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STRUCTURE BASED ALIGNMENT |
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A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| ASNIDU0842 | HHREALAESLAVFIQLTVGLAADLSV | NPNTTAWAWGFAAMMAIYISGG | | ASNIDU0857 | YCREAFSEFFGTLILVLFGNGVVAQV | DYQSISWGWGLGVMLGVYVSG- | | ASNIDU0872 | NLIAMTGEFVGTFLFLFFSFAGTQVA | ALLYSALAFGFSLMVNIWAFYR | | ASNIDU0884 | DLKPYAAEFLGTGLIIVIGDGVVAQA | TWLSINLAWAAAVCLSGYLA-- | | ASNIDU1049 | YCREAFSEFFGTLILVLFGNGVVAQV | DYQSISWGWGLGVMLGVYVSG~ |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
|
| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| ASNIDU0842 | PKRKMPEYFAAQFIGAFVAALAVYG | PQTAFFNEFLGTVVLTVTVLALG | | ASNIDU0857 | PWRKWPVYAISQLLGGMSAAAIVYG | RTGQFFSEFVASSILMFVIFALI | | ASNIDU0872 | PAYRGLFVFAAQIVGGIAAAGVVSA | ISQGLFIEMFLTAQLVFVIIMLA | | ASNIDU0884 | QWKKIPGKLLAQFLGGFVGALLVYI | NWEAAFNEVLGAAVLMFGVLSVS | | ASNIDU1049 | PWRKWPVYAISQLLGGMSAAAIVYG | RTGQFFSEFVASSILMFVIFALI |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
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WIFWVGPFIGAALAVLIYDFI
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| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| ASNIDU0842 | MNALVVGLMVYTLSITFSY | YGPWAGSFCGAFIGAFLYDFM | | ASNIDU0857 | FMPLGMFFTIFGIGACFGW | QRYQLWPPSSGGSVAWSDRTL | | ASNIDU0872 | LAPVAIGIAFFVTEMIGDY | WIYWVGPLLGSLLACGFYYFL | | ASNIDU0884 | SPQLSMFLLLVAIGAALGW | VVPLFAPFIGCFVGASVYDSF | | ASNIDU1049 | FMPLGMFFTIFGIGACFGW | WVPVVAPFFGCTFGGWLYDMF |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| ASNIDU0842 | AHLNPTITCMLWFY | GAALNPSRDFGPRLAL | | ASNIDU0857 | SHLNPAVTFAMCVL | GYAINLARDFGPRLVS | | ASNIDU0872 | LLFNPAVTLALCLV | GGSLNPARSLGPDVIN | | ASNIDU0884 | PACNPAISIIMALI | GYAINPARDFGPRLFS | | ASNIDU1049 | SHLNPAVTFAMCVL | GYAINLARDFGPRLVS |
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