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STRUCTURE BASED ALIGNMENT |
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A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| CABRIG0320 | IYSKCAAEFIAVLLFVYIGSMQAAGG | GVLHAAFAHGVAIFVLAATFGG | | CABRIG0321 | LVRAALAEFTGTFLLCLIGLSVVAQK | EFIGVNVGFGIAIVFGVAVSAK | | CABRIG0322 | LLTKCVAEFLGDLTFVYVGTMQAHLF | DILHAAFAHGLTIFILATAFGH | | CABRIG0323 | LIRAFIAELFCTAFLVFGGECVNAQY | EWIGVSVGWGIALMLAVLMGSK | | CABRIG0324 | LLRNALSEFFGTFMLLFIGIGIVMQF | TWININLGWGLAIAFCVYLCSK | | CABRIG0325 | LISRCYAEFLGTFIFIFSGTMQANVY | GLSHAALTHGFATIVVIAVFGK | | CABRIG0326 | LWRNLISEFFGTFLLCFIGLSIVFQF | EWIGVNIGWGFAIMFAVMATAR | | CABRIG0327 | NAQLFLYELIGTIQMCTCVYENGII- | KNYGFPAIFLCVGLLLTAGGIF |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
|
| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| CABRIG0320 | SPIHAVCYIASQLLGSVFGALLVRI | WQEGLTAEIVTTYILVQTVLLCA | | CABRIG0321 | TVVQFIAYFFAQFLGAFFGAAVVYA | LLNGFVDQFVATAVFVFLIAHIV | | CABRIG0322 | PIWHLPFYVVSQLFGGFCGAMLTAS | WWQGLIAETVVTFFLVHTILITA | | CABRIG0323 | NVIRFLVYVVAQNIGAFIGAFGVFC | TFNAIVDQIAGTLVLCLGVAAIT | | CABRIG0324 | PLKDFLVYCVVQTIGAALGSLAAFG | NTTCFFDQFAGTAILVLFVCVII | | CABRIG0325 | PPLALPFYMASQFFGGFCGNLLSAC | WWEGLMSETITTYFFVTVILMLV | | CABRIG0326 | KLAWVPLYAIAQTAGAFVASLAMYS | VWGPYIDQCVGTGVLAYFLCVVI | | CABRIG0327 | GSSKFVTILSAQLIGAAFASKVAYL | AGIVIGFEIIGAFVVRVVVSLLL |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
|
WIFWVGPFIGAALAVLIYDFI
|
| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| CABRIG0320 | LAPLAIGFSLIIEILAAGA | WIYYVGPVIGAFIAAGVYRLF | | CABRIG0321 | LQPILVGTGFVAIGAAFGY | WVPIVGPFVGAVVGIWFYYFL | | CABRIG0322 | LAPLAIGLTLSIDILSTGS | YIYWAGPLLGSTIALCIYKLF | | CABRIG0323 | LQPAWIAGLLSFLGMSMAL | WIPIICPMIGGVLGAWIYEFF | | CABRIG0324 | AHPLLFGLVVMMIGTAYGM | WIPVIAPLFGAVAGAWSYTFF | | CABRIG0325 | ATPLYLGLMVIVNIFATAS | YIYWAGPYLGSTIAVLGYKLL | | CABRIG0326 | WHPMFFGFLVMMIGTGFGM | IAPALAPFVGALVGGWFYHLS | | CABRIG0327 | LIPFAISAYLTLALYIVG- | FVGQKGPVKKTAKEVKAAKKE |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| CABRIG0320 | AHINPAVTFGIALV | GASMNPARSFGPNIMG | | CABRIG0321 | GHINPAVSLAFLTV | GYPVNPARDLAPRLFT | | CABRIG0322 | FFSGGHFNPAVSWA | GASMNPARSLGPSIVG | | CABRIG0323 | AHLNPAVSFFQLTQ | GYAINPARDFAPRLFS | | CABRIG0324 | GHFNPAVSIAFLTL | GYPINPARDLGPRIVT | | CABRIG0325 | AHLNPVVSWAMVLC | GTAMNPVRALSPNVVA | | CABRIG0326 | GHLNPAVSLLLWSL | GYPINPARDLGPRLFS | | CABRIG0327 | AWTNCAPIFEQFIF | VPGLNPIVATARLYGC |
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