|
STRUCTURE BASED ALIGNMENT |
| |
A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| ASFLAV0894 | RLREPFAEWLGTTVAMLIGLCATLAI | NKLTLYWAWGLAITVGIYIAGG | | ASFLAV0900 | YIRDGASEFFGTMILVLFGDGVVAQV | DYQSISWGWGLGVMLGVYASG- | | ASFLAV0908 | HHREALAESLAVFVQLTIGFCADISV | NPNTTAWAWGFATMIAIYVSGG | | ASFLAV0928 | NVIAVIGEFVGTFLFLFFSFAGTQVS | NLLYSALSFGFSLMVNVWAFYR | | ASFLAV0935 | TFVAVVGEFVGTFMFLFFAFAGGQVS | NLLYLSLSFGFSLLVNVWTFYR | | ASFLAV0938 | VLKPYAAEFLGTALLIVLGDGVVAQC | YGTWLSINMSWAAAVCISGYLA | | ASFLAV0957 | LWKFACLECIASMMNVFISAWVTLHE | SPLFGGLTNLLLTPLLIYTFAP |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
|
| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| ASFLAV0894 | PGRRCIYYVIAQILGALTAGGLAYC | NVTAFFNEFVAAAILICTIFAMG | | ASFLAV0900 | PWRKFPIYLVAQVLGAMCGAAIVYG | QTGQFFSEFIASAILMFMIFALK | | ASFLAV0908 | PKRKMPEYFLAQFVGAFVAALTAYG | PATAFFTEFLGTALTATTILALG | | ASFLAV0928 | SPIRGVLVFAAQIVAGIASAGVVSA | ISQGLFIEMFLTAQLVFVIIMLA | | ASFLAV0935 | PV-RGVLVFASQIIAGIASAGVVSC | ISQGLFIEMFLTAHLVFVVIMLA | | ASFLAV0938 | QWKKLPGKLFAQFLGGFVGAALVYI | NWEAAFNEVLGSAVLMFGGLTIS | | ASFLAV0957 | TFPRAILYMAGQTLGGALAGFAIHT | VNAALIIEFFACLVLIFLAFGVA |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
|
WIFWVGPFIGAALAVLIYDFI
|
| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| ASFLAV0894 | MHSFIIGLLIFVLAIGFGY | WGAWLATISGALVGGAMYDIF | | ASFLAV0900 | LTPLALFFVVFGIGACFGW | WVPIIAPFLGCTFGGWIYDMF | | ASFLAV0908 | MNSLIVGLMVFVLSNTFSY | YGPWAGSLCGAMIGAFLYDFM | | ASFLAV0928 | LAPVGIGLVFFVTEMIGDY | WIYWVGPLLGSLLACGFFGLL | | ASFLAV0935 | LAPVGIGLVLFVNQLVGTY | WIYWVGPLLGSLLASGFYGFL | | ASFLAV0938 | SPQLSSFLLLLAIGASLGW | VVPLFAPIIGCIVGAATYDSL | | ASFLAV0957 | LVGVVLGVVCWATAFTRPG | WVHWVAPLAAAVAHGLVYLID |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| ASFLAV0894 | GHLNPAISISLWIY | GGCFNPARDLGPRLVA | | ASFLAV0900 | SHINPAVTLASCIL | GYAINLARDFGPRLLT | | ASFLAV0908 | AHLNPSVTIMLWFY | GAAFNPSRDFGPRLAL | | ASFLAV0928 | GLFNPAVTLALCLV | GGSLNPARSLGPDVIN | | ASFLAV0935 | GLFNPVVTLALCLC | GCALNPARALGPDVIN | | ASFLAV0938 | PTINPAVTICTALI | GYAINPARDFGPRLFS | | ASFLAV0957 | GHISPTITLATLFA | GASLNPARCFGVYVAS |
|
