARNLIAEFFGTFLLCFIGLSIVFQF | EWIGVNIGWGFAIMFAVMATAR | | CAELEG0336 | FTRELLAECIGTFFLLLIGNAANIQA | NSTSCHIAWGIGFMFAVYLAAS | | CAELEG0337 | FYGSVFAIFYGTLQICVPMFDVGTIL | NYGLLGVFVEITVIELANCYFQ | | CAELEG0338 | NSQLFLYELIGTIQMCTCVYENGI-- | FKNYGFPAIFICVALLLTAGNI |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
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| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| CAELEG0328 | SPIHAVCYVVSQLLGSVFGALLVRI | WQEGLTAEIVTTYILVQTVLLCA | | CAELEG0329 | PIFHLPFYVVSQLLGGICGAFLTAA | WWQGLIAETVVTFFLVHTILITA | | CAELEG0330 | TIVQFIAYFVAQFFGAFFGAATVYA | LVNGFVDQFVATAVFVFLIAHIV | | CAELEG0331 | TIVQFIAYFVAQFFGAFFGAATVYA | LVNGFVDQFVATAVFVFLIAHIV | | CAELEG0332 | NLIRFLVYAVAQNIGAFLGAFGVFC | TFNAIVDQIAGTLVLCLGVAAIT | | CAELEG0333 | PFKDFLVYCVVQTIGAALGSAAAFG | NTTAFFDQFAGTALLVLFVCVVI | | CAELEG0334 | HPFELPFYMFSQFFGGFAGNLLSAC | WWEGLISETITTYFFVTVILMNV | | CAELEG0335 | KLAWVPLYAIAQTAGAFVASLGMYS | VWGPYIDQCVGTGVLAYFLCVVI | | CAELEG0336 | PPWKIIPYAIAQVIGAFLGAAVAYF | VWGSLLDQIIGTAMLSGLVCLIT | | CAELEG0337 | AIRRGIYVFLVQLAAAYLSYFVARL | ITTGCIIEGVATFVAKWFEKYVD | | CAELEG0338 | GSSKFLTILSAQLIGATFASKFAYL | AGIVIGFEIVGAFVVRIVVAQLL |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
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WIFWVGPFIGAALAVLIYDFI
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| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| CAELEG0328 | LAPLAIGFSLIIEILAAGA | WIYYIGPIIGAFIAAGVYRMF | | CAELEG0329 | LAPLAIGLTLSIDILSTGS | YIYWAGPLLGSTIALCIYKLF | | CAELEG0330 | LQPILVGTGFVAIGAAFGY | WVPIVGPFVGAVVGIWLYYFL | | CAELEG0331 | LQPILVGTGFVAIGAAFGY | WVPIVGPFVGAVVGIWLYYFL | | CAELEG0332 | LQPAWIGALLAFLGMSLAL | WIPIICPMIGGVLGAWLYEFF | | CAELEG0333 | AHPLLFGLVVMMIGTAYGM | WIPVIAPLFGAIFGAWSYTFF | | CAELEG0334 | ATPFIIGMMVIVNIFATAS | YIYWAGPYLGSTIAVIGFKLL | | CAELEG0335 | WHPMFFGFLVMMIGTGFGM | LAPAIAPFVGALVGGWFYHFS | | CAELEG0336 | VVPVLAGSIMSMVAMTFGA | WIPIVGALIGSIIGAWIYKIF | | CAELEG0337 | LCSIANCLFSGLLCAIGIN | FVYWLSPLIAWYFAEIVFGSE | | CAELEG0338 | LIPFAISAYLSLALYVVG- | ILYWFCPVLGWLTGAYVVGQK |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| CAELEG0328 | AHINPAVTFGIALV | GASMNPARSFGPNIMG | | CAELEG0329 | GHFNPAVSWAIAGA | GASMNPARSLGPSIIG | | CAELEG0330 | GHINPAVSFAFLSV | GYPVNPARDFAPRLFT | | CAELEG0331 | GHINPAVSFAFLSV | GYPVNPARDFAPRLFT | | CAELEG0332 | AHLNPAVSFFQLTQ | GYAINPARDFAPRLFN | | CAELEG0333 | GHFNPAVSIAFLTL | GYPINPARDLGPRLFS | | CAELEG0334 | GHFNPVVSWAMVLC | GTAMNPVRALSPNIVG | | CAELEG0335 | GHLNPAVSLLLWSL | GYPINPARDLGPRLFS | | CAELEG0336 | GHLNPAISVAQSIL | GFAINPARDFGPRVFC | | CAELEG0337 | AHPCPLVTNCYRKS | GMYANPIVAWACTFNC | | CAELEG0338 | AMTNCAPIFEQFVF | VPGLNPIVATARLYGC |
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