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STRUCTURE BASED ALIGNMENT |
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A conserved positions at helix-helix interface A
Ar/R selectivity filter
| Protein |
Helix 1 |
Helix 2 |
| 1J4N |
FWRAVVAEFLAMILFIFISIGSALGF |
DNVKVSLAFGLSIATLAQSVGH |
| 1FX8 |
LKGQCIAEFLGTGLLIFFGVGCVAAL |
GQWEISVIWGLGVAMAIYLTAG |
| 1RC2 |
MFRKLAAECFGTFWLVFGGCGSAVLA |
GFAGVALAFGLTVLTMAFAVGH |
| 1Z98 |
FWRAAIAEFIATLLFLYITVATVIGH |
GLLGIAWAFGGMIFVLVYCTAG |
| 2B60 |
FWRAIFAEFFATLFYVFFGLGASLRW |
HVLQVALAFGLALATLVQAVGH |
| 2F2B |
LTKRCIAEFIGTFILVFFGAGSAAVT |
DWVAIGLAFGFAIAASIYALGN |
| APMELL0297 | IFTIALSETIGTAILVFIGCAGCIGS | SVLQISLTFGLAVLIAIQSIGH | | APMELL0298 | LWRAVAVECFATFLFSLIVSGAAASS | SVLATAVASGFAISAICFIFGH | | APMELL0299 | TVLTALAEMIGTSMLVFLGCMGCVGS | SHFQIALTFGLAVMIVIQSLGH | | APMELL0300 | FVRSLFLEAIATGELCGACFELIIIA | DNWGVSMYGVYLFVLTIWWSLN | | APMELL0301 | FVRSLFLEAIATGELCGACFELIIIA | DNWGVSMYGVYLFVLTIWWSLN | | APMELL0302 | LYRALVAEFLGTLLLNFFGCGSVITG | NVVAISLAFGLAVATAIQGVGH | | APMELL0303 | ~--MLLAETLGTFLLVLIGCASCITW | TVVHIAFTFGLAVASLAHVLGP |
| Protein |
Helix 3 |
Helix 4 |
| 1J4N |
SVLRAIMYIIAQCVGAIVATAILSG |
SGQGLGIEIIGTLQLVLCVLATT
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| 1FX8 |
DKRKVIPFIVSQVAGAFCAAALVYG |
FVQAFAVEMVITAILMGLILALT |
| 1RC2 |
PAKEVVGYVIAQVVGGIVAAALLYL |
MLSALVVELVLSAGFLLVIHGAT |
| 1Z98 |
SLLRALVYMIAQCLGAICGVGLVKA |
KGTALGAEIIGTFVLVYTVFSAT |
| 2B60 |
SLLRAICYVVAQLLGAVAGAAVLYS |
VGQATIVEIFLTLQFVLCIFATY |
| 2F2B |
PGREVVPYIIAQLLGAAFGSFIFLQ |
YWQAMLAEVVGTFLLMITIMGIA |
| APMELL0297 | SLSMSILYIIAQCIGGVLGYGLLKV | IFQGIMAEFLATLVLVLFACGLW | | APMELL0298 | SFLRAALYIAAQCGGGIAGAAMLYG | PIERLLVELTLSVLIVLAHFTSE | | APMELL0299 | TIPEGLVYLLSQVVGGVLGFGMLKV | AIQGLLLEGISTAVLMLVACAVW | | APMELL0300 | SVRDAFLLIWAELVGGLAVFRYIQL | VIFGAFIECVATCIYRVVSRGLN | | APMELL0301 | SVRDAFLLIWAELVGGLAVFRYIQL | VIFGAFIECVATCIYRVVSRGLN | | APMELL0302 | PVIRGLLYVILQCIGAIAGSGILRA | PVQGFGIEFFLAFVLVLVVCGAC | | APMELL0303 | SFLKTVCYIVCQCCGAIAGSGVLKL | ESQGIFMEAIITFLLLLVVHAVT |
| Protein |
Helix 5 |
Helix 6 |
| 1J4N |
SGPLAIGFSVALGHLLAID
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WIFWVGPFIGAALAVLIYDFI
|
| 1FX8 |
LAPLLIGLLIAVIGASMGP |
LVPLFGPIVGAIVGAFAYRKL |
| 1RC2 |
FAPIAIGLALTLIHLISIP |
WFFWVVPIVGGIIGGLIYRTL |
| 1Z98 |
LAPLPIGFAVFMVHLATIP |
WIFWVGPFIGAAVAAAYHQYV |
| 2B60 |
SVALAVGFSLTLGHLFGMY |
WVYWVGPVIGAGLGSLLYDFL |
| 2F2B |
FAGIIIGLTVAGIITTLGN |
SIYVIGPIVGAVLAALTYQYL |
| APMELL0297 | SVPIRFGFCITVLCLIFIP | WVYWLGPICGAIVASMIYRYI | | APMELL0298 | ISSKPAGVLAAAYTAATL- | WVYWVGPLSGSAVAALLHEYV | | APMELL0299 | SVPIRFGLTVAALALAVGP | WIYWFGPIGGALLSSFTYKTI | | APMELL0300 | SFIGTTLVIAGLIMISAFD | IVYWVGACAGSIASLRVYKSP | | APMELL0301 | TTLVIAGFCFIFILISAFD | IVYWVGACAGSIASLRVYKSP | | APMELL0302 | IAPLIIGLSVSVGHIIGVP | WLYWIGPILGGMAAGLIYAFV | | APMELL0303 | WAPLAIGLTITVSHMAAVP | WVYWIGPIIGACAAGVLYKMA |
| Protein |
Loop B |
Loop E |
| 1J4N |
AHLNPAVTLGLLLS |
GCGINPARSFGSSVIT |
| 1FX8 |
AHLNPAVTIALWLF |
GFAMNPARDFGPKVFA |
| 1RC2 |
GHFNPAVTIGLWAG |
NTSVNPARSTAVAI-F |
| 1Z98 |
GHINPAVTFGLFLA |
GTGINPARSFGAAVIF |
| 2B60 |
AHVNPAVTFAFLVG |
GAGMNPARSFAPAILT |
| 2F2B |
CHINPAVTIGLWSV |
GSSLNPARTFGPYLND |
| APMELL0297 | AHINPSITVAALIL | GCSLNPARTLGPAIWN | | APMELL0298 | SHVNPAVSVSFALC | SPFLNPARALGPAFVS | | APMELL0299 | AHINPAITVGSVVL | GCSMNPARSLAPALWN | | APMELL0300 | ATACPYTHIEEVVE | GGYFNPALATSLKYGC | | APMELL0301 | ATACPYTHIEEVVE | GGYFNPALATSLKYGC | | APMELL0302 | GHVNPAVTFGLMVI | GAGMNPARSFGSAVVM | | APMELL0303 | CHVNPAVSVGLLVS | GSSMNPARTLGPAVIL |
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