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STRUCTURE BASED ALIGNMENT |
| |
A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| BOTAUR0312 | FWRAICAEFFASLFYVFFGLGASLRW | HVLQVALAFGLALATLVQAVGH | | BOTAUR0313 | FLKAVFAEFLATLIFVFFGLGSALKW | SVLQISLAFGLAIGTMAQALGP | | BOTAUR0314 | ISRALFAEFLATGLYVFFGVGSALRW | SVLQIAITFNLATAVIVQITWK | | BOTAUR0315 | FWKAVTAEFLAMLIFVLLSLGSTINW | DMVLISLCFGLSIATMVQCFGH | | BOTAUR0316 | FWRAVVAEFLAMILFIFISIGSALGF | DNVKVSLAFGLSIATLAQSVGH | | BOTAUR0317 | LAKETLSEFLGTFIMIVLGCGSVAQA | GIITINTGFSMAVAMAIYVSAG | | BOTAUR0318 | NVREFLAEFISTYVMMVFGLGAVADM | SYLAVNLGFGFGVTIGVHMAGN | | BOTAUR0319 | LLRQALAECLGTLILVMFGCGSVAQV | GFLTINLAFGFAVTLGILIAGQ | | BOTAUR0487 | FSRAVLAEFLATLLFVFFGLGSALNW | SVLQIAMAFGLAIGTLVQALGH | | BOTAUR0488 | MAHAFVLEFLATFQLCFCTHELQLLS | ~PLHPTWPLTLIYFFSMVHGLT |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
|
| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| BOTAUR0312 | SLLRAICYMVAQLLGAVAGAAVLYS | VGQATIVEIFLTLQFVLCIFATY | | BOTAUR0313 | SLLRAVFYVVAQLVGAIAGAAILYG | AGQAVVAEMILTFQLALCVFSST | | BOTAUR0314 | SLPRAVAYVAAQLAGATAGAALLYG | TGQAVAVELILTLQLVLCVFAST | | BOTAUR0315 | SIAKSVFYIAAQCLGAIIGAGILYL | AGHGLLVELIITFQLVFTIFASC | | BOTAUR0316 | SVLRAIMYIIAQCVGAIVATAILSG | SGQGLGIEIIGTLQLVLCVLATT | | BOTAUR0317 | KWFKFPFYVGAQFLGAFAGAATLFG | LVNAFAEQVVATMFLLIVIFAIF | | BOTAUR0318 | SWKKFPVYVLGQFLGSFVAAATIYG | LWRGFLDEVVVTGMLQLCLLAIA | | BOTAUR0319 | PWIKLPVYTLAQTLGAFLGAGIIFG | MVNGFFDQFIGTASLIVCVLAIV | | BOTAUR0487 | SFLRAVFYVAAQLLGAVAGAALLHE | AGQAVTVELFLTLQLVLCIFAST | | BOTAUR0488 | SAETGAIRLLAQLIGALCSRYCMSA | LPKAVIIEAVCSFIFHSALLHFQ |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
|
WIFWVGPFIGAALAVLIYDFI
|
| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| BOTAUR0312 | SVALAVGFSLTLGHLFGMY | WVYWVGPVIGAGLGSLLYDFL | | BOTAUR0313 | SPALSIGLSVTLGHLVGIY | WVFWVGPIVGAAVAAIIYFYL | | BOTAUR0314 | SPAATIGASVAVGHLIGIY | WIFWVGPLTGAVLASLIYNFI | | BOTAUR0315 | SIALAIGISVAIGHLFAIN | WIYWVGPIIGAVLAGGLYEYV | | BOTAUR0316 | SGPLAIGFSVALGHLLAID | WIFWVGPFIGAALAVLIYDFI | | BOTAUR0317 | LEPVVIGFLIVTIASSLGM | WIPVVGPLVGAAAGGLVYFLL | | BOTAUR0318 | TQAIVTGILVVIIGISLGM | WVPVVAPPLGAYCGAIIYLFF | | BOTAUR0319 | LEAFTVGLVVLVIGTSMGF | WVPIVSPLLGSIAGVFVYQLM | | BOTAUR0487 | TPALSIGFSVALGHLLGIH | WVFWIGPLVGAIVASLLYNYV | | BOTAUR0488 | LRIHLLSALITFLVYAGGS | IVYWLSPSLGILLMIVMFNFF |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| BOTAUR0312 | AHVNPAVTFAFLVG | GAGMNPARSFAPAILT | | BOTAUR0313 | GHMNPAITLALLVG | GCSMNPARSFGPSVIM | | BOTAUR0314 | AHVNPAVTLAFLVG | GCSMNPARSFGSAVIV | | BOTAUR0315 | GHINPAVTVAMVCT | GASMNPARSFGPAVIM | | BOTAUR0316 | AHLNPAVTLGLLLS | GCGINPARSFGSSVIT | | BOTAUR0317 | GHINPAVSFALCLF | GCAMNPARDLSPRLFT | | BOTAUR0318 | AHMNAALTFTSCAL | GYAINPSRDLPPRFFT | | BOTAUR0319 | AHLNPAVTFAMCFL | GYAVNPARDFGPRLFT | | BOTAUR0487 | AHINPAVTVACLVG | GCSMNPARSLAPAIVT | | BOTAUR0488 | TSSNPCGVMMQIML | GAVFNPTLALSLHFKC |
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